Oleic acid_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 0.170562
FN1 fibronectin 1 0.0789835
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0673747
FTH1 ferritin, heavy polypeptide 1 0.0666451
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0562627
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0556338
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0545182
AHNAK AHNAK nucleoprotein 0.0526609
PLEC plectin 0.0524603
SOD2 superoxide dismutase 2, mitochondrial 0.0507734
MYH9 myosin, heavy chain 9, non-muscle 0.0495565
ASPH aspartate beta-hydroxylase 0.0480483
HLA-E major histocompatibility complex, class I, E 0.0480304
EEF2 eukaryotic translation elongation factor 2 0.0469508
SMAD3 SMAD family member 3 0.0441346
CXCL8 chemokine (C-X-C motif) ligand 8 0.0436283
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.043455
TFPI2 tissue factor pathway inhibitor 2 0.0424923
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0405803
HMGA2 high mobility group AT-hook 2 0.0365854
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0355452
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0348775
NPAS2 neuronal PAS domain protein 2 0.032943
ZBTB38 zinc finger and BTB domain containing 38 0.0315406
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0310073
CD109 CD109 molecule 0.0304044
ERRFI1 ERBB receptor feedback inhibitor 1 0.0303379
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0293452
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.028587
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0284738
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0281594
ARHGAP35 Rho GTPase activating protein 35 0.0274564
HDLBP high density lipoprotein binding protein 0.0271802
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0268494
TWIST2 twist family bHLH transcription factor 2 0.0268006
EXT1 exostosin glycosyltransferase 1 0.0263937
RUNX1 runt-related transcription factor 1 0.0262217
VEGFA vascular endothelial growth factor A 0.0257811
H1-0 H1.0 linker histone 0.0251154
FLNA filamin A, alpha 0.0248948
GOLGB1 golgin B1 0.024873
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0246128
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0245709
CANX calnexin 0.0243315
FAM20C family with sequence similarity 20, member C 0.0238158
OGA O-GlcNAcase 0.0237106
DST dystonin 0.0232254
ZSWIM6 zinc finger, SWIM-type containing 6 0.0231778
HOOK2 hook microtubule-tethering protein 2 0.0227411
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0225644
NFE2L2 nuclear factor, erythroid 2-like 2 0.0222454
KDM3A lysine (K)-specific demethylase 3A 0.0222447
NAV2 neuron navigator 2 0.0221196
USP9X ubiquitin specific peptidase 9, X-linked 0.0218524
ARRDC3 arrestin domain containing 3 0.0217914
PDLIM5 PDZ and LIM domain 5 0.0216221
CALR calreticulin 0.0216148
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0215955
NAMPT nicotinamide phosphoribosyltransferase 0.0215518
HPCAL1 hippocalcin-like 1 0.0214078
ALCAM activated leukocyte cell adhesion molecule 0.0213497
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0210686
PHF3 PHD finger protein 3 0.0210321
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0209428
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0204028
GLS2 glutaminase 2 (liver, mitochondrial) 0.0203849
SNX14 sorting nexin 14 0.0202621
MACF1 microtubule-actin crosslinking factor 1 0.0199517
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0197488
EIF4A2 eukaryotic translation initiation factor 4A2 0.0197472
TMF1 TATA element modulatory factor 1 0.019456
KYNU kynureninase 0.0194308
FMNL2 formin-like 2 0.0193732
DSCAM Down syndrome cell adhesion molecule 0.019247
NRIP1 nuclear receptor interacting protein 1 0.0190966
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0190827
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0188628
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0188443
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0188212
FGFR1 fibroblast growth factor receptor 1 0.018742
ICAM1 intercellular adhesion molecule 1 0.0186586
SP100 SP100 nuclear antigen 0.0182831
SEPTIN9 septin 9 0.0181241
TGM2 transglutaminase 2 0.0179948
APP amyloid beta (A4) precursor protein 0.0178499
HSPA8 heat shock 70kDa protein 8 0.0177843
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0175558
EREG epiregulin 0.0174678
MBD5 methyl-CpG binding domain protein 5 0.0172666
FAT1 FAT atypical cadherin 1 0.0172576
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0171251
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0171242
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0167938
LOC112694756 uncharaterized LOC112694756 0.0166455
HLA-C major histocompatibility complex, class I, C 0.016643
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.016177
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0160701
IFI44L interferon-induced protein 44-like 0.0160217
ANXA2 annexin A2 0.0159948
