Oleic acid_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.133104
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0889129
TMEM156 transmembrane protein 156 0.0797906
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0753258
ITGA1 integrin, alpha 1 0.0698817
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0698566
FNDC3B fibronectin type III domain containing 3B 0.0690693
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.066581
EXT1 exostosin glycosyltransferase 1 0.0664392
HIPK2 homeodomain interacting protein kinase 2 0.0625817
NRP1 neuropilin 1 0.0611603
SFTPA2 surfactant protein A2 0.060587
CD109 CD109 molecule 0.0605058
SOS1 son of sevenless homolog 1 (Drosophila) 0.0583369
EREG epiregulin 0.0583343
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.056711
MAP1B microtubule-associated protein 1B 0.0542563
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0525049
TXNIP thioredoxin interacting protein 0.0523505
SMAD3 SMAD family member 3 0.0503113
ASPH aspartate beta-hydroxylase 0.0501018
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0476032
AKAP12 A kinase (PRKA) anchor protein 12 0.0475897
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0466563
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.044186
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0434124
VEGFA vascular endothelial growth factor A 0.0431946
STC2 stanniocalcin 2 0.0431457
MYH9 myosin, heavy chain 9, non-muscle 0.0410417
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0389412
VEGFC vascular endothelial growth factor C 0.0388253
OSMR oncostatin M receptor 0.0384721
ARHGAP35 Rho GTPase activating protein 35 0.0384407
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0384188
HMGA2 high mobility group AT-hook 2 0.0378795
SVIL supervillin 0.0371774
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.036861
TXNRD1 thioredoxin reductase 1 0.0359783
H1-0 H1.0 linker histone 0.0355344
ANKRD28 ankyrin repeat domain 28 0.0348507
NFE2L2 nuclear factor, erythroid 2-like 2 0.0347997
GLIS3 GLIS family zinc finger 3 0.0342259
NPAS2 neuronal PAS domain protein 2 0.03411
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.033361
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0329731
KMT2E lysine (K)-specific methyltransferase 2E 0.0316356
SSH1 slingshot protein phosphatase 1 0.0313577
MCTP2 multiple C2 domains, transmembrane 2 0.0310222
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0303985
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0303946
MKI67 marker of proliferation Ki-67 0.0298316
PRRC2C proline-rich coiled-coil 2C 0.0297184
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0297073
AHRR aryl-hydrocarbon receptor repressor 0.0291007
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0290011
CENPF centromere protein F, 350/400kDa 0.0285505
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0283595
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0282126
SYNJ2 synaptojanin 2 0.0279597
B2M beta-2-microglobulin 0.0277597
IL6ST interleukin 6 signal transducer 0.0272086
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.026948
KLHL5 kelch-like family member 5 0.026804
ESYT2 extended synaptotagmin-like protein 2 0.0267622
LMNA lamin A/C 0.0260052
FAT1 FAT atypical cadherin 1 0.025588
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0255044
KDM2A lysine (K)-specific demethylase 2A 0.0252524
FNBP1 formin binding protein 1 0.0251051
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0250541
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0248297
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0247699
EFNA5 ephrin-A5 0.0247532
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0247441
RUNX1 runt-related transcription factor 1 0.0245531
RUNX2 runt-related transcription factor 2 0.0244619
PTK2 protein tyrosine kinase 2 0.0242187
SGMS2 sphingomyelin synthase 2 0.0241876
MB21D2 Mab-21 domain containing 2 0.0237266
SNX9 sorting nexin 9 0.0236293
LTBP1 latent transforming growth factor beta binding protein 1 0.0235935
ZC3H12C zinc finger CCCH-type containing 12C 0.0232483
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0232344
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0230257
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0227047
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0224579
SSBP2 single-stranded DNA binding protein 2 0.0223677
EEF2 eukaryotic translation elongation factor 2 0.0221284
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0217786
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0215455
POTEF POTE ankyrin domain family, member F 0.0215382
DSTN destrin (actin depolymerizing factor) 0.0214621
IDS iduronate 2-sulfatase 0.0212245
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0211154
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0209839
