Omeprazole (sodium)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.356247
PEG10 paternally expressed 10 0.111315
PABPC1 poly(A) binding protein, cytoplasmic 1 0.102734
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0942644
CALR calreticulin 0.0651938
EEF2 eukaryotic translation elongation factor 2 0.0595508
ZNF292 zinc finger protein 292 0.0543827
VCL vinculin 0.051846
RNF145 ring finger protein 145 0.0503242
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0495047
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0459183
ITGAV integrin, alpha V 0.045204
MEOX2 mesenchyme homeobox 2 0.0447319
SFTPA2 surfactant protein A2 0.0441482
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0440341
ANKRD17 ankyrin repeat domain 17 0.043841
PDIA3 protein disulfide isomerase family A, member 3 0.0423057
MKI67 marker of proliferation Ki-67 0.0418713
ENAH enabled homolog (Drosophila) 0.0417899
KMT2C lysine (K)-specific methyltransferase 2C 0.0413387
RPS2 ribosomal protein S2 0.0410809
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.040594
CAPRIN1 cell cycle associated protein 1 0.0404819
MATR3 matrin 3 0.0404164
ENO1 enolase 1, (alpha) 0.0400295
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0398041
PCM1 pericentriolar material 1 0.0377601
GOLGA4 golgin A4 0.0369565
BTBD3 BTB (POZ) domain containing 3 0.0349025
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0344104
SNX3 sorting nexin 3 0.0338444
RPL3 ribosomal protein L3 0.0333685
RBM39 RNA binding motif protein 39 0.0328224
PIAS1 protein inhibitor of activated STAT, 1 0.0327837
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.0324078
CSDE1 cold shock domain containing E1, RNA-binding 0.0320817
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0318606
PRRC2C proline-rich coiled-coil 2C 0.0312592
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0310929
OGA O-GlcNAcase 0.0310732
ZFP36L1 ZFP36 ring finger protein-like 1 0.0309348
SRRM2 serine/arginine repetitive matrix 2 0.0307922
TMSB4X thymosin beta 4, X-linked 0.0307918
SEPTIN11 septin 11 0.0307598
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0303747
SET SET nuclear proto-oncogene 0.0302805
GMPS guanine monphosphate synthase 0.030195
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.029208
MED13L mediator complex subunit 13-like 0.0290985
UTRN utrophin 0.0290325
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0287188
RSBN1L round spermatid basic protein 1-like 0.028712
SOS1 son of sevenless homolog 1 (Drosophila) 0.0284219
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0279737
TRA2A transformer 2 alpha homolog (Drosophila) 0.0279153
TM9SF3 transmembrane 9 superfamily member 3 0.0278991
FTH1 ferritin, heavy polypeptide 1 0.0277031
CENPF centromere protein F, 350/400kDa 0.0276366
SRRM1 serine/arginine repetitive matrix 1 0.0274743
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0274659
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0270203
KLHDC10 kelch domain containing 10 0.0268842
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0267952
PELI1 pellino E3 ubiquitin protein ligase 1 0.0267814
EXT1 exostosin glycosyltransferase 1 0.0267642
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0267137
TXNRD1 thioredoxin reductase 1 0.0265683
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0264497
KMT2A lysine (K)-specific methyltransferase 2A 0.0261384
RAD21 RAD21 homolog (S. pombe) 0.0260172
SEC31A SEC31 homolog A (S. cerevisiae) 0.0258568
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0258388
CKAP5 cytoskeleton associated protein 5 0.0255555
YBX1 Y box binding protein 1 0.0254008
ARHGAP21 Rho GTPase activating protein 21 0.0250961
B2M beta-2-microglobulin 0.0250106
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0248577
BUB3 BUB3 mitotic checkpoint protein 0.0248233
TNPO1 transportin 1 0.0247924
SETD2 SET domain containing 2 0.0246672
GTF2I general transcription factor IIi 0.0246369
FGFR2 fibroblast growth factor receptor 2 0.0245981
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0245643
SGCE sarcoglycan, epsilon 0.0245599
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0244273
CEP350 centrosomal protein 350kDa 0.0242077
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0241228
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.024096
TPK1 thiamin pyrophosphokinase 1 0.0236607
PAPOLA poly(A) polymerase alpha 0.0235964
PTMA prothymosin, alpha 0.0235388
SEPTIN2 septin 2 0.0235188
TLK1 tousled-like kinase 1 0.0234167
RAD23B RAD23 homolog B (S. cerevisiae) 0.0234086
R3HDM1 R3H domain containing 1 0.023299
ARID1A AT rich interactive domain 1A (SWI-like) 0.0230117
SON SON DNA binding protein 0.0229851
BOC BOC cell adhesion associated, oncogene regulated 0.0229109
PRPF8 pre-mRNA processing factor 8 0.0227479
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0226852

decreased expression

Symbol Name Standardized Value
