Oleic acid_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.111847
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0942814
FNDC3B fibronectin type III domain containing 3B 0.0934138
CXCL8 chemokine (C-X-C motif) ligand 8 0.0928596
SOD2 superoxide dismutase 2, mitochondrial 0.0920705
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0840337
SMAD3 SMAD family member 3 0.0820919
CD44 CD44 molecule (Indian blood group) 0.0818025
SDK1 sidekick cell adhesion molecule 1 0.0790541
EFNA5 ephrin-A5 0.0784868
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0776994
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.073459
EEF2 eukaryotic translation elongation factor 2 0.0727823
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0707716
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0699622
NAV2 neuron navigator 2 0.0633442
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0592586
TGM2 transglutaminase 2 0.0579038
LOXL2 lysyl oxidase-like 2 0.0551608
FAM20C family with sequence similarity 20, member C 0.0542586
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0503719
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0489905
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0484965
VEGFA vascular endothelial growth factor A 0.0472835
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.046694
DOCK5 dedicator of cytokinesis 5 0.0456253
GRB10 growth factor receptor-bound protein 10 0.0442594
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0434771
STC1 stanniocalcin 1 0.0434108
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0430622
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0427295
AADAC arylacetamide deacetylase 0.0426812
LOX lysyl oxidase 0.0422836
SEPTIN9 septin 9 0.0422464
ATXN1 ataxin 1 0.040788
EREG epiregulin 0.0406705
ZSWIM6 zinc finger, SWIM-type containing 6 0.0405914
FAM107B family with sequence similarity 107, member B 0.0405044
MYO10 myosin X 0.0400329
EGFR epidermal growth factor receptor 0.0393451
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0390823
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0384036
BIRC3 baculoviral IAP repeat containing 3 0.0383696
GREB1L growth regulation by estrogen in breast cancer-like 0.0374476
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0371585
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0370715
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0356894
HIPK2 homeodomain interacting protein kinase 2 0.0356855
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0351259
PCBP2 poly(rC) binding protein 2 0.034849
NPAS2 neuronal PAS domain protein 2 0.0347814
RUNX1 runt-related transcription factor 1 0.0342124
APLP2 amyloid beta (A4) precursor-like protein 2 0.0338999
MACF1 microtubule-actin crosslinking factor 1 0.033789
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.03364
SFTPA2 surfactant protein A2 0.0333421
PDLIM5 PDZ and LIM domain 5 0.032962
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0326377
SHB Src homology 2 domain containing adaptor protein B 0.0314529
NFE2L2 nuclear factor, erythroid 2-like 2 0.0308568
MSRB3 methionine sulfoxide reductase B3 0.0307514
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0306069
GATA6 GATA binding protein 6 0.0298138
EXT1 exostosin glycosyltransferase 1 0.0296242
ECE1 endothelin converting enzyme 1 0.0295878
RAD51B RAD51 paralog B 0.0295612
HMGA2 high mobility group AT-hook 2 0.0294657
FTH1 ferritin, heavy polypeptide 1 0.0294305
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0291037
MEF2A myocyte enhancer factor 2A 0.029003
GPATCH2L G patch domain containing 2-like 0.0286104
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0285526
CA12 carbonic anhydrase XII 0.0281934
LIMCH1 LIM and calponin homology domains 1 0.028125
LOC102724023 ES1 protein homolog, mitochondrial 0.0271642
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0267827
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0266753
INTS6 integrator complex subunit 6 0.0266753
SIK3 SIK family kinase 3 0.0263424
PLEC plectin 0.0262723
MAML3 mastermind-like 3 (Drosophila) 0.0261972
NDRG1 N-myc downstream regulated 1 0.0260352
PDGFA platelet-derived growth factor alpha polypeptide 0.0260142
TRIO trio Rho guanine nucleotide exchange factor 0.0257898
ERRFI1 ERBB receptor feedback inhibitor 1 0.0257387
ASPH aspartate beta-hydroxylase 0.0252963
GLS2 glutaminase 2 (liver, mitochondrial) 0.0244847
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0244624
ANTXR2 anthrax toxin receptor 2 0.0243955
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0241866
WLS wntless Wnt ligand secretion mediator 0.0241178
IGFBP3 insulin-like growth factor binding protein 3 0.0239898
BACE2 beta-site APP-cleaving enzyme 2 0.0238214
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0236485
IL1B interleukin 1, beta 0.0235678
PRKCA protein kinase C, alpha 0.0234006
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.023232
