Oleic acid_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.119663
MYH9 myosin, heavy chain 9, non-muscle 0.101433
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.10017
FTH1 ferritin, heavy polypeptide 1 0.0901625
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0813042
AHNAK AHNAK nucleoprotein 0.0698694
SOD2 superoxide dismutase 2, mitochondrial 0.063963
PDIA4 protein disulfide isomerase family A, member 4 0.0521843
NAMPT nicotinamide phosphoribosyltransferase 0.0476195
KYNU kynureninase 0.0469108
NDRG1 N-myc downstream regulated 1 0.0461407
ERRFI1 ERBB receptor feedback inhibitor 1 0.0454157
STC1 stanniocalcin 1 0.045036
FAM13A family with sequence similarity 13, member A 0.0447559
ELL2 elongation factor, RNA polymerase II, 2 0.0416646
HIP1 huntingtin interacting protein 1 0.0414167
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0406527
FNDC3B fibronectin type III domain containing 3B 0.0389514
CXCL8 chemokine (C-X-C motif) ligand 8 0.0375973
HOOK2 hook microtubule-tethering protein 2 0.0368285
ZNF292 zinc finger protein 292 0.0367273
PLEC plectin 0.0365707
SDC4 syndecan 4 0.0360251
EEF2 eukaryotic translation elongation factor 2 0.0357501
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0312319
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0307389
CANX calnexin 0.0304637
CADM1 cell adhesion molecule 1 0.0301429
SFTPA2 surfactant protein A2 0.0301406
FLNA filamin A, alpha 0.0297067
ARRDC3 arrestin domain containing 3 0.0289203
HDLBP high density lipoprotein binding protein 0.0272129
TTC3 tetratricopeptide repeat domain 3 0.0268589
OGA O-GlcNAcase 0.0261464
UBE2H ubiquitin-conjugating enzyme E2H 0.0261256
IQGAP1 IQ motif containing GTPase activating protein 1 0.0258426
FNDC3A fibronectin type III domain containing 3A 0.0256084
AKAP9 A kinase (PRKA) anchor protein 9 0.0255109
SEC24D SEC24 family member D 0.0254154
MEF2A myocyte enhancer factor 2A 0.0243909
ANO6 anoctamin 6 0.0236887
ECE1 endothelin converting enzyme 1 0.0236464
ESYT2 extended synaptotagmin-like protein 2 0.0236371
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0230684
COPB1 coatomer protein complex, subunit beta 1 0.0227528
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0226472
RND3 Rho family GTPase 3 0.0224028
MYOF myoferlin 0.0222364
SPAG9 sperm associated antigen 9 0.0220502
LOC112694756 uncharaterized LOC112694756 0.0218437
COL6A1 collagen, type VI, alpha 1 0.0217852
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0217108
ZNF395 zinc finger protein 395 0.0216952
IRF1 interferon regulatory factor 1 0.021406
ZSWIM6 zinc finger, SWIM-type containing 6 0.0210234
RNF24 ring finger protein 24 0.0209845
DSCAM Down syndrome cell adhesion molecule 0.0209419
APP amyloid beta (A4) precursor protein 0.0208776
PDLIM5 PDZ and LIM domain 5 0.0205837
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0203935
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0202372
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0202114
DPYSL2 dihydropyrimidinase-like 2 0.0201744
SMAD3 SMAD family member 3 0.0194519
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0193196
KMT2E lysine (K)-specific methyltransferase 2E 0.0190759
SHB Src homology 2 domain containing adaptor protein B 0.018963
SSBP2 single-stranded DNA binding protein 2 0.0189457
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0188978
SEC31A SEC31 homolog A (S. cerevisiae) 0.0188029
XPO1 exportin 1 0.0185962
MACF1 microtubule-actin crosslinking factor 1 0.0183825
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0182296
GPBP1 GC-rich promoter binding protein 1 0.0180939
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0180819
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0180114
BZW1 basic leucine zipper and W2 domains 1 0.0179074
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0178589
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0178276
EMP1 epithelial membrane protein 1 0.0176625
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0173884
PFKP phosphofructokinase, platelet 0.0173751
GCC2 GRIP and coiled-coil domain containing 2 0.0170307
ASPH aspartate beta-hydroxylase 0.0169501
COPA coatomer protein complex, subunit alpha 0.0168777
RICTOR RPTOR independent companion of MTOR, complex 2 0.0165816
DDIT4 DNA-damage-inducible transcript 4 0.0165497
TRIO trio Rho guanine nucleotide exchange factor 0.016524
TXNRD1 thioredoxin reductase 1 0.0163899
PAPOLA poly(A) polymerase alpha 0.0163809
CLINT1 clathrin interactor 1 0.0162609
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0162144
RLF rearranged L-myc fusion 0.0161932
CCDC47 coiled-coil domain containing 47 0.0161618
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0160876
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0158015
TRA2A transformer 2 alpha homolog (Drosophila) 0.0156949
