Oleic acid_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.239003
PLEC plectin 0.14631
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.129542
EEF2 eukaryotic translation elongation factor 2 0.121162
MYH9 myosin, heavy chain 9, non-muscle 0.10033
FTH1 ferritin, heavy polypeptide 1 0.0958052
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0859485
TSC22D2 TSC22 domain family, member 2 0.0849231
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0820892
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0811521
EZR ezrin 0.0766154
FNDC3B fibronectin type III domain containing 3B 0.0752581
ELL2 elongation factor, RNA polymerase II, 2 0.0724587
MYO5B myosin VB 0.0670363
LAMC2 laminin, gamma 2 0.0644938
ASPH aspartate beta-hydroxylase 0.0644491
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0637479
UBA6 ubiquitin-like modifier activating enzyme 6 0.0632915
MSN moesin 0.0623632
LOC112694756 uncharaterized LOC112694756 0.0608698
ANXA2 annexin A2 0.060629
TRIO trio Rho guanine nucleotide exchange factor 0.0583653
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0569347
LAMB3 laminin, beta 3 0.0566238
F11R F11 receptor 0.0563493
G0S2 G0/G1 switch 2 0.0555519
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0552306
ADAM9 ADAM metallopeptidase domain 9 0.0542048
SDC4 syndecan 4 0.0531228
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.052245
AKAP13 A kinase (PRKA) anchor protein 13 0.0514731
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0492475
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0488752
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0474315
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0472979
BHLHE40 basic helix-loop-helix family, member e40 0.0469199
PTK2 protein tyrosine kinase 2 0.0464156
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0463296
TACSTD2 tumor-associated calcium signal transducer 2 0.0450742
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0446281
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0443837
PPARD peroxisome proliferator-activated receptor delta 0.0439135
FLNA filamin A, alpha 0.0413661
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0411987
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0409864
AHNAK AHNAK nucleoprotein 0.0403394
MT2A metallothionein 2A 0.0402612
FLNB filamin B, beta 0.0402142
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0393598
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0392945
RNF145 ring finger protein 145 0.0389288
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0385582
SFTPA2 surfactant protein A2 0.0384722
MYO10 myosin X 0.0382878
MYO6 myosin VI 0.0381585
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0370267
TXNRD1 thioredoxin reductase 1 0.0368641
APLP2 amyloid beta (A4) precursor-like protein 2 0.0368362
POTEF POTE ankyrin domain family, member F 0.0361671
SGMS2 sphingomyelin synthase 2 0.0355127
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0352716
DSPP dentin sialophosphoprotein 0.0350801
MAP1B microtubule-associated protein 1B 0.0344732
GRB10 growth factor receptor-bound protein 10 0.0341473
TJP2 tight junction protein 2 0.0336844
FXR1 fragile X mental retardation, autosomal homolog 1 0.0335289
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0330579
TNIP1 TNFAIP3 interacting protein 1 0.0323537
KDM6A lysine (K)-specific demethylase 6A 0.03224
DSCAM Down syndrome cell adhesion molecule 0.032142
MCL1 myeloid cell leukemia 1 0.0321239
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0319711
TPM3 tropomyosin 3 0.0314591
APP amyloid beta (A4) precursor protein 0.0312962
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0311441
SMAD3 SMAD family member 3 0.0310466
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0306998
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0304833
CD44 CD44 molecule (Indian blood group) 0.0302158
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0301037
SLMAP sarcolemma associated protein 0.0300478
FAM3C family with sequence similarity 3, member C 0.0299459
HSPA8 heat shock 70kDa protein 8 0.0298727
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0298555
EMP1 epithelial membrane protein 1 0.0297979
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0297326
ARRDC3 arrestin domain containing 3 0.0295383
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.029471
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0291857
DTNA dystrobrevin, alpha 0.0291297
BRD2 bromodomain containing 2 0.0289481
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0288621
FAM13A family with sequence similarity 13, member A 0.0287003
RAD23B RAD23 homolog B (S. cerevisiae) 0.0285808
RASA2 RAS p21 protein activator 2 0.0280716
SQSTM1 sequestosome 1 0.0280587
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0278653
ANXA5 annexin A5 0.0277113
DUSP5 dual specificity phosphatase 5 0.0268758
