Oligospermia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

401 genes co-occuring with the disease Oligospermia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
DAZ1 deleted in azoospermia 1 3.094
USP9Y ubiquitin specific peptidase 9, Y-linked 2.556
AMH anti-Mullerian hormone 2.538
DAZ3 deleted in azoospermia 3 2.53
DAZL deleted in azoospermia-like 2.523
DAZ2 deleted in azoospermia 2 2.521
PRM2 protamine 2 2.515
HSFY1 heat shock transcription factor, Y-linked 1 2.47
TSSK6 testis-specific serine kinase 6 2.462
BPY2B basic charge, Y-linked, 2B 2.428
BPY2C basic charge, Y-linked, 2C 2.428
BPY2 basic charge, Y-linked, 2 2.399
TNP1 transition protein 1 (during histone to protamine replacement) 2.35
TNP2 transition protein 2 (during histone to protamine replacement) 2.346
SRY sex determining region Y 2.311
CDY2A chromodomain protein, Y-linked, 2A 2.306
TSSK4 testis-specific serine kinase 4 2.298
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.282
RBMY1A1 RNA binding motif protein, Y-linked, family 1, member A1 2.259
CDY1 chromodomain protein, Y-linked, 1 2.218
PRL prolactin 2.215
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.189
KLHL10 kelch-like family member 10 2.172
SYCP3 synaptonemal complex protein 3 2.17
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.166
SHBG sex hormone-binding globulin 2.088
TSSK3 testis-specific serine kinase 3 2.074
SPEM1 spermatid maturation 1 2.062
CATSPER1 cation channel, sperm associated 1 2.044
CDY1B chromodomain protein, Y-linked, 1B 2.041
TEX101 testis expressed 101 2.04
DAZ4 deleted in azoospermia 4 2.035
TSSK2 testis-specific serine kinase 2 2.035
USP26 ubiquitin specific peptidase 26 2.034
RPS4Y2 ribosomal protein S4, Y-linked 2 2.029
AR androgen receptor 2.002
BOLL boule-like RNA-binding protein 1.996
SPATA16 spermatogenesis associated 16 1.996
PRM1 protamine 1 1.983
INSL3 insulin-like 3 (Leydig cell) 1.956
STAR steroidogenic acute regulatory protein 1.903
AKAP4 A kinase (PRKA) anchor protein 4 1.896
DNAH1 dynein, axonemal, heavy chain 1 1.893
NR0B1 nuclear receptor subfamily 0, group B, member 1 1.873
STRA8 stimulated by retinoic acid 8 1.873
AKAP3 A kinase (PRKA) anchor protein 3 1.872
HSFY2 heat shock transcription factor, Y linked 2 1.861
ACR acrosin 1.854
PLCZ1 phospholipase C, zeta 1 1.85
DPY19L2 dpy-19-like 2 (C. elegans) 1.846
ODF1 outer dense fiber of sperm tails 1 1.84
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.836
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.827
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.826
SYCP1 synaptonemal complex protein 1 1.82
TSKS testis-specific serine kinase substrate 1.819
FSHR follicle stimulating hormone receptor 1.816
SPATA6 spermatogenesis associated 6 1.815
SPO11 SPO11 meiotic protein covalently bound to DSB 1.807
SPATA22 spermatogenesis associated 22 1.786
TEX11 testis expressed 11 1.783
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.775
HSFX1 heat shock transcription factor family, X linked 1 1.764
ZFY zinc finger protein, Y-linked 1.749
CRISP2 cysteine-rich secretory protein 2 1.748
MEST mesoderm specific transcript 1.745
KDM5D lysine (K)-specific demethylase 5D 1.741
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 1.74
H1-7 H1.7 linker histone 1.736
YBX2 Y box binding protein 2 1.73
CDY2B chromodomain protein, Y-linked, 2B 1.73
TGIF2LY TGFB-induced factor homeobox 2-like, Y-linked 1.717
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.716
POMC proopiomelanocortin 1.715
SPATC1 spermatogenesis and centriole associated 1 1.714
SPACA1 sperm acrosome associated 1 1.713
SEPTIN12 septin 12 1.71
