Oleic acid_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.0785161
TSC22D2 TSC22 domain family, member 2 0.0738062
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0647801
EEF2 eukaryotic translation elongation factor 2 0.0618599
ANKRD33B ankyrin repeat domain 33B 0.0486237
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0423095
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0408127
SAMD4A sterile alpha motif domain containing 4A 0.0389201
ZEB2 zinc finger E-box binding homeobox 2 0.0349826
ZNF292 zinc finger protein 292 0.0349096
MED13L mediator complex subunit 13-like 0.0348633
PGAP1 post-GPI attachment to proteins 1 0.0337042
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0318612
RERE arginine-glutamic acid dipeptide (RE) repeats 0.029317
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0292561
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0285677
PRPF8 pre-mRNA processing factor 8 0.028543
DSCAM Down syndrome cell adhesion molecule 0.0284225
JMJD1C jumonji domain containing 1C 0.027865
RAD23B RAD23 homolog B (S. cerevisiae) 0.0256329
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0255676
BRD2 bromodomain containing 2 0.0255501
H1-0 H1.0 linker histone 0.024435
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0239314
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0230321
TRAK1 trafficking protein, kinesin binding 1 0.0229962
MYH9 myosin, heavy chain 9, non-muscle 0.0228466
AQR aquarius intron-binding spliceosomal factor 0.0226069
PUM1 pumilio RNA-binding family member 1 0.0224188
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0220928
KIF1B kinesin family member 1B 0.0219953
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0216555
RBM20 RNA binding motif protein 20 0.0215749
KMT2C lysine (K)-specific methyltransferase 2C 0.0213486
SON SON DNA binding protein 0.0213278
DIDO1 death inducer-obliterator 1 0.0211646
KMT2E lysine (K)-specific methyltransferase 2E 0.0211019
PCDH18 protocadherin 18 0.0208836
VMP1 vacuole membrane protein 1 0.0208376
USP15 ubiquitin specific peptidase 15 0.0208273
XPO1 exportin 1 0.0207789
MEMO1 mediator of cell motility 1 0.0207427
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0202177
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0197859
CDC73 cell division cycle 73 0.0195246
CLTC clathrin, heavy chain (Hc) 0.0192084
AKAP13 A kinase (PRKA) anchor protein 13 0.0190713
NCKAP1 NCK-associated protein 1 0.0189413
ENAH enabled homolog (Drosophila) 0.0186649
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0179084
WNT5B wingless-type MMTV integration site family, member 5B 0.0178626
TRA2A transformer 2 alpha homolog (Drosophila) 0.0178562
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0176834
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0175295
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0174918
TRIO trio Rho guanine nucleotide exchange factor 0.0174491
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0173669
YAP1 Yes-associated protein 1 0.0172622
CCDC88A coiled-coil domain containing 88A 0.0172367
APLP2 amyloid beta (A4) precursor-like protein 2 0.0169411
SCAF8 SR-related CTD-associated factor 8 0.0168932
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0168742
GPHN gephyrin 0.0167348
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0164701
TJP1 tight junction protein 1 0.0163197
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0163044
APP amyloid beta (A4) precursor protein 0.016287
TPM3 tropomyosin 3 0.0158189
LRP12 low density lipoprotein receptor-related protein 12 0.0158068
PICALM phosphatidylinositol binding clathrin assembly protein 0.0157671
SRP54 signal recognition particle 54kDa 0.0157509
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0155796
SPAG9 sperm associated antigen 9 0.0154912
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.0153684
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0153656
RLIM ring finger protein, LIM domain interacting 0.0153083
GPC4 glypican 4 0.0151591
EVI5 ecotropic viral integration site 5 0.0150657
FNDC3B fibronectin type III domain containing 3B 0.0150312
NCOR2 nuclear receptor corepressor 2 0.015021
YARS1 tyrosyl-tRNA synthetase 1 0.0150085
TGFB2 transforming growth factor, beta 2 0.0147231
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.0147054
HEATR5A HEAT repeat containing 5A 0.0145965
COPA coatomer protein complex, subunit alpha 0.0145731
LRRN3 leucine rich repeat neuronal 3 0.0145665
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0145489
RAB7A RAB7A, member RAS oncogene family 0.01452
NHSL1 NHS-like 1 0.0144489
OSBPL10 oxysterol binding protein-like 10 0.014375
PTBP2 polypyrimidine tract binding protein 2 0.0143061
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0142559
MACF1 microtubule-actin crosslinking factor 1 0.0142466
NCOR1 nuclear receptor corepressor 1 0.0142421
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0142394
