Oleic acid_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.210485
AKAP12 A kinase (PRKA) anchor protein 12 0.194181
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.161294
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.130264
FNDC3B fibronectin type III domain containing 3B 0.111501
MYH9 myosin, heavy chain 9, non-muscle 0.0946151
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0901269
TRIO trio Rho guanine nucleotide exchange factor 0.0900006
SFTPA2 surfactant protein A2 0.0894049
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0865798
AHNAK AHNAK nucleoprotein 0.0864534
SEPTIN9 septin 9 0.0845007
SAMD4B sterile alpha motif domain containing 4B 0.0814135
FBL fibrillarin 0.081105
SMAD3 SMAD family member 3 0.0797422
MACF1 microtubule-actin crosslinking factor 1 0.0771204
APLP2 amyloid beta (A4) precursor-like protein 2 0.0760188
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0754381
EEF2 eukaryotic translation elongation factor 2 0.0747793
DST dystonin 0.0703255
ASPH aspartate beta-hydroxylase 0.0679608
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0662635
PTK2 protein tyrosine kinase 2 0.0661556
LOC112694756 uncharaterized LOC112694756 0.0660712
ZSWIM6 zinc finger, SWIM-type containing 6 0.0632737
WWTR1 WW domain containing transcription regulator 1 0.0625022
ATXN1 ataxin 1 0.059382
PLEC plectin 0.0583046
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0578915
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.057389
ANKRD11 ankyrin repeat domain 11 0.0571872
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0568649
INTS6 integrator complex subunit 6 0.056154
JMJD1C jumonji domain containing 1C 0.0528765
FTH1 ferritin, heavy polypeptide 1 0.0525156
NUP98 nucleoporin 98kDa 0.0504718
MYO1E myosin IE 0.050286
CENPF centromere protein F, 350/400kDa 0.0490247
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0477734
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0471449
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0469715
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0467885
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0466713
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0453802
ANO6 anoctamin 6 0.0453523
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0450377
DSCAM Down syndrome cell adhesion molecule 0.0446339
THSD4 thrombospondin, type I, domain containing 4 0.0445989
NAV2 neuron navigator 2 0.043277
TRIP12 thyroid hormone receptor interactor 12 0.0421324
SRRM2 serine/arginine repetitive matrix 2 0.0416523
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0414843
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0414064
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0410486
SDK1 sidekick cell adhesion molecule 1 0.0408446
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0407482
MYO10 myosin X 0.0390334
LPP LIM domain containing preferred translocation partner in lipoma 0.0381869
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0376822
AKAP13 A kinase (PRKA) anchor protein 13 0.037546
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0373182
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0370017
PDE10A phosphodiesterase 10A 0.0369321
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0365304
WNK1 WNK lysine deficient protein kinase 1 0.0364058
MCL1 myeloid cell leukemia 1 0.0362824
NCOR2 nuclear receptor corepressor 2 0.0357244
YAP1 Yes-associated protein 1 0.0353581
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0350955
TPM3 tropomyosin 3 0.0349633
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0349603
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0347452
KTN1 kinectin 1 (kinesin receptor) 0.034724
SOX9 SRY (sex determining region Y)-box 9 0.0347016
ERBIN erbb2 interacting protein 0.0345299
MED13L mediator complex subunit 13-like 0.0345086
BRD2 bromodomain containing 2 0.0341378
PRELID2 PRELI domain containing 2 0.0336843
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.033478
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0334343
MCTP1 multiple C2 domains, transmembrane 1 0.0334024
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0331037
ZFAND3 zinc finger, AN1-type domain 3 0.0328276
CTBP2 C-terminal binding protein 2 0.0328227
IPO7 importin 7 0.0325094
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0324326
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0324057
BIRC3 baculoviral IAP repeat containing 3 0.032237
MSN moesin 0.0320389
MKI67 marker of proliferation Ki-67 0.0319134
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0318004
HSPA8 heat shock 70kDa protein 8 0.0315311
PDLIM5 PDZ and LIM domain 5 0.0312207
SIK3 SIK family kinase 3 0.0311487
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0306665
MYOF myoferlin 0.0306021
EFNA5 ephrin-A5 0.0305934
