Omeprazole (sodium)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0469599
RNF43 ring finger protein 43 0.0295718
NRIP1 nuclear receptor interacting protein 1 0.028512
SPRED1 sprouty-related, EVH1 domain containing 1 0.0212254
RNF149 ring finger protein 149 0.0201953
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0200758
IFNGR1 interferon gamma receptor 1 0.0192809
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0189759
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0185114
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0184097
PTBP3 polypyrimidine tract binding protein 3 0.0178639
ARGLU1 arginine and glutamate rich 1 0.0175379
IL20RA interleukin 20 receptor, alpha 0.0170168
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0165251
MBNL2 muscleblind-like splicing regulator 2 0.0154881
TXNIP thioredoxin interacting protein 0.0154617
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0154414
ABHD2 abhydrolase domain containing 2 0.0146353
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0144764
ZNF148 zinc finger protein 148 0.0129028
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.012853
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0127972
PTEN phosphatase and tensin homolog 0.0126804
GOLGA4 golgin A4 0.012414
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0117521
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0113519
ARRDC3 arrestin domain containing 3 0.0113359
ZDHHC20 zinc finger, DHHC-type containing 20 0.0112522
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0112373
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0111088
KLF3 Kruppel-like factor 3 (basic) 0.0109013
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0108675
WDR26 WD repeat domain 26 0.010782
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0105873
STEAP2 STEAP family member 2, metalloreductase 0.0105784
ITCH itchy E3 ubiquitin protein ligase 0.01053
SREBF2 sterol regulatory element binding transcription factor 2 0.0105179
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0104631
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.0102412
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.00994603
SBF2 SET binding factor 2 0.00994334
PRPF8 pre-mRNA processing factor 8 0.00990917
TENT2 terminal nucleotidyltransferase 2 0.00978987
HGD homogentisate 1,2-dioxygenase 0.00977059
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.00974752
KCTD3 potassium channel tetramerization domain containing 3 0.0095942
TJP2 tight junction protein 2 0.00949971
TMEM62 transmembrane protein 62 0.00948591
NCKAP1 NCK-associated protein 1 0.00939993
SP3 Sp3 transcription factor 0.00934693
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.00924709
CCDC14 coiled-coil domain containing 14 0.00921492
KMT2E lysine (K)-specific methyltransferase 2E 0.00919822
TM9SF2 transmembrane 9 superfamily member 2 0.00916882
EHF ets homologous factor 0.00909741
YEATS2 YEATS domain containing 2 0.00907624
USP3 ubiquitin specific peptidase 3 0.00899343
FRK fyn-related Src family tyrosine kinase 0.00880079
AOPEP aminopeptidase O (putative) 0.00877513
PDZD8 PDZ domain containing 8 0.00866237
SPRED2 sprouty-related, EVH1 domain containing 2 0.00861039
RHOBTB3 Rho-related BTB domain containing 3 0.0085921
ARHGAP32 Rho GTPase activating protein 32 0.00859128
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.00850152
OGA O-GlcNAcase 0.00849137
CREB3L2 cAMP responsive element binding protein 3-like 2 0.00844191
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00841275
GSK3B glycogen synthase kinase 3 beta 0.00841132
CLTC clathrin, heavy chain (Hc) 0.00823518
SLK STE20-like kinase 0.00818025
GIGYF2 GRB10 interacting GYF protein 2 0.00816313
BHLHE40 basic helix-loop-helix family, member e40 0.00813656
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 0.00809192
LRRC1 leucine rich repeat containing 1 0.0080625
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.00799793
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.00793458
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00787175
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.00786586
RC3H2 ring finger and CCCH-type domains 2 0.00785902
MLPH melanophilin 0.0078077
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.00780139
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.00777777
STK39 serine threonine kinase 39 0.0077246
DENND4C DENN/MADD domain containing 4C 0.00770076
SCAF11 SR-related CTD-associated factor 11 0.00755812
PEX13 peroxisomal biogenesis factor 13 0.00745021
RCOR3 REST corepressor 3 0.00745004
RBM33 RNA binding motif protein 33 0.00744188
ZMYM2 zinc finger, MYM-type 2 0.00741949
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00740433
SGK1 serum/glucocorticoid regulated kinase 1 0.00736537
RNF145 ring finger protein 145 0.00735588
HOMER2 homer scaffolding protein 2 0.00734265
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.00733796
MKI67 marker of proliferation Ki-67 0.00731532
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.007272
