Oleic acid_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.3328
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.146506
GRAMD1B GRAM domain containing 1B 0.131084
EEF2 eukaryotic translation elongation factor 2 0.110043
THSD4 thrombospondin, type I, domain containing 4 0.0984817
ERRFI1 ERBB receptor feedback inhibitor 1 0.0897581
OSMR oncostatin M receptor 0.0849286
YBX3 Y box binding protein 3 0.0776578
TXNRD1 thioredoxin reductase 1 0.0755959
MCL1 myeloid cell leukemia 1 0.0706407
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0670509
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0654257
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0647529
IGF1R insulin-like growth factor 1 receptor 0.0628964
DOCK5 dedicator of cytokinesis 5 0.0610481
KRT18 keratin 18, type I 0.0600196
PDE4D phosphodiesterase 4D, cAMP-specific 0.0597395
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0592063
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0590731
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.058823
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0587935
MACF1 microtubule-actin crosslinking factor 1 0.0573635
EXOC4 exocyst complex component 4 0.0560406
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0553189
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.055087
TPM3 tropomyosin 3 0.0529076
TRIP12 thyroid hormone receptor interactor 12 0.0518754
RAD51B RAD51 paralog B 0.0499949
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0499362
MYH9 myosin, heavy chain 9, non-muscle 0.0498698
AHNAK AHNAK nucleoprotein 0.0498195
TRIO trio Rho guanine nucleotide exchange factor 0.049371
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0476803
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0475704
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0472923
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0470964
ATP11A ATPase, class VI, type 11A 0.047066
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0459437
ANO6 anoctamin 6 0.0457382
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.04553
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0452046
DST dystonin 0.0442503
NF1 neurofibromin 1 0.0442372
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0441847
PDE10A phosphodiesterase 10A 0.0435068
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0434435
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0420317
ELL2 elongation factor, RNA polymerase II, 2 0.0419408
WNK1 WNK lysine deficient protein kinase 1 0.0417319
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0417069
VCL vinculin 0.041263
JMJD1C jumonji domain containing 1C 0.0410893
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0408182
TFPI2 tissue factor pathway inhibitor 2 0.0406447
RIMS2 regulating synaptic membrane exocytosis 2 0.040554
EXT1 exostosin glycosyltransferase 1 0.0404712
HMGA2 high mobility group AT-hook 2 0.0404126
YAP1 Yes-associated protein 1 0.0399178
ZFAND3 zinc finger, AN1-type domain 3 0.0398398
CDK17 cyclin-dependent kinase 17 0.0389222
ADAR adenosine deaminase, RNA-specific 0.0387788
PDLIM5 PDZ and LIM domain 5 0.0384955
SMAD3 SMAD family member 3 0.038298
TAS2R14 taste receptor, type 2, member 14 0.0382263
PTK2 protein tyrosine kinase 2 0.038134
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0380604
STC1 stanniocalcin 1 0.0377016
SPTBN1 spectrin, beta, non-erythrocytic 1 0.03768
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0370669
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0369136
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0368065
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0364915
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0364116
PLEC plectin 0.0358636
FMNL2 formin-like 2 0.0354532
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0352572
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0349947
ATXN1 ataxin 1 0.0349411
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0348758
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0347047
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0345567
BZW1 basic leucine zipper and W2 domains 1 0.0343517
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0342509
CSDE1 cold shock domain containing E1, RNA-binding 0.0338835
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0336244
SVIL supervillin 0.0335807
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0335576
ACTG1 actin gamma 1 0.0332255
RERE arginine-glutamic acid dipeptide (RE) repeats 0.032921
FNDC3B fibronectin type III domain containing 3B 0.0328626
NFE2L2 nuclear factor, erythroid 2-like 2 0.0326784
WWOX WW domain containing oxidoreductase 0.0324744
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.032448
ZSWIM6 zinc finger, SWIM-type containing 6 0.032109
KTN1 kinectin 1 (kinesin receptor) 0.032027
VMP1 vacuole membrane protein 1 0.0314054
