Omeprazole (sodium)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.067158
NDRG1 N-myc downstream regulated 1 0.051219
FN1 fibronectin 1 0.0479021
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0402453
PRELID2 PRELI domain containing 2 0.0392121
CHSY1 chondroitin sulfate synthase 1 0.0338247
KMT2C lysine (K)-specific methyltransferase 2C 0.0324194
NBAS neuroblastoma amplified sequence 0.0318677
CCNL1 cyclin L1 0.0294657
TMEM178B transmembrane protein 178B 0.0271725
LEF1 lymphoid enhancer-binding factor 1 0.0266395
RNF145 ring finger protein 145 0.026405
POTEF POTE ankyrin domain family, member F 0.0263091
CDC73 cell division cycle 73 0.0262696
NUP58 nucleoporin 58 0.0258123
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0256282
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0249947
FBXO7 F-box protein 7 0.0248565
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0247456
SPRED1 sprouty-related, EVH1 domain containing 1 0.0245302
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0244741
ICAM1 intercellular adhesion molecule 1 0.0243489
KMT2E lysine (K)-specific methyltransferase 2E 0.023853
ZNF292 zinc finger protein 292 0.0232014
EEF2 eukaryotic translation elongation factor 2 0.022851
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0228242
PHF21A PHD finger protein 21A 0.0226404
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0224254
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0212821
ZNF638 zinc finger protein 638 0.0211207
FOXJ3 forkhead box J3 0.0209946
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0205231
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0199333
MEF2A myocyte enhancer factor 2A 0.0196697
CDK19 cyclin-dependent kinase 19 0.0190731
PPME1 protein phosphatase methylesterase 1 0.0189328
HIPK3 homeodomain interacting protein kinase 3 0.0184591
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0182424
RNF150 ring finger protein 150 0.017936
VEGFA vascular endothelial growth factor A 0.0179283
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0177546
ANXA5 annexin A5 0.0176846
UBA6 ubiquitin-like modifier activating enzyme 6 0.0176091
YEATS2 YEATS domain containing 2 0.0171156
SNX13 sorting nexin 13 0.0169732
FRMD6 FERM domain containing 6 0.0165453
PCDH7 protocadherin 7 0.0165328
ESYT2 extended synaptotagmin-like protein 2 0.0165158
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0163637
IL6ST interleukin 6 signal transducer 0.0161143
STOM stomatin 0.015958
TRA2B transformer 2 beta homolog (Drosophila) 0.0159027
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0156766
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.015533
SERGEF secretion regulating guanine nucleotide exchange factor 0.0155327
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0154537
MSN moesin 0.0153195
CHD1L chromodomain helicase DNA binding protein 1-like 0.0152766
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.015276
KIAA1549L KIAA1549-like 0.0151773
MBNL2 muscleblind-like splicing regulator 2 0.0150548
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0150248
SRRM2 serine/arginine repetitive matrix 2 0.0148592
JARID2 jumonji, AT rich interactive domain 2 0.0148301
ASPH aspartate beta-hydroxylase 0.0148289
SBF2 SET binding factor 2 0.0147731
RPL3 ribosomal protein L3 0.0147611
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0147087
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0146211
CTTNBP2 cortactin binding protein 2 0.0142897
KDM6A lysine (K)-specific demethylase 6A 0.0142741
PRPF8 pre-mRNA processing factor 8 0.0141829
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0141693
SETD5 SET domain containing 5 0.0139803
FAM117B family with sequence similarity 117, member B 0.0138995
FOSL1 FOS-like antigen 1 0.0133908
FMNL2 formin-like 2 0.013372
FUBP1 far upstream element (FUSE) binding protein 1 0.0132725
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0130834
A2M alpha-2-macroglobulin 0.0130711
MKI67 marker of proliferation Ki-67 0.013061
MYH9 myosin, heavy chain 9, non-muscle 0.0130393
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0130051
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0129852
ETNK1 ethanolamine kinase 1 0.0127421
PDCD10 programmed cell death 10 0.0126504
RBM33 RNA binding motif protein 33 0.0126434
ATP13A3 ATPase type 13A3 0.0126399
NAMPT nicotinamide phosphoribosyltransferase 0.0126221
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 0.0125787
ZNF654 zinc finger protein 654 0.0125659
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.012479
PEA15 phosphoprotein enriched in astrocytes 15 0.0123636
TMEM255B transmembrane protein 255B 0.0123316
MYO1B myosin IB 0.0122309
RIPK4 receptor-interacting serine-threonine kinase 4 0.0122286
SCAF4 SR-related CTD-associated factor 4 0.0121682
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0120592
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0120321
