Omeprazole (sodium)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.141709
FNDC3B fibronectin type III domain containing 3B 0.0902967
CXCL8 chemokine (C-X-C motif) ligand 8 0.078346
EGFR epidermal growth factor receptor 0.0744811
DGKD diacylglycerol kinase, delta 130kDa 0.0739143
SMAD3 SMAD family member 3 0.0633479
AKAP12 A kinase (PRKA) anchor protein 12 0.0591062
TRIO trio Rho guanine nucleotide exchange factor 0.0583433
DST dystonin 0.0556048
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0529284
STC1 stanniocalcin 1 0.0524462
NAMPT nicotinamide phosphoribosyltransferase 0.0479283
ANKRD17 ankyrin repeat domain 17 0.0476845
ATP13A3 ATPase type 13A3 0.0476732
INHBA inhibin, beta A 0.0473686
LOX lysyl oxidase 0.0468739
NDRG1 N-myc downstream regulated 1 0.0453156
SBF2 SET binding factor 2 0.0452333
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0419973
ANO6 anoctamin 6 0.0393932
ERRFI1 ERBB receptor feedback inhibitor 1 0.0389581
RTN4 reticulon 4 0.0389351
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0384041
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0381159
OSMR oncostatin M receptor 0.0377931
MACF1 microtubule-actin crosslinking factor 1 0.0370219
MSN moesin 0.0363277
TNNC1 troponin C type 1 (slow) 0.0342247
COPB1 coatomer protein complex, subunit beta 1 0.0341683
TTC3 tetratricopeptide repeat domain 3 0.0340561
ELL2 elongation factor, RNA polymerase II, 2 0.0340555
HDAC9 histone deacetylase 9 0.0331479
CADM1 cell adhesion molecule 1 0.0330709
SNX13 sorting nexin 13 0.0308009
USP47 ubiquitin specific peptidase 47 0.0307871
GARS1 glycyl-tRNA synthetase 1 0.0305859
WWTR1 WW domain containing transcription regulator 1 0.0304347
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0302747
TMEM39A transmembrane protein 39A 0.0299726
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0299298
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0298655
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.029858
CLTC clathrin, heavy chain (Hc) 0.0296007
YEATS2 YEATS domain containing 2 0.02914
FNIP1 folliculin interacting protein 1 0.028809
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0287631
SAMD4A sterile alpha motif domain containing 4A 0.0286224
GOLGB1 golgin B1 0.0285568
MYOF myoferlin 0.0285232
COPA coatomer protein complex, subunit alpha 0.0284808
HELZ helicase with zinc finger 0.0284793
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.028231
CANX calnexin 0.0281031
MYH9 myosin, heavy chain 9, non-muscle 0.0279021
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0276472
TXNIP thioredoxin interacting protein 0.0275898
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0274027
MBD5 methyl-CpG binding domain protein 5 0.0271239
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0269073
OGA O-GlcNAcase 0.0268495
AVL9 AVL9 homolog (S. cerevisiase) 0.026814
ZCCHC7 zinc finger, CCHC domain containing 7 0.0267066
COG5 component of oligomeric golgi complex 5 0.0263126
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0262533
SEC23A Sec23 homolog A (S. cerevisiae) 0.0261578
VMP1 vacuole membrane protein 1 0.0257824
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0256817
LRRC49 leucine rich repeat containing 49 0.0254639
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0250606
MAP1B microtubule-associated protein 1B 0.0246639
EXT1 exostosin glycosyltransferase 1 0.0246122
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0246086
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0245807
SETD5 SET domain containing 5 0.0244707
WDR26 WD repeat domain 26 0.0241441
RARS1 arginyl-tRNA synthetase 1 0.0241276
UBA6 ubiquitin-like modifier activating enzyme 6 0.0241205
HSPA8 heat shock 70kDa protein 8 0.0240657
RASA2 RAS p21 protein activator 2 0.0236424
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.02341
LMAN1 lectin, mannose-binding, 1 0.0232983
MON2 MON2 homolog (S. cerevisiae) 0.0231474
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0225943
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0225915
ANKRD28 ankyrin repeat domain 28 0.0224513
CCDC14 coiled-coil domain containing 14 0.0222673
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0219609
FAM13A family with sequence similarity 13, member A 0.0218843
ANKIB1 ankyrin repeat and IBR domain containing 1 0.021848
TNS3 tensin 3 0.0215206
PMM2 phosphomannomutase 2 0.0213947
NFE2L1 nuclear factor, erythroid 2-like 1 0.0213457
PRKCSH protein kinase C substrate 80K-H 0.021221
GOLGA4 golgin A4 0.0212079
ZNF841 zinc finger protein 841 0.0210584
FAM114A1 family with sequence similarity 114, member A1 0.0205348
ERBIN erbb2 interacting protein 0.0205283
ADAM17 ADAM metallopeptidase domain 17 0.0204709
PRELID2 PRELI domain containing 2 0.0204338