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 1.705
PMFBP1 polyamine modulated factor 1 binding protein 1 1.702
BRDT bromodomain, testis-specific 1.702
TSPY1 testis specific protein, Y-linked 1 1.701
SPEF2 sperm flagellar 2 1.699
KATNAL1 katanin p60 subunit A-like 1 1.694
PIWIL1 piwi-like RNA-mediated gene silencing 1 1.689
TEKT4 tektin 4 1.684
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) 1.682
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.668
SPEM2 SPEM family member 2 1.664
EPPIN epididymal peptidase inhibitor 1.657
CSNK2A2 casein kinase 2, alpha prime polypeptide 1.654
GKAP1 G kinase anchoring protein 1 1.649
RIMBP3 RIMS binding protein 3 1.64
ESR1 estrogen receptor 1 1.63
CCDC54 coiled-coil domain containing 54 1.629
NANOS2 nanos homolog 2 (Drosophila) 1.627
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.615
ARMC12 armadillo repeat containing 12 1.615
AURKC aurora kinase C 1.615
PIWIL4 piwi-like RNA-mediated gene silencing 4 1.605
SNRPN small nuclear ribonucleoprotein polypeptide N 1.603
AMELY amelogenin, Y-linked 1.596
ZBTB16 zinc finger and BTB domain containing 16 1.595
DMRT1 doublesex and mab-3 related transcription factor 1 1.592
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.591
FSHB follicle stimulating hormone, beta polypeptide 1.589
ZFX zinc finger protein, X-linked 1.586
MCM9 minichromosome maintenance complex component 9 1.573
C11ORF71 chromosome 11 open reading frame 71 1.57
CFAP74 cilia and flagella associated protein 74 1.57
ANOS1 anosmin 1 1.569
KISS1 KiSS-1 metastasis-suppressor 1.567
LHCGR luteinizing hormone/choriogonadotropin receptor 1.566
RPS4Y1 ribosomal protein S4, Y-linked 1 1.562
SUN5 Sad1 and UNC84 domain containing 5 1.56
CATSPER2 cation channel, sperm associated 2 1.559
HSFX2 heat shock transcription factor family, X linked 2 1.558
FAM47C family with sequence similarity 47, member C 1.558
VCY variable charge, Y-linked 1.556
VCY1B variable charge, Y-linked 1B 1.554
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.553
TSACC TSSK6 activating co-chaperone 1.55
IZUMO1 izumo sperm-egg fusion 1 1.533
TDRD9 tudor domain containing 9 1.532
TERB1 telomere repeat binding bouquet formation protein 1 1.529
RIMBP3C RIMS binding protein 3C 1.527
RHOXF2B Rhox homeobox family, member 2B 1.519
TEX15 testis expressed 15 1.519
C22ORF23 chromosome 22 open reading frame 23 1.506
SPATA3 spermatogenesis associated 3 1.499
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.498
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 1.496
ZMYND15 zinc finger, MYND-type containing 15 1.494
PEX10 peroxisomal biogenesis factor 10 1.492
INS insulin 1.492
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 1.488
RHOXF2 Rhox homeobox family, member 2 1.487
SPATA33 spermatogenesis associated 33 1.482
TSGA10 testis specific, 10 1.481
GFRA1 GDNF family receptor alpha 1 1.48
TBL1Y transducin (beta)-like 1, Y-linked 1.474
SPACA4 sperm acrosome associated 4 1.472
ALB albumin 1.471
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 1.471
CBY2 chibby family member 2 1.47
PYGO2 pygopus family PHD finger 2 1.469
FANK1 fibronectin type III and ankyrin repeat domains 1 1.469
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 1.468
HOOK1 hook microtubule-tethering protein 1 1.468
PIWIL2 piwi-like RNA-mediated gene silencing 2 1.468
H1-6 H1.6 linker histone, cluster member 1.466
SHCBP1L SHC SH2-domain binding protein 1-like 1.466
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 1.465
CFAP65 cilia and flagella associated protein 65 1.464
CCER1 coiled-coil glutamate-rich protein 1 1.453
GNRHR gonadotropin-releasing hormone receptor 1.452
