Oleic acid_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.237706
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.202768
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.187285
ZNF438 zinc finger protein 438 0.176736
FRMD6 FERM domain containing 6 0.172795
NAV3 neuron navigator 3 0.12967
PABPC1 poly(A) binding protein, cytoplasmic 1 0.128677
FLNB filamin B, beta 0.127391
FRMD4A FERM domain containing 4A 0.108001
HMGA2 high mobility group AT-hook 2 0.106461
HDAC9 histone deacetylase 9 0.100485
LOC112694756 uncharaterized LOC112694756 0.0970691
EXT1 exostosin glycosyltransferase 1 0.0913685
ENO1 enolase 1, (alpha) 0.0879995
DLC1 DLC1 Rho GTPase activating protein 0.0858207
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0801508
STC1 stanniocalcin 1 0.0793849
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0793765
AGO2 argonaute RISC catalytic component 2 0.077475
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0669961
ARHGAP22 Rho GTPase activating protein 22 0.0669387
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0636982
SGMS2 sphingomyelin synthase 2 0.0623251
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0604678
NAV2 neuron navigator 2 0.0602521
SAMD4A sterile alpha motif domain containing 4A 0.0599661
EGR1 early growth response 1 0.0589997
RPS4X ribosomal protein S4, X-linked 0.0578558
IFI16 interferon, gamma-inducible protein 16 0.0574907
AHNAK AHNAK nucleoprotein 0.0570892
JMJD1C jumonji domain containing 1C 0.0570469
ELL2 elongation factor, RNA polymerase II, 2 0.056839
ZSWIM6 zinc finger, SWIM-type containing 6 0.0549904
MCTP1 multiple C2 domains, transmembrane 1 0.0539399
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0529776
C2CD2 C2 calcium-dependent domain containing 2 0.0526313
DGKI diacylglycerol kinase, iota 0.0514477
FLNA filamin A, alpha 0.0495821
FHIT fragile histidine triad 0.0489748
NABP1 nucleic acid binding protein 1 0.0485142
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0481051
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0478293
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0467024
MCL1 myeloid cell leukemia 1 0.0464
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0461386
RAB7A RAB7A, member RAS oncogene family 0.0454033
ZEB1 zinc finger E-box binding homeobox 1 0.0446558
PGK1 phosphoglycerate kinase 1 0.0439957
SLC38A2 solute carrier family 38, member 2 0.0439147
RCOR1 REST corepressor 1 0.0428769
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0422783
SP100 SP100 nuclear antigen 0.0418841
DST dystonin 0.0415253
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0412815
PBX3 pre-B-cell leukemia homeobox 3 0.0409678
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0406777
RAD51B RAD51 paralog B 0.0392626
PTPRG protein tyrosine phosphatase, receptor type, G 0.0385943
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0384948
SRRM2 serine/arginine repetitive matrix 2 0.0382789
RPS6 ribosomal protein S6 0.0382739
POTEF POTE ankyrin domain family, member F 0.0378687
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0374659
ASPH aspartate beta-hydroxylase 0.0365881
BNC2 basonuclin 2 0.0365776
RPLP0 ribosomal protein, large, P0 0.0364189
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0362274
INTS6 integrator complex subunit 6 0.0361882
ZBTB38 zinc finger and BTB domain containing 38 0.0351866
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0351248
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0346916
ALCAM activated leukocyte cell adhesion molecule 0.0346276
MT2A metallothionein 2A 0.0346065
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0338139
RPL4 ribosomal protein L4 0.0337352
EEF1G eukaryotic translation elongation factor 1 gamma 0.0334343
RPL8 ribosomal protein L8 0.0332369
EXOC4 exocyst complex component 4 0.0330388
EFNB2 ephrin-B2 0.0330336
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0329722
SQSTM1 sequestosome 1 0.0328452
CALR calreticulin 0.0325933
LRMDA leucine rich melanocyte differentiation associated 0.032552
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0325141
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0316037
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0314997
RPLP1 ribosomal protein, large, P1 0.0312558
ANXA2 annexin A2 0.0311813
LDHA lactate dehydrogenase A 0.0310499
LPP LIM domain containing preferred translocation partner in lipoma 0.0304129
PDIA3 protein disulfide isomerase family A, member 3 0.0302504
FTL ferritin, light polypeptide 0.0301982
KLF10 Kruppel-like factor 10 0.0300553
ACTG1 actin gamma 1 0.0298724
TPM4 tropomyosin 4 0.0297815
RPL23 ribosomal protein L23 0.0297117
IARS1 isoleucyl-tRNA synthetase 1 0.0290282
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0289945
RPL35 ribosomal protein L35 0.0289158
ZBTB20 zinc finger and BTB domain containing 20 0.0288379

decreased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0837799