ZNF608 zinc finger protein 608 0.014132
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0140738
AHNAK AHNAK nucleoprotein 0.0140169
PBX3 pre-B-cell leukemia homeobox 3 0.013994
INTS6 integrator complex subunit 6 0.0139542

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.218513
TMSB10 thymosin beta 10 -0.186374
PTMA prothymosin, alpha -0.125237
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.1161
GPC3 glypican 3 -0.116009
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.111319
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.097162
CADM2 cell adhesion molecule 2 -0.0901864
PCDH9 protocadherin 9 -0.0875504
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0805733
TPT1 tumor protein, translationally-controlled 1 -0.0741848
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0698554
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0646901
RPLP1 ribosomal protein, large, P1 -0.0629059
RPL35A ribosomal protein L35a -0.0624127
RPS16 ribosomal protein S16 -0.0595382
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.057154
RPS6 ribosomal protein S6 -0.0555834
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.054533
RPS19 ribosomal protein S19 -0.0525534
RPL37A ribosomal protein L37a -0.0521856
RPS8 ribosomal protein S8 -0.0503629
RPLP2 ribosomal protein, large, P2 -0.0490971
ADGRV1 adhesion G protein-coupled receptor V1 -0.0489762
RPS21 ribosomal protein S21 -0.0487264
NRG1 neuregulin 1 -0.0478978
MDK midkine (neurite growth-promoting factor 2) -0.045681
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0453344
COL11A1 collagen, type XI, alpha 1 -0.0440299
HMGB1 high mobility group box 1 -0.0434788
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0426965
ACTG1 actin gamma 1 -0.0423909
MKI67 marker of proliferation Ki-67 -0.041642
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0408018
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0404973
RPS12 ribosomal protein S12 -0.0404237
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0403392
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0402256
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0397607
CENPF centromere protein F, 350/400kDa -0.0397492
COL1A2 collagen, type I, alpha 2 -0.0387969
RPL34 ribosomal protein L34 -0.0375385
PFN1 profilin 1 -0.0372696
RPS27A ribosomal protein S27a -0.0372163
PRELID2 PRELI domain containing 2 -0.0369695
CALR calreticulin -0.0368984
NCAM2 neural cell adhesion molecule 2 -0.0364824
EIF1 eukaryotic translation initiation factor 1 -0.0363732
FTL ferritin, light polypeptide -0.0361455
S100A10 S100 calcium binding protein A10 -0.0361227
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0361073
RPL31 ribosomal protein L31 -0.0358995
TXNRD1 thioredoxin reductase 1 -0.0353587
RPS24 ribosomal protein S24 -0.0352122
MT2A metallothionein 2A -0.0352034
RPL19 ribosomal protein L19 -0.0348622
RPL37 ribosomal protein L37 -0.034293
RPL38 ribosomal protein L38 -0.0342039
RPL36A ribosomal protein L36a -0.0341625
MYL12B myosin, light chain 12B, regulatory -0.0340731
RPL36 ribosomal protein L36 -0.0329806
PLPP1 phospholipid phosphatase 1 -0.0327149
CENPE centromere protein E, 312kDa -0.0321899
ITGAV integrin, alpha V -0.0320389
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0319649
RPS13 ribosomal protein S13 -0.0318191
RPL28 ribosomal protein L28 -0.0317742
SEPTIN7 septin 7 -0.0316697
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0314457
ARHGAP15 Rho GTPase activating protein 15 -0.0313079
RPS29 ribosomal protein S29 -0.0312679
SHROOM3 shroom family member 3 -0.0305329
CCDC102B coiled-coil domain containing 102B -0.0301009
RPS3 ribosomal protein S3 -0.0294315
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0292316
COL3A1 collagen, type III, alpha 1 -0.0291308
RPS25 ribosomal protein S25 -0.0288379
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0287355
RPL32 ribosomal protein L32 -0.028163
STMN1 stathmin 1 -0.0279629
SFRP4 secreted frizzled-related protein 4 -0.0278557
RPS27 ribosomal protein S27 -0.0276027
CNRIP1 cannabinoid receptor interacting protein 1 -0.0276005
KCTD16 potassium channel tetramerization domain containing 16 -0.0275828
RPL9 ribosomal protein L9 -0.0274702
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0274368
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0271983
USH2A Usher syndrome 2A (autosomal recessive, mild) -0.0267253
RPS23 ribosomal protein S23 -0.0263735
METAP2 methionyl aminopeptidase 2 -0.0261441
TPX2 TPX2, microtubule-associated -0.0260908
WSB1 WD repeat and SOCS box containing 1 -0.0260537
PCLO piccolo presynaptic cytomatrix protein -0.0258887
SMYD3 SET and MYND domain containing 3 -0.0254696
HMCN1 hemicentin 1 -0.025434
CKAP2 cytoskeleton associated protein 2 -0.0252872
NUSAP1 nucleolar and spindle associated protein 1 -0.0252763
MRPS30 mitochondrial ribosomal protein S30 -0.0249494
RAD51B RAD51 paralog B -0.0247787
RPLP0 ribosomal protein, large, P0 -0.0243858