Omeprazole (sodium)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.249892
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.179404
AKAP12 A kinase (PRKA) anchor protein 12 0.158033
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.119873
TRIO trio Rho guanine nucleotide exchange factor 0.119744
PODXL podocalyxin-like 0.104683
CDH13 cadherin 13 0.0879889
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0874678
NAV1 neuron navigator 1 0.0772629
SLC39A11 solute carrier family 39, member 11 0.0718542
COL8A1 collagen, type VIII, alpha 1 0.0686515
IGFBP3 insulin-like growth factor binding protein 3 0.0654372
POTEF POTE ankyrin domain family, member F 0.0645171
COL5A1 collagen, type V, alpha 1 0.0627328
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0597111
ABI3BP ABI family, member 3 (NESH) binding protein 0.0569122
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0564276
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0542179
L1CAM L1 cell adhesion molecule 0.0539703
EGFR epidermal growth factor receptor 0.0522985
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0480753
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0453043
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.044238
DST dystonin 0.0438431
MAP1B microtubule-associated protein 1B 0.0416317
PBX3 pre-B-cell leukemia homeobox 3 0.0410115
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0404715
HDAC9 histone deacetylase 9 0.0403126
FN1 fibronectin 1 0.0400909
MSN moesin 0.0385436
MACF1 microtubule-actin crosslinking factor 1 0.0384842
MYOF myoferlin 0.0378477
DLG1 discs, large homolog 1 (Drosophila) 0.0377589
RUNX1 runt-related transcription factor 1 0.0374202
PLAT plasminogen activator, tissue 0.0352634
DCLK2 doublecortin-like kinase 2 0.0351395
ZFP36L1 ZFP36 ring finger protein-like 1 0.0348983
ADAM9 ADAM metallopeptidase domain 9 0.0347558
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0341411
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0335906
PEA15 phosphoprotein enriched in astrocytes 15 0.0323296
SETD5 SET domain containing 5 0.0321146
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0314152
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0303605
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0303493
PGK1 phosphoglycerate kinase 1 0.0299456
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.02948
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0293206
ASPH aspartate beta-hydroxylase 0.0290811
NCOR2 nuclear receptor corepressor 2 0.0285942
FNDC3B fibronectin type III domain containing 3B 0.0284351
ZMIZ1 zinc finger, MIZ-type containing 1 0.028097
SP3 Sp3 transcription factor 0.0277501
TIMP2 TIMP metallopeptidase inhibitor 2 0.0271827
ANO6 anoctamin 6 0.0269065
ELL2 elongation factor, RNA polymerase II, 2 0.0268978
NFE2L1 nuclear factor, erythroid 2-like 1 0.0255702
TENM3 teneurin transmembrane protein 3 0.0254575
MSI2 musashi RNA-binding protein 2 0.0251255
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0250105
LOXL2 lysyl oxidase-like 2 0.0249779
EFNA5 ephrin-A5 0.0248137
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0247272
C1D C1D nuclear receptor corepressor 0.0245087
DGKG diacylglycerol kinase, gamma 90kDa 0.0237521
FOSL1 FOS-like antigen 1 0.0235175
FLNB filamin B, beta 0.0231206
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0222719
TOX thymocyte selection-associated high mobility group box 0.0222627
CUX1 cut-like homeobox 1 0.0221917
DSPP dentin sialophosphoprotein 0.0221386
PDIA3 protein disulfide isomerase family A, member 3 0.0219387
SPIRE1 spire-type actin nucleation factor 1 0.0217813
TNIP1 TNFAIP3 interacting protein 1 0.0212106
VEGFA vascular endothelial growth factor A 0.021049
SYTL3 synaptotagmin-like 3 0.0210025
LIMCH1 LIM and calponin homology domains 1 0.0209319
AUTS2 autism susceptibility candidate 2 0.0208718
TPM1 tropomyosin 1 (alpha) 0.0208616
FLT1 fms-related tyrosine kinase 1 0.0208546
ZNF292 zinc finger protein 292 0.0206714
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0201907
PDE4D phosphodiesterase 4D, cAMP-specific 0.0201317
SEPTIN9 septin 9 0.0200082
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0199479
ZNF462 zinc finger protein 462 0.0194044
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0193657
PKM pyruvate kinase, muscle 0.0190235
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0189437
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0187817
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0187005
DTNA dystrobrevin, alpha 0.0185221
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.0185079
SAMD9 sterile alpha motif domain containing 9 0.0183499
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0183467
CD109 CD109 molecule 0.018318
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0180033
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0180016
