Oleic acid_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.22932
FTH1 ferritin, heavy polypeptide 1 0.206192
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.19643
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.16092
THSD4 thrombospondin, type I, domain containing 4 0.138182
PDE4D phosphodiesterase 4D, cAMP-specific 0.136619
AKAP12 A kinase (PRKA) anchor protein 12 0.13364
DOCK4 dedicator of cytokinesis 4 0.113467
CMIP c-Maf inducing protein 0.108005
SAMD4A sterile alpha motif domain containing 4A 0.0992694
IGFBP3 insulin-like growth factor binding protein 3 0.0975329
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0897862
FNDC3B fibronectin type III domain containing 3B 0.0830642
AHNAK AHNAK nucleoprotein 0.0823686
SVIL supervillin 0.0794123
UBASH3B ubiquitin associated and SH3 domain containing B 0.0780867
FAM107B family with sequence similarity 107, member B 0.0768143
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0755463
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0749713
EEF2 eukaryotic translation elongation factor 2 0.0701467
FMNL2 formin-like 2 0.0688937
MYOF myoferlin 0.0681317
KYNU kynureninase 0.0668106
VIM vimentin 0.0638702
EGFR epidermal growth factor receptor 0.0620239
TRIO trio Rho guanine nucleotide exchange factor 0.0619718
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0602014
FLNB filamin B, beta 0.0597117
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0595123
ARHGAP26 Rho GTPase activating protein 26 0.0590452
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0589577
DOCK5 dedicator of cytokinesis 5 0.0586037
LPP LIM domain containing preferred translocation partner in lipoma 0.0580348
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0565017
DST dystonin 0.0564382
ATXN1 ataxin 1 0.0561357
ASPH aspartate beta-hydroxylase 0.0557974
LDHA lactate dehydrogenase A 0.0545052
SMOC1 SPARC related modular calcium binding 1 0.0543766
MCL1 myeloid cell leukemia 1 0.0543337
EXT1 exostosin glycosyltransferase 1 0.0536778
PTPRM protein tyrosine phosphatase, receptor type, M 0.0530515
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.052629
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0525287
STC1 stanniocalcin 1 0.0524967
PYGL phosphorylase, glycogen, liver 0.0514099
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0512677
SOD2 superoxide dismutase 2, mitochondrial 0.0512238
MACF1 microtubule-actin crosslinking factor 1 0.0495742
S100A6 S100 calcium binding protein A6 0.0478462
NRG1 neuregulin 1 0.0476128
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0469454
MAML3 mastermind-like 3 (Drosophila) 0.0467456
LOC112694756 uncharaterized LOC112694756 0.0465125
OSMR oncostatin M receptor 0.0453692
GLIS3 GLIS family zinc finger 3 0.0448305
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0437074
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0436293
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0432025
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0431957
USP34 ubiquitin specific peptidase 34 0.0429607
IER3 immediate early response 3 0.0417985
CXCL8 chemokine (C-X-C motif) ligand 8 0.0416018
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0415812
BIRC6 baculoviral IAP repeat containing 6 0.0415368
CUX1 cut-like homeobox 1 0.0414329
EHBP1 EH domain binding protein 1 0.0413291
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0403219
SNX14 sorting nexin 14 0.0394618
UTRN utrophin 0.0392063
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0391042
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0380919
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0378226
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0371792
ACTN1 actinin, alpha 1 0.0368112
AGO2 argonaute RISC catalytic component 2 0.0365266
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0363092
NF1 neurofibromin 1 0.0359938
RAD51B RAD51 paralog B 0.0357263
GRAMD1B GRAM domain containing 1B 0.035632
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0356035
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0355973
MYO1E myosin IE 0.0354334
JMJD1C jumonji domain containing 1C 0.0353941
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0353225
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0353027
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0352931
FLNA filamin A, alpha 0.0350479
ELL2 elongation factor, RNA polymerase II, 2 0.0350221
NEBL nebulette 0.0344613
BASP1 brain abundant, membrane attached signal protein 1 0.0341816
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0341646
EFNA5 ephrin-A5 0.0341383
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0340078
NDRG1 N-myc downstream regulated 1 0.0339931
GLG1 golgi glycoprotein 1 0.0339756
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0339266
ACTG1 actin gamma 1 0.0337413
BICC1 BicC family RNA binding protein 1 0.0333346
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0327504