ARHGAP12 Rho GTPase activating protein 12 0.0072213
YAP1 Yes-associated protein 1 0.00722088
UBE3A ubiquitin protein ligase E3A 0.00718252
NCOA6 nuclear receptor coactivator 6 0.0071728

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.150029
LMO7 LIM domain 7 -0.124231
B2M beta-2-microglobulin -0.12182
RNF213 ring finger protein 213 -0.120628
EPSTI1 epithelial stromal interaction 1 (breast) -0.119155
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0972713
ANXA2 annexin A2 -0.090415
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0843306
PTMA prothymosin, alpha -0.079315
LCN2 lipocalin 2 -0.0779397
EZR ezrin -0.0779358
EGR1 early growth response 1 -0.077475
SP100 SP100 nuclear antigen -0.0771456
RIGI RNA sensor RIG-I -0.0712996
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0676975
SQSTM1 sequestosome 1 -0.0669839
IFI6 interferon, alpha-inducible protein 6 -0.0654311
MX2 MX dynamin-like GTPase 2 -0.064988
MX1 MX dynamin-like GTPase 1 -0.0641055
HLA-B major histocompatibility complex, class I, B -0.0637301
PERP PERP, TP53 apoptosis effector -0.0626454
RAB7A RAB7A, member RAS oncogene family -0.0620496
GCLC glutamate-cysteine ligase, catalytic subunit -0.0614742
C6ORF132 chromosome 6 open reading frame 132 -0.0562594
INTS6 integrator complex subunit 6 -0.0538382
GMDS GDP-mannose 4,6-dehydratase -0.0496845
LYZ lysozyme -0.0489617
XAF1 XIAP associated factor 1 -0.0488517
IRF1 interferon regulatory factor 1 -0.0482988
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.047187
AREG amphiregulin -0.0468479
TJP1 tight junction protein 1 -0.0465404
PLSCR1 phospholipid scramblase 1 -0.0464697
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0458996
RABGAP1L RAB GTPase activating protein 1-like -0.0435319
JUN jun proto-oncogene -0.0434341
LOC102724023 ES1 protein homolog, mitochondrial -0.0431434
TMSB10 thymosin beta 10 -0.0426648
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0417083
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0416941
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.041339
EXT1 exostosin glycosyltransferase 1 -0.0413157
ACTG1 actin gamma 1 -0.0413066
STS steroid sulfatase (microsomal), isozyme S -0.0412721
RRBP1 ribosome binding protein 1 -0.0412278
RPS6 ribosomal protein S6 -0.041158
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0403584
RPL35A ribosomal protein L35a -0.039441
IFI27 interferon, alpha-inducible protein 27 -0.0392862
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0384408
RPL23 ribosomal protein L23 -0.036425
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0361401
AKAP13 A kinase (PRKA) anchor protein 13 -0.0356918
PMP22 peripheral myelin protein 22 -0.0356914
MCL1 myeloid cell leukemia 1 -0.0354
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0352317
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0336285
IRS2 insulin receptor substrate 2 -0.0332287
PKM pyruvate kinase, muscle -0.0330148
MAP7 microtubule-associated protein 7 -0.0329625
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0328387
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0322283
VCL vinculin -0.0312101
MYO1E myosin IE -0.0311054
FNDC3B fibronectin type III domain containing 3B -0.0309318
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.030898
SLC38A1 solute carrier family 38, member 1 -0.0307894
FTL ferritin, light polypeptide -0.0307693
HLA-C major histocompatibility complex, class I, C -0.0302402
RPL34 ribosomal protein L34 -0.0300333
BLZF1 basic leucine zipper nuclear factor 1 -0.0298403
TSHZ2 teashirt zinc finger homeobox 2 -0.0298394
NPSR1 neuropeptide S receptor 1 -0.0298318
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0295689
TM4SF1 transmembrane 4 L six family member 1 -0.0295614
LPP LIM domain containing preferred translocation partner in lipoma -0.0292488
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0286829
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0286191
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0285118
S100A10 S100 calcium binding protein A10 -0.0285095
ENO1 enolase 1, (alpha) -0.0283567
BTBD9 BTB (POZ) domain containing 9 -0.0282522
HM13 histocompatibility (minor) 13 -0.028208
RPS24 ribosomal protein S24 -0.027939
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0278013
EIF1 eukaryotic translation initiation factor 1 -0.0277836
KLF6 Kruppel-like factor 6 -0.0277776
RPS8 ribosomal protein S8 -0.0277186
SPAG9 sperm associated antigen 9 -0.0274198
TM4SF19 transmembrane 4 L six family member 19 -0.0274197
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0268471
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0262958
ANKRD10 ankyrin repeat domain 10 -0.0260849
S100A6 S100 calcium binding protein A6 -0.0259025
SEC31A SEC31 homolog A (S. cerevisiae) -0.0258431
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0257518
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0256041
RPL19 ribosomal protein L19 -0.0255274
ARHGAP26 Rho GTPase activating protein 26 -0.0254712
MT2A metallothionein 2A -0.0253895