RAB8B RAB8B, member RAS oncogene family 0.0203216

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.163091
VIM vimentin -0.147722
PTMA prothymosin, alpha -0.11754
MT2A metallothionein 2A -0.108153
HLA-B major histocompatibility complex, class I, B -0.107227
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0997471
B2M beta-2-microglobulin -0.0990104
NALF1 NALCN channel auxiliary factor 1 -0.0930648
TPT1 tumor protein, translationally-controlled 1 -0.0907819
IGFBP3 insulin-like growth factor binding protein 3 -0.0824824
RPL35A ribosomal protein L35a -0.0809371
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0763178
FN1 fibronectin 1 -0.0716094
RPS8 ribosomal protein S8 -0.0647935
RPS6 ribosomal protein S6 -0.0627054
PDE4D phosphodiesterase 4D, cAMP-specific -0.0625461
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0618728
RPL37A ribosomal protein L37a -0.0582058
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0578181
HLA-A major histocompatibility complex, class I, A -0.0576436
RPS13 ribosomal protein S13 -0.0568724
FTL ferritin, light polypeptide -0.0563386
RPLP1 ribosomal protein, large, P1 -0.050524
NLGN1 neuroligin 1 -0.0497083
ENO2 enolase 2 (gamma, neuronal) -0.0494082
RPL23 ribosomal protein L23 -0.0487
RPL31 ribosomal protein L31 -0.0455119
WSB1 WD repeat and SOCS box containing 1 -0.0455075
RPLP2 ribosomal protein, large, P2 -0.0447711
RPS25 ribosomal protein S25 -0.0425883
RPL34 ribosomal protein L34 -0.0422994
RPL9 ribosomal protein L9 -0.0419297
GRB10 growth factor receptor-bound protein 10 -0.0411333
RPL28 ribosomal protein L28 -0.040254
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0402185
IGFBP5 insulin-like growth factor binding protein 5 -0.0397009
RPS24 ribosomal protein S24 -0.0362382
IGF2 insulin-like growth factor 2 -0.0345498
ACTG1 actin gamma 1 -0.0341716
ENO1 enolase 1, (alpha) -0.0341121
RPS23 ribosomal protein S23 -0.0335025
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0329941
SEC61G Sec61 gamma subunit -0.0322777
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0315811
TPM4 tropomyosin 4 -0.0314663
RPS16 ribosomal protein S16 -0.0309677
RPS27A ribosomal protein S27a -0.0308863
RPL11 ribosomal protein L11 -0.030165
PRSS23 protease, serine, 23 -0.0294242
RPS29 ribosomal protein S29 -0.0294042
RPS11 ribosomal protein S11 -0.0291849
RPL7A ribosomal protein L7a -0.0289245
RPS12 ribosomal protein S12 -0.028466
RPL38 ribosomal protein L38 -0.027145
RPL37 ribosomal protein L37 -0.0268165
S100A10 S100 calcium binding protein A10 -0.0266941
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0266156
RPS21 ribosomal protein S21 -0.0264943
HLA-C major histocompatibility complex, class I, C -0.0262453
RPS3 ribosomal protein S3 -0.0260874
FAM162A family with sequence similarity 162, member A -0.0260311
S100A6 S100 calcium binding protein A6 -0.0259224
PSD3 pleckstrin and Sec7 domain containing 3 -0.0258412
RPS17 ribosomal protein S17 -0.0258137
S100A9 S100 calcium binding protein A9 -0.0257418
RPS19 ribosomal protein S19 -0.0256487
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0255529
RPS14 ribosomal protein S14 -0.025329
RPL27A ribosomal protein L27a -0.0249458
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0248264
RPL12 ribosomal protein L12 -0.0248039
NAP1L1 nucleosome assembly protein 1-like 1 -0.0245299
RPL36 ribosomal protein L36 -0.0245214
RACK1 receptor for activated C kinase 1 -0.0241978
SQSTM1 sequestosome 1 -0.02411
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0236955
GNAS GNAS complex locus -0.0236457
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0230306
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.022972
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0224105
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0223931
RPS5 ribosomal protein S5 -0.0223841
FBXO11 F-box protein 11 -0.0219808
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0219466
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0218765
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0217595
DTNA dystrobrevin, alpha -0.0216842
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0213
POTEF POTE ankyrin domain family, member F -0.021018
DGKI diacylglycerol kinase, iota -0.0209065
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0204239
RPS10 ribosomal protein S10 -0.0201075
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0200318
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0198973
HILPDA hypoxia inducible lipid droplet-associated -0.0198853
ZNF804A zinc finger protein 804A -0.0198068
ATF4 activating transcription factor 4 -0.0197808
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0196586
TUBB4B tubulin, beta 4B class IVb -0.0196216
VDAC1 voltage-dependent anion channel 1 -0.0195733