Oleic acid_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.177874
FMN1 formin 1 0.0997666
FNDC3B fibronectin type III domain containing 3B 0.0916855
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0794163
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0711309
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0607938
SFTPA2 surfactant protein A2 0.0604193
NRG3 neuregulin 3 0.0589959
LSAMP limbic system-associated membrane protein 0.0577559
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0566849
FRMD4A FERM domain containing 4A 0.0555038
DST dystonin 0.0540074
PLEC plectin 0.0513945
IGFBP3 insulin-like growth factor binding protein 3 0.0504596
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0480361
SEPTIN9 septin 9 0.0463213
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0436447
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0390691
RNF213 ring finger protein 213 0.0345576
AKAP12 A kinase (PRKA) anchor protein 12 0.0336071
FMNL2 formin-like 2 0.0327226
CCND1 cyclin D1 0.0321608
FLNA filamin A, alpha 0.0319716
TOB2 transducer of ERBB2, 2 0.0317405
SMAD3 SMAD family member 3 0.0316185
EHBP1 EH domain binding protein 1 0.0313408
MSI2 musashi RNA-binding protein 2 0.0311689
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0311083
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.030201
LINGO2 leucine rich repeat and Ig domain containing 2 0.0301919
SOX10 SRY (sex determining region Y)-box 10 0.0291974
MAML3 mastermind-like 3 (Drosophila) 0.0282825
CA8 carbonic anhydrase VIII 0.028181
SP100 SP100 nuclear antigen 0.0275813
BACE2 beta-site APP-cleaving enzyme 2 0.0274911
LPP LIM domain containing preferred translocation partner in lipoma 0.02743
IGF1R insulin-like growth factor 1 receptor 0.0266107
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.02661
CDK6 cyclin-dependent kinase 6 0.0262615
INPP5F inositol polyphosphate-5-phosphatase F 0.0259771
ICAM1 intercellular adhesion molecule 1 0.0259703
CFAP20DC CFAP20 domain containing 0.025158
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0248733
CADM1 cell adhesion molecule 1 0.0244218
JMJD1C jumonji domain containing 1C 0.0241676
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0240983
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0240046
BHLHE40 basic helix-loop-helix family, member e40 0.0234458
SVIL supervillin 0.0231143
MAML2 mastermind-like 2 (Drosophila) 0.0227117
HDAC9 histone deacetylase 9 0.0223767
PTPRG protein tyrosine phosphatase, receptor type, G 0.0223473
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0221251
SOX6 SRY (sex determining region Y)-box 6 0.0218378
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0215598
SOD2 superoxide dismutase 2, mitochondrial 0.0213213
ZMIZ1 zinc finger, MIZ-type containing 1 0.0211776
IL1RAP interleukin 1 receptor accessory protein 0.0205574
ASPH aspartate beta-hydroxylase 0.0203044
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0201135
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0199638
MELTF melanotransferrin 0.0198616
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0197863
IFI44L interferon-induced protein 44-like 0.0193465
CUX1 cut-like homeobox 1 0.0193292
FGGY FGGY carbohydrate kinase domain containing 0.0189594
DENND1A DENN/MADD domain containing 1A 0.0187631
OSBPL10 oxysterol binding protein-like 10 0.0187312
LOC102724023 ES1 protein homolog, mitochondrial 0.0186355
CABIN1 calcineurin binding protein 1 0.0183046
PAX3 paired box 3 0.0182233
HDAC4 histone deacetylase 4 0.0181888
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0181705
FTH1 ferritin, heavy polypeptide 1 0.0180674
TAS2R14 taste receptor, type 2, member 14 0.0179666
CD96 CD96 molecule 0.017915
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0177056
SNX14 sorting nexin 14 0.0176109
CSNK1E casein kinase 1, epsilon 0.0174633
TMEM51 transmembrane protein 51 0.0174565
NRP2 neuropilin 2 0.0174344
ANKRD11 ankyrin repeat domain 11 0.0174335
ATXN1 ataxin 1 0.0172406
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0171143
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0170728
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0169421
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0166606
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.016628
PRKCSH protein kinase C substrate 80K-H 0.0164897
PTK2 protein tyrosine kinase 2 0.0164645
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0164472
EGLN1 egl-9 family hypoxia-inducible factor 1 0.016411
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0163438
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.016309
TNIK TRAF2 and NCK interacting kinase 0.0162875
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0162256
MBNL1 muscleblind-like splicing regulator 1 0.0162037
