Omeprazole (sodium)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.0492929
NRIP1 nuclear receptor interacting protein 1 0.046102
FNDC3B fibronectin type III domain containing 3B 0.0431544
VCL vinculin 0.0427227
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0406538
ZCCHC7 zinc finger, CCHC domain containing 7 0.0400202
INTS6 integrator complex subunit 6 0.0391258
GPC6 glypican 6 0.0375253
NRP2 neuropilin 2 0.034735
PDLIM5 PDZ and LIM domain 5 0.0346429
SEPTIN9 septin 9 0.0344355
SMAD3 SMAD family member 3 0.0341586
ZSWIM6 zinc finger, SWIM-type containing 6 0.0339999
CXCL8 chemokine (C-X-C motif) ligand 8 0.0327555
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0319891
KYNU kynureninase 0.0310343
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0299023
ADM adrenomedullin 0.0291888
EGFR epidermal growth factor receptor 0.0286591
PALLD palladin, cytoskeletal associated protein 0.0273387
TGFB2 transforming growth factor, beta 2 0.0272838
NUP98 nucleoporin 98kDa 0.0245058
MYH9 myosin, heavy chain 9, non-muscle 0.0243692
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0240953
SAMD4A sterile alpha motif domain containing 4A 0.0237503
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0235934
CMIP c-Maf inducing protein 0.023312
PDE4D phosphodiesterase 4D, cAMP-specific 0.0230048
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0229562
TGM2 transglutaminase 2 0.0224691
RAD51B RAD51 paralog B 0.0223094
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0221544
JAK1 Janus kinase 1 0.0220857
P3H2 prolyl 3-hydroxylase 2 0.0220771
MSN moesin 0.0217415
ELOVL5 ELOVL fatty acid elongase 5 0.0215639
CYB5R3 cytochrome b5 reductase 3 0.0213174
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0211539
ZFP36L1 ZFP36 ring finger protein-like 1 0.0211042
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0206992
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0206958
PAX8 paired box 8 0.0205353
ITGAV integrin, alpha V 0.0202223
MB21D2 Mab-21 domain containing 2 0.0201477
CSF1 colony stimulating factor 1 (macrophage) 0.0200435
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0196042
CUX1 cut-like homeobox 1 0.0194514
ANKRD17 ankyrin repeat domain 17 0.0194212
LPP LIM domain containing preferred translocation partner in lipoma 0.0193793
MBNL1 muscleblind-like splicing regulator 1 0.0192895
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0189943
FAT1 FAT atypical cadherin 1 0.0189874
TIMP2 TIMP metallopeptidase inhibitor 2 0.0182975
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0181688
VMP1 vacuole membrane protein 1 0.0179152
CTBP2 C-terminal binding protein 2 0.0176404
PILRA paired immunoglobin-like type 2 receptor alpha 0.0175462
WASL Wiskott-Aldrich syndrome-like 0.0173989
DST dystonin 0.0173952
GOSR2 golgi SNAP receptor complex member 2 0.017385
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0172399
COPA coatomer protein complex, subunit alpha 0.0172037
MKI67 marker of proliferation Ki-67 0.0168757
PBX1 pre-B-cell leukemia homeobox 1 0.01638
RIC8B RIC8 guanine nucleotide exchange factor B 0.0163352
DOCK5 dedicator of cytokinesis 5 0.0163118
MYO1E myosin IE 0.0162961
UBAP2 ubiquitin associated protein 2 0.0160133
GDI2 GDP dissociation inhibitor 2 0.0160079
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0159643
LIMA1 LIM domain and actin binding 1 0.0159085
MRTFA myocardin related transcription factor A 0.0155554
EML4 echinoderm microtubule associated protein like 4 0.0154501
CLIP2 CAP-GLY domain containing linker protein 2 0.015407
ADAM17 ADAM metallopeptidase domain 17 0.0153258
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0152857
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0151952
SIK3 SIK family kinase 3 0.0151914
MAML2 mastermind-like 2 (Drosophila) 0.0149118
TNS3 tensin 3 0.0148315
ATP13A3 ATPase type 13A3 0.0147826
RNF220 ring finger protein 220 0.0146958
USP47 ubiquitin specific peptidase 47 0.0146784
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0145893
BPTF bromodomain PHD finger transcription factor 0.0143007
CPAP centrosome assembly and centriole elongation protein 0.0142785
SDK1 sidekick cell adhesion molecule 1 0.0140761
CRY1 cryptochrome circadian clock 1 0.0138717
TPST1 tyrosylprotein sulfotransferase 1 0.01383
SRRM2 serine/arginine repetitive matrix 2 0.0136806
CREB5 cAMP responsive element binding protein 5 0.0135428
MTAP methylthioadenosine phosphorylase 0.0135277
GLIS3 GLIS family zinc finger 3 0.0134188
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0133072
SUCO SUN domain containing ossification factor 0.0132498
VEGFA vascular endothelial growth factor A 0.0132417
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0131423
CLIC4 chloride intracellular channel 4 0.0130947
BIRC3 baculoviral IAP repeat containing 3 0.0129372