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0566166
RBM39 RNA binding motif protein 39 -0.0553432
NUP58 nucleoporin 58 -0.0498748
PTK2 protein tyrosine kinase 2 -0.0430931
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0418077
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0379905
KMT2C lysine (K)-specific methyltransferase 2C -0.0368867
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0365741
RLF rearranged L-myc fusion -0.0356375
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.035332
RPS2 ribosomal protein S2 -0.0347885
USP3 ubiquitin specific peptidase 3 -0.0341931
RAD21 RAD21 homolog (S. pombe) -0.0319294
KDM6A lysine (K)-specific demethylase 6A -0.0317161
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0307025
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0294833
CHD1 chromodomain helicase DNA binding protein 1 -0.0294241
ZNF292 zinc finger protein 292 -0.0293903
RBM25 RNA binding motif protein 25 -0.0291149
NCKAP1 NCK-associated protein 1 -0.028827
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.028614
KDM3A lysine (K)-specific demethylase 3A -0.0285232
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.028343
CELF1 CUGBP, Elav-like family member 1 -0.0283398
ADAM17 ADAM metallopeptidase domain 17 -0.0281624
OGA O-GlcNAcase -0.0276472
BRWD3 bromodomain and WD repeat domain containing 3 -0.027156
FRS2 fibroblast growth factor receptor substrate 2 -0.0269595
SBF2 SET binding factor 2 -0.0268544
MARCHF6 membrane associated ring-CH-type finger 6 -0.0266851
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0262972
PNISR PNN-interacting serine/arginine-rich protein -0.0261352
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0257107
PUM2 pumilio RNA-binding family member 2 -0.0256325
TPD52 tumor protein D52 -0.0255857
WDR43 WD repeat domain 43 -0.0251837
NCOR1 nuclear receptor corepressor 1 -0.0251406
SCAF11 SR-related CTD-associated factor 11 -0.0250923
WAC WW domain containing adaptor with coiled-coil -0.0249892
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0247992
TPT1 tumor protein, translationally-controlled 1 -0.0246845
PTBP2 polypyrimidine tract binding protein 2 -0.0246703
ECPAS Ecm29 proteasome adaptor and scaffold -0.0246321
FOXJ3 forkhead box J3 -0.0243636
NEMF nuclear export mediator factor -0.0243499
PICALM phosphatidylinositol binding clathrin assembly protein -0.023468
KAT6A K(lysine) acetyltransferase 6A -0.0232512
DSCAM Down syndrome cell adhesion molecule -0.0230844
RB1CC1 RB1-inducible coiled-coil 1 -0.0228684
SCAF8 SR-related CTD-associated factor 8 -0.022181
TENT2 terminal nucleotidyltransferase 2 -0.0220861
SPAG9 sperm associated antigen 9 -0.0220439
RBM33 RNA binding motif protein 33 -0.0219526
MATR3 matrin 3 -0.0219131
YTHDC1 YTH domain containing 1 -0.0218837
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0218744
ARGLU1 arginine and glutamate rich 1 -0.0218336
ATAD2 ATPase family, AAA domain containing 2 -0.0217425
CHIC2 cysteine-rich hydrophobic domain 2 -0.0217076
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0216429
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.0216185
HELZ helicase with zinc finger -0.0215694
RAB6A RAB6A, member RAS oncogene family -0.0213554
ZFC3H1 zinc finger, C3H1-type containing -0.0212464
GOLGA4 golgin A4 -0.0211151
CDK17 cyclin-dependent kinase 17 -0.0207549
PIAS1 protein inhibitor of activated STAT, 1 -0.020753
ZFAND3 zinc finger, AN1-type domain 3 -0.0207075
ZMYM2 zinc finger, MYM-type 2 -0.0207001
BBX bobby sox homolog (Drosophila) -0.0206695
CLINT1 clathrin interactor 1 -0.0205137
WSB1 WD repeat and SOCS box containing 1 -0.0203212
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0202745
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0202697
SEPTIN7 septin 7 -0.0202394
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0202192
TM9SF3 transmembrane 9 superfamily member 3 -0.0202066
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0201735
TMF1 TATA element modulatory factor 1 -0.0198491
RTN4 reticulon 4 -0.0196878
PRRC2C proline-rich coiled-coil 2C -0.0196671
NEK7 NIMA-related kinase 7 -0.0196651
LRRC8C leucine rich repeat containing 8 family, member C -0.0196402
RNF24 ring finger protein 24 -0.0195624
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0195581
NIPBL Nipped-B homolog (Drosophila) -0.0194056
NAMPT nicotinamide phosphoribosyltransferase -0.0193838
YEATS2 YEATS domain containing 2 -0.0192656
MTF2 metal response element binding transcription factor 2 -0.0192617
ZNF654 zinc finger protein 654 -0.0192524
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0192335
RAB18 RAB18, member RAS oncogene family -0.0192052
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 -0.0189147
RNF145 ring finger protein 145 -0.0188227
FOXO3 forkhead box O3 -0.0188038
OLA1 Obg-like ATPase 1 -0.0187133
SET SET nuclear proto-oncogene -0.0186966
FCHO2 FCH domain only 2 -0.0186698
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0186417