Oleic acid_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0911507
ANKRD17 ankyrin repeat domain 17 0.0665912
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0565768
MED13L mediator complex subunit 13-like 0.0561968
DSCAM Down syndrome cell adhesion molecule 0.0550444
LOC112694756 uncharaterized LOC112694756 0.0549138
USP34 ubiquitin specific peptidase 34 0.0535807
SLC38A2 solute carrier family 38, member 2 0.0515278
SMYD3 SET and MYND domain containing 3 0.0506779
EFNA5 ephrin-A5 0.0503291
MYOF myoferlin 0.0494299
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0452002
ANXA2 annexin A2 0.0446039
SPAG9 sperm associated antigen 9 0.0437663
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0419569
ANKHD1 ankyrin repeat and KH domain containing 1 0.0416905
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0405193
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0386853
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0370778
FNIP1 folliculin interacting protein 1 0.0370035
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0366704
TXNRD1 thioredoxin reductase 1 0.0364412
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0350736
EEF2 eukaryotic translation elongation factor 2 0.0350691
FMNL2 formin-like 2 0.0344259
PRRC2C proline-rich coiled-coil 2C 0.0338834
DST dystonin 0.0332075
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0330672
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0325395
TRIP12 thyroid hormone receptor interactor 12 0.0322649
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0322504
ARRDC3 arrestin domain containing 3 0.0322378
CADM2 cell adhesion molecule 2 0.0321731
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.032115
PGK1 phosphoglycerate kinase 1 0.0317483
XRN2 5'-3' exoribonuclease 2 0.0316648
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0316561
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0315585
FBXO11 F-box protein 11 0.0305385
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0304588
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0303037
EPS8 epidermal growth factor receptor pathway substrate 8 0.0292167
NCOR1 nuclear receptor corepressor 1 0.0288952
EGFR epidermal growth factor receptor 0.0285389
FHL2 four and a half LIM domains 2 0.0284107
ATXN1 ataxin 1 0.0283714
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0282424
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0280042
ARHGAP26 Rho GTPase activating protein 26 0.0278274
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0276097
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0272402
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0271186
CAMTA1 calmodulin binding transcription activator 1 0.0266659
GLS2 glutaminase 2 (liver, mitochondrial) 0.0263971
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0263668
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.0262097
PRELID2 PRELI domain containing 2 0.0259611
PSD3 pleckstrin and Sec7 domain containing 3 0.0259575
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0259197
RICTOR RPTOR independent companion of MTOR, complex 2 0.0256968
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0255164
C6ORF62 chromosome 6 open reading frame 62 0.0253452
BAIAP2L1 BAI1-associated protein 2-like 1 0.0252926
ATF6 activating transcription factor 6 0.0252427
SMAD3 SMAD family member 3 0.0248705
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0247438
NKD1 naked cuticle homolog 1 (Drosophila) 0.0242418
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0239249
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0238697
CENPF centromere protein F, 350/400kDa 0.0237757
EZR ezrin 0.0237322
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0236732
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0232635
HMGA2 high mobility group AT-hook 2 0.0232344
HIPK2 homeodomain interacting protein kinase 2 0.0224789
FN1 fibronectin 1 0.0223588
SAMD4A sterile alpha motif domain containing 4A 0.0221807
RAD21 RAD21 homolog (S. pombe) 0.0221374
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0219853
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0217601
TPM4 tropomyosin 4 0.0217052
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0213768
CANX calnexin 0.0208258
SPG11 spastic paraplegia 11 (autosomal recessive) 0.0208225
TPST1 tyrosylprotein sulfotransferase 1 0.0208211
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0203082
RORA RAR-related orphan receptor A 0.0195126
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0191956
FLNB filamin B, beta 0.0187464
PDE10A phosphodiesterase 10A 0.0183376
HDLBP high density lipoprotein binding protein 0.0177379
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0176401
TFG TRK-fused gene 0.0175689
TUT7 terminal uridylyl transferase 7 0.0173076
RAD51B RAD51 paralog B 0.0170656
SBF2 SET binding factor 2 0.0170072
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0167537
RPS16 ribosomal protein S16 0.0161415
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0158143