SDC4 syndecan 4 0.015961

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.239469
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.21964
COL1A1 collagen, type I, alpha 1 -0.141107
TMSB10 thymosin beta 10 -0.14048
B2M beta-2-microglobulin -0.134525
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.120535
COL1A2 collagen, type I, alpha 2 -0.119923
HLA-B major histocompatibility complex, class I, B -0.0981502
FTL ferritin, light polypeptide -0.095286
POTEF POTE ankyrin domain family, member F -0.0758519
IFI6 interferon, alpha-inducible protein 6 -0.0643244
FRMD4A FERM domain containing 4A -0.0618312
NRP1 neuropilin 1 -0.0611861
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0585828
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0525832
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0518321
TIMP3 TIMP metallopeptidase inhibitor 3 -0.050258
TPM1 tropomyosin 1 (alpha) -0.0469385
TGFBI transforming growth factor, beta-induced, 68kDa -0.0453636
S100A6 S100 calcium binding protein A6 -0.0448261
ZEB1 zinc finger E-box binding homeobox 1 -0.0442775
NDRG1 N-myc downstream regulated 1 -0.0428073
CDH13 cadherin 13 -0.0418556
MEF2A myocyte enhancer factor 2A -0.0410831
RAB7A RAB7A, member RAS oncogene family -0.0403499
TNS3 tensin 3 -0.0372373
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0367848
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0351881
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0350579
ZMYND8 zinc finger, MYND-type containing 8 -0.0309062
INHBA inhibin, beta A -0.030743
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0303001
PTMA prothymosin, alpha -0.030159
GLIS3 GLIS family zinc finger 3 -0.0287868
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0286523
RPS21 ribosomal protein S21 -0.0285524
C1R complement component 1, r subcomponent -0.0282942
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0281162
RPL35A ribosomal protein L35a -0.0274903
DLG1 discs, large homolog 1 (Drosophila) -0.0267829
ITGA11 integrin, alpha 11 -0.0267311
S100A9 S100 calcium binding protein A9 -0.0263658
IFITM3 interferon induced transmembrane protein 3 -0.0258711
TENT5A terminal nucleotidyltransferase 5A -0.0258455
EML5 echinoderm microtubule associated protein like 5 -0.0254386
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0250716
TMEM178B transmembrane protein 178B -0.0247801
PFN1 profilin 1 -0.0244373
ZBTB20 zinc finger and BTB domain containing 20 -0.0233213
IGFBP5 insulin-like growth factor binding protein 5 -0.0228932
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0226658
VCAN versican -0.0226571
GNAS GNAS complex locus -0.0226131
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0224964
RPS19 ribosomal protein S19 -0.022414
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0221889
PRSS23 protease, serine, 23 -0.0217466
ENO2 enolase 2 (gamma, neuronal) -0.0212623
CST3 cystatin C -0.0212485
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0210078
F3 coagulation factor III (thromboplastin, tissue factor) -0.020934
S100A11 S100 calcium binding protein A11 -0.0208121
TAGLN2 transgelin 2 -0.020761
ENO1 enolase 1, (alpha) -0.0204177
TNNC1 troponin C type 1 (slow) -0.0202428
LPAR1 lysophosphatidic acid receptor 1 -0.0199886
ARL4C ADP-ribosylation factor-like 4C -0.0199044
TMEM87A transmembrane protein 87A -0.0197058
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0196391
MMP12 matrix metallopeptidase 12 -0.019477
NAV1 neuron navigator 1 -0.0194209
CADM1 cell adhesion molecule 1 -0.0191498
CALD1 caldesmon 1 -0.019034
EGR1 early growth response 1 -0.0186568
ACTG1 actin gamma 1 -0.018216
EIF5B eukaryotic translation initiation factor 5B -0.017927
IFI16 interferon, gamma-inducible protein 16 -0.0176981
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0175009
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0172638
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0172471
TCF12 transcription factor 12 -0.0171693
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0169363
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.0167337
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0167086
CLMP CXADR-like membrane protein -0.0166361
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0164643
MAML3 mastermind-like 3 (Drosophila) -0.0163348
SERF2 small EDRK-rich factor 2 -0.0162383
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0159097
CDKN2A cyclin-dependent kinase inhibitor 2A -0.0156235
LINC02762 long intergenic non-protein coding RNA 2762 -0.0155563
NBAS neuroblastoma amplified sequence -0.01555
MT2A metallothionein 2A -0.0154873
TPI1 triosephosphate isomerase 1 -0.0154629
RAB2A RAB2A, member RAS oncogene family -0.0154138
TAPBP TAP binding protein (tapasin) -0.0154109
ATP13A3 ATPase type 13A3 -0.0152356
IFITM1 interferon induced transmembrane protein 1 -0.0152341
PRRX1 paired related homeobox 1 -0.0152223
EPSTI1 epithelial stromal interaction 1 (breast) -0.0151532