decreased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 -0.056178
RTN4 reticulon 4 -0.0554972
WDR43 WD repeat domain 43 -0.051333
RPS12 ribosomal protein S12 -0.0470805
TFPI2 tissue factor pathway inhibitor 2 -0.0450667
PTMA prothymosin, alpha -0.0392511
RBM39 RNA binding motif protein 39 -0.0383617
USP3 ubiquitin specific peptidase 3 -0.0357024
YBX3 Y box binding protein 3 -0.0336413
RPS2 ribosomal protein S2 -0.0326721
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0324322
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0314886
PFDN2 prefoldin subunit 2 -0.0310829
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0295798
MIS18BP1 MIS18 binding protein 1 -0.0294671
BCLAF1 BCL2-associated transcription factor 1 -0.0286601
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0282444
RAD21 RAD21 homolog (S. pombe) -0.0281464
CYRIB CYFIP related Rac1 interactor B -0.0273081
CCNL1 cyclin L1 -0.0268393
RHEB Ras homolog enriched in brain -0.0267332
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0265952
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0262715
RPL37A ribosomal protein L37a -0.0261024
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0260034
EIF1 eukaryotic translation initiation factor 1 -0.0258481
NAMPT nicotinamide phosphoribosyltransferase -0.0257213
RBM25 RNA binding motif protein 25 -0.0256048
ZNF292 zinc finger protein 292 -0.0241693
TRA2B transformer 2 beta homolog (Drosophila) -0.0239298
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0235973
TFG TRK-fused gene -0.0221524
NOP58 NOP58 ribonucleoprotein -0.0216395
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0215864
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0214643
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0214273
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0210282
TMSB10 thymosin beta 10 -0.0207538
TOP2A topoisomerase (DNA) II alpha 170kDa -0.020681
PNISR PNN-interacting serine/arginine-rich protein -0.0203742
RPS29 ribosomal protein S29 -0.0199903
ATP5F1B ATP synthase F1 subunit beta -0.0198656
RPS21 ribosomal protein S21 -0.0198535
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0197913
RPS3 ribosomal protein S3 -0.0197612
RPL5 ribosomal protein L5 -0.0194394
WTAP Wilms tumor 1 associated protein -0.0191677
RPS25 ribosomal protein S25 -0.0191592
RPL7 ribosomal protein L7 -0.0189004
FGB fibrinogen beta chain -0.0186926
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0185317
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0184985
AREG amphiregulin -0.0184202
ILF2 interleukin enhancer binding factor 2 -0.0183206
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.018111
RBM8A RNA binding motif protein 8A -0.0178644
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -0.0176944
HBS1L HBS1-like translational GTPase -0.0176515
RPL36 ribosomal protein L36 -0.0174496
RNF145 ring finger protein 145 -0.0173135
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0171168
NUP58 nucleoporin 58 -0.0171008
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -0.0169733
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0169605
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -0.016922
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0168535
MORF4L1 mortality factor 4 like 1 -0.0168461
RFWD3 ring finger and WD repeat domain 3 -0.0168175
RPL23 ribosomal protein L23 -0.016694
ANLN anillin, actin binding protein -0.0166846
ECT2 epithelial cell transforming 2 -0.0166439
MATR3 matrin 3 -0.016418
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0163527
MARCHF6 membrane associated ring-CH-type finger 6 -0.016297
PRPF39 pre-mRNA processing factor 39 -0.0162766
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0162759
ADAM9 ADAM metallopeptidase domain 9 -0.0162189
RPL9 ribosomal protein L9 -0.0161528
SF1 splicing factor 1 -0.0161514
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0161179
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -0.0157698
TPX2 TPX2, microtubule-associated -0.0157446
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0157418
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0157404
RPS27A ribosomal protein S27a -0.0157248
QKI QKI, KH domain containing, RNA binding -0.0157092
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0154636
IST1 increased sodium tolerance 1 homolog (yeast) -0.0154213
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0153923
NUP153 nucleoporin 153kDa -0.0152941
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0151954
OLA1 Obg-like ATPase 1 -0.0150222
WBP11 WW domain binding protein 11 -0.0149877
SCAF4 SR-related CTD-associated factor 4 -0.0147905
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0147834
ADAM17 ADAM metallopeptidase domain 17 -0.0146325
SRSF11 serine/arginine-rich splicing factor 11 -0.0145897
CMC2 C-x(9)-C motif containing 2 -0.0145871
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0145243
SRSF5 serine/arginine-rich splicing factor 5 -0.0144616