Olopatadine Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5281071
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Genes

200 proteins with high or low expression in Olopatadine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
SPATA2L spermatogenesis associated 2-like 0.62
ZFP37 ZFP37 zinc finger protein 0.54
PLCB4 phospholipase C, beta 4 0.53
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.46
RARG retinoic acid receptor, gamma 0.46
ZNF624 zinc finger protein 624 0.45
LMF1 lipase maturation factor 1 0.43
CDK10 cyclin-dependent kinase 10 0.42
ZNF227 zinc finger protein 227 0.42
TTLL4 tubulin tyrosine ligase-like family member 4 0.41
CARD8 caspase recruitment domain family, member 8 0.41
TICRR TOPBP1-interacting checkpoint and replication regulator 0.39
NRP1 neuropilin 1 0.39
FGD6 FYVE, RhoGEF and PH domain containing 6 0.39
GPANK1 G patch domain and ankyrin repeats 1 0.38
NOTCH3 notch 3 0.37
SERAC1 serine active site containing 1 0.33
C5ORF34 chromosome 5 open reading frame 34 0.33
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.33
CDKN3 cyclin-dependent kinase inhibitor 3 0.32
AMACR alpha-methylacyl-CoA racemase 0.32
ZMAT5 zinc finger, matrin-type 5 0.32
TWSG1 twisted gastrulation BMP signaling modulator 1 0.31
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.31
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.3
ZNF431 zinc finger protein 431 0.3
C12ORF4 chromosome 12 open reading frame 4 0.3
C9ORF40 chromosome 9 open reading frame 40 0.3
THBS2 thrombospondin 2 0.3
ZNF367 zinc finger protein 367 0.29
RPL36AL ribosomal protein L36a-like 0.29
CC2D2A coiled-coil and C2 domain containing 2A 0.29
SCARA3 scavenger receptor class A, member 3 0.29
CKM creatine kinase, muscle 0.29
ZNF460 zinc finger protein 460 0.29
CRPPA CDP-L-ribitol pyrophosphorylase A 0.28
CTSH cathepsin H 0.28
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.27
E2F2 E2F transcription factor 2 0.27
FKTN fukutin 0.26
ZFP36L2 ZFP36 ring finger protein-like 2 0.26
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 0.26
DOCK11 dedicator of cytokinesis 11 0.26
MDM4 MDM4, p53 regulator 0.26
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone 0.26
PIP prolactin-induced protein 0.26
GTSF1 gametocyte specific factor 1 0.26
SLC35A4 solute carrier family 35, member A4 0.26
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.26
FAM104A family with sequence similarity 104, member A 0.26
CLCN7 chloride channel, voltage-sensitive 7 0.25
MPHOSPH9 M-phase phosphoprotein 9 0.25
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.25
ZBED6 zinc finger, BED-type containing 6 0.25
SYTL3 synaptotagmin-like 3 0.25
PUM2 pumilio RNA-binding family member 2 0.24
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.24
ZNF729 zinc finger protein 729 0.24
KMT2B lysine (K)-specific methyltransferase 2B 0.24
SLC45A1 solute carrier family 45, member 1 0.23
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 0.23
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 0.23
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 0.23
CENPJ centromere protein J 0.23
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 0.22
SASH1 SAM and SH3 domain containing 1 0.22
SATB1 SATB homeobox 1 0.22
AEN apoptosis enhancing nuclease 0.22
COMMD9 COMM domain containing 9 0.22
COA5 cytochrome c oxidase assembly factor 5 0.22
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.22
OASL 2'-5'-oligoadenylate synthetase-like 0.22
CEP72 centrosomal protein 72kDa 0.22
RNF115 ring finger protein 115 0.22
TP73 tumor protein p73 0.22
PPHLN1 periphilin 1 0.21
KRT222 keratin 222, type II 0.21
EWSR1 EWS RNA-binding protein 1 0.21
PFN2 profilin 2 0.21
LYRM7 LYR motif containing 7 0.21
CCDC170 coiled-coil domain containing 170 0.21
SMIM26 small integral membrane protein 26 0.21
MOCS1 molybdenum cofactor synthesis 1 0.21
CCNF cyclin F 0.21
VRK1 vaccinia related kinase 1 0.21
DCAF17 DDB1 and CUL4 associated factor 17 0.21
RNF170 ring finger protein 170 0.2
RBL2 retinoblastoma-like 2 0.2
PAQR4 progestin and adipoQ receptor family member IV 0.2
UBXN2A UBX domain protein 2A 0.2
UPP1 uridine phosphorylase 1 0.2
AHI1 Abelson helper integration site 1 0.2
CEP63 centrosomal protein 63kDa 0.2
RNASEH2C ribonuclease H2, subunit C 0.2
CCDC18 coiled-coil domain containing 18 0.2
RNF6 ring finger protein (C3H2C3 type) 6 0.2
GLRX2 glutaredoxin 2 0.2
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.2
CAB39L calcium binding protein 39-like 0.2
CFAP58 cilia and flagella associated protein 58 0.19

