Oleic acid_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.11911
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.105584
KRT17 keratin 17, type I 0.103512
CXCL8 chemokine (C-X-C motif) ligand 8 0.092954
IGF2 insulin-like growth factor 2 0.0852616
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0840243
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0824535
ELL2 elongation factor, RNA polymerase II, 2 0.0812151
MT2A metallothionein 2A 0.0710919
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0705918
NAV2 neuron navigator 2 0.0700455
BRD2 bromodomain containing 2 0.0693301
RPS6 ribosomal protein S6 0.0687802
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0671131
SQSTM1 sequestosome 1 0.0665909
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0665815
DSCAM Down syndrome cell adhesion molecule 0.0639716
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0623941
MCL1 myeloid cell leukemia 1 0.0568092
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0565781
MYO10 myosin X 0.0561897
FTH1 ferritin, heavy polypeptide 1 0.055704
EEF2 eukaryotic translation elongation factor 2 0.0554534
AKAP12 A kinase (PRKA) anchor protein 12 0.054558
ERRFI1 ERBB receptor feedback inhibitor 1 0.0538018
ZNF292 zinc finger protein 292 0.0526658
RPS12 ribosomal protein S12 0.0511631
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0505588
FLNB filamin B, beta 0.0503849
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.049365
PDIA3 protein disulfide isomerase family A, member 3 0.0487405
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.048523
CDH13 cadherin 13 0.048026
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0471237
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0462443
AHNAK AHNAK nucleoprotein 0.0459692
HIPK2 homeodomain interacting protein kinase 2 0.0444898
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0440881
PHC3 polyhomeotic homolog 3 (Drosophila) 0.043585
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0431472
DSPP dentin sialophosphoprotein 0.0425503
ARHGAP26 Rho GTPase activating protein 26 0.0421549
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0421315
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0416269
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0414366
GOLGA4 golgin A4 0.041299
FMNL2 formin-like 2 0.0409956
HSPH1 heat shock 105kDa/110kDa protein 1 0.0406406
RIGI RNA sensor RIG-I 0.040058
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0399893
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0399064
TPT1 tumor protein, translationally-controlled 1 0.0394611
RBM39 RNA binding motif protein 39 0.0388374
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0380736
HOOK2 hook microtubule-tethering protein 2 0.0380713
OSBP oxysterol binding protein 0.0370667
RPL12 ribosomal protein L12 0.0354349
NUMB numb homolog (Drosophila) 0.0351308
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0350495
FNBP4 formin binding protein 4 0.0350117
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0340419
PAPOLA poly(A) polymerase alpha 0.0338632
JUN jun proto-oncogene 0.0331246
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0329202
TSC22D2 TSC22 domain family, member 2 0.0327537
COPB1 coatomer protein complex, subunit beta 1 0.0325697
CANX calnexin 0.0322777
ITCH itchy E3 ubiquitin protein ligase 0.0320722
GPHN gephyrin 0.0320663
NRIP1 nuclear receptor interacting protein 1 0.0319689
MAP2K4 mitogen-activated protein kinase kinase 4 0.0317043
RPL37A ribosomal protein L37a 0.0314593
ACTG1 actin gamma 1 0.0313609
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0310634
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.030818
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0305741
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0305025
DST dystonin 0.0304332
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0304118
COL6A1 collagen, type VI, alpha 1 0.0304106
FAF1 Fas (TNFRSF6) associated factor 1 0.0303
CDK14 cyclin-dependent kinase 14 0.0302107
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0298866
TTC3 tetratricopeptide repeat domain 3 0.0298665
SEPTIN9 septin 9 0.029707
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0296747
CLIP2 CAP-GLY domain containing linker protein 2 0.0295887
ATXN1 ataxin 1 0.029241
SBF2 SET binding factor 2 0.0291606
LOC112694756 uncharaterized LOC112694756 0.0290586
CTBP2 C-terminal binding protein 2 0.0290571
MLEC malectin 0.0289146
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0286008
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.028278
MYH9 myosin, heavy chain 9, non-muscle 0.0279358
MYOF myoferlin 0.0278375
GOLT1B golgi transport 1B 0.0277093
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0276363
LMAN1 lectin, mannose-binding, 1 0.0274104
PCM1 pericentriolar material 1 0.0273616

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.151755
MYO1E myosin IE -0.133166
