Oligohydramnios Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion. (Human Disease Ontology, DOID_12215)
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Genes

239 genes co-occuring with the disease Oligohydramnios in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 2.781
OXT oxytocin/neurophysin I prepropeptide 2.766
PAPPA pregnancy-associated plasma protein A, pappalysin 1 2.372
ACE angiotensin I converting enzyme 2.309
AFP alpha-fetoprotein 2.293
REN renin 2.277
PGF placental growth factor 2.185
AQP8 aquaporin 8 2.101
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.071
AQP3 aquaporin 3 (Gill blood group) 2.059
FREM2 FRAS1 related extracellular matrix protein 2 2.05
FGR FGR proto-oncogene, Src family tyrosine kinase 2.042
AQP9 aquaporin 9 2.024
FRAS1 Fraser extracellular matrix complex subunit 1 2.024
PAX2 paired box 2 2.001
TMEM67 transmembrane protein 67 1.986
AGTR1 angiotensin II receptor, type 1 1.948
NPHP3 nephronophthisis 3 (adolescent) 1.945
HNF1B HNF1 homeobox B 1.91
PKD1 polycystic kidney disease 1 (autosomal dominant) 1.885
DZIP1L DAZ interacting zinc finger protein 1-like 1.878
NPHP1 nephronophthisis 1 (juvenile) 1.867
TBX4 T-box 4 1.863
ALB albumin 1.82
CRP C-reactive protein, pentraxin-related 1.805
AQP7 aquaporin 7 1.791
INS insulin 1.79
PKD2 polycystic kidney disease 2 (autosomal dominant) 1.743
F2 coagulation factor II (thrombin) 1.705
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.684
EYA1 EYA transcriptional coactivator and phosphatase 1 1.658
CC2D2A coiled-coil and C2 domain containing 2A 1.658
INVS inversin 1.655
FLT1 fms-related tyrosine kinase 1 1.651
PAPPA2 pappalysin 2 1.648
B2M beta-2-microglobulin 1.627
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 1.622
IL6 interleukin 6 1.617
NEK8 NIMA-related kinase 8 1.607
MKS1 Meckel syndrome, type 1 1.597
ALG8 ALG8, alpha-1,3-glucosyltransferase 1.596
AQP1 aquaporin 1 (Colton blood group) 1.591
TMEM70 transmembrane protein 70 1.588
GANAB glucosidase, alpha; neutral AB 1.585
F3 coagulation factor III (thromboplastin, tissue factor) 1.572
TMEM216 transmembrane protein 216 1.563
IGFBP1 insulin-like growth factor binding protein 1 1.561
EDN1 endothelin 1 1.553
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.512
SSB Sjogren syndrome antigen B (autoantigen La) 1.489
CSH2 chorionic somatomammotropin hormone 2 1.488
AQP11 aquaporin 11 1.485
AVPR2 arginine vasopressin receptor 2 1.482
NPHP4 nephronophthisis 4 1.471
FREM1 FRAS1 related extracellular matrix 1 1.466
COQ9 coenzyme Q9 1.458
CEP290 centrosomal protein 290kDa 1.444
TCTN2 tectonic family member 2 1.437
AVP arginine vasopressin 1.437
B9D1 B9 protein domain 1 1.432
NEK9 NIMA-related kinase 9 1.428
GPHRB golgi pH regulator B 1.428
ENG endoglin 1.427
UMOD uromodulin 1.413
TMEM231 transmembrane protein 231 1.401
GDF5 growth differentiation factor 5 1.393
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 1.393
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.392
SMAD9 SMAD family member 9 1.391
ITGA8 integrin, alpha 8 1.39
TMEM11 transmembrane protein 11 1.379
AHI1 Abelson helper integration site 1 1.376
AGTR2 angiotensin II receptor, type 2 1.372
PTGFR prostaglandin F receptor (FP) 1.37
ERBB2 erb-b2 receptor tyrosine kinase 2 1.368
GREB1L growth regulation by estrogen in breast cancer-like 1.366
EPO erythropoietin 1.362
TALDO1 transaldolase 1 1.359
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 1.358
RBM10 RNA binding motif protein 10 1.356
LGALS13 lectin, galactoside-binding, soluble, 13 1.355
MMP8 matrix metallopeptidase 8 1.353
SRD5A3 steroid 5 alpha-reductase 3 1.347
SALL1 spalt-like transcription factor 1 1.346
FOXRED1 FAD-dependent oxidoreductase domain containing 1 1.344
PDE5A phosphodiesterase 5A, cGMP-specific 1.34
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.339
IL1B interleukin 1, beta 1.339
ETFDH electron-transferring-flavoprotein dehydrogenase 1.338
TRIM21 tripartite motif containing 21 1.335
EDNRB endothelin receptor type B 1.332
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 1.327
RPGRIP1L RPGRIP1-like 1.327
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 1.326
ACTG2 actin, gamma 2, smooth muscle, enteric 1.32
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 1.315
TNF tumor necrosis factor 1.315
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 1.313
AMH anti-Mullerian hormone 1.31
POMC proopiomelanocortin 1.305
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 1.304
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.304
IGF1 insulin-like growth factor 1 (somatomedin C) 1.303
FOXF1 forkhead box F1 1.3
VPS33B vacuolar protein sorting 33 homolog B (yeast) 1.291
ETFB electron-transfer-flavoprotein, beta polypeptide 1.289
TGFB1 transforming growth factor, beta 1 1.288
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.286
TTC21B tetratricopeptide repeat domain 21B 1.282
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 1.275
TTN titin 1.269
ACE2 angiotensin I converting enzyme 2 1.26
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 1.259
FN1 fibronectin 1 1.257
TTC19 tetratricopeptide repeat domain 19 1.255
CHD1L chromodomain helicase DNA binding protein 1-like 1.252
