Omeprazole (sodium)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0277797
MEF2A myocyte enhancer factor 2A 0.0253557
VCL vinculin 0.0236226
LMO7 LIM domain 7 0.022545
NRIP1 nuclear receptor interacting protein 1 0.0191914
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0189258
DOCK5 dedicator of cytokinesis 5 0.0188798
MYOF myoferlin 0.0186753
RAI14 retinoic acid induced 14 0.0179274
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0171038
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0160509
LOXL2 lysyl oxidase-like 2 0.0156332
MEGF6 multiple EGF-like-domains 6 0.0154526
PLAT plasminogen activator, tissue 0.0150064
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0145568
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0144952
CAPRIN2 caprin family member 2 0.0141076
AHNAK2 AHNAK nucleoprotein 2 0.0131737
FOXO1 forkhead box O1 0.013103
FRMD6 FERM domain containing 6 0.0126704
RASA3 RAS p21 protein activator 3 0.0121083
FAM107B family with sequence similarity 107, member B 0.011647
OSMR oncostatin M receptor 0.0115378
CUL4B cullin 4B 0.0114683
NRG1 neuregulin 1 0.011283
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.011094
KIF16B kinesin family member 16B 0.0107667
CEMIP cell migration inducing protein, hyaluronan binding 0.0106394
NAV2 neuron navigator 2 0.0105746
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0104653
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.0103839
EHF ets homologous factor 0.0101063
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.00995228
PDLIM5 PDZ and LIM domain 5 0.00991085
ARHGAP23 Rho GTPase activating protein 23 0.00983186
ZC3H12C zinc finger CCCH-type containing 12C 0.0096643
PPARG peroxisome proliferator-activated receptor gamma 0.00961411
FNIP1 folliculin interacting protein 1 0.00950879
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.00939872
BMAL2 basic helix-loop-helix ARNT like 2 0.00933243
NCOA3 nuclear receptor coactivator 3 0.00932776
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.00909267
DGKD diacylglycerol kinase, delta 130kDa 0.00907508
MYO9A myosin IXA 0.00906729
MYH9 myosin, heavy chain 9, non-muscle 0.0090132
ABI3BP ABI family, member 3 (NESH) binding protein 0.00898659
ADAM19 ADAM metallopeptidase domain 19 0.00897986
ANKH ANKH inorganic pyrophosphate transport regulator 0.00882985
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.00878088
COG3 component of oligomeric golgi complex 3 0.00865516
SLC45A4 solute carrier family 45, member 4 0.00857335
MBNL1 muscleblind-like splicing regulator 1 0.00853322
MINDY2 MINDY lysine 48 deubiquitinase 2 0.00827464
AOPEP aminopeptidase O (putative) 0.00826702
C4BPB complement component 4 binding protein, beta 0.00820922
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.00800714
PER3 period circadian clock 3 0.0078778
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.00773384
COG6 component of oligomeric golgi complex 6 0.00768654
ZCCHC7 zinc finger, CCHC domain containing 7 0.00766731
NLRP1 NLR family, pyrin domain containing 1 0.00756356
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.00753079
NTSR1 neurotensin receptor 1 (high affinity) 0.00752622
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.00745876
LPAR1 lysophosphatidic acid receptor 1 0.00732215
LRRC8C leucine rich repeat containing 8 family, member C 0.00728687
PDGFB platelet-derived growth factor beta polypeptide 0.00720145
FAM114A1 family with sequence similarity 114, member A1 0.00719323
ARHGAP29 Rho GTPase activating protein 29 0.00711693
SEPTIN9 septin 9 0.00709786
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.00708229
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0070627
AVL9 AVL9 homolog (S. cerevisiase) 0.00695235
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0069288
PARP4 poly (ADP-ribose) polymerase family, member 4 0.00690629
AKAP9 A kinase (PRKA) anchor protein 9 0.00685934
MN1 meningioma (disrupted in balanced translocation) 1 0.00679956
URI1 URI1, prefoldin-like chaperone 0.00677611
ITPRID2 ITPR interacting domain containing 2 0.0065985
LAMC2 laminin, gamma 2 0.00657515
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.006556
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.00639134
KDM7A lysine (K)-specific demethylase 7A 0.00637731
PDIA5 protein disulfide isomerase family A, member 5 0.00634377
DDB2 damage-specific DNA binding protein 2, 48kDa 0.00632538
DNAH5 dynein, axonemal, heavy chain 5 0.00632517
TMF1 TATA element modulatory factor 1 0.00630683
PALM2AKAP2 PALM2 and AKAP2 fusion 0.00623163
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.00622553
PRELID2 PRELI domain containing 2 0.00620205
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.00616902
SZT2 seizure threshold 2 homolog (mouse) 0.00613258
GPR176 G protein-coupled receptor 176 0.00609155
COL5A1 collagen, type V, alpha 1 0.00604283