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0313879
CCND2 cyclin D2 0.0309324
SFPQ splicing factor proline/glutamine-rich 0.0309288
RAB7A RAB7A, member RAS oncogene family 0.0300024

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0674684
RPS3 ribosomal protein S3 -0.0548111
RPL35A ribosomal protein L35a -0.0503279
RPL37A ribosomal protein L37a -0.0497868
PTMA prothymosin, alpha -0.0467721
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0437476
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0392232
RPL37 ribosomal protein L37 -0.0375192
RPS29 ribosomal protein S29 -0.0345171
WSB1 WD repeat and SOCS box containing 1 -0.0318155
RPS8 ribosomal protein S8 -0.0310549
RPLP2 ribosomal protein, large, P2 -0.0305628
RPL26 ribosomal protein L26 -0.0296601
RPS19 ribosomal protein S19 -0.0287907
RPS12 ribosomal protein S12 -0.0286977
RPLP1 ribosomal protein, large, P1 -0.0277345
RPS27 ribosomal protein S27 -0.0272902
RPL9 ribosomal protein L9 -0.0268345
TPT1 tumor protein, translationally-controlled 1 -0.0267084
RPL36 ribosomal protein L36 -0.0261013
RPS21 ribosomal protein S21 -0.0259452
RPL31 ribosomal protein L31 -0.0258103
VIM vimentin -0.0251078
RPL36A ribosomal protein L36a -0.0246336
MT2A metallothionein 2A -0.0236763
RPS6 ribosomal protein S6 -0.0231188
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0224051
RPS27A ribosomal protein S27a -0.0222516
RPS25 ribosomal protein S25 -0.0221604
RPL11 ribosomal protein L11 -0.0216153
FTL ferritin, light polypeptide -0.0211527
RPL28 ribosomal protein L28 -0.0211427
RPS13 ribosomal protein S13 -0.0210673
RPL23 ribosomal protein L23 -0.0210246
RPL12 ribosomal protein L12 -0.0202533
PFN1 profilin 1 -0.0200463
RPS10 ribosomal protein S10 -0.0197258
RPS15 ribosomal protein S15 -0.019659
RPL8 ribosomal protein L8 -0.0182281
RPS23 ribosomal protein S23 -0.0176086
RPL5 ribosomal protein L5 -0.0173756
RPLP0 ribosomal protein, large, P0 -0.0172117
EIF1 eukaryotic translation initiation factor 1 -0.01715
RPS24 ribosomal protein S24 -0.0169011
GOLGA4 golgin A4 -0.0162029
MYL12B myosin, light chain 12B, regulatory -0.0158032
VDAC1 voltage-dependent anion channel 1 -0.0152115
RPL38 ribosomal protein L38 -0.0151934
RPL13A ribosomal protein L13a -0.014815
EIF5B eukaryotic translation initiation factor 5B -0.0145678
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0140926
ACBD3 acyl-CoA binding domain containing 3 -0.0135913
RACK1 receptor for activated C kinase 1 -0.013532
HMGA1 high mobility group AT-hook 1 -0.0132834
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0132002
RPS14 ribosomal protein S14 -0.0131437
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0129726
WASF2 WAS protein family, member 2 -0.0127024
TMEM165 transmembrane protein 165 -0.0125917
PNISR PNN-interacting serine/arginine-rich protein -0.0125333
RPL30 ribosomal protein L30 -0.0125254
RSF1 remodeling and spacing factor 1 -0.0125245
RPS16 ribosomal protein S16 -0.0125122
RPL32 ribosomal protein L32 -0.0122162
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0121317
RAN RAN, member RAS oncogene family -0.0119995
RTN4 reticulon 4 -0.0118104
NAP1L1 nucleosome assembly protein 1-like 1 -0.01163
MTDH metadherin -0.0115166
RPS20 ribosomal protein S20 -0.0114749
NACA nascent polypeptide-associated complex alpha subunit -0.011453
ROMO1 reactive oxygen species modulator 1 -0.011422
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0113844
IGF2 insulin-like growth factor 2 -0.0113463
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0111784
IKBIP IKBKB interacting protein -0.0111485
RPL7A ribosomal protein L7a -0.0110664
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0110256
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0110049
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0109443
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0109315
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0106897
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0106635
RPL34 ribosomal protein L34 -0.0106481
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0104819
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0103333
RPL27 ribosomal protein L27 -0.0101882
S100A11 S100 calcium binding protein A11 -0.0100524
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.00996701
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.00987861
SRSF11 serine/arginine-rich splicing factor 11 -0.00984851
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.00984757
GARS1 glycyl-tRNA synthetase 1 -0.00983067
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.00962294
GSTP1 glutathione S-transferase pi 1 -0.00961598
RPS17 ribosomal protein S17 -0.00956243
SEC61G Sec61 gamma subunit -0.00937587
HSPB1 heat shock 27kDa protein 1 -0.00935944
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -0.00931534
ARF4 ADP-ribosylation factor 4 -0.00926394