HPCAL1 hippocalcin-like 1 0.0231315
H1-0 H1.0 linker histone 0.023021
KDM2A lysine (K)-specific demethylase 2A 0.0228801

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.154333
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0873307
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0638493
NAMPT nicotinamide phosphoribosyltransferase -0.0606709
FN1 fibronectin 1 -0.0475171
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0473668
PTMA prothymosin, alpha -0.0469536
RPS29 ribosomal protein S29 -0.0444304
VIM vimentin -0.0409469
RBM39 RNA binding motif protein 39 -0.0407878
WSB1 WD repeat and SOCS box containing 1 -0.0398239
RPL37A ribosomal protein L37a -0.0392187
PSD3 pleckstrin and Sec7 domain containing 3 -0.0338655
FTL ferritin, light polypeptide -0.0327513
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0316691
RPS12 ribosomal protein S12 -0.0299094
RPL36 ribosomal protein L36 -0.0294799
TPT1 tumor protein, translationally-controlled 1 -0.029183
RPS19 ribosomal protein S19 -0.0288177
GLCCI1 glucocorticoid induced 1 -0.0274359
KDM3A lysine (K)-specific demethylase 3A -0.0257736
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0254633
NPEPPS aminopeptidase puromycin sensitive -0.0254609
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0250355
RPLP2 ribosomal protein, large, P2 -0.0248721
MT2A metallothionein 2A -0.0246975
RPL28 ribosomal protein L28 -0.0244589
RPS21 ribosomal protein S21 -0.0241727
ELL2 elongation factor, RNA polymerase II, 2 -0.0241706
EIF1 eukaryotic translation initiation factor 1 -0.0241584
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0237876
RPS3 ribosomal protein S3 -0.0227732
GPC6 glypican 6 -0.0227719
RPL38 ribosomal protein L38 -0.0227025
RPS13 ribosomal protein S13 -0.0226401
SLC38A1 solute carrier family 38, member 1 -0.0224886
TM4SF1 transmembrane 4 L six family member 1 -0.0223339
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0217804
NPC1 Niemann-Pick disease, type C1 -0.0216022
PRRX1 paired related homeobox 1 -0.0215913
ZMYND8 zinc finger, MYND-type containing 8 -0.0213089
RPS25 ribosomal protein S25 -0.0212535
GCC2 GRIP and coiled-coil domain containing 2 -0.0210879
DPYD dihydropyrimidine dehydrogenase -0.0209782
RPS23 ribosomal protein S23 -0.0208717
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0208058
RPL37 ribosomal protein L37 -0.0208057
RPL35A ribosomal protein L35a -0.0199964
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0199716
OSMR oncostatin M receptor -0.0198958
RPS24 ribosomal protein S24 -0.0197837
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0196866
RPS27A ribosomal protein S27a -0.0194757
ZEB2 zinc finger E-box binding homeobox 2 -0.0194379
RPL13A ribosomal protein L13a -0.0191443
RAB27B RAB27B, member RAS oncogene family -0.019099
RPL31 ribosomal protein L31 -0.0185135
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0181167
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0180385
CDK17 cyclin-dependent kinase 17 -0.0178948
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0178573
RPS15 ribosomal protein S15 -0.017502
TPM4 tropomyosin 4 -0.017374
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0172323
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.01721
TRPS1 trichorhinophalangeal syndrome I -0.0171993
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0170198
RPLP1 ribosomal protein, large, P1 -0.0167855
RAB13 RAB13, member RAS oncogene family -0.0166891
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0166445
PTGIS prostaglandin I2 (prostacyclin) synthase -0.0164526
RPL7A ribosomal protein L7a -0.0160952
TBL1X transducin (beta)-like 1X-linked -0.016024
FOXO3 forkhead box O3 -0.0159894
VMP1 vacuole membrane protein 1 -0.0156525
RPL19 ribosomal protein L19 -0.015442
AOPEP aminopeptidase O (putative) -0.0153728
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0153533
RPS8 ribosomal protein S8 -0.0150214
SYAP1 synapse associated protein 1 -0.0149556
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0148971
CCDC68 coiled-coil domain containing 68 -0.0148283
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0147519
RPS11 ribosomal protein S11 -0.0147137
KYNU kynureninase -0.0146919
MECOM MDS1 and EVI1 complex locus -0.0146002
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0144704
ABI1 abl-interactor 1 -0.0142434
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0142342
USP3 ubiquitin specific peptidase 3 -0.0142264
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0141612
LTBP1 latent transforming growth factor beta binding protein 1 -0.0141128
PRR16 proline rich 16 -0.0140436
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0138762
DPYSL3 dihydropyrimidinase-like 3 -0.013825
MARCHF6 membrane associated ring-CH-type finger 6 -0.013689
NECTIN2 nectin cell adhesion molecule 2 -0.0136415
SYT1 synaptotagmin I -0.0134584
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0132311
BMERB1 bMERB domain containing 1 -0.0129989