Oleic acid_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.253039
SNAP25 synaptosomal-associated protein, 25kDa 0.108039
VGF VGF nerve growth factor inducible 0.0859858
SMOC1 SPARC related modular calcium binding 1 0.0700357
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0652148
EEF2 eukaryotic translation elongation factor 2 0.0555922
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0529518
TENT5A terminal nucleotidyltransferase 5A 0.0484801
PCM1 pericentriolar material 1 0.0461325
FAT1 FAT atypical cadherin 1 0.0452967
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0441271
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0435141
FNDC3A fibronectin type III domain containing 3A 0.0422551
INHBA inhibin, beta A 0.040193
MYH9 myosin, heavy chain 9, non-muscle 0.0401778
TTC19 tetratricopeptide repeat domain 19 0.0391389
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0388292
SIK2 salt-inducible kinase 2 0.0376108
PRPF8 pre-mRNA processing factor 8 0.0353619
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0334895
MBNL1 muscleblind-like splicing regulator 1 0.0318518
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0312392
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0312334
NRXN1 neurexin 1 0.0303327
IRS2 insulin receptor substrate 2 0.0297857
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0292802
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0284748
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0282851
RUNX1 runt-related transcription factor 1 0.0280259
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0276505
CENPF centromere protein F, 350/400kDa 0.0272308
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0263871
H1-0 H1.0 linker histone 0.0262503
LOC112694756 uncharaterized LOC112694756 0.0259928
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0259472
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0256821
TENM1 teneurin transmembrane protein 1 0.0243896
DSCAM Down syndrome cell adhesion molecule 0.0241598
NFIA nuclear factor I/A 0.0239131
PBX3 pre-B-cell leukemia homeobox 3 0.0237054
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0231594
NFIB nuclear factor I/B 0.0227178
FCHSD2 FCH and double SH3 domains 2 0.0225314
MBNL2 muscleblind-like splicing regulator 2 0.0215679
SPIDR scaffolding protein involved in DNA repair 0.0214837
LCOR ligand dependent nuclear receptor corepressor 0.0207434
HOMER1 homer scaffolding protein 1 0.0206504
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0205933
XPO1 exportin 1 0.0200856
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0199392
PCBP3 poly(rC) binding protein 3 0.0198489
CHD1 chromodomain helicase DNA binding protein 1 0.0197273
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0197006
SINHCAF SIN3-HDAC complex associated factor 0.0196213
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0194233
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0193952
SFPQ splicing factor proline/glutamine-rich 0.0192845
CAMTA1 calmodulin binding transcription activator 1 0.0191747
POU2F1 POU class 2 homeobox 1 0.019166
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.0190397
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.018931
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0188814
RAD23B RAD23 homolog B (S. cerevisiae) 0.0183623
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0181238
ANLN anillin, actin binding protein 0.0179698
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0178824
AFF1 AF4/FMR2 family, member 1 0.0177128
ZNF292 zinc finger protein 292 0.0171977
APLP2 amyloid beta (A4) precursor-like protein 2 0.0170636
SGMS2 sphingomyelin synthase 2 0.0169803
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0167969
RIMBP2 RIMS binding protein 2 0.0167581
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0166698
TPST1 tyrosylprotein sulfotransferase 1 0.0165591
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 0.016474
DHFR dihydrofolate reductase 0.0163934
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0163661
CABIN1 calcineurin binding protein 1 0.016347
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0161191
TMEM178B transmembrane protein 178B 0.0160187
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0159483
SASH1 SAM and SH3 domain containing 1 0.0159329
DIAPH1 diaphanous-related formin 1 0.0158211
ZCCHC7 zinc finger, CCHC domain containing 7 0.0158197
LIFR leukemia inhibitory factor receptor alpha 0.0157368
PCBP2 poly(rC) binding protein 2 0.0157094
USP9X ubiquitin specific peptidase 9, X-linked 0.015622
ADAM17 ADAM metallopeptidase domain 17 0.0155891
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0154997
CKAP5 cytoskeleton associated protein 5 0.0153338
TXNRD1 thioredoxin reductase 1 0.0153034
NUP58 nucleoporin 58 0.0152992
TUFT1 tuftelin 1 0.0152669
POTEF POTE ankyrin domain family, member F 0.0151478
PUM2 pumilio RNA-binding family member 2 0.0150274