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.132316
BACE2 beta-site APP-cleaving enzyme 2 -0.108447
ATOSA atos homolog A -0.102387
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.095257
OSMR oncostatin M receptor -0.0805182
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0796826
ANTXR2 anthrax toxin receptor 2 -0.0792479
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0781677
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0766176
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0754135
RBM47 RNA binding motif protein 47 -0.0751223
KATNBL1 katanin p80 subunit B-like 1 -0.0691174
GLIS3 GLIS family zinc finger 3 -0.0678851
LAMB3 laminin, beta 3 -0.0662622
NPEPPS aminopeptidase puromycin sensitive -0.0660421
PDE4D phosphodiesterase 4D, cAMP-specific -0.0643357
TM4SF1 transmembrane 4 L six family member 1 -0.0627601
GRB10 growth factor receptor-bound protein 10 -0.0619738
F3 coagulation factor III (thromboplastin, tissue factor) -0.0617916
LAMC2 laminin, gamma 2 -0.059657
SAMD4A sterile alpha motif domain containing 4A -0.0593792
CUX1 cut-like homeobox 1 -0.0578583
SVIL supervillin -0.0577649
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0574313
PLAUR plasminogen activator, urokinase receptor -0.0565804
PRSS23 protease, serine, 23 -0.0546901
TMCC3 transmembrane and coiled-coil domain family 3 -0.0538239
ASPH aspartate beta-hydroxylase -0.0525667
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.05169
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0506991
TMEM87A transmembrane protein 87A -0.0502121
RAB31 RAB31, member RAS oncogene family -0.0493819
ZBTB20 zinc finger and BTB domain containing 20 -0.0488128
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0487004
MUC16 mucin 16, cell surface associated -0.0483591
ZNF217 zinc finger protein 217 -0.0481415
PATJ PATJ crumbs cell polarity complex component -0.0476913
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0472097
VCL vinculin -0.0468709
CP ceruloplasmin (ferroxidase) -0.0467312
DENND2C DENN/MADD domain containing 2C -0.0464415
ANXA11 annexin A11 -0.04593
BIRC6 baculoviral IAP repeat containing 6 -0.0458838
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0446224
VCAN versican -0.0445104
PTPRM protein tyrosine phosphatase, receptor type, M -0.0442212
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.043716
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0433825
STC1 stanniocalcin 1 -0.0431056
BPTF bromodomain PHD finger transcription factor -0.0428353
ANXA2 annexin A2 -0.0428064
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0424599
IFI16 interferon, gamma-inducible protein 16 -0.0422746
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0420865
MYO5C myosin VC -0.0418352
SERINC1 serine incorporator 1 -0.0415199
TXNIP thioredoxin interacting protein -0.0414435
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0414045
CSNK1A1 casein kinase 1, alpha 1 -0.0413148
GRAMD1B GRAM domain containing 1B -0.0411106
PTMA prothymosin, alpha -0.0409649
CEMIP cell migration inducing protein, hyaluronan binding -0.0406831
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0403343
NCOA2 nuclear receptor coactivator 2 -0.0400886
AK1 adenylate kinase 1 -0.0398498
LIMCH1 LIM and calponin homology domains 1 -0.0394805
ABHD17C abhydrolase domain containing 17C -0.0394802
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0392971
FMN1 formin 1 -0.0386877
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0381086
BABAM2 BRISC and BRCA1 A complex member 2 -0.0373527
LPP LIM domain containing preferred translocation partner in lipoma -0.0372667
MACC1 metastasis associated in colon cancer 1 -0.0368674
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0367105
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0361113
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0354497
EFNA5 ephrin-A5 -0.0353905
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0353044
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0352916
PRDM1 PR domain containing 1, with ZNF domain -0.0346481
TMSB10 thymosin beta 10 -0.0344895
CDCP1 CUB domain containing protein 1 -0.0344221
CCNI cyclin I -0.034003
GRAMD2B GRAM domain containing 2B -0.0338956
TPM4 tropomyosin 4 -0.0336183
ARHGAP5 Rho GTPase activating protein 5 -0.0332811
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.033091
NCOR2 nuclear receptor corepressor 2 -0.032822
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0327604
TBC1D22A TBC1 domain family, member 22A -0.0326922
TNRC18 trinucleotide repeat containing 18 -0.0325246
BASP1 brain abundant, membrane attached signal protein 1 -0.0325085
DLG1 discs, large homolog 1 (Drosophila) -0.032436
PHIP pleckstrin homology domain interacting protein -0.0323548
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0322
CDK13 cyclin-dependent kinase 13 -0.0321746
PPARD peroxisome proliferator-activated receptor delta -0.0320686
SYNJ2 synaptojanin 2 -0.031767