Oleic acid_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.126851
IER3 immediate early response 3 0.0704193
HILPDA hypoxia inducible lipid droplet-associated 0.0688701
ANXA1 annexin A1 0.0652995
EEF2 eukaryotic translation elongation factor 2 0.0637492
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0619219
CLIP2 CAP-GLY domain containing linker protein 2 0.0543144
EGFR epidermal growth factor receptor 0.0540589
IGFBP3 insulin-like growth factor binding protein 3 0.0514389
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0502136
SQSTM1 sequestosome 1 0.0445083
KRT18 keratin 18, type I 0.0444563
RPLP0 ribosomal protein, large, P0 0.0443007
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0440127
FTH1 ferritin, heavy polypeptide 1 0.0433061
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0432432
SNX9 sorting nexin 9 0.0412598
NCEH1 neutral cholesterol ester hydrolase 1 0.0411618
GDF15 growth differentiation factor 15 0.0405498
PTMA prothymosin, alpha 0.0395579
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0392982
BIRC3 baculoviral IAP repeat containing 3 0.0375668
LMO7 LIM domain 7 0.0369252
LOC112694756 uncharaterized LOC112694756 0.0366683
ANXA2 annexin A2 0.0357315
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0340008
SFTPA2 surfactant protein A2 0.0333197
ARHGAP42 Rho GTPase activating protein 42 0.0327717
IARS1 isoleucyl-tRNA synthetase 1 0.0314222
CLTC clathrin, heavy chain (Hc) 0.0311962
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0306789
DDIT4 DNA-damage-inducible transcript 4 0.0304784
FOSL1 FOS-like antigen 1 0.0301904
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.030069
RNF145 ring finger protein 145 0.0300375
OSBPL10 oxysterol binding protein-like 10 0.0289415
KPNB1 karyopherin (importin) beta 1 0.0283681
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0281499
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0280545
SGMS2 sphingomyelin synthase 2 0.0279653
SPRED2 sprouty-related, EVH1 domain containing 2 0.027721
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0274765
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0272052
ZFP36L1 ZFP36 ring finger protein-like 1 0.0269719
LOC102724023 ES1 protein homolog, mitochondrial 0.0268971
RPS6 ribosomal protein S6 0.0265745
LMAN1 lectin, mannose-binding, 1 0.0264754
EFNB2 ephrin-B2 0.0262277
RAD23B RAD23 homolog B (S. cerevisiae) 0.0260974
ESYT2 extended synaptotagmin-like protein 2 0.025414
ARF1 ADP-ribosylation factor 1 0.0252822
BAMBI BMP and activin membrane-bound inhibitor 0.024968
ERRFI1 ERBB receptor feedback inhibitor 1 0.0249445
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0248636
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0245297
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0243637
MYH14 myosin, heavy chain 14, non-muscle 0.0242665
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0238581
TXNIP thioredoxin interacting protein 0.0236076
LAMA4 laminin, alpha 4 0.0233969
ABR active BCR-related 0.0232036
RPLP1 ribosomal protein, large, P1 0.0229962
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0229584
NFE2L2 nuclear factor, erythroid 2-like 2 0.0228645
TMEM123 transmembrane protein 123 0.0228417
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.022752
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0224248
TSC22D2 TSC22 domain family, member 2 0.0222288
GARS1 glycyl-tRNA synthetase 1 0.0219923
KIF5B kinesin family member 5B 0.0215153
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0214975
PDLIM5 PDZ and LIM domain 5 0.0211164
SEC31A SEC31 homolog A (S. cerevisiae) 0.0209817
MXI1 MAX interactor 1, dimerization protein 0.0207412
EGR1 early growth response 1 0.0206849
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0206514
ALCAM activated leukocyte cell adhesion molecule 0.0206268
JMJD1C jumonji domain containing 1C 0.020535
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0204957
HSPA8 heat shock 70kDa protein 8 0.0202299
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0200596
LDHA lactate dehydrogenase A 0.0200504
JARID2 jumonji, AT rich interactive domain 2 0.0199749
GPBP1 GC-rich promoter binding protein 1 0.0198898
RPS2 ribosomal protein S2 0.0198296
USP3 ubiquitin specific peptidase 3 0.0194878
RLIM ring finger protein, LIM domain interacting 0.0194284
UBXN4 UBX domain protein 4 0.019326
FMNL2 formin-like 2 0.019326
LGALS3 lectin, galactoside-binding, soluble, 3 0.0192968
SON SON DNA binding protein 0.0192058
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0191182
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0189585
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0187661
TUBB tubulin, beta class I 0.0184974
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0183867
TOB2 transducer of ERBB2, 2 0.0180771
BRD2 bromodomain containing 2 0.0180286