SPDL1 spindle apparatus coiled-coil protein 1 0.0179967
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.01798

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.19221
TMSB10 thymosin beta 10 -0.134108
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.106847
VIM vimentin -0.0949998
MT2A metallothionein 2A -0.0904532
HLA-B major histocompatibility complex, class I, B -0.0707285
COL3A1 collagen, type III, alpha 1 -0.0655275
FBN1 fibrillin 1 -0.0652474
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0632067
PTMA prothymosin, alpha -0.0543633
S100A10 S100 calcium binding protein A10 -0.0537037
COL1A2 collagen, type I, alpha 2 -0.0503307
MEIS2 Meis homeobox 2 -0.0493719
SQSTM1 sequestosome 1 -0.0482766
LMNA lamin A/C -0.0479891
S100A6 S100 calcium binding protein A6 -0.0473136
TPT1 tumor protein, translationally-controlled 1 -0.0431188
LOC112694756 uncharaterized LOC112694756 -0.0422558
CANX calnexin -0.0417147
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0414931
HLA-E major histocompatibility complex, class I, E -0.0413329
ANXA2 annexin A2 -0.0410297
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0382431
COL5A2 collagen, type V, alpha 2 -0.0379117
AHNAK AHNAK nucleoprotein -0.0374022
CAVIN1 caveolae associated protein 1 -0.0364515
HLA-C major histocompatibility complex, class I, C -0.0358367
NAP1L1 nucleosome assembly protein 1-like 1 -0.0344497
IFITM3 interferon induced transmembrane protein 3 -0.0343565
UBC ubiquitin C -0.0337472
RRBP1 ribosome binding protein 1 -0.0331522
FBXL7 F-box and leucine-rich repeat protein 7 -0.0321513
RPS24 ribosomal protein S24 -0.0314504
B2M beta-2-microglobulin -0.0307703
EIF1 eukaryotic translation initiation factor 1 -0.0291374
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0288888
OGA O-GlcNAcase -0.0280762
TTC3 tetratricopeptide repeat domain 3 -0.0260686
HDLBP high density lipoprotein binding protein -0.0258859
IFI16 interferon, gamma-inducible protein 16 -0.0255479
GLIS3 GLIS family zinc finger 3 -0.0249344
NPR2 natriuretic peptide receptor 2 -0.0243454
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0239106
RHOBTB3 Rho-related BTB domain containing 3 -0.0237916
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0233679
TM4SF1 transmembrane 4 L six family member 1 -0.0233284
RPL35A ribosomal protein L35a -0.0231941
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0226875
RPL23 ribosomal protein L23 -0.02215
SP100 SP100 nuclear antigen -0.0220542
H3-3B H3.3 histone B -0.021998
FTL ferritin, light polypeptide -0.0217241
RBM39 RNA binding motif protein 39 -0.0214978
MT1X metallothionein 1X -0.0213672
ANKRD10 ankyrin repeat domain 10 -0.0212223
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0211993
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0208824
KPNB1 karyopherin (importin) beta 1 -0.0204659
ZNF207 zinc finger protein 207 -0.0204575
RABGAP1L RAB GTPase activating protein 1-like -0.0202533
RPL19 ribosomal protein L19 -0.020121
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0200681
TMSB4X thymosin beta 4, X-linked -0.0199983
RPS19 ribosomal protein S19 -0.0199756
RPL34 ribosomal protein L34 -0.019948
RPS6 ribosomal protein S6 -0.0198893
SMC4 structural maintenance of chromosomes 4 -0.0198843
WSB1 WD repeat and SOCS box containing 1 -0.0198316
RPL26 ribosomal protein L26 -0.0196399
RPS27A ribosomal protein S27a -0.0193809
S100A4 S100 calcium binding protein A4 -0.0192887
RPL12 ribosomal protein L12 -0.0191451
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0189795
VDAC1 voltage-dependent anion channel 1 -0.0189386
GNAS GNAS complex locus -0.0189093
ARL4C ADP-ribosylation factor-like 4C -0.018761
RAD21 RAD21 homolog (S. pombe) -0.0186938
ARF1 ADP-ribosylation factor 1 -0.0186619
STK17A serine/threonine kinase 17a -0.0184656
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0184549
PNRC1 proline-rich nuclear receptor coactivator 1 -0.018384
IFITM1 interferon induced transmembrane protein 1 -0.0183557
TUBB tubulin, beta class I -0.0183119
AKAP9 A kinase (PRKA) anchor protein 9 -0.0182222
RPLP2 ribosomal protein, large, P2 -0.0180201
NF1 neurofibromin 1 -0.0179568
MX2 MX dynamin-like GTPase 2 -0.0176856
STC1 stanniocalcin 1 -0.0176521
HMGB2 high mobility group box 2 -0.0176131
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0175314
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0174854
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.017472
HIP1 huntingtin interacting protein 1 -0.0173479
RIGI RNA sensor RIG-I -0.0173391
FTH1 ferritin, heavy polypeptide 1 -0.0172816
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0172624
TXNIP thioredoxin interacting protein -0.0170835
AOPEP aminopeptidase O (putative) -0.0170341
TRIM56 tripartite motif containing 56 -0.0166301
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0166097