Oleic acid_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.376583
STC1 stanniocalcin 1 0.30001
EEF2 eukaryotic translation elongation factor 2 0.144608
MYH9 myosin, heavy chain 9, non-muscle 0.139616
CD44 CD44 molecule (Indian blood group) 0.134036
COL6A1 collagen, type VI, alpha 1 0.0945682
FTH1 ferritin, heavy polypeptide 1 0.0856144
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0832024
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0765287
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0731894
VEGFA vascular endothelial growth factor A 0.0717454
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.071179
SOD2 superoxide dismutase 2, mitochondrial 0.0699426
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0613089
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0576997
NDRG1 N-myc downstream regulated 1 0.0554524
MYO10 myosin X 0.0553773
RUNX1 runt-related transcription factor 1 0.0544567
FNDC3B fibronectin type III domain containing 3B 0.0534554
B2M beta-2-microglobulin 0.052449
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0517955
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0491689
NOTCH2 notch 2 0.0484547
ASPH aspartate beta-hydroxylase 0.0481855
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0480598
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0472937
PLEC plectin 0.0471594
MSN moesin 0.0470148
SFTPA2 surfactant protein A2 0.0467499
FLNA filamin A, alpha 0.0449123
HIPK2 homeodomain interacting protein kinase 2 0.0448453
HLA-E major histocompatibility complex, class I, E 0.03998
MT2A metallothionein 2A 0.0396721
SMAD3 SMAD family member 3 0.0386846
SEPTIN9 septin 9 0.0383014
LOC112694756 uncharaterized LOC112694756 0.0378731
DST dystonin 0.0369367
ZSWIM6 zinc finger, SWIM-type containing 6 0.0365393
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0362155
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0349015
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0348341
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0334628
TGFBI transforming growth factor, beta-induced, 68kDa 0.0333912
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0331455
NAV1 neuron navigator 1 0.0327099
HLA-A major histocompatibility complex, class I, A 0.031026
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0307815
BRD2 bromodomain containing 2 0.0307238
HLA-B major histocompatibility complex, class I, B 0.0305125
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0300342
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0299178
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0295292
IGFBP7 insulin-like growth factor binding protein 7 0.0291829
GOLGB1 golgin B1 0.0291522
LOX lysyl oxidase 0.029021
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0285092
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0283822
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0280633
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0280518
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0279167
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0276874
CALR calreticulin 0.0276757
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0275048
ANKRD28 ankyrin repeat domain 28 0.0271866
TNIP1 TNFAIP3 interacting protein 1 0.0271137
CXCL8 chemokine (C-X-C motif) ligand 8 0.0270208
STC2 stanniocalcin 2 0.0270196
EPAS1 endothelial PAS domain protein 1 0.0267852
SETD5 SET domain containing 5 0.0265997
COL4A1 collagen, type IV, alpha 1 0.0263517
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0262249
KMT2E lysine (K)-specific methyltransferase 2E 0.0257663
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0257418
MCL1 myeloid cell leukemia 1 0.02562
NPTX1 neuronal pentraxin I 0.0254947
TRIO trio Rho guanine nucleotide exchange factor 0.0247648
ENO1 enolase 1, (alpha) 0.0246042
ALCAM activated leukocyte cell adhesion molecule 0.0243786
TIMP2 TIMP metallopeptidase inhibitor 2 0.0236172
ZBTB38 zinc finger and BTB domain containing 38 0.0234622
SET SET nuclear proto-oncogene 0.0231472
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0231187
TMF1 TATA element modulatory factor 1 0.0230874
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0229118
APLP2 amyloid beta (A4) precursor-like protein 2 0.0228354
VEGFC vascular endothelial growth factor C 0.0222949
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0220233
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0220131
KTN1 kinectin 1 (kinesin receptor) 0.0219944
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0219219
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0218683
ATXN1 ataxin 1 0.0214919
TPM3 tropomyosin 3 0.0214267
TNS1 tensin 1 0.0214087
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0212513
COPA coatomer protein complex, subunit alpha 0.0211183
APP amyloid beta (A4) precursor protein 0.0210921
SRRM2 serine/arginine repetitive matrix 2 0.0208637
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0207969