GOLGB1 golgin B1 0.0060213
SLC35F3 solute carrier family 35, member F3 0.00601085
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.00597166
MAST4 microtubule associated serine/threonine kinase family member 4 0.00592996
SYNJ2 synaptojanin 2 0.00590444
KLF7 Kruppel-like factor 7 (ubiquitous) 0.00589024

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.118531
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103612
B2M beta-2-microglobulin -0.0937698
PTMA prothymosin, alpha -0.0913129
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0911003
RPS21 ribosomal protein S21 -0.085963
RPS6 ribosomal protein S6 -0.0744353
TPT1 tumor protein, translationally-controlled 1 -0.07102
POTEF POTE ankyrin domain family, member F -0.0696804
TMSB10 thymosin beta 10 -0.0682606
RPS8 ribosomal protein S8 -0.0682485
LMNA lamin A/C -0.0584967
S100A10 S100 calcium binding protein A10 -0.0572506
RPL11 ribosomal protein L11 -0.0553499
RPLP2 ribosomal protein, large, P2 -0.0523056
HLA-B major histocompatibility complex, class I, B -0.0506763
RPS13 ribosomal protein S13 -0.0505575
GNAS GNAS complex locus -0.0501971
ENO1 enolase 1, (alpha) -0.0461935
KRT17 keratin 17, type I -0.0451272
MT2A metallothionein 2A -0.043938
RPL37 ribosomal protein L37 -0.0439213
RPLP1 ribosomal protein, large, P1 -0.0437776
CAV1 caveolin 1, caveolae protein, 22kDa -0.04347
IFITM3 interferon induced transmembrane protein 3 -0.0425568
RPS24 ribosomal protein S24 -0.0419647
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0405188
TMSB4X thymosin beta 4, X-linked -0.0403156
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0402518
LDHA lactate dehydrogenase A -0.0396248
RPS19 ribosomal protein S19 -0.039604
S100A9 S100 calcium binding protein A9 -0.0392277
RPL23 ribosomal protein L23 -0.0383256
RBM39 RNA binding motif protein 39 -0.0367766
ANXA2 annexin A2 -0.036281
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.035554
RPS25 ribosomal protein S25 -0.0348277
DSTN destrin (actin depolymerizing factor) -0.0343368
RPS3 ribosomal protein S3 -0.0339048
RPL34 ribosomal protein L34 -0.0336331
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0334396
DPYD dihydropyrimidine dehydrogenase -0.0331371
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0329672
IFITM1 interferon induced transmembrane protein 1 -0.0328602
HSPG2 heparan sulfate proteoglycan 2 -0.032782
RPL5 ribosomal protein L5 -0.0322848
CLU clusterin -0.0319788
RPL37A ribosomal protein L37a -0.0318591
RPS12 ribosomal protein S12 -0.0317801
ANXA1 annexin A1 -0.0312548
RPL26 ribosomal protein L26 -0.0309126
NAP1L1 nucleosome assembly protein 1-like 1 -0.030749
RPL19 ribosomal protein L19 -0.0307074
PKM pyruvate kinase, muscle -0.0305906
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0304934
IFI6 interferon, alpha-inducible protein 6 -0.0295115
PDE4D phosphodiesterase 4D, cAMP-specific -0.0292825
RPL12 ribosomal protein L12 -0.0292808
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0290461
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0285649
FTL ferritin, light polypeptide -0.0283448
RPL35A ribosomal protein L35a -0.0283088
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0282214
RPS14 ribosomal protein S14 -0.0281234
RPLP0 ribosomal protein, large, P0 -0.028037
S100A2 S100 calcium binding protein A2 -0.0276391
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0275315
RPL31 ribosomal protein L31 -0.0272469
RACK1 receptor for activated C kinase 1 -0.0272322
S100A6 S100 calcium binding protein A6 -0.0270767
RPS27A ribosomal protein S27a -0.0269587
RPL8 ribosomal protein L8 -0.0269532
LOC112694756 uncharaterized LOC112694756 -0.0269359
RPL27A ribosomal protein L27a -0.0264345
KRT14 keratin 14, type I -0.0263594
PRRC2C proline-rich coiled-coil 2C -0.0263069
RPL9 ribosomal protein L9 -0.0262682
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.026231
IFI27 interferon, alpha-inducible protein 27 -0.0253526
RPL7A ribosomal protein L7a -0.0253432
RPL35 ribosomal protein L35 -0.0253258
YBX1 Y box binding protein 1 -0.0250175
RPS23 ribosomal protein S23 -0.0244394
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0244376
PFN1 profilin 1 -0.024225
S100A11 S100 calcium binding protein A11 -0.0241622
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0238837
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0238129
ZNFX1 zinc finger, NFX1-type containing 1 -0.02358
HLA-E major histocompatibility complex, class I, E -0.0234859
RPS4X ribosomal protein S4, X-linked -0.0232984
RPS20 ribosomal protein S20 -0.0231629
RPL28 ribosomal protein L28 -0.023111
FOXP1 forkhead box P1 -0.0229645
PGK1 phosphoglycerate kinase 1 -0.0229483
EIF1 eukaryotic translation initiation factor 1 -0.0229051
RPL36 ribosomal protein L36 -0.0228639
RPS16 ribosomal protein S16 -0.0228443
RPS29 ribosomal protein S29 -0.0227991
IGF2 insulin-like growth factor 2 -0.0225472