LRP5 low density lipoprotein receptor-related protein 5 0.0209675
RAI14 retinoic acid induced 14 0.0208238
NAMPT nicotinamide phosphoribosyltransferase 0.0207771
SH3KBP1 SH3-domain kinase binding protein 1 0.0205142
ARFGEF3 ARFGEF family member 3 0.0202224

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.0935674
TMSB10 thymosin beta 10 -0.0857063
RPS12 ribosomal protein S12 -0.0779182
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0648247
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.064355
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0618948
RPL37A ribosomal protein L37a -0.0599969
PTMA prothymosin, alpha -0.0593163
RPL26 ribosomal protein L26 -0.0542444
RPL31 ribosomal protein L31 -0.0498112
RPS6 ribosomal protein S6 -0.049353
RPS3 ribosomal protein S3 -0.0472858
RPS27A ribosomal protein S27a -0.0472181
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0444491
RPS29 ribosomal protein S29 -0.0438166
CANX calnexin -0.0435955
RPS8 ribosomal protein S8 -0.0433162
RPS24 ribosomal protein S24 -0.0432018
SQSTM1 sequestosome 1 -0.0409742
WSB1 WD repeat and SOCS box containing 1 -0.0407532
RPL9 ribosomal protein L9 -0.0400139
INTS6 integrator complex subunit 6 -0.0393237
RPS16 ribosomal protein S16 -0.0354708
RPL38 ribosomal protein L38 -0.0338704
EIF1 eukaryotic translation initiation factor 1 -0.0324204
RPLP1 ribosomal protein, large, P1 -0.0313392
RPS25 ribosomal protein S25 -0.0308342
RPL35A ribosomal protein L35a -0.0292937
RPS23 ribosomal protein S23 -0.0292427
NAP1L1 nucleosome assembly protein 1-like 1 -0.0290622
RPL36 ribosomal protein L36 -0.0280929
HLA-B major histocompatibility complex, class I, B -0.0274904
RPL12 ribosomal protein L12 -0.0269978
IER3 immediate early response 3 -0.0265328
MT2A metallothionein 2A -0.0265037
RPL19 ribosomal protein L19 -0.0265021
VCL vinculin -0.0263959
VIM vimentin -0.0258898
RPL37 ribosomal protein L37 -0.0257089
RPL13A ribosomal protein L13a -0.02547
RPLP2 ribosomal protein, large, P2 -0.0254055
RPL11 ribosomal protein L11 -0.0249965
RPS17 ribosomal protein S17 -0.0238083
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0234673
RPL34 ribosomal protein L34 -0.0234174
RPS13 ribosomal protein S13 -0.0231686
RPL36A ribosomal protein L36a -0.0229789
RPL23 ribosomal protein L23 -0.022218
RPL7A ribosomal protein L7a -0.0216346
S100A10 S100 calcium binding protein A10 -0.0216296
RPS5 ribosomal protein S5 -0.021558
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0213474
TOP1 topoisomerase (DNA) I -0.0210733
RPL28 ribosomal protein L28 -0.0197403
RPS11 ribosomal protein S11 -0.0196009
RPS15 ribosomal protein S15 -0.0193201
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0187814
RPL7 ribosomal protein L7 -0.0184188
AEBP2 AE binding protein 2 -0.0183717
CD63 CD63 molecule -0.018335
RPL30 ribosomal protein L30 -0.01794
RPS20 ribosomal protein S20 -0.0178969
ACTG1 actin gamma 1 -0.0177865
RPLP0 ribosomal protein, large, P0 -0.017669
RPS10 ribosomal protein S10 -0.0175874
FTL ferritin, light polypeptide -0.0174627
NRG1 neuregulin 1 -0.0173613
MORF4L2 mortality factor 4 like 2 -0.0170811
CALR calreticulin -0.0170577
LRRC23 leucine rich repeat containing 23 -0.0169671
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0169131
RACK1 receptor for activated C kinase 1 -0.0165073
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0159787
COX6C cytochrome c oxidase subunit VIc -0.0158238
NDRG1 N-myc downstream regulated 1 -0.0155574
RPS27 ribosomal protein S27 -0.0155275
RPL27 ribosomal protein L27 -0.0149438
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0149213
HLA-E major histocompatibility complex, class I, E -0.0148566
RPS19 ribosomal protein S19 -0.0148348
RPS21 ribosomal protein S21 -0.014735
HLA-A major histocompatibility complex, class I, A -0.0143937
IFI6 interferon, alpha-inducible protein 6 -0.0139427
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0135599
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0135527
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0134308
RPL32 ribosomal protein L32 -0.0132773
GNAS GNAS complex locus -0.0132261
KDM3A lysine (K)-specific demethylase 3A -0.0131926
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0130666
NACA nascent polypeptide-associated complex alpha subunit -0.0129151
LARP1B La ribonucleoprotein domain family, member 1B -0.0128533
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0126335
UBC ubiquitin C -0.0125642
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0124807
DDIT3 DNA-damage-inducible transcript 3 -0.012429
PNISR PNN-interacting serine/arginine-rich protein -0.0122372
RPL36AL ribosomal protein L36a-like -0.0121259
EDF1 endothelial differentiation-related factor 1 -0.0119373
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0118463