GOLGA4 golgin A4 0.0156569
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0156566
MBNL2 muscleblind-like splicing regulator 2 0.015535

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.198304
VIM vimentin -0.189975
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.151513
MT2A metallothionein 2A -0.127724
TGFBI transforming growth factor, beta-induced, 68kDa -0.1087
HLA-B major histocompatibility complex, class I, B -0.102129
MT1X metallothionein 1X -0.0984214
POTEF POTE ankyrin domain family, member F -0.0876546
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0875036
COL1A1 collagen, type I, alpha 1 -0.0771988
F3 coagulation factor III (thromboplastin, tissue factor) -0.0670384
COL1A2 collagen, type I, alpha 2 -0.0667554
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.058357
ENO1 enolase 1, (alpha) -0.0507394
PRSS23 protease, serine, 23 -0.0487934
FTL ferritin, light polypeptide -0.0477882
B2M beta-2-microglobulin -0.0473287
TPM1 tropomyosin 1 (alpha) -0.045308
CALD1 caldesmon 1 -0.0449356
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0377405
S100A9 S100 calcium binding protein A9 -0.0349618
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0339015
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0332255
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0318893
S100A6 S100 calcium binding protein A6 -0.0314974
SLPI secretory leukocyte peptidase inhibitor -0.0298062
PFN1 profilin 1 -0.0289518
TUBA1B tubulin, alpha 1b -0.0280064
IGFBP3 insulin-like growth factor binding protein 3 -0.0279564
TIMP1 TIMP metallopeptidase inhibitor 1 -0.027479
SEPTIN7 septin 7 -0.0272685
RPL35A ribosomal protein L35a -0.0263457
VDAC1 voltage-dependent anion channel 1 -0.0261989
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0259754
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0257769
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0256199
KAZN kazrin, periplakin interacting protein -0.0253941
PTMA prothymosin, alpha -0.0249468
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0249316
MAP1B microtubule-associated protein 1B -0.0245959
PKM pyruvate kinase, muscle -0.0245881
TFPI2 tissue factor pathway inhibitor 2 -0.0243235
NAV1 neuron navigator 1 -0.0242547
LMNA lamin A/C -0.0241297
HMGA2 high mobility group AT-hook 2 -0.0230127
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0228281
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0222069
RPS21 ribosomal protein S21 -0.0220141
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -0.0215716
RPL31 ribosomal protein L31 -0.0214798
TPT1 tumor protein, translationally-controlled 1 -0.0213757
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0213577
TUBB tubulin, beta class I -0.0213575
RTN4 reticulon 4 -0.0211547
HLA-A major histocompatibility complex, class I, A -0.0207711
PTN pleiotrophin -0.020727
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0206195
SMIM44 small integral membrane protein 44 -0.020351
ENO2 enolase 2 (gamma, neuronal) -0.0201392
MYADM myeloid-associated differentiation marker -0.0199395
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0199308
LAMB1 laminin, beta 1 -0.0196594
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0196444
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.019446
VCL vinculin -0.019325
FRMD4A FERM domain containing 4A -0.0192979
CST3 cystatin C -0.0192628
LDHA lactate dehydrogenase A -0.0191307
CYB5R3 cytochrome b5 reductase 3 -0.0190854
ARF4 ADP-ribosylation factor 4 -0.0185067
RAB7A RAB7A, member RAS oncogene family -0.018394
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0181371
CLMP CXADR-like membrane protein -0.0180749
TAGLN2 transgelin 2 -0.0180285
FN1 fibronectin 1 -0.0180027
TMSB4X thymosin beta 4, X-linked -0.0179039
TMEM165 transmembrane protein 165 -0.0178375
BRD4 bromodomain containing 4 -0.0177879
CDH13 cadherin 13 -0.0177453
SEC61G Sec61 gamma subunit -0.0176453
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0176052
RPS8 ribosomal protein S8 -0.0175507
RPL27A ribosomal protein L27a -0.0175384
ACTG1 actin gamma 1 -0.0175272
HSPB1 heat shock 27kDa protein 1 -0.0173314
CDK6 cyclin-dependent kinase 6 -0.0172905
TPM4 tropomyosin 4 -0.0172834
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0170898
RRBP1 ribosome binding protein 1 -0.0165843
GARS1 glycyl-tRNA synthetase 1 -0.0165045
RBM25 RNA binding motif protein 25 -0.0163529
RPLP1 ribosomal protein, large, P1 -0.0162158
ANKRD12 ankyrin repeat domain 12 -0.0161904
COL7A1 collagen, type VII, alpha 1 -0.0159828
CHD9 chromodomain helicase DNA binding protein 9 -0.0159256
TPI1 triosephosphate isomerase 1 -0.0158994
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0158729
RPLP2 ribosomal protein, large, P2 -0.0158088
CA9 carbonic anhydrase IX -0.0155734
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0155696