NANOS3 nanos homolog 3 (Drosophila) 1.449
PRSS55 protease, serine, 55 1.445
TEX53 testis expressed 53 1.438
ACTRT2 actin-related protein T2 1.431
TMEM95 transmembrane protein 95 1.425
PROKR2 prokineticin receptor 2 1.424
ODF2 outer dense fiber of sperm tails 2 1.423
PRDM9 PR domain containing 9 1.422
GPX3 glutathione peroxidase 3 1.42
TEKT2 tektin 2 (testicular) 1.42
SPATA31A5 SPATA31 subfamily A, member 5 1.416
PCDH11Y protocadherin 11 Y-linked 1.416
CFAP44 cilia and flagella associated protein 44 1.415
GPX5 glutathione peroxidase 5 1.413
OR2W3 olfactory receptor, family 2, subfamily W, member 3 1.411
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 1.407
TNF tumor necrosis factor 1.407
GPX4 glutathione peroxidase 4 1.406
RBMY1D RNA binding motif protein, Y-linked, family 1, member D 1.403
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 1.403
PEG3 paternally expressed 3 1.4
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 1.399
SOX9 SRY (sex determining region Y)-box 9 1.396
BMP15 bone morphogenetic protein 15 1.395
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 1.393
AMHR2 anti-Mullerian hormone receptor, type II 1.391
ADAM32 ADAM metallopeptidase domain 32 1.388
GPX6 glutathione peroxidase 6 1.385
GPRC6A G protein-coupled receptor, class C, group 6, member A 1.385
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 1.38
ADGRA3 adhesion G protein-coupled receptor A3 1.38
M1AP meiosis 1 associated protein 1.379
FHL5 four and a half LIM domains 5 1.375
RXFP2 relaxin/insulin-like family peptide receptor 2 1.375
PHF7 PHD finger protein 7 1.374
GPX8 glutathione peroxidase 8 (putative) 1.373
CCDC158 coiled-coil domain containing 158 1.371
GPX7 glutathione peroxidase 7 1.37
PPIAP39 peptidylprolyl isomerase A pseudogene 39 1.369
GSTM1 glutathione S-transferase mu 1 1.367
ACTL7B actin-like 7B 1.367
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 1.366
TGIF2LX TGFB-induced factor homeobox 2-like, X-linked 1.365
CLGN calmegin 1.364
GPX2 glutathione peroxidase 2 1.361
SOX5 SRY (sex determining region Y)-box 5 1.359
DNAH17 dynein, axonemal, heavy chain 17 1.357
ANKRD7 ankyrin repeat domain 7 1.356
SPZ1 spermatogenic leucine zipper 1 1.356
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.355
AMELX amelogenin, X-linked 1.352
PCSK4 proprotein convertase subtilisin/kexin type 4 1.346
PRSS37 protease, serine, 37 1.34
CFAP69 cilia and flagella associated protein 69 1.337
CNTROB centrobin, centrosomal BRCA2 interacting protein 1.337
ACRV1 acrosomal vesicle protein 1 1.335
LEP leptin 1.331
ZPBP zona pellucida binding protein 1.331
BCL2 B-cell CLL/lymphoma 2 1.328
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 1.328
ACTB actin, beta 1.326
CAPZA3 capping protein (actin filament) muscle Z-line, alpha 3 1.324
CLDN11 claudin 11 1.323
SPAG6 sperm associated antigen 6 1.322
IL6 interleukin 6 1.322
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 1.321
CFAP43 cilia and flagella associated protein 43 1.32
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 1.32
C2CD6 C2 calcium dependent domain containing 6 1.319
SPATA4 spermatogenesis associated 4 1.317
CEP112 centrosomal protein 112kDa 1.315
OCLN occludin 1.315
GDNF glial cell derived neurotrophic factor 1.314
FSCB fibrous sheath CABYR binding protein 1.311
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.302
MCM8 minichromosome maintenance complex component 8 1.302
ETV5 ets variant 5 1.302
MEIOB meiosis specific with OB domains 1.301
DHRS11 dehydrogenase/reductase (SDR family) member 11 1.3
TSNAXIP1 translin-associated factor X interacting protein 1 1.299
KDM3A lysine (K)-specific demethylase 3A 1.296