NOTCH2 notch 2 0.0118955

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.25144
VIM vimentin -0.226071
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.163304
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.134628
VGF VGF nerve growth factor inducible -0.0911044
S100A6 S100 calcium binding protein A6 -0.0796619
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0787421
IFI16 interferon, gamma-inducible protein 16 -0.0714448
GDF15 growth differentiation factor 15 -0.0696261
TMSB10 thymosin beta 10 -0.0641705
FMN1 formin 1 -0.0621428
IER3 immediate early response 3 -0.0609943
LOC112694756 uncharaterized LOC112694756 -0.0573436
RPLP1 ribosomal protein, large, P1 -0.0566252
IFRD1 interferon-related developmental regulator 1 -0.0499839
ACTG1 actin gamma 1 -0.0495561
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0492207
GPC6 glypican 6 -0.0459598
CALU calumenin -0.0443394
EGR1 early growth response 1 -0.0435572
PTMA prothymosin, alpha -0.0434144
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0426067
HLA-B major histocompatibility complex, class I, B -0.0412962
NPR2 natriuretic peptide receptor 2 -0.0399339
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0397945
LOC102724023 ES1 protein homolog, mitochondrial -0.0396666
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.03918
RHEB Ras homolog enriched in brain -0.03822
WSB1 WD repeat and SOCS box containing 1 -0.0380887
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0373149
GNAS GNAS complex locus -0.0370531
PTCHD4 patched domain containing 4 -0.0365291
AHNAK AHNAK nucleoprotein -0.0363167
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0362001
TPT1 tumor protein, translationally-controlled 1 -0.0356182
LMNA lamin A/C -0.0348981
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0344418
FTL ferritin, light polypeptide -0.0343616
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0339706
ENO1 enolase 1, (alpha) -0.033696
RPS8 ribosomal protein S8 -0.0336721
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0336664
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0336262
CANX calnexin -0.0335201
PNRC1 proline-rich nuclear receptor coactivator 1 -0.032666
RAB7A RAB7A, member RAS oncogene family -0.0326606
FUS FUS RNA binding protein -0.0317008
S100A9 S100 calcium binding protein A9 -0.0309501
RPLP0 ribosomal protein, large, P0 -0.0307265
FRMD4A FERM domain containing 4A -0.0295964
PDIA4 protein disulfide isomerase family A, member 4 -0.0291858
DENND1A DENN/MADD domain containing 1A -0.0291548
APP amyloid beta (A4) precursor protein -0.028956
RPL35A ribosomal protein L35a -0.0283766
HILPDA hypoxia inducible lipid droplet-associated -0.0282686
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0275581
TLE4 transducin-like enhancer of split 4 -0.0274406
RAD21 RAD21 homolog (S. pombe) -0.0269776
SLC38A1 solute carrier family 38, member 1 -0.0269479
RRBP1 ribosome binding protein 1 -0.0265831
CUX1 cut-like homeobox 1 -0.0264938
KDM5B lysine (K)-specific demethylase 5B -0.026239
RPS3 ribosomal protein S3 -0.0260201
VDAC1 voltage-dependent anion channel 1 -0.0259957
ZMYND8 zinc finger, MYND-type containing 8 -0.0255069
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0253867
S100A10 S100 calcium binding protein A10 -0.0250356
RPLP2 ribosomal protein, large, P2 -0.0245448
CD63 CD63 molecule -0.0245176
RPL12 ribosomal protein L12 -0.0244079
EIF1 eukaryotic translation initiation factor 1 -0.024194
NPAS2 neuronal PAS domain protein 2 -0.0241897
LRRC23 leucine rich repeat containing 23 -0.0241244
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0239861
IGFBP5 insulin-like growth factor binding protein 5 -0.0239729
NCOA7 nuclear receptor coactivator 7 -0.0235458
CUL1 cullin 1 -0.023518
DDIT4 DNA-damage-inducible transcript 4 -0.0234463
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0231617
IFITM3 interferon induced transmembrane protein 3 -0.0231066
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0229085
RPS19 ribosomal protein S19 -0.0228657
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0228457
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.022758
COG5 component of oligomeric golgi complex 5 -0.022753
FRMD5 FERM domain containing 5 -0.0226016
CALR calreticulin -0.0224273
AKAP9 A kinase (PRKA) anchor protein 9 -0.0223148
ADNP activity-dependent neuroprotector homeobox -0.0220641
ZBTB20 zinc finger and BTB domain containing 20 -0.0217173
NAV3 neuron navigator 3 -0.0216705
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0212362
EMP1 epithelial membrane protein 1 -0.0206727
LAMB1 laminin, beta 1 -0.0206474
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0206266
MTPN myotrophin -0.0205828
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0204426
JUN jun proto-oncogene -0.0204139
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0202843
RPS24 ribosomal protein S24 -0.0202496