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.017999
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0179943

decreased expression

Symbol Name Standardized Value
RPS27A ribosomal protein S27a -0.0972547
UBC ubiquitin C -0.0837378
RPS3 ribosomal protein S3 -0.0699256
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0653759
RPS29 ribosomal protein S29 -0.0598056
RPL37A ribosomal protein L37a -0.0571098
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0549028
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0523863
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0515363
RPS12 ribosomal protein S12 -0.0499737
RPL23 ribosomal protein L23 -0.0491783
TMSB10 thymosin beta 10 -0.0454281
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0446439
RPS24 ribosomal protein S24 -0.0418064
SFPQ splicing factor proline/glutamine-rich -0.0417849
RPL9 ribosomal protein L9 -0.03912
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0384182
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0372565
PCBP2 poly(rC) binding protein 2 -0.0372275
RPLP2 ribosomal protein, large, P2 -0.0370427
ENO1 enolase 1, (alpha) -0.036836
PHF14 PHD finger protein 14 -0.0357497
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0356447
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0354408
RBM25 RNA binding motif protein 25 -0.035128
FERMT1 fermitin family member 1 -0.034575
PKM pyruvate kinase, muscle -0.0338914
EXOC4 exocyst complex component 4 -0.0334171
CCSER1 coiled-coil serine-rich protein 1 -0.0323716
MTAP methylthioadenosine phosphorylase -0.0320239
KDM3A lysine (K)-specific demethylase 3A -0.0317214
AKAP12 A kinase (PRKA) anchor protein 12 -0.0291591
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.029074
AHNAK AHNAK nucleoprotein -0.0288489
ANXA11 annexin A11 -0.028848
RNF43 ring finger protein 43 -0.0287404
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0286441
CD36 CD36 molecule (thrombospondin receptor) -0.0284127
RPL26 ribosomal protein L26 -0.0280075
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0278763
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0278168
PNISR PNN-interacting serine/arginine-rich protein -0.0276061
TBC1D22A TBC1 domain family, member 22A -0.0275202
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0264668
ITPRID2 ITPR interacting domain containing 2 -0.026461
VCL vinculin -0.0264072
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0259044
ACTN4 actinin, alpha 4 -0.0259001
ASPH aspartate beta-hydroxylase -0.0256754
EZR ezrin -0.0255387
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0253722
RPL36 ribosomal protein L36 -0.0253473
OGA O-GlcNAcase -0.0251362
CUL3 cullin 3 -0.0249734
LAMC2 laminin, gamma 2 -0.02436
NBAS neuroblastoma amplified sequence -0.0240568
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0240086
KDM4C lysine (K)-specific demethylase 4C -0.0235574
RPL31 ribosomal protein L31 -0.0232906
RPL37 ribosomal protein L37 -0.0231217
RPL28 ribosomal protein L28 -0.0226588
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0224015
SMYD3 SET and MYND domain containing 3 -0.0223927
CD9 CD9 molecule -0.0220962
RPS25 ribosomal protein S25 -0.0215309
RANBP9 RAN binding protein 9 -0.0214678
CARD16 caspase recruitment domain family, member 16 -0.0212014
PLAUR plasminogen activator, urokinase receptor -0.0208539
WDR33 WD repeat domain 33 -0.0206461
ANKRD17 ankyrin repeat domain 17 -0.0204883
FAF1 Fas (TNFRSF6) associated factor 1 -0.0204853
NEK7 NIMA-related kinase 7 -0.020234
LAMB3 laminin, beta 3 -0.0201227
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa -0.0199844
WSB1 WD repeat and SOCS box containing 1 -0.019902
SLC38A2 solute carrier family 38, member 2 -0.019692
EXOC6B exocyst complex component 6B -0.0196598
FRYL FRY-like -0.0195455
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0194498
NAV2 neuron navigator 2 -0.019381
RPS15A ribosomal protein S15a -0.0192023
DOCK5 dedicator of cytokinesis 5 -0.0191748
RPS23 ribosomal protein S23 -0.0190459
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0189761
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0189486
SENP5 SUMO1/sentrin specific peptidase 5 -0.0189286
RPL5 ribosomal protein L5 -0.0187043
RPL7A ribosomal protein L7a -0.0185849
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0185614
SKAP1 src kinase associated phosphoprotein 1 -0.0184958
TOP1 topoisomerase (DNA) I -0.0183232
RPL38 ribosomal protein L38 -0.018313
RABGGTB Rab geranylgeranyltransferase, beta subunit -0.0183072
ZFAND3 zinc finger, AN1-type domain 3 -0.0182749
DIAPH2 diaphanous-related formin 2 -0.0181871
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -0.0181517
USP6NL USP6 N-terminal like -0.0180057
VMP1 vacuole membrane protein 1 -0.0178345
SRSF11 serine/arginine-rich splicing factor 11 -0.0174998
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0174775