ERRFI1 ERBB receptor feedback inhibitor 1 0.0267912

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.145096
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.143132
TMSB10 thymosin beta 10 -0.0975798
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0946916
FBXO32 F-box protein 32 -0.076049
RPL35A ribosomal protein L35a -0.0691153
LPP LIM domain containing preferred translocation partner in lipoma -0.0648628
EIF1 eukaryotic translation initiation factor 1 -0.0620474
TMSB4X thymosin beta 4, X-linked -0.0614795
TPT1 tumor protein, translationally-controlled 1 -0.0566903
CANX calnexin -0.0563058
IFI16 interferon, gamma-inducible protein 16 -0.0561436
ISG15 ISG15 ubiquitin-like modifier -0.0558751
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0538736
EXT1 exostosin glycosyltransferase 1 -0.0534921
TPM4 tropomyosin 4 -0.0522704
SOX4 SRY (sex determining region Y)-box 4 -0.0514017
RPL34 ribosomal protein L34 -0.0504623
ACTG1 actin gamma 1 -0.0495143
LIMCH1 LIM and calponin homology domains 1 -0.0452699
IFIH1 interferon induced with helicase C domain 1 -0.0447895
RPLP1 ribosomal protein, large, P1 -0.0437771
F3 coagulation factor III (thromboplastin, tissue factor) -0.040339
SAMD4A sterile alpha motif domain containing 4A -0.0403096
IFI6 interferon, alpha-inducible protein 6 -0.039599
RPS8 ribosomal protein S8 -0.0393636
RPS24 ribosomal protein S24 -0.0360842
ARHGAP20 Rho GTPase activating protein 20 -0.0357812
SLC38A1 solute carrier family 38, member 1 -0.0349573
FBXO34 F-box protein 34 -0.034346
VCL vinculin -0.0325392
ARHGAP5 Rho GTPase activating protein 5 -0.0323251
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0320672
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0319896
TTC3 tetratricopeptide repeat domain 3 -0.0308985
RPS29 ribosomal protein S29 -0.030582
CAVIN1 caveolae associated protein 1 -0.0297583
PALLD palladin, cytoskeletal associated protein -0.0291258
EPCAM epithelial cell adhesion molecule -0.0289412
CEP350 centrosomal protein 350kDa -0.0287812
RPL23 ribosomal protein L23 -0.0284108
RIGI RNA sensor RIG-I -0.0281622
RNF213 ring finger protein 213 -0.028052
S100A10 S100 calcium binding protein A10 -0.0279539
ANKRD17 ankyrin repeat domain 17 -0.0279184
RPS19 ribosomal protein S19 -0.0269965
IFITM3 interferon induced transmembrane protein 3 -0.0269854
CSTB cystatin B (stefin B) -0.0269342
RPS13 ribosomal protein S13 -0.0265193
RPS27A ribosomal protein S27a -0.0256911
WARS1 tryptophanyl-tRNA synthetase 1 -0.0255911
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0255192
RPS14 ribosomal protein S14 -0.0247939
TMEM263 transmembrane protein 263 -0.0246338
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0245172
IFITM1 interferon induced transmembrane protein 1 -0.0243223
SH3KBP1 SH3-domain kinase binding protein 1 -0.0242079
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.024135
CCND1 cyclin D1 -0.0240373
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0240331
RRBP1 ribosome binding protein 1 -0.0235207
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0227477
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0226641
MDK midkine (neurite growth-promoting factor 2) -0.0225973
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0223637
SP100 SP100 nuclear antigen -0.021951
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.021853
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0216964
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0216812
MX2 MX dynamin-like GTPase 2 -0.0214475
YY1 YY1 transcription factor -0.0213617
C15ORF48 chromosome 15 open reading frame 48 -0.0213542
RPS21 ribosomal protein S21 -0.0212852
MAML2 mastermind-like 2 (Drosophila) -0.0210916
IFI27 interferon, alpha-inducible protein 27 -0.0209592
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0207088
HSPB1 heat shock 27kDa protein 1 -0.0206707
FNIP1 folliculin interacting protein 1 -0.0205604
RPS23 ribosomal protein S23 -0.0204779
KPNB1 karyopherin (importin) beta 1 -0.0203981
BASP1 brain abundant, membrane attached signal protein 1 -0.0203949
RACK1 receptor for activated C kinase 1 -0.020357
GNAS GNAS complex locus -0.0203529
TMEM123 transmembrane protein 123 -0.0203148
CD2AP CD2-associated protein -0.0201308
EFNA5 ephrin-A5 -0.0199768
INTS6 integrator complex subunit 6 -0.019949
RPL9 ribosomal protein L9 -0.019917
RPL37A ribosomal protein L37a -0.0199033
GOLGA4 golgin A4 -0.0198667
APOL6 apolipoprotein L, 6 -0.0197155
ARF1 ADP-ribosylation factor 1 -0.019533
HMGB1 high mobility group box 1 -0.0195014
RAD21 RAD21 homolog (S. pombe) -0.0191788
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0190917
RPL36A ribosomal protein L36a -0.0189992
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.018979
RPLP2 ribosomal protein, large, P2 -0.018944
COPB1 coatomer protein complex, subunit beta 1 -0.0188777
RBM47 RNA binding motif protein 47 -0.0188591