Oleic acid_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.103344
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.100315
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.093172
INTS6 integrator complex subunit 6 0.0903882
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0865402
EEF2 eukaryotic translation elongation factor 2 0.0824145
BIRC3 baculoviral IAP repeat containing 3 0.0769702
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0665371
ZSWIM6 zinc finger, SWIM-type containing 6 0.0664048
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0589396
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0571789
LOC112694756 uncharaterized LOC112694756 0.0556793
FLNA filamin A, alpha 0.0552306
PLEC plectin 0.0476394
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0475796
ASPH aspartate beta-hydroxylase 0.0444886
PDIA4 protein disulfide isomerase family A, member 4 0.0422063
SOD2 superoxide dismutase 2, mitochondrial 0.0416005
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0401853
SMAD3 SMAD family member 3 0.0399694
SQSTM1 sequestosome 1 0.0390915
GLS2 glutaminase 2 (liver, mitochondrial) 0.0386584
YAP1 Yes-associated protein 1 0.038201
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0380244
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0372255
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0366496
GOLGB1 golgin B1 0.0365803
TXNRD1 thioredoxin reductase 1 0.0357713
CALR calreticulin 0.035753
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0346797
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0341012
AKAP9 A kinase (PRKA) anchor protein 9 0.0335664
MYH9 myosin, heavy chain 9, non-muscle 0.0334892
BRD2 bromodomain containing 2 0.0320656
GPC5 glypican 5 0.0319596
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0315243
EIF4A2 eukaryotic translation initiation factor 4A2 0.0310826
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.030837
SET SET nuclear proto-oncogene 0.0307518
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0304679
LOC102724023 ES1 protein homolog, mitochondrial 0.0304644
TLE4 transducin-like enhancer of split 4 0.0303594
IRAK2 interleukin-1 receptor-associated kinase 2 0.0302312
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0300131
DSCAM Down syndrome cell adhesion molecule 0.0298548
MACF1 microtubule-actin crosslinking factor 1 0.0298288
APLP2 amyloid beta (A4) precursor-like protein 2 0.0294152
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0290581
HSPA8 heat shock 70kDa protein 8 0.0290011
MSN moesin 0.0288638
RPS12 ribosomal protein S12 0.0282105
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0278723
COG6 component of oligomeric golgi complex 6 0.0274989
NCEH1 neutral cholesterol ester hydrolase 1 0.0270617
CXCL8 chemokine (C-X-C motif) ligand 8 0.0268461
ANXA1 annexin A1 0.0263742
NABP1 nucleic acid binding protein 1 0.0256575
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0255618
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0250321
CEP250 centrosomal protein 250kDa 0.0246168
EXT1 exostosin glycosyltransferase 1 0.0242289
PCNX4 pecanex 4 0.0242281
SPTBN1 spectrin, beta, non-erythrocytic 1 0.024141
NFE2L2 nuclear factor, erythroid 2-like 2 0.0237334
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0225108
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.022463
TMF1 TATA element modulatory factor 1 0.0224583
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0224446
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0224054
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.022137
KTN1 kinectin 1 (kinesin receptor) 0.0221276
USP12 ubiquitin specific peptidase 12 0.0221128
SAMD4A sterile alpha motif domain containing 4A 0.0221041
IDS iduronate 2-sulfatase 0.0219176
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0218908
MBNL2 muscleblind-like splicing regulator 2 0.0217867
CCNL1 cyclin L1 0.0217452
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0216032
ITPRID2 ITPR interacting domain containing 2 0.0213586
IRF1 interferon regulatory factor 1 0.0212266
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0212097
COPA coatomer protein complex, subunit alpha 0.0211726
CHD1 chromodomain helicase DNA binding protein 1 0.0207241
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.020616
HLA-C major histocompatibility complex, class I, C 0.0204312
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0203892
PCBP2 poly(rC) binding protein 2 0.0201564
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0200674
SFPQ splicing factor proline/glutamine-rich 0.0199935
AGO3 argonaute RISC catalytic component 3 0.0193158
EIF5 eukaryotic translation initiation factor 5 0.0192776
RPS17 ribosomal protein S17 0.0191705
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0191218
ATF3 activating transcription factor 3 0.0188347
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0188247
ADIPOR2 adiponectin receptor 2 0.0185115
TBC1D22A TBC1 domain family, member 22A 0.0184962
IARS1 isoleucyl-tRNA synthetase 1 0.0182802
PDIA3 protein disulfide isomerase family A, member 3 0.0182795