MED13L mediator complex subunit 13-like 0.0149902
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0149726
TPX2 TPX2, microtubule-associated 0.0149034
PSD3 pleckstrin and Sec7 domain containing 3 0.0148973
ECT2 epithelial cell transforming 2 0.0148612

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.142464
NRG1 neuregulin 1 -0.141981
IGFBP5 insulin-like growth factor binding protein 5 -0.114782
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.101797
STC1 stanniocalcin 1 -0.0999038
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0941481
PTMA prothymosin, alpha -0.0910042
GPC6 glypican 6 -0.0849794
NDRG1 N-myc downstream regulated 1 -0.0844782
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.078747
RIMS2 regulating synaptic membrane exocytosis 2 -0.0786414
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0776527
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0772081
GPC5 glypican 5 -0.0758045
RORA RAR-related orphan receptor A -0.0736466
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0733663
KIF26B kinesin family member 26B -0.0718026
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0676834
ACTG1 actin gamma 1 -0.0674371
CALCA calcitonin-related polypeptide alpha -0.0672857
MT2A metallothionein 2A -0.0666495
RPL26 ribosomal protein L26 -0.0661273
ZBTB20 zinc finger and BTB domain containing 20 -0.0652561
SNTG1 syntrophin, gamma 1 -0.0645975
RPS3 ribosomal protein S3 -0.0643499
TSHZ2 teashirt zinc finger homeobox 2 -0.0641327
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0628727
RPL37A ribosomal protein L37a -0.0595308
ESRRG estrogen-related receptor gamma -0.0569938
SMYD3 SET and MYND domain containing 3 -0.0549861
IFI6 interferon, alpha-inducible protein 6 -0.054733
TPT1 tumor protein, translationally-controlled 1 -0.0542188
ENO1 enolase 1, (alpha) -0.0530042
RPS6 ribosomal protein S6 -0.052311
RPS8 ribosomal protein S8 -0.0508125
SCG2 secretogranin II -0.0497333
RIT2 Ras-like without CAAX 2 -0.0495468
RPL38 ribosomal protein L38 -0.0494583
RPS21 ribosomal protein S21 -0.0490123
TMSB4X thymosin beta 4, X-linked -0.0479642
RPL37 ribosomal protein L37 -0.0435609
RPS29 ribosomal protein S29 -0.0429247
RPS25 ribosomal protein S25 -0.041028
RPL23 ribosomal protein L23 -0.0408276
FTL ferritin, light polypeptide -0.0397847
RPS27A ribosomal protein S27a -0.0380429
NAV2 neuron navigator 2 -0.0378245
DOCK5 dedicator of cytokinesis 5 -0.0375826
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0370449
GNAS GNAS complex locus -0.0368622
RPL36A ribosomal protein L36a -0.0366918
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0366508
MMP26 matrix metallopeptidase 26 -0.0347664
COL22A1 collagen, type XXII, alpha 1 -0.0346622
CHGA chromogranin A -0.0343692
ST18 suppression of tumorigenicity 18, zinc finger -0.0334085
PGK1 phosphoglycerate kinase 1 -0.0332584
RPL11 ribosomal protein L11 -0.0331474
ASIC2 acid sensing (proton gated) ion channel 2 -0.0330093
RPLP2 ribosomal protein, large, P2 -0.0327945
ISG15 ISG15 ubiquitin-like modifier -0.0325378
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0316707
WSB1 WD repeat and SOCS box containing 1 -0.0315362
RPS27 ribosomal protein S27 -0.0311109
RPL31 ribosomal protein L31 -0.0309145
SRP72 signal recognition particle 72kDa -0.0306276
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0305511
UQCRB ubiquinol-cytochrome c reductase binding protein -0.030313
EGR1 early growth response 1 -0.0302358
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0301311
EFNA5 ephrin-A5 -0.0295618
RPS17 ribosomal protein S17 -0.0295151
NELL1 NEL-like 1 (chicken) -0.029497
BACE2 beta-site APP-cleaving enzyme 2 -0.0291268
AKAP12 A kinase (PRKA) anchor protein 12 -0.0291236
RPLP1 ribosomal protein, large, P1 -0.0287668
S100A9 S100 calcium binding protein A9 -0.0285477
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0283922
KPNB1 karyopherin (importin) beta 1 -0.0283572
RPL35A ribosomal protein L35a -0.0277744
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0277296
EPHA6 EPH receptor A6 -0.0275843
MYT1L myelin transcription factor 1-like -0.02758
RPS5 ribosomal protein S5 -0.0270762
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0269467
RPS19 ribosomal protein S19 -0.0268558
DGKD diacylglycerol kinase, delta 130kDa -0.0267929
PAEP progestagen-associated endometrial protein -0.0267651
RPS12 ribosomal protein S12 -0.0263557
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.026064
CNKSR3 CNKSR family member 3 -0.0257409
RPL34 ribosomal protein L34 -0.0257365
SEC11C SEC11 homolog C (S. cerevisiae) -0.0256171
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0252518
RPH3AL rabphilin 3A-like (without C2 domains) -0.0252504
RPL36 ribosomal protein L36 -0.0251329
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0250904
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0247518
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 -0.0244088
TFF3 trefoil factor 3 (intestinal) -0.0241791