SOX30 SRY (sex determining region Y)-box 30 1.296
BAX BCL2-associated X protein 1.293
CLVS2 clavesin 2 1.293
GSR glutathione reductase 1.291
STPG2 sperm-tail PG-rich repeat containing 2 1.29
REC8 REC8 meiotic recombination protein 1.288
IGF1 insulin-like growth factor 1 (somatomedin C) 1.286
GDF9 growth differentiation factor 9 1.283
KLK3 kallikrein-related peptidase 3 1.283
SHOX short stature homeobox 1.273
DNAH6 dynein, axonemal, heavy chain 6 1.269
ZNF157 zinc finger protein 157 1.269
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) 1.268
FSIP2 fibrous sheath interacting protein 2 1.265
UTF1 undifferentiated embryonic cell transcription factor 1 1.264
BRWD1 bromodomain and WD repeat domain containing 1 1.264
ESR2 estrogen receptor 2 (ER beta) 1.263
TEX55 testis expressed 55 1.26
STX10 syntaxin 10 1.259
NXF2 nuclear RNA export factor 2 1.258
CFAP299 cilia and flagella associated protein 299 1.254
TEX38 testis expressed 38 1.254
CREM cAMP responsive element modulator 1.252
HSF2 heat shock transcription factor 2 1.25
SPATC1L spermatogenesis and centriole associated 1-like 1.248
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 1.248
SPATS1 spermatogenesis associated, serine-rich 1 1.244
PXDNL peroxidasin-like 1.243
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough 1.24
CEP135 centrosomal protein 135kDa 1.235
CEP162 centrosomal protein 162kDa 1.233
NXF2B nuclear RNA export factor 2B 1.229
PXDN peroxidasin 1.226
ABLIM1 actin binding LIM protein 1 1.226
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.225
RAD21L1 RAD21-like 1 (S. pombe) 1.216
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 1.215
TCP11 t-complex 11, testis-specific 1.208
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.207
IL1B interleukin 1, beta 1.207
CCDC42 coiled-coil domain containing 42 1.201
HORMAD1 HORMA domain containing 1 1.199
SPA17 sperm autoantigenic protein 17 1.198
CYCS cytochrome c, somatic 1.195
POLG polymerase (DNA directed), gamma 1.193
SEMG2 semenogelin II 1.193
SMCP sperm mitochondria-associated cysteine-rich protein 1.191
RBMY1F RNA binding motif protein, Y-linked, family 1, member F 1.19
MAGEE2 melanoma antigen family E2 1.19
TEX12 testis expressed 12 1.189
TMPRSS12 transmembrane (C-terminal) protease, serine 12 1.188
HIPK4 homeodomain interacting protein kinase 4 1.181
PCNA proliferating cell nuclear antigen 1.181
POU5F1 POU class 5 homeobox 1 1.18
ADGRG2 adhesion G protein-coupled receptor G2 1.18
PROK2 prokineticin 2 1.171
ADCY10 adenylate cyclase 10 (soluble) 1.17
MCMDC2 minichromosome maintenance domain containing 2 1.167
CATSPERD catsper channel auxiliary subunit delta 1.167
PMIS2 PMIS2 transmembrane protein 1.166
TP53 tumor protein p53 1.165
IGF2 insulin-like growth factor 2 1.164
MSH4 mutS homolog 4 1.163
LRRC8C-DT LRRC8C divergent transcript 1.163
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 1.162
TDRD6 tudor domain containing 6 1.162
ZCCHC13 zinc finger, CCHC domain containing 13 1.162
PRMT6 protein arginine methyltransferase 6 1.161
ATG7 autophagy related 7 1.161
TJP1 tight junction protein 1 1.159
VCX3B variable charge, X-linked 3B 1.149
PEG10 paternally expressed 10 1.148
DRC7 dynein regulatory complex subunit 7 1.147
FNDC3A fibronectin type III domain containing 3A 1.142
TGFB1 transforming growth factor, beta 1 1.141
TMSB4Y thymosin beta 4, Y-linked 1.136
CFAP47 cilia and flagella associated protein 47 1.135
CDYL chromodomain protein, Y-like 1.134
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 1.133
CCDC177 coiled-coil domain containing 177 1.131
DNAH5 dynein, axonemal, heavy chain 5 1.13
SEPTIN4 septin 4 1.129