ZNF292 zinc finger protein 292 0.0158113

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.164209
IGF2 insulin-like growth factor 2 -0.0909216
PTMA prothymosin, alpha -0.0669897
STC1 stanniocalcin 1 -0.0657379
AKAP12 A kinase (PRKA) anchor protein 12 -0.0593985
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0587707
CALU calumenin -0.0544361
RPL23 ribosomal protein L23 -0.052151
KMT2C lysine (K)-specific methyltransferase 2C -0.0513541
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0508344
TMSB10 thymosin beta 10 -0.0497235
RPL35A ribosomal protein L35a -0.0459255
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0425286
INHBA inhibin, beta A -0.0425043
WSB1 WD repeat and SOCS box containing 1 -0.0424066
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0423111
RNF213 ring finger protein 213 -0.0419781
MYO1E myosin IE -0.0410377
BPTF bromodomain PHD finger transcription factor -0.0410191
EXT1 exostosin glycosyltransferase 1 -0.0403545
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0399052
TPT1 tumor protein, translationally-controlled 1 -0.0385098
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0382074
NF1 neurofibromin 1 -0.0379766
ZBTB20 zinc finger and BTB domain containing 20 -0.0365162
MMP1 matrix metallopeptidase 1 -0.035971
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0353928
KPNB1 karyopherin (importin) beta 1 -0.0349951
JMJD1C jumonji domain containing 1C -0.0346309
MCL1 myeloid cell leukemia 1 -0.0344466
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0341595
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0340879
MACF1 microtubule-actin crosslinking factor 1 -0.0340829
ANKRD12 ankyrin repeat domain 12 -0.0338112
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0314953
PARD3 par-3 family cell polarity regulator -0.0300227
FAM13A family with sequence similarity 13, member A -0.0298266
GPC6 glypican 6 -0.0296485
FNDC3B fibronectin type III domain containing 3B -0.0291227
RPL34 ribosomal protein L34 -0.0288294
CALR calreticulin -0.0288071
TMEM65 transmembrane protein 65 -0.027943
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0279287
B2M beta-2-microglobulin -0.0271514
LAMB3 laminin, beta 3 -0.0248187
RPS6 ribosomal protein S6 -0.0247107
SEPTIN9 septin 9 -0.0245329
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0232131
RPS8 ribosomal protein S8 -0.0227646
ASPH aspartate beta-hydroxylase -0.021216
CD44 CD44 molecule (Indian blood group) -0.0208024
DLG1 discs, large homolog 1 (Drosophila) -0.0200285
PCBP2 poly(rC) binding protein 2 -0.0194685
RPL7 ribosomal protein L7 -0.0191817
RPS23 ribosomal protein S23 -0.0190606
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0187078
EXOC4 exocyst complex component 4 -0.0184718
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0183302
RPLP1 ribosomal protein, large, P1 -0.0181912
HLA-B major histocompatibility complex, class I, B -0.0179798
NPAS2 neuronal PAS domain protein 2 -0.0172925
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0169357
SETD5 SET domain containing 5 -0.0169257
AREG amphiregulin -0.016912
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0167311
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0163666
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0163516
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0162141
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0153766
DOCK4 dedicator of cytokinesis 4 -0.0152858
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0150108
BCL2L1 BCL2-like 1 -0.0148713
RPS13 ribosomal protein S13 -0.014763
CLTC clathrin, heavy chain (Hc) -0.0139245
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0129039
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0127356
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0126559
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0118452
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0118446
TM4SF1 transmembrane 4 L six family member 1 -0.0117696
TOP1 topoisomerase (DNA) I -0.0108647
STAU1 staufen double-stranded RNA binding protein 1 -0.010803
GMDS GDP-mannose 4,6-dehydratase -0.0103011
GCLC glutamate-cysteine ligase, catalytic subunit -0.0102191
PNISR PNN-interacting serine/arginine-rich protein -0.00958017
ESYT2 extended synaptotagmin-like protein 2 -0.00949121
MT2A metallothionein 2A -0.00914133
STAT1 signal transducer and activator of transcription 1, 91kDa -0.00902315
KRT18 keratin 18, type I -0.008736
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.00823099
RPL19 ribosomal protein L19 -0.00821547
NCOA3 nuclear receptor coactivator 3 -0.00797683
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.00778298
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.00747004
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.00740932
RPL26 ribosomal protein L26 -0.00737834
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.00730564
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0070615
GOLGA4 golgin A4 -0.00697416
RPS3 ribosomal protein S3 -0.00690453