TXNDC15 thioredoxin domain containing 15 1.25
BBS1 Bardet-Biedl syndrome 1 1.247
FLNA filamin A, alpha 1.247
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 1.245
TMEM107 transmembrane protein 107 1.244
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 1.237
MNX1 motor neuron and pancreas homeobox 1 1.237
OFD1 oral-facial-digital syndrome 1 1.236
SIX2 SIX homeobox 2 1.236
GPHRA golgi pH regulator A 1.235
NOS3 nitric oxide synthase 3 (endothelial cell) 1.232
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 1.228
BBS2 Bardet-Biedl syndrome 2 1.225
PITX1 paired-like homeodomain 1 1.219
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 1.218
NPPB natriuretic peptide B 1.218
WDR35 WD repeat domain 35 1.216
IQCB1 IQ motif containing B1 1.216
FARSB phenylalanyl-tRNA synthetase, beta subunit 1.213
CXCL8 chemokine (C-X-C motif) ligand 8 1.212
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.21
WT1 Wilms tumor 1 1.209
SIX5 SIX homeobox 5 1.208
ACP6 acid phosphatase 6, lysophosphatidic 1.202
FMO5 flavin containing monooxygenase 5 1.199
ECEL1 endothelin converting enzyme-like 1 1.198
LYRM7 LYR motif containing 7 1.196
TBC1D3H TBC1 domain family, member 3H 1.196
WDR19 WD repeat domain 19 1.196
FGF10 fibroblast growth factor 10 1.193
APOH apolipoprotein H (beta-2-glycoprotein I) 1.193
KIF3A kinesin family member 3A 1.188
SFTPB surfactant protein B 1.185
SNX24 sorting nexin 24 1.18
TPM2 tropomyosin 2 (beta) 1.176
ESPN espin 1.175
PRL prolactin 1.173
BBS10 Bardet-Biedl syndrome 10 1.173
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.166
ETFA electron-transfer-flavoprotein, alpha polypeptide 1.164
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.162
OXTR oxytocin receptor 1.161
ELN elastin 1.16
BNC2 basonuclin 2 1.157
GDNF glial cell derived neurotrophic factor 1.156
AQP2 aquaporin 2 (collecting duct) 1.154
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 1.153
NBPF14 neuroblastoma breakpoint family, member 14 1.15
SOX9 SRY (sex determining region Y)-box 9 1.148
CCNQ cyclin Q 1.147
TRIM8 tripartite motif containing 8 1.147
IL10 interleukin 10 1.147
TBX1 T-box 1 1.138
SHH sonic hedgehog 1.137
WDR73 WD repeat domain 73 1.136
PRKD1 protein kinase D1 1.136
KIAA0586 KIAA0586 1.135
TBX6 T-box 6 1.133
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 1.133
FBN1 fibrillin 1 1.132
UPK3A uroplakin 3A 1.132
EXOC3L2 exocyst complex component 3-like 2 1.129
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 1.128
DUT-AS1 DUT antisense RNA 1 1.111
SIX1 SIX homeobox 1 1.111
BMP7 bone morphogenetic protein 7 1.11
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 1.109
WNT9B wingless-type MMTV integration site family, member 9B 1.108
COQ4 coenzyme Q4 1.108
NBPF20 neuroblastoma breakpoint family, member 20 1.106
PMM2 phosphomannomutase 2 1.105
SMN2 survival of motor neuron 2, centromeric 1.104
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 1.103
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 1.102
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 1.088
GJA8 gap junction protein, alpha 8, 50kDa 1.088
BMP4 bone morphogenetic protein 4 1.085
ARL13B ADP-ribosylation factor-like 13B 1.083
MRPS34 mitochondrial ribosomal protein S34 1.082
IGF2 insulin-like growth factor 2 1.08
CEP55 centrosomal protein 55kDa 1.079
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 1.078
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.075
PRKCSH protein kinase C substrate 80K-H 1.074
SMN1 survival of motor neuron 1, telomeric 1.072
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 1.071
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 1.069
NKX2-1 NK2 homeobox 1 1.064
DNAH8 dynein, axonemal, heavy chain 8 1.062
EGF epidermal growth factor 1.061
CHRM3 cholinergic receptor, muscarinic 3 1.059
NIPBL Nipped-B homolog (Drosophila) 1.055
EDNRA endothelin receptor type A 1.055
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 1.055
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.051
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 1.048
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 1.048
ARRB1 arrestin, beta 1 1.047
NPPA natriuretic peptide A 1.044
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.044
TBX18 T-box 18 1.039
ACR acrosin 1.037
DOLK dolichol kinase 1.036
DHCR7 7-dehydrocholesterol reductase 1.035
C19ORF33 chromosome 19 open reading frame 33 1.033
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.022
COL4A4 collagen, type IV, alpha 4 1.021
ARSL arylsulfatase L 1.021
SEC63 SEC63 homolog (S. cerevisiae) 1.021
BSX brain-specific homeobox 1.018
C18ORF63 chromosome 18 open reading frame 63 1.017
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.016
ZSWIM2 zinc finger, SWIM-type containing 2 1.016
EGFR epidermal growth factor receptor 1.009
OSGEP O-sialoglycoprotein endopeptidase 1.009
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 1.009
CUL7 cullin 7 1.007
PREPL prolyl endopeptidase-like 1.007
FARSA phenylalanyl-tRNA synthetase, alpha subunit 1.007
SDCCAG8 serologically defined colon cancer antigen 8 1.006
CRH corticotropin releasing hormone 1.005
FGF20 fibroblast growth factor 20 1.004
MIP major intrinsic protein of lens fiber 1.001