| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Omeprazole (sodium) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Omeprazole (sodium)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 0.0694236 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0470182 |
| SVIL | supervillin | 0.0426232 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0360284 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0342154 |
| VCL | vinculin | 0.0337386 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0319014 |
| SDC4 | syndecan 4 | 0.0316255 |
| MRTFA | myocardin related transcription factor A | 0.0307288 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0268414 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0265993 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0246664 |
| BCL2L1 | BCL2-like 1 | 0.0243986 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.024147 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0234081 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0233951 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0221481 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0220313 |
| ITGB5 | integrin, beta 5 | 0.0220013 |
| SMAD3 | SMAD family member 3 | 0.0217246 |
| FAT1 | FAT atypical cadherin 1 | 0.0215067 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0203463 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0198244 |
| SKI | SKI proto-oncogene | 0.0195081 |
| FOXO1 | forkhead box O1 | 0.0194766 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0192822 |
| INTS6 | integrator complex subunit 6 | 0.0189994 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.018947 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0186309 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0184167 |
| KIAA1217 | KIAA1217 | 0.0183539 |
| ACTN4 | actinin, alpha 4 | 0.0182701 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0182463 |
| RIGI | RNA sensor RIG-I | 0.0182415 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0178718 |
| FNIP1 | folliculin interacting protein 1 | 0.0178003 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0175873 |
| FOXP1 | forkhead box P1 | 0.0173368 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0172911 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.017224 |
| KRT8 | keratin 8, type II | 0.0171677 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0165379 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.016537 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0163443 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0162627 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0162132 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0160679 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | 0.0158528 |
| JAG1 | jagged 1 | 0.015803 |
| CUL3 | cullin 3 | 0.0157885 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0157067 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0156367 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0156075 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0155979 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0155203 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0154691 |
| FERMT2 | fermitin family member 2 | 0.0154307 |
| HNMT | histamine N-methyltransferase | 0.0151442 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0151201 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0149821 |
| YAP1 | Yes-associated protein 1 | 0.0146812 |
| PTCHD4 | patched domain containing 4 | 0.0146008 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0144678 |
| STK24 | serine/threonine kinase 24 | 0.0144616 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0142968 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0142883 |
| DTNA | dystrobrevin, alpha | 0.0142322 |
| CFB | complement factor B | 0.0141648 |
| UBAP1 | ubiquitin associated protein 1 | 0.0140295 |
| PUM1 | pumilio RNA-binding family member 1 | 0.013975 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0138896 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0137535 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0135976 |
| ATP13A3 | ATPase type 13A3 | 0.0135682 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0134461 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0132446 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0131273 |
| RPL4 | ribosomal protein L4 | 0.0130829 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0129775 |
| NCKAP1 | NCK-associated protein 1 | 0.0127544 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.012685 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.012647 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0125571 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0125013 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.012437 |
| RCOR1 | REST corepressor 1 | 0.0124309 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0122516 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0122018 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0120354 |
| MYO1E | myosin IE | 0.012 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0119188 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.011823 |
| MYO1D | myosin ID | 0.0118052 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0116941 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0116736 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0116556 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.0116366 |
| SP3 | Sp3 transcription factor | 0.0115999 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0115839 |
| FN1 | fibronectin 1 | 0.0115837 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.203342 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.104889 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0991419 |
| MT2A | metallothionein 2A | -0.0783661 |
| AHSG | alpha-2-HS-glycoprotein | -0.0770389 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0729035 |
| APOA2 | apolipoprotein A-II | -0.0664989 |
| RPS6 | ribosomal protein S6 | -0.0606979 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0579954 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0540072 |
| ENO1 | enolase 1, (alpha) | -0.0533151 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0531398 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0511073 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0507279 |
| EHBP1 | EH domain binding protein 1 | -0.0501828 |
| C3 | complement component 3 | -0.0489583 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0464781 |
| CPE | carboxypeptidase E | -0.0441796 |
| GPC3 | glypican 3 | -0.0428351 |
| PLIN2 | perilipin 2 | -0.0422464 |
| ITGA1 | integrin, alpha 1 | -0.0421486 |
| CP | ceruloplasmin (ferroxidase) | -0.0416998 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0415639 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0384765 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0376502 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0374508 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0369129 |
| LDHA | lactate dehydrogenase A | -0.0365055 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0362811 |
| FTL | ferritin, light polypeptide | -0.0357658 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.035405 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0349074 |
| PERP | PERP, TP53 apoptosis effector | -0.0340182 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0335529 |
| TMEM123 | transmembrane protein 123 | -0.033381 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0332235 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0320536 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0316074 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0314694 |
| PCBP2 | poly(rC) binding protein 2 | -0.0313669 |
| LYZ | lysozyme | -0.031187 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0306785 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0301966 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0298781 |
| TRIM26 | tripartite motif containing 26 | -0.0288481 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0287911 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0284381 |
| DSPP | dentin sialophosphoprotein | -0.0275531 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0274958 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0274409 |
| NDRG1 | N-myc downstream regulated 1 | -0.0273532 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0268596 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0267198 |
| APOA1 | apolipoprotein A-I | -0.0257946 |
| RPS8 | ribosomal protein S8 | -0.0257239 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0255811 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0252938 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0252399 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0251843 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.024715 |
| RPS12 | ribosomal protein S12 | -0.0245279 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0242758 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0242542 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.0242489 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0237765 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0236505 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0231781 |
| TF | transferrin | -0.0230422 |
| DENND4A | DENN/MADD domain containing 4A | -0.0230165 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.023004 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0229101 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0225026 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0222642 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0221584 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0216517 |
| PEG3 | paternally expressed 3 | -0.0213203 |
| NPR2 | natriuretic peptide receptor 2 | -0.0212788 |
| RPLP0 | ribosomal protein, large, P0 | -0.0210642 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0208664 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0208188 |
| RPL12 | ribosomal protein L12 | -0.020313 |
| TPM4 | tropomyosin 4 | -0.0202816 |
| HMGA1 | high mobility group AT-hook 1 | -0.0202427 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0201416 |
| INSIG2 | insulin induced gene 2 | -0.0201295 |
| DOK6 | docking protein 6 | -0.0200416 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.020002 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0195168 |
| STK17A | serine/threonine kinase 17a | -0.0194383 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0194325 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0194137 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0193649 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0190705 |
| CLMN | calmin (calponin-like, transmembrane) | -0.019052 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0190384 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0187095 |
| PEG10 | paternally expressed 10 | -0.018699 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0186033 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0185549 |
| DUSP6 | dual specificity phosphatase 6 | -0.018488 |
