Oleic acid_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.251888
FN1 fibronectin 1 0.152872
PDE4D phosphodiesterase 4D, cAMP-specific 0.0886206
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0825453
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0714979
IGFBP3 insulin-like growth factor binding protein 3 0.0692627
P3H2 prolyl 3-hydroxylase 2 0.0660854
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0642596
CDH13 cadherin 13 0.0628586
BZW1 basic leucine zipper and W2 domains 1 0.059693
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0538608
SMAD2 SMAD family member 2 0.0533035
SMOC1 SPARC related modular calcium binding 1 0.051661
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0473258
KYNU kynureninase 0.046449
FTH1 ferritin, heavy polypeptide 1 0.0452186
MAP7 microtubule-associated protein 7 0.0450751
AUTS2 autism susceptibility candidate 2 0.0412245
PDLIM5 PDZ and LIM domain 5 0.0392509
EEF2 eukaryotic translation elongation factor 2 0.0382554
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0372269
FNDC3A fibronectin type III domain containing 3A 0.0354645
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0347451
STC1 stanniocalcin 1 0.034705
PSD3 pleckstrin and Sec7 domain containing 3 0.0338389
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0324021
CUX1 cut-like homeobox 1 0.0320886
PRKN parkin RBR E3 ubiquitin protein ligase 0.0317661
PDE10A phosphodiesterase 10A 0.0317133
AGTPBP1 ATP/GTP binding protein 1 0.0315047
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.030916
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0302505
CHL1 cell adhesion molecule L1-like 0.0302422
SFTPA2 surfactant protein A2 0.0301005
FMNL2 formin-like 2 0.0297707
XYLT1 xylosyltransferase I 0.0294435
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0292518
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0291177
SH3KBP1 SH3-domain kinase binding protein 1 0.0290818
MAML3 mastermind-like 3 (Drosophila) 0.0289288
LSAMP limbic system-associated membrane protein 0.0282662
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0276651
PTPRM protein tyrosine phosphatase, receptor type, M 0.0272449
RPLP0 ribosomal protein, large, P0 0.0269679
DST dystonin 0.0269298
LOC102724023 ES1 protein homolog, mitochondrial 0.0260983
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0254987
STC2 stanniocalcin 2 0.0243649
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0242655
FAM107B family with sequence similarity 107, member B 0.0238818
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0236075
NTN4 netrin 4 0.023133
ADGRD1 adhesion G protein-coupled receptor D1 0.0231276
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0229055
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0228164
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.02265
NFE2L2 nuclear factor, erythroid 2-like 2 0.0224633
SOD2 superoxide dismutase 2, mitochondrial 0.022294
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0213961
TPT1 tumor protein, translationally-controlled 1 0.0213158
PDE7B phosphodiesterase 7B 0.0209329
INTS6 integrator complex subunit 6 0.0208503
TBXT T-box transcription factor T 0.0208039
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0204626
DOCK5 dedicator of cytokinesis 5 0.0202964
RAB31 RAB31, member RAS oncogene family 0.0202575
LOC112694756 uncharaterized LOC112694756 0.0201892
SOX4 SRY (sex determining region Y)-box 4 0.0198675
ZSWIM6 zinc finger, SWIM-type containing 6 0.0195941
OXSR1 oxidative stress responsive 1 0.0192455
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0189918
SVIL supervillin 0.0188824
ABLIM1 actin binding LIM protein 1 0.0188147
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0183923
NT5C2 5'-nucleotidase, cytosolic II 0.0174971
IRS2 insulin receptor substrate 2 0.0174933
RAB7A RAB7A, member RAS oncogene family 0.0171628
DENND1A DENN/MADD domain containing 1A 0.0170534
TOB1 transducer of ERBB2, 1 0.0165359
SEPTIN9 septin 9 0.0165077
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0164535
INHBA inhibin, beta A 0.0163101
DGKD diacylglycerol kinase, delta 130kDa 0.0158395
NFX1 nuclear transcription factor, X-box binding 1 0.0158237
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0156856
RPS6 ribosomal protein S6 0.0156636
NEFL neurofilament, light polypeptide 0.0156455
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0156022
BMP6 bone morphogenetic protein 6 0.0153318
IER3 immediate early response 3 0.0152458
NRXN3 neurexin 3 0.0150624
ASTN2 astrotactin 2 0.0149918
ATXN1 ataxin 1 0.0149285
CRTC3 CREB regulated transcription coactivator 3 0.0149069
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0147999
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0147641
EGR1 early growth response 1 0.0146975
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0145743
CREB3L2 cAMP responsive element binding protein 3-like 2 0.014544