RRBP1 ribosome binding protein 1 0.0160123
MACROD2 MACRO domain containing 2 0.0158713
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0158688

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.261648
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.153033
UBC ubiquitin C -0.149636
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126399
RPS3 ribosomal protein S3 -0.101016
TMSB10 thymosin beta 10 -0.0873955
MT2A metallothionein 2A -0.0764219
RPS27A ribosomal protein S27a -0.0764083
ENO1 enolase 1, (alpha) -0.0730978
RPL23 ribosomal protein L23 -0.0662545
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0648591
PCBP2 poly(rC) binding protein 2 -0.0598651
TXNRD1 thioredoxin reductase 1 -0.0551742
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0545521
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0470487
LDHA lactate dehydrogenase A -0.0449512
RPLP1 ribosomal protein, large, P1 -0.0435358
TM4SF1 transmembrane 4 L six family member 1 -0.041216
RPS12 ribosomal protein S12 -0.0404675
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0390116
PTMA prothymosin, alpha -0.0355626
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0352413
PGK1 phosphoglycerate kinase 1 -0.0351637
RPS21 ribosomal protein S21 -0.0344498
RPS13 ribosomal protein S13 -0.0339136
ACTG1 actin gamma 1 -0.0338628
POTEF POTE ankyrin domain family, member F -0.0334701
EIF1 eukaryotic translation initiation factor 1 -0.0334523
PKM pyruvate kinase, muscle -0.0333147
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0327848
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0324774
RPL37A ribosomal protein L37a -0.031296
RPLP2 ribosomal protein, large, P2 -0.0301852
CD44 CD44 molecule (Indian blood group) -0.0301154
RPS8 ribosomal protein S8 -0.0296996
CALU calumenin -0.0291537
SLC38A1 solute carrier family 38, member 1 -0.0285892
RPL12 ribosomal protein L12 -0.0285281
GOLGA4 golgin A4 -0.0284975
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.028117
CANX calnexin -0.0280449
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0274825
RPL36A ribosomal protein L36a -0.027388
FTL ferritin, light polypeptide -0.0272548
TPM3 tropomyosin 3 -0.0269329
PDIA3 protein disulfide isomerase family A, member 3 -0.0264998
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0264962
RPS23 ribosomal protein S23 -0.0264268
MCL1 myeloid cell leukemia 1 -0.0254923
RPS29 ribosomal protein S29 -0.0252235
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.025019
WSB1 WD repeat and SOCS box containing 1 -0.0246805
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0243126
NAP1L1 nucleosome assembly protein 1-like 1 -0.0242079
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0240891
RPL5 ribosomal protein L5 -0.0240259
RPL15 ribosomal protein L15 -0.0238879
RPL31 ribosomal protein L31 -0.0238118
RPL34 ribosomal protein L34 -0.0235772
CSNK1A1 casein kinase 1, alpha 1 -0.0235301
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0234024
EMP1 epithelial membrane protein 1 -0.0233608
RBM39 RNA binding motif protein 39 -0.0233217
RTN4 reticulon 4 -0.0232807
RPL28 ribosomal protein L28 -0.0229847
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0229134
RACK1 receptor for activated C kinase 1 -0.0227594
RPL9 ribosomal protein L9 -0.0216585
VMP1 vacuole membrane protein 1 -0.0214779
ELL2 elongation factor, RNA polymerase II, 2 -0.0209986
RHOA ras homolog family member A -0.0209799
RPS24 ribosomal protein S24 -0.020915
RPS19 ribosomal protein S19 -0.0206278
SET SET nuclear proto-oncogene -0.0205822
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0198347
RPL4 ribosomal protein L4 -0.0196517
PCLO piccolo presynaptic cytomatrix protein -0.0194438
PDCD6IP programmed cell death 6 interacting protein -0.0186538
CAMTA1 calmodulin binding transcription activator 1 -0.0185424
CLIC4 chloride intracellular channel 4 -0.0183411
GARS1 glycyl-tRNA synthetase 1 -0.0183274
RPL32 ribosomal protein L32 -0.0182447
RBM25 RNA binding motif protein 25 -0.017827
DIAPH1 diaphanous-related formin 1 -0.0178176
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0178044
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0177861
RPL36 ribosomal protein L36 -0.01743
CALR calreticulin -0.0174253
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0174162
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0172996
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0172846
RPL8 ribosomal protein L8 -0.0172352
XPO1 exportin 1 -0.0171447
RPS6 ribosomal protein S6 -0.0169557
MTPN myotrophin -0.0168111
NBAS neuroblastoma amplified sequence -0.0166959
JUN jun proto-oncogene -0.0166611
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0165845
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0165328
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0164142