FLNA filamin A, alpha 0.0304924
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0301931
RRM2 ribonucleotide reductase M2 0.0295503

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.18033
PTMA prothymosin, alpha -0.15302
VIM vimentin -0.151272
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.142062
RPS16 ribosomal protein S16 -0.111936
TMSB10 thymosin beta 10 -0.103102
RPLP2 ribosomal protein, large, P2 -0.0626791
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0537234
RPL35A ribosomal protein L35a -0.0509779
TPT1 tumor protein, translationally-controlled 1 -0.0475319
RPS3 ribosomal protein S3 -0.046104
WSB1 WD repeat and SOCS box containing 1 -0.0433587
RPL37A ribosomal protein L37a -0.0428119
RPL36A ribosomal protein L36a -0.0396455
RPS25 ribosomal protein S25 -0.0381028
RPS24 ribosomal protein S24 -0.0361007
TMEM41B transmembrane protein 41B -0.0343998
EIF1 eukaryotic translation initiation factor 1 -0.0309787
RPL31 ribosomal protein L31 -0.0292664
CANX calnexin -0.0285082
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0281236
RPS27A ribosomal protein S27a -0.0277673
RPS8 ribosomal protein S8 -0.0276215
RPS13 ribosomal protein S13 -0.0276098
RPL28 ribosomal protein L28 -0.0265388
RPS29 ribosomal protein S29 -0.0263288
GOLGA4 golgin A4 -0.0254613
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0249523
CTSD cathepsin D -0.0242116
RPS23 ribosomal protein S23 -0.0238778
RTN4 reticulon 4 -0.0233889
CALR calreticulin -0.0232319
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0229204
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0227287
RPS19 ribosomal protein S19 -0.022625
RPLP1 ribosomal protein, large, P1 -0.0225101
FTL ferritin, light polypeptide -0.022407
CAVIN1 caveolae associated protein 1 -0.0222348
SEC63 SEC63 homolog (S. cerevisiae) -0.0220158
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0217102
RPL38 ribosomal protein L38 -0.0216027
HLA-B major histocompatibility complex, class I, B -0.021542
RPL36 ribosomal protein L36 -0.0207115
RPS21 ribosomal protein S21 -0.0202173
S100A6 S100 calcium binding protein A6 -0.0196352
KPNB1 karyopherin (importin) beta 1 -0.019486
VDAC1 voltage-dependent anion channel 1 -0.0187403
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0185456
HM13 histocompatibility (minor) 13 -0.0184535
RPS12 ribosomal protein S12 -0.018171
TMEM263 transmembrane protein 263 -0.018157
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0181569
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0175871
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0175193
MT2A metallothionein 2A -0.0174247
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0171365
ACBD3 acyl-CoA binding domain containing 3 -0.0170224
C15ORF48 chromosome 15 open reading frame 48 -0.0166882
RPS14 ribosomal protein S14 -0.0166045
MYL12B myosin, light chain 12B, regulatory -0.016598
TMEM123 transmembrane protein 123 -0.0160979
RPS27 ribosomal protein S27 -0.0157557
RPL37 ribosomal protein L37 -0.0156251
IFITM3 interferon induced transmembrane protein 3 -0.0154757
WDR45B WD repeat domain 45B -0.0153763
NUCB2 nucleobindin 2 -0.0152906
RPL26 ribosomal protein L26 -0.0151675
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.015129
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0149976
RUSC2 RUN and SH3 domain containing 2 -0.0149574
MON2 MON2 homolog (S. cerevisiae) -0.0144001
ZMYND8 zinc finger, MYND-type containing 8 -0.0143848
KDM3A lysine (K)-specific demethylase 3A -0.0143586
PTPRF protein tyrosine phosphatase, receptor type, F -0.0142421
MORF4L2 mortality factor 4 like 2 -0.0140428
MTDH metadherin -0.0138816
SERF2 small EDRK-rich factor 2 -0.0137628
CD47 CD47 molecule -0.0136966
CLINT1 clathrin interactor 1 -0.0136917
RPL34 ribosomal protein L34 -0.0136329
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0135196
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0135195
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0133969
RPS5 ribosomal protein S5 -0.0132551
RPL32 ribosomal protein L32 -0.0131022
SRP54 signal recognition particle 54kDa -0.0129934
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.0129647
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0128989
LMAN1 lectin, mannose-binding, 1 -0.0128051
CSTB cystatin B (stefin B) -0.0124327
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0124194
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0123045
RPL9 ribosomal protein L9 -0.0122142
RPS15 ribosomal protein S15 -0.0121598
NKTR natural killer cell triggering receptor -0.0121152
GCC2 GRIP and coiled-coil domain containing 2 -0.0120814
WASF2 WAS protein family, member 2 -0.0120472
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0120048
UGCG UDP-glucose ceramide glucosyltransferase -0.0119788
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0119662