JARID2 jumonji, AT rich interactive domain 2 0.018221

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.187997
VIM vimentin -0.18353
TMSB10 thymosin beta 10 -0.15823
BASP1 brain abundant, membrane attached signal protein 1 -0.0941593
FNDC3B fibronectin type III domain containing 3B -0.0900382
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.074128
ZMYND8 zinc finger, MYND-type containing 8 -0.067567
IGF2 insulin-like growth factor 2 -0.0673926
PTMA prothymosin, alpha -0.0663725
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0663251
ANGPTL4 angiopoietin-like 4 -0.0639703
ZBTB20 zinc finger and BTB domain containing 20 -0.0637887
TM4SF1 transmembrane 4 L six family member 1 -0.0620812
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0614175
AKAP13 A kinase (PRKA) anchor protein 13 -0.0612054
LDHA lactate dehydrogenase A -0.0573534
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0554121
DNER delta/notch-like EGF repeat containing -0.0547897
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0540447
CD44 CD44 molecule (Indian blood group) -0.0529366
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0507974
TPT1 tumor protein, translationally-controlled 1 -0.0507522
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0502875
PRKCA protein kinase C, alpha -0.0502467
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0502215
OSMR oncostatin M receptor -0.0495516
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0493595
NT5E 5'-nucleotidase, ecto (CD73) -0.0488869
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.048381
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0478057
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0462402
RBM39 RNA binding motif protein 39 -0.0454335
PRSS23 protease, serine, 23 -0.0439965
FLNB filamin B, beta -0.0424791
HMGA2 high mobility group AT-hook 2 -0.0423395
RPL35A ribosomal protein L35a -0.0415586
DPYD dihydropyrimidine dehydrogenase -0.0392769
SMYD3 SET and MYND domain containing 3 -0.0390533
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0386513
FMN1 formin 1 -0.0381718
PTK2 protein tyrosine kinase 2 -0.0379685
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0377119
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0363471
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0361962
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0358113
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0355566
PRR16 proline rich 16 -0.0347672
THSD4 thrombospondin, type I, domain containing 4 -0.0346338
DEK DEK proto-oncogene -0.0344302
DERA deoxyribose-phosphate aldolase (putative) -0.0342424
ZFAND3 zinc finger, AN1-type domain 3 -0.0336657
MATR3 matrin 3 -0.033665
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0336259
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0333964
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0325072
MT2A metallothionein 2A -0.0322876
CCDC91 coiled-coil domain containing 91 -0.0322117
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0321595
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0320094
YBX3 Y box binding protein 3 -0.0317238
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0314868
NAV2 neuron navigator 2 -0.0309786
SCAPER S-phase cyclin A-associated protein in the ER -0.0308295
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0300913
IGFBP4 insulin-like growth factor binding protein 4 -0.0296481
NALCN sodium leak channel, non selective -0.0295692
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0294528
RAI14 retinoic acid induced 14 -0.0294367
RGS17 regulator of G-protein signaling 17 -0.0289869
NCOR1 nuclear receptor corepressor 1 -0.0286648
DENND5B DENN/MADD domain containing 5B -0.0286637
SEPTIN7 septin 7 -0.0285531
SDC4 syndecan 4 -0.0285091
NPAS2 neuronal PAS domain protein 2 -0.0282305
ARB2A ARB2 cotranscriptional regulator A -0.0277179
RIN2 Ras and Rab interactor 2 -0.0275871
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0274237
GPC6 glypican 6 -0.0273274
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0271146
TRIO trio Rho guanine nucleotide exchange factor -0.0270616
H3-3B H3.3 histone B -0.0270091
RBM25 RNA binding motif protein 25 -0.026646
FNDC3A fibronectin type III domain containing 3A -0.0263471
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0263414
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0262048
PHF21A PHD finger protein 21A -0.0261942
ETV6 ets variant 6 -0.0261232
NF1 neurofibromin 1 -0.0260374
PNISR PNN-interacting serine/arginine-rich protein -0.0259504
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0258594
LMO7 LIM domain 7 -0.0258179
PYGL phosphorylase, glycogen, liver -0.0255794
MT1X metallothionein 1X -0.0255615
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0254222
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0253601
IL1RAP interleukin 1 receptor accessory protein -0.0253102
ANXA2 annexin A2 -0.0252768
TPM4 tropomyosin 4 -0.0251173
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0250211
TCF12 transcription factor 12 -0.0249171