Oleic acid_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.10751
KRT18 keratin 18, type I 0.0806116
LMO7 LIM domain 7 0.0772806
INTS6 integrator complex subunit 6 0.0645824
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0597051
TJP1 tight junction protein 1 0.0547909
PLEC plectin 0.052308
SQSTM1 sequestosome 1 0.0494605
SVIL supervillin 0.0468346
H1-0 H1.0 linker histone 0.0428142
HLA-C major histocompatibility complex, class I, C 0.042679
ZSWIM6 zinc finger, SWIM-type containing 6 0.0415129
MYO1E myosin IE 0.0413113
SPTBN1 spectrin, beta, non-erythrocytic 1 0.039562
MYO5B myosin VB 0.0360567
FN1 fibronectin 1 0.0349902
LPP LIM domain containing preferred translocation partner in lipoma 0.0344141
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0343425
SMAD3 SMAD family member 3 0.0340856
SEPTIN9 septin 9 0.0335854
DSG2 desmoglein 2 0.0335844
SH3KBP1 SH3-domain kinase binding protein 1 0.0315671
HDAC9 histone deacetylase 9 0.031196
MX1 MX dynamin-like GTPase 1 0.0310771
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0307912
GOLGB1 golgin B1 0.0280776
PDLIM5 PDZ and LIM domain 5 0.0278643
ARHGAP5 Rho GTPase activating protein 5 0.0275757
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0267675
MACF1 microtubule-actin crosslinking factor 1 0.0257499
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0255449
FLNA filamin A, alpha 0.0254115
VEGFA vascular endothelial growth factor A 0.0252161
SIK3 SIK family kinase 3 0.0250103
BZW1 basic leucine zipper and W2 domains 1 0.0244521
EFNB2 ephrin-B2 0.0243558
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0238709
SGMS2 sphingomyelin synthase 2 0.0231433
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0230226
PATJ PATJ crumbs cell polarity complex component 0.0229496
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0229091
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0228413
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0224217
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0221448
SP100 SP100 nuclear antigen 0.0221129
MAML2 mastermind-like 2 (Drosophila) 0.0220511
EGFR epidermal growth factor receptor 0.0220509
EXT1 exostosin glycosyltransferase 1 0.0218564
PLAU plasminogen activator, urokinase 0.0217144
AFDN afadin, adherens junction formation factor 0.0215851
RNF213 ring finger protein 213 0.0215789
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0214402
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0213785
FAM107B family with sequence similarity 107, member B 0.0212943
SOX9 SRY (sex determining region Y)-box 9 0.0211813
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.020748
SFTPA2 surfactant protein A2 0.0201209
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0200928
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.0193804
EEF2 eukaryotic translation elongation factor 2 0.0193663
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0191801
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0191716
MYH14 myosin, heavy chain 14, non-muscle 0.0191529
PPARD peroxisome proliferator-activated receptor delta 0.0188417
AKAP12 A kinase (PRKA) anchor protein 12 0.0188067
MACC1 metastasis associated in colon cancer 1 0.018672
ATXN1 ataxin 1 0.0186044
BCAR3 breast cancer anti-estrogen resistance 3 0.0185201
HLA-E major histocompatibility complex, class I, E 0.0184494
JARID2 jumonji, AT rich interactive domain 2 0.0183627
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0182332
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0179699
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0179698
BACE2 beta-site APP-cleaving enzyme 2 0.0178575
TLE4 transducin-like enhancer of split 4 0.0177876
AHNAK2 AHNAK nucleoprotein 2 0.0177168
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0176963
PLSCR1 phospholipid scramblase 1 0.017673
LOC102724023 ES1 protein homolog, mitochondrial 0.0176019
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0175979
SAMD4A sterile alpha motif domain containing 4A 0.0173193
LAMB3 laminin, beta 3 0.0170336
STC2 stanniocalcin 2 0.0170153
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.016988
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0167986
CD2AP CD2-associated protein 0.0165071
MELTF melanotransferrin 0.0164282
ERRFI1 ERBB receptor feedback inhibitor 1 0.0163858
BAG3 BCL2-associated athanogene 3 0.0162353
PSEN1 presenilin 1 0.0161029
F11R F11 receptor 0.0160247
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0158703
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0157082
MAML3 mastermind-like 3 (Drosophila) 0.0156892
VCL vinculin 0.0156574
CUX1 cut-like homeobox 1 0.0156371
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0156055
DST dystonin 0.015589