low expression

Symbol Name Standardized Value
TSPAN3 tetraspanin 3 -0.72
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -0.7
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -0.55
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.54
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -0.51
CD63 CD63 molecule -0.5
RPP25 ribonuclease P/MRP 25kDa subunit -0.49
B9D1 B9 protein domain 1 -0.48
DUSP7 dual specificity phosphatase 7 -0.47
SBNO2 strawberry notch homolog 2 (Drosophila) -0.47
ACVR2A activin A receptor, type IIA -0.46
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -0.46
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -0.45
PIGX phosphatidylinositol glycan anchor biosynthesis, class X -0.43
CENPL centromere protein L -0.42
EFCAB7 EF-hand calcium binding domain 7 -0.42
METTL7A methyltransferase like 7A -0.42
FAM171A2 family with sequence similarity 171, member A2 -0.41
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) -0.4
GPN2 GPN-loop GTPase 2 -0.4
MID2 midline 2 -0.39
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.38
ABLIM2 actin binding LIM protein family, member 2 -0.36
FN1 fibronectin 1 -0.35
PLCD1 phospholipase C, delta 1 -0.35
PLPP3 phospholipid phosphatase 3 -0.34
SLC22A18 solute carrier family 22, member 18 -0.34
UST uronyl-2-sulfotransferase -0.34
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -0.34
HSPA1L heat shock 70kDa protein 1-like -0.33
NDFIP1 Nedd4 family interacting protein 1 -0.33
CASP10 caspase 10, apoptosis-related cysteine peptidase -0.32
PES1 pescadillo ribosomal biogenesis factor 1 -0.31
ECHDC3 enoyl CoA hydratase domain containing 3 -0.3
RNF149 ring finger protein 149 -0.3
FTH1 ferritin, heavy polypeptide 1 -0.3
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) -0.3
ZNRD1 zinc ribbon domain containing 1 -0.3
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -0.29
TMEM62 transmembrane protein 62 -0.29
ZNF16 zinc finger protein 16 -0.29
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.29
ZDHHC8 zinc finger, DHHC-type containing 8 -0.28
SUSD1 sushi domain containing 1 -0.28
MEGF8 multiple EGF-like-domains 8 -0.28
ZNF337 zinc finger protein 337 -0.28
CCNQ cyclin Q -0.27
ZNF513 zinc finger protein 513 -0.27
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -0.27
KLK7 kallikrein-related peptidase 7 -0.27
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -0.27
IFITM3 interferon induced transmembrane protein 3 -0.27
NDFIP2 Nedd4 family interacting protein 2 -0.27
MDP1 magnesium-dependent phosphatase 1 -0.26
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.26
RNF167 ring finger protein 167 -0.25
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.25
ICOSLG inducible T-cell co-stimulator ligand -0.25
GGT1 gamma-glutamyltransferase 1 -0.25
LPIN3 lipin 3 -0.25
S100A14 S100 calcium binding protein A14 -0.25
SPPL2B signal peptide peptidase like 2B -0.25
MSL3P1 male-specific lethal 3 homolog (Drosophila) pseudogene 1 -0.24
CDA cytidine deaminase -0.24
ADGRF1 adhesion G protein-coupled receptor F1 -0.24
TNK2 tyrosine kinase, non-receptor, 2 -0.24
PTK6 protein tyrosine kinase 6 -0.24
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide -0.24
PHYH phytanoyl-CoA 2-hydroxylase -0.24
KMT2C lysine (K)-specific methyltransferase 2C -0.24
TYRO3 TYRO3 protein tyrosine kinase -0.23
ACTN4 actinin, alpha 4 -0.23
MAF1 MAF1 homolog (S. cerevisiae) -0.23
FLII flightless I homolog (Drosophila) -0.23
MED19 mediator complex subunit 19 -0.23
ZDHHC9 zinc finger, DHHC-type containing 9 -0.23
IQGAP2 IQ motif containing GTPase activating protein 2 -0.23
CCAR2 cell cycle and apoptosis regulator 2 -0.22
DUOX1 dual oxidase 1 -0.22
RAB27B RAB27B, member RAS oncogene family -0.22
NAP1L1 nucleosome assembly protein 1-like 1 -0.22
LMBR1 limb development membrane protein 1 -0.22
ADIRF adipogenesis regulatory factor -0.22
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.22
CECR2 cat eye syndrome chromosome region, candidate 2 -0.22
PCDH1 protocadherin 1 -0.22
JRKL JRK-like -0.22
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 -0.22
DDAH2 dimethylarginine dimethylaminohydrolase 2 -0.22
PER2 period circadian clock 2 -0.22
RCAN3 RCAN family member 3 -0.21
RFLNB refilin B -0.21
SAMD4A sterile alpha motif domain containing 4A -0.21
PLD1 phospholipase D1, phosphatidylcholine-specific -0.21
PRIMPOL primase and polymerase (DNA-directed) -0.21
ATG4A autophagy related 4A, cysteine peptidase -0.21
KLF3 Kruppel-like factor 3 (basic) -0.21
NDRG2 NDRG family member 2 -0.21
MED31 mediator complex subunit 31 -0.21
R3HCC1L R3H domain and coiled-coil containing 1-like -0.21