RAD51B RAD51 paralog B 0.0144392

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.13483
TXNRD1 thioredoxin reductase 1 -0.114074
TMSB10 thymosin beta 10 -0.0940289
NAMPT nicotinamide phosphoribosyltransferase -0.0871344
RPS27A ribosomal protein S27a -0.0822406
GRAMD1B GRAM domain containing 1B -0.0800862
UBC ubiquitin C -0.0789582
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0787915
EFNA5 ephrin-A5 -0.0733937
TM4SF1 transmembrane 4 L six family member 1 -0.0715888
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.060532
NRCAM neuronal cell adhesion molecule -0.0584736
PCBP2 poly(rC) binding protein 2 -0.0564786
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0554135
NEK7 NIMA-related kinase 7 -0.0546403
RTN4 reticulon 4 -0.0546002
LIMCH1 LIM and calponin homology domains 1 -0.0544102
ENO1 enolase 1, (alpha) -0.0542576
TNPO1 transportin 1 -0.0528424
TRIO trio Rho guanine nucleotide exchange factor -0.0515664
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0477075
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0476576
PTMA prothymosin, alpha -0.0470734
RPL23 ribosomal protein L23 -0.0432683
PRRC2C proline-rich coiled-coil 2C -0.0406924
MCL1 myeloid cell leukemia 1 -0.0404305
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0399144
RPS12 ribosomal protein S12 -0.0391861
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0388752
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0369481
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.036079
OGA O-GlcNAcase -0.0359178
SFPQ splicing factor proline/glutamine-rich -0.0356178
ENAH enabled homolog (Drosophila) -0.0354148
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0348485
PTGR1 prostaglandin reductase 1 -0.0345491
MFF mitochondrial fission factor -0.0345128
RPS3 ribosomal protein S3 -0.0341373
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0341114
NAP1L1 nucleosome assembly protein 1-like 1 -0.0340202
RPL37A ribosomal protein L37a -0.0339256
CENPF centromere protein F, 350/400kDa -0.0335739
CTSC cathepsin C -0.0334337
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0332194
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0329128
PRDX1 peroxiredoxin 1 -0.0323266
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0315265
RPLP2 ribosomal protein, large, P2 -0.0310224
RBM25 RNA binding motif protein 25 -0.0304297
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0303068
RBM39 RNA binding motif protein 39 -0.029968
ANKRD28 ankyrin repeat domain 28 -0.0299192
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0282806
COL5A2 collagen, type V, alpha 2 -0.0282076
VMP1 vacuole membrane protein 1 -0.028123
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0275109
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0272372
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0261772
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.026143
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0257082
SET SET nuclear proto-oncogene -0.0254321
ARHGAP29 Rho GTPase activating protein 29 -0.0253548
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.025166
RPL26 ribosomal protein L26 -0.025035
AGFG1 ArfGAP with FG repeats 1 -0.0249594
GIGYF2 GRB10 interacting GYF protein 2 -0.0244554
AHNAK AHNAK nucleoprotein -0.0240646
FLNB filamin B, beta -0.0240041
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0239724
RAI1 retinoic acid induced 1 -0.0236472
RPS24 ribosomal protein S24 -0.0227968
ANLN anillin, actin binding protein -0.0226923
SMYD3 SET and MYND domain containing 3 -0.0226331
SRPK2 SRSF protein kinase 2 -0.0223093
NBAS neuroblastoma amplified sequence -0.0222627
CFLAR CASP8 and FADD-like apoptosis regulator -0.0218612
PTEN phosphatase and tensin homolog -0.0218271
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0217425
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0216873
ATP5F1B ATP synthase F1 subunit beta -0.0216022
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0214078
SLF1 SMC5-SMC6 complex localization factor 1 -0.021341
USP9X ubiquitin specific peptidase 9, X-linked -0.0211646
NALF1 NALCN channel auxiliary factor 1 -0.0210844
DIAPH3 diaphanous-related formin 3 -0.021043
PLCB4 phospholipase C, beta 4 -0.0209966
BCAR3 breast cancer anti-estrogen resistance 3 -0.0209938
PKM pyruvate kinase, muscle -0.0209868
RPL9 ribosomal protein L9 -0.0209632
SRGN serglycin -0.0209305
TM9SF3 transmembrane 9 superfamily member 3 -0.02091
RPS29 ribosomal protein S29 -0.0206054
TPM3 tropomyosin 3 -0.0201822
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0198437
CENPE centromere protein E, 312kDa -0.0197058
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0195193
SMC4 structural maintenance of chromosomes 4 -0.0195124
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0194105
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0193767
ATP13A3 ATPase type 13A3 -0.019097