PDIA4 protein disulfide isomerase family A, member 4 0.0204388

decreased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 -0.214963
ADGRB3 adhesion G protein-coupled receptor B3 -0.122113
COL6A3 collagen, type VI, alpha 3 -0.121738
PRKG1 protein kinase, cGMP-dependent, type I -0.108806
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.10813
TMSB10 thymosin beta 10 -0.106637
NALF1 NALCN channel auxiliary factor 1 -0.0992687
OXR1 oxidation resistance 1 -0.0928422
ABI3BP ABI family, member 3 (NESH) binding protein -0.0899346
MMP1 matrix metallopeptidase 1 -0.080544
CAVIN1 caveolae associated protein 1 -0.080265
TPT1 tumor protein, translationally-controlled 1 -0.0766858
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.067022
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0566132
VIM vimentin -0.0546397
COL1A2 collagen, type I, alpha 2 -0.0542148
GREM1 gremlin 1, DAN family BMP antagonist -0.0444308
ACTG1 actin gamma 1 -0.0441638
RAI14 retinoic acid induced 14 -0.0440208
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0439971
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0434657
ZEB1 zinc finger E-box binding homeobox 1 -0.0409376
CDH13 cadherin 13 -0.0409206
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0405743
PRSS23 protease, serine, 23 -0.0396787
WSB1 WD repeat and SOCS box containing 1 -0.0391703
ATP13A3 ATPase type 13A3 -0.0378089
PRRX1 paired related homeobox 1 -0.0371707
RPL34 ribosomal protein L34 -0.03626
KIAA1549L KIAA1549-like -0.0348295
DIAPH2 diaphanous-related formin 2 -0.0319748
RPS24 ribosomal protein S24 -0.0317197
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.031444
SEPTIN11 septin 11 -0.0311468
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0304615
CCDC102B coiled-coil domain containing 102B -0.0302808
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0279267
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0273595
CAV1 caveolin 1, caveolae protein, 22kDa -0.0270538
FRMD4A FERM domain containing 4A -0.0264994
EMP1 epithelial membrane protein 1 -0.0259235
ARHGAP24 Rho GTPase activating protein 24 -0.025626
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0239583
RPL38 ribosomal protein L38 -0.0239379
ITGA1 integrin, alpha 1 -0.0236166
COL3A1 collagen, type III, alpha 1 -0.0227116
RPL35A ribosomal protein L35a -0.0223566
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0221597
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0217054
HAS2 hyaluronan synthase 2 -0.0215656
PRR16 proline rich 16 -0.0214717
VCAN versican -0.0210907
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0208358
PTMA prothymosin, alpha -0.0207817
DDR2 discoidin domain receptor tyrosine kinase 2 -0.020442
DLC1 DLC1 Rho GTPase activating protein -0.020384
GLIS3 GLIS family zinc finger 3 -0.0194739
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0193927
SAMD3 sterile alpha motif domain containing 3 -0.0193765
NCKAP5 NCK-associated protein 5 -0.0193764
TFPI2 tissue factor pathway inhibitor 2 -0.019055
S100A6 S100 calcium binding protein A6 -0.0185811
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0184703
AKAP12 A kinase (PRKA) anchor protein 12 -0.018265
EIF1 eukaryotic translation initiation factor 1 -0.0182145
EFCAB13 EF-hand calcium binding domain 13 -0.0179826
SBF2 SET binding factor 2 -0.0173414
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0171483
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0168962
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0167936
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0167594
TPM4 tropomyosin 4 -0.0167295
RPL37A ribosomal protein L37a -0.0166675
CHSY3 chondroitin sulfate synthase 3 -0.0165971
RPL31 ribosomal protein L31 -0.0165186
FRMPD4 FERM and PDZ domain containing 4 -0.0165077
RUNX2 runt-related transcription factor 2 -0.0163233
TENT5A terminal nucleotidyltransferase 5A -0.0162187
TSHZ3 teashirt zinc finger homeobox 3 -0.0160934
RPS29 ribosomal protein S29 -0.0159953
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0158661
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 -0.0158359
BAALC brain and acute leukemia, cytoplasmic -0.0157822
RPS21 ribosomal protein S21 -0.0157517
RPL26 ribosomal protein L26 -0.0156706
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0155087
EDNRA endothelin receptor type A -0.0153163
RASAL2 RAS protein activator like 2 -0.0150516
FUS FUS RNA binding protein -0.014898
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0147834
RPL28 ribosomal protein L28 -0.0145234
FBN1 fibrillin 1 -0.014451
TMEM165 transmembrane protein 165 -0.0144267
PGK1 phosphoglycerate kinase 1 -0.0144133
BTG1 B-cell translocation gene 1, anti-proliferative -0.0143684
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.014366
RPL9 ribosomal protein L9 -0.0143283
RPL23 ribosomal protein L23 -0.0142042
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0140037
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.013962