PRKG1 protein kinase, cGMP-dependent, type I -0.126746
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.119778
CADM2 cell adhesion molecule 2 -0.101894
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0731646
HMGA2 high mobility group AT-hook 2 -0.0704342
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0685112
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0570821
MYOF myoferlin -0.0510261
TRIO trio Rho guanine nucleotide exchange factor -0.0490713
PDE4D phosphodiesterase 4D, cAMP-specific -0.0486184
IGF2R insulin-like growth factor 2 receptor -0.0476411
RPS24 ribosomal protein S24 -0.041811
EXOC4 exocyst complex component 4 -0.0415991
CTBP2 C-terminal binding protein 2 -0.040389
SLC38A2 solute carrier family 38, member 2 -0.0396341
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0395854
IER3 immediate early response 3 -0.0380912
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0370418
DENND5A DENN/MADD domain containing 5A -0.035882
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0357693
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0348077
DMXL1 Dmx-like 1 -0.034564
RPL28 ribosomal protein L28 -0.0341066
ANO6 anoctamin 6 -0.0339926
ZEB1 zinc finger E-box binding homeobox 1 -0.0334182
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0333251
MEIS2 Meis homeobox 2 -0.0332172
ZFAND3 zinc finger, AN1-type domain 3 -0.0324941
FBXO11 F-box protein 11 -0.0302898
LCORL ligand dependent nuclear receptor corepressor-like -0.030063
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0296745
NBEA neurobeachin -0.0295582
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0293925
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0290099
GPC6 glypican 6 -0.0284168
VIM vimentin -0.0278525
RAB7A RAB7A, member RAS oncogene family -0.0277888
KDM4C lysine (K)-specific demethylase 4C -0.0275801
CLIP2 CAP-GLY domain containing linker protein 2 -0.0271559
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0268658
SMYD3 SET and MYND domain containing 3 -0.026044
DENND1A DENN/MADD domain containing 1A -0.0259943
INTS6 integrator complex subunit 6 -0.0256754
TMSB10 thymosin beta 10 -0.0255136
RPLP1 ribosomal protein, large, P1 -0.025432
FNDC3B fibronectin type III domain containing 3B -0.0252117
MSRB3 methionine sulfoxide reductase B3 -0.0251236
TRIM9 tripartite motif containing 9 -0.0241051
FLNB filamin B, beta -0.0240517
RSU1 Ras suppressor protein 1 -0.0238433
HBP1 HMG-box transcription factor 1 -0.0237314
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0235714
WSB1 WD repeat and SOCS box containing 1 -0.0231883
DIAPH2 diaphanous-related formin 2 -0.0231645
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0231081
FRMD6 FERM domain containing 6 -0.0228215
NCOR2 nuclear receptor corepressor 2 -0.0227973
JAM3 junctional adhesion molecule 3 -0.0226903
SENP6 SUMO1/sentrin specific peptidase 6 -0.0225582
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0223065
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.0220831
ANK2 ankyrin 2, neuronal -0.0219465
RPLP2 ribosomal protein, large, P2 -0.0217467
CMIP c-Maf inducing protein -0.0217238
PARD3 par-3 family cell polarity regulator -0.0215595
GMDS GDP-mannose 4,6-dehydratase -0.0214596
PRKCE protein kinase C, epsilon -0.021164
RAI1 retinoic acid induced 1 -0.020952
AGO2 argonaute RISC catalytic component 2 -0.0209135
TPT1 tumor protein, translationally-controlled 1 -0.0208514
EVL Enah/Vasp-like -0.0206916
DENND5B DENN/MADD domain containing 5B -0.0205258
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0204979
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0204553
ATXN2 ataxin 2 -0.0203887
JMJD1C jumonji domain containing 1C -0.0203416
TPST1 tyrosylprotein sulfotransferase 1 -0.0200628
RPL35A ribosomal protein L35a -0.0200616
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0199221
ZFHX3 zinc finger homeobox 3 -0.0199052
NHSL1 NHS-like 1 -0.0198262
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0194607
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.019457
TTC28 tetratricopeptide repeat domain 28 -0.0192768
LRRC23 leucine rich repeat containing 23 -0.0192584
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0190169
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0189751
KANK1 KN motif and ankyrin repeat domains 1 -0.0189286
LPP LIM domain containing preferred translocation partner in lipoma -0.0188648
RSRC1 arginine/serine-rich coiled-coil 1 -0.0187643
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0186856
MSI2 musashi RNA-binding protein 2 -0.0186734
FBXO33 F-box protein 33 -0.0185084
MAML2 mastermind-like 2 (Drosophila) -0.0183755
AOPEP aminopeptidase O (putative) -0.0182471
TSC22D2 TSC22 domain family, member 2 -0.0181793
PBRM1 polybromo 1 -0.0181569
HMGB1 high mobility group box 1 -0.0180741
AHI1 Abelson helper integration site 1 -0.0180497
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0179605