TEKT1 tektin 1 1.128
TEX10 testis expressed 10 1.123
HMOX1 heme oxygenase 1 1.122
SEMG1 semenogelin I 1.119
PACRG PARK2 co-regulated 1.118
PGK2 phosphoglycerate kinase 2 1.118
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.114
CATSPER3 cation channel, sperm associated 3 1.113
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.112
RHCG Rh family, C glycoprotein 1.111
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.107
ESX1 ESX homeobox 1 1.106
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.103
ADAM2 ADAM metallopeptidase domain 2 1.102
LIMS3 LIM and senescent cell antigen-like domains 3 1.099
CFAP70 cilia and flagella associated protein 70 1.095
RHOXF1 Rhox homeobox family, member 1 1.09
ECM1 extracellular matrix protein 1 1.09
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 1.089
AFP alpha-fetoprotein 1.085
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 1.082
OAZ3 ornithine decarboxylase antizyme 3 1.082
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.081
DICER1 dicer 1, ribonuclease type III 1.081
LDHC lactate dehydrogenase C 1.079
CST9L cystatin 9-like 1.078
CCDC63 coiled-coil domain containing 63 1.077
RSPH3 radial spoke 3 homolog (Chlamydomonas) 1.077
TAS2R38 taste receptor, type 2, member 38 1.075
AK7 adenylate kinase 7 1.073
DAZAP1 DAZ associated protein 1 1.073
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 1.072
SYCP2 synaptonemal complex protein 2 1.071
VCX2 variable charge, X-linked 2 1.07
BCL6B B-cell CLL/lymphoma 6, member B 1.068
RNF133 ring finger protein 133 1.065
IL1A interleukin 1, alpha 1.062
H3-3B H3.3 histone B 1.061
KITLG KIT ligand 1.06
IL2 interleukin 2 1.06
AGO2 argonaute RISC catalytic component 2 1.056
UBR2 ubiquitin protein ligase E3 component n-recognin 2 1.055
SYCE1 synaptonemal complex central element protein 1 1.05
FMR1NB fragile X mental retardation 1 neighbor 1.049
MRPL42 mitochondrial ribosomal protein L42 1.048
GJA1 gap junction protein, alpha 1, 43kDa 1.048
TAC3 tachykinin 3 1.047
LY86 lymphocyte antigen 86 1.045
CRH corticotropin releasing hormone 1.044
LRWD1 leucine-rich repeats and WD repeat domain containing 1 1.042
ACE2 angiotensin I converting enzyme 2 1.042
TEX14 testis expressed 14 1.04
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 1.039
ARMC2 armadillo repeat containing 2 1.039
GATA4 GATA binding protein 4 1.039
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 1.036
CATSPERB catsper channel auxiliary subunit beta 1.034
PDLIM1 PDZ and LIM domain 1 1.033
NANOS1 nanos homolog 1 (Drosophila) 1.031
FAM228A family with sequence similarity 228, member A 1.029
HSPA4L heat shock 70kDa protein 4-like 1.029
PIWIL3 piwi-like RNA-mediated gene silencing 3 1.028
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.026
GPR137B G protein-coupled receptor 137B 1.026
SHOC1 shortage in chiasmata 1 1.025
H3C12 H3 clustered histone 12 1.024
EFHC2 EF-hand domain (C-terminal) containing 2 1.022
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.021
CFAP97D1 CFAP97 domain containing 1 1.02
LYZL6 lysozyme-like 6 1.016
WT1 Wilms tumor 1 1.016
ZSWIM7 zinc finger, SWIM-type containing 7 1.011
CKB creatine kinase, brain 1.009
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.009
ACE angiotensin I converting enzyme 1.009
DCDC2C doublecortin domain containing 2C 1.009
ADAM21 ADAM metallopeptidase domain 21 1.007
CRISP1 cysteine-rich secretory protein 1 1.006
PLAGL1 pleiomorphic adenoma gene-like 1 1.006
EPSTI1 epithelial stromal interaction 1 (breast) 1.005
CETN1 centrin, EF-hand protein, 1 1.005
SMC1B structural maintenance of chromosomes 1B 1.002
POU3F1 POU class 3 homeobox 1 1.001