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0129171

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137776
IGFBP3 insulin-like growth factor binding protein 3 -0.12488
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.105457
NAMPT nicotinamide phosphoribosyltransferase -0.0907458
VIM vimentin -0.0861956
TMSB10 thymosin beta 10 -0.0800566
ASPH aspartate beta-hydroxylase -0.0682234
RRBP1 ribosome binding protein 1 -0.0675522
TXNRD1 thioredoxin reductase 1 -0.0514203
RPS4X ribosomal protein S4, X-linked -0.0490881
HSPB1 heat shock 27kDa protein 1 -0.0450195
FTL ferritin, light polypeptide -0.0422865
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.041733
LOC112694756 uncharaterized LOC112694756 -0.0377712
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0373865
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0372468
CANX calnexin -0.0372368
NAP1L1 nucleosome assembly protein 1-like 1 -0.0368268
CALU calumenin -0.0368117
GARS1 glycyl-tRNA synthetase 1 -0.0361448
FTH1 ferritin, heavy polypeptide 1 -0.036016
RPL30 ribosomal protein L30 -0.0350697
MAP1B microtubule-associated protein 1B -0.0350241
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0343929
RPLP1 ribosomal protein, large, P1 -0.0342701
ANXA2 annexin A2 -0.0338318
LMNA lamin A/C -0.0336978
RPS6 ribosomal protein S6 -0.0336896
KPNB1 karyopherin (importin) beta 1 -0.0331672
RTN4 reticulon 4 -0.0327088
CP ceruloplasmin (ferroxidase) -0.0327061
GNAS GNAS complex locus -0.0314133
HMGB1 high mobility group box 1 -0.03075
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0300959
CBX3 chromobox homolog 3 -0.0299431
RNF213 ring finger protein 213 -0.029785
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0296164
TPM4 tropomyosin 4 -0.0292521
RPL12 ribosomal protein L12 -0.0289346
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0289291
PFN1 profilin 1 -0.0287617
RPS19 ribosomal protein S19 -0.0282005
RPL19 ribosomal protein L19 -0.0279953
S100A6 S100 calcium binding protein A6 -0.0278742
LMAN1 lectin, mannose-binding, 1 -0.0276086
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0273607
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0256268
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0253924
TUSC3 tumor suppressor candidate 3 -0.0253159
PDIA3 protein disulfide isomerase family A, member 3 -0.024821
SEC62 SEC62 homolog (S. cerevisiae) -0.0245506
RAB2A RAB2A, member RAS oncogene family -0.0244949
TKT transketolase -0.0243007
CD44 CD44 molecule (Indian blood group) -0.023958
RPLP0 ribosomal protein, large, P0 -0.0238558
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0236746
RPL23 ribosomal protein L23 -0.0234412
RAD21 RAD21 homolog (S. pombe) -0.0233131
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0229028
SDCBP syndecan binding protein (syntenin) -0.0226713
B2M beta-2-microglobulin -0.0222047
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0215797
RPL35 ribosomal protein L35 -0.0211753
TRAM1 translocation associated membrane protein 1 -0.0207074
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G -0.0206941
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0204356
RIGI RNA sensor RIG-I -0.0203725
SEPTIN7 septin 7 -0.0203485
KLF6 Kruppel-like factor 6 -0.0201445
RPL27A ribosomal protein L27a -0.0200996
SRP72 signal recognition particle 72kDa -0.0200963
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0200501
TAGLN2 transgelin 2 -0.0199535
GDF15 growth differentiation factor 15 -0.019797
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0196049
GLS2 glutaminase 2 (liver, mitochondrial) -0.0195876
HDLBP high density lipoprotein binding protein -0.0195667
IFIH1 interferon induced with helicase C domain 1 -0.0195469
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0195137
RPS2 ribosomal protein S2 -0.0195077
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.019325
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0188761
CKAP4 cytoskeleton-associated protein 4 -0.0188008
MYADM myeloid-associated differentiation marker -0.0184897
MTDH metadherin -0.0184637
CAV1 caveolin 1, caveolae protein, 22kDa -0.0182363
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0181785
WAC WW domain containing adaptor with coiled-coil -0.0180363
RPS5 ribosomal protein S5 -0.0179857
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0179755
KTN1 kinectin 1 (kinesin receptor) -0.0179207
ANXA1 annexin A1 -0.0178105
GGNBP2 gametogenetin binding protein 2 -0.017718
RPL36 ribosomal protein L36 -0.0176915
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0176531
MT2A metallothionein 2A -0.0175127
RAB1A RAB1A, member RAS oncogene family -0.0174658
NOP58 NOP58 ribonucleoprotein -0.0174422
RPL7 ribosomal protein L7 -0.0173991
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.017368