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0154886
RPL13A ribosomal protein L13a 0.0154766

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228169
TMSB10 thymosin beta 10 -0.141818
PTMA prothymosin, alpha -0.139296
UBC ubiquitin C -0.112674
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0899708
RPL23 ribosomal protein L23 -0.0862584
B2M beta-2-microglobulin -0.0822616
PCBP2 poly(rC) binding protein 2 -0.0820229
KRT17 keratin 17, type I -0.0752611
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0659629
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0632069
RPS27A ribosomal protein S27a -0.0623753
KRT7 keratin 7, type II -0.0551843
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0543755
POTEF POTE ankyrin domain family, member F -0.0528366
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0520516
LDHA lactate dehydrogenase A -0.0467583
NAMPT nicotinamide phosphoribosyltransferase -0.0455034
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0454613
RPS3 ribosomal protein S3 -0.0430483
PLAT plasminogen activator, tissue -0.0426195
CANX calnexin -0.042193
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0415163
EZR ezrin -0.0410332
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0405092
SMC4 structural maintenance of chromosomes 4 -0.0397315
TXNIP thioredoxin interacting protein -0.039645
RBM25 RNA binding motif protein 25 -0.0373287
CALR calreticulin -0.0355805
ZFAND3 zinc finger, AN1-type domain 3 -0.0348504
HMGB2 high mobility group box 2 -0.0344479
AHNAK AHNAK nucleoprotein -0.0337738
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0334091
PDIA3 protein disulfide isomerase family A, member 3 -0.0331797
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0320256
MT2A metallothionein 2A -0.0319291
LY6E lymphocyte antigen 6 complex, locus E -0.0317509
PKM pyruvate kinase, muscle -0.0316793
RPLP1 ribosomal protein, large, P1 -0.0312786
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0306766
ANLN anillin, actin binding protein -0.0303906
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0294757
IFI27 interferon, alpha-inducible protein 27 -0.0289919
S100A6 S100 calcium binding protein A6 -0.0287827
EPCAM epithelial cell adhesion molecule -0.02847
EEF1G eukaryotic translation elongation factor 1 gamma -0.028374
XPO1 exportin 1 -0.0283118
DIAPH3 diaphanous-related formin 3 -0.0283014
VMP1 vacuole membrane protein 1 -0.0282934
DLG1 discs, large homolog 1 (Drosophila) -0.0276743
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0274985
ACTN4 actinin, alpha 4 -0.0269623
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.026962
DEK DEK proto-oncogene -0.0265831
MKI67 marker of proliferation Ki-67 -0.0264192
RAD21 RAD21 homolog (S. pombe) -0.0261645
ENO1 enolase 1, (alpha) -0.0255218
GOLGA4 golgin A4 -0.0247216
KRT8 keratin 8, type II -0.024536
TOP1 topoisomerase (DNA) I -0.0243369
TFG TRK-fused gene -0.023969
MATR3 matrin 3 -0.0239463
RPS19 ribosomal protein S19 -0.0238026
RBM39 RNA binding motif protein 39 -0.0236724
RPS21 ribosomal protein S21 -0.0232797
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0227386
ATAD2 ATPase family, AAA domain containing 2 -0.022702
ZNF207 zinc finger protein 207 -0.0226965
SEPTIN7 septin 7 -0.0226787
ZNF148 zinc finger protein 148 -0.0226448
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0225727
ADAM9 ADAM metallopeptidase domain 9 -0.022469
ECT2 epithelial cell transforming 2 -0.0223292
CD47 CD47 molecule -0.0222266
RPS13 ribosomal protein S13 -0.0219509
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0219338
C15ORF48 chromosome 15 open reading frame 48 -0.0215005
SRSF11 serine/arginine-rich splicing factor 11 -0.0214165
RTN4 reticulon 4 -0.0213849
NPEPPS aminopeptidase puromycin sensitive -0.0209917
TM4SF1 transmembrane 4 L six family member 1 -0.0209729
RPL35A ribosomal protein L35a -0.0206443
UGCG UDP-glucose ceramide glucosyltransferase -0.0206043
TC2N tandem C2 domains, nuclear -0.0204561
STK24 serine/threonine kinase 24 -0.0204197
RPL34 ribosomal protein L34 -0.0201941
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.02018
RIOK3 RIO kinase 3 -0.0201576
RPL8 ribosomal protein L8 -0.0201103
RPL32 ribosomal protein L32 -0.0200904
PICALM phosphatidylinositol binding clathrin assembly protein -0.0200575
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0198784
EHF ets homologous factor -0.0198495
THBS1 thrombospondin 1 -0.0197675
TM9SF3 transmembrane 9 superfamily member 3 -0.0197583
WSB1 WD repeat and SOCS box containing 1 -0.0195864
CENPF centromere protein F, 350/400kDa -0.0195632
PRRC2C proline-rich coiled-coil 2C -0.0194679
MYL12B myosin, light chain 12B, regulatory -0.0192071
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0191646