Omeprazole (sodium)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0734247
ATP13A3 ATPase type 13A3 0.0577152
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0447474
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0418624
NAMPT nicotinamide phosphoribosyltransferase 0.0377688
ELL2 elongation factor, RNA polymerase II, 2 0.0354544
SLC12A8 solute carrier family 12, member 8 0.0349831
TRIO trio Rho guanine nucleotide exchange factor 0.0337519
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0300723
ZNF841 zinc finger protein 841 0.0287812
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0247802
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0231124
HEG1 heart development protein with EGF-like domains 1 0.0227431
SOD2 superoxide dismutase 2, mitochondrial 0.0219954
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0209684
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0206104
FLNB filamin B, beta 0.0204264
ZEB2 zinc finger E-box binding homeobox 2 0.020114
NEK7 NIMA-related kinase 7 0.0195768
TGFB2 transforming growth factor, beta 2 0.0195508
ITCH itchy E3 ubiquitin protein ligase 0.0190526
ARF4 ADP-ribosylation factor 4 0.0188409
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0186289
MYH9 myosin, heavy chain 9, non-muscle 0.0185979
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0178168
NUP58 nucleoporin 58 0.0173884
GRAMD2B GRAM domain containing 2B 0.016843
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.015903
NUP153 nucleoporin 153kDa 0.0156353
FNDC3B fibronectin type III domain containing 3B 0.0150982
CUL4B cullin 4B 0.01509
MARCHF6 membrane associated ring-CH-type finger 6 0.0150827
TMEM39A transmembrane protein 39A 0.0141408
CCDC14 coiled-coil domain containing 14 0.014033
DST dystonin 0.0139084
CLTC clathrin, heavy chain (Hc) 0.0137325
TM9SF2 transmembrane 9 superfamily member 2 0.0136758
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0135459
OSMR oncostatin M receptor 0.0134342
UBQLN1 ubiquilin 1 0.0133537
COL5A1 collagen, type V, alpha 1 0.0131216
UBA6 ubiquitin-like modifier activating enzyme 6 0.0128541
SUCO SUN domain containing ossification factor 0.0128259
COG6 component of oligomeric golgi complex 6 0.0127837
GSK3B glycogen synthase kinase 3 beta 0.0126695
RAB18 RAB18, member RAS oncogene family 0.0126267
ODF2 outer dense fiber of sperm tails 2 0.0125998
ANKRD10 ankyrin repeat domain 10 0.0125366
SCFD2 sec1 family domain containing 2 0.0122869
TMEM178B transmembrane protein 178B 0.011994
CCNL1 cyclin L1 0.0117625
GPR107 G protein-coupled receptor 107 0.0117613
LOX lysyl oxidase 0.0117102
ARGLU1 arginine and glutamate rich 1 0.0116174
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0115931
PICALM phosphatidylinositol binding clathrin assembly protein 0.0115802
SPAG9 sperm associated antigen 9 0.0114802
MED14 mediator complex subunit 14 0.0113834
GLIS3 GLIS family zinc finger 3 0.0113602
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0113383
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0112904
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0111285
MB21D2 Mab-21 domain containing 2 0.0111016
NCKAP1 NCK-associated protein 1 0.0110824
RAD23B RAD23 homolog B (S. cerevisiae) 0.0110424
PGK1 phosphoglycerate kinase 1 0.0109949
FAR1 fatty acyl CoA reductase 1 0.0109809
ZFC3H1 zinc finger, C3H1-type containing 0.0109733
IL6ST interleukin 6 signal transducer 0.0109656
XPO6 exportin 6 0.0108931
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0108891
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0107989
TMEM41B transmembrane protein 41B 0.0106677
ELOVL5 ELOVL fatty acid elongase 5 0.0106459
RAB6A RAB6A, member RAS oncogene family 0.0106448
USP9X ubiquitin specific peptidase 9, X-linked 0.0105797
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0105673
WRN Werner syndrome, RecQ helicase-like 0.0104758
AGFG1 ArfGAP with FG repeats 1 0.0104447
RLIM ring finger protein, LIM domain interacting 0.0102897
SRP54 signal recognition particle 54kDa 0.0101767
CAPRIN1 cell cycle associated protein 1 0.0101494
COPA coatomer protein complex, subunit alpha 0.010142
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0101147
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0100599
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.00998541
ANKRD36 ankyrin repeat domain 36 0.00994231
SNX4 sorting nexin 4 0.00977139
NUP214 nucleoporin 214kDa 0.0097456
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.00969699
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00963335
H1-4 H1.4 linker histone, cluster member 0.00962445
ZFAND3 zinc finger, AN1-type domain 3 0.00933079
GOLGA3 golgin A3 0.00925107
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00915382
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00908406
ADAM17 ADAM metallopeptidase domain 17 0.00905372
RAB8B RAB8B, member RAS oncogene family 0.00892548
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00888796
FAT1 FAT atypical cadherin 1 0.00883239

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.156247
MT2A metallothionein 2A -0.139776
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121292
HLA-B major histocompatibility complex, class I, B -0.110653
RPS6 ribosomal protein S6 -0.0773738
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0726676
IGFBP3 insulin-like growth factor binding protein 3 -0.0720258
VIM vimentin -0.0708253
NDRG1 N-myc downstream regulated 1 -0.0649892
RPL35A ribosomal protein L35a -0.0607842
TMSB10 thymosin beta 10 -0.0521425
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0514533
PTMA prothymosin, alpha -0.0507725
FN1 fibronectin 1 -0.0484532
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0483051
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0473429
POTEF POTE ankyrin domain family, member F -0.047188
RPS8 ribosomal protein S8 -0.0454674
B2M beta-2-microglobulin -0.0440262
DEK DEK proto-oncogene -0.0426788
TPT1 tumor protein, translationally-controlled 1 -0.0423228
ENO1 enolase 1, (alpha) -0.0411913
NALF1 NALCN channel auxiliary factor 1 -0.0399664
PKM pyruvate kinase, muscle -0.0393163
RPLP2 ribosomal protein, large, P2 -0.0385785
ACTG1 actin gamma 1 -0.0382903
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0370128
RPLP1 ribosomal protein, large, P1 -0.0337019
RPL23 ribosomal protein L23 -0.0336509
INTS6 integrator complex subunit 6 -0.0313652
ABI3BP ABI family, member 3 (NESH) binding protein -0.0312171
LDHA lactate dehydrogenase A -0.0309333
HLA-A major histocompatibility complex, class I, A -0.0305284
S100A10 S100 calcium binding protein A10 -0.0292005
HMGB1 high mobility group box 1 -0.028967
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.028414
RPL12 ribosomal protein L12 -0.0282421
TPM4 tropomyosin 4 -0.0281234
KRT7 keratin 7, type II -0.027936
RPL37 ribosomal protein L37 -0.0276598
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0269095
FTH1 ferritin, heavy polypeptide 1 -0.0268491
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0267266
RPS13 ribosomal protein S13 -0.0264032
DLG1 discs, large homolog 1 (Drosophila) -0.0258299
RPL7A ribosomal protein L7a -0.0254928
RPS3 ribosomal protein S3 -0.025
CENPF centromere protein F, 350/400kDa -0.0249423
ASPH aspartate beta-hydroxylase -0.0248477
KTN1 kinectin 1 (kinesin receptor) -0.0247596
S100A6 S100 calcium binding protein A6 -0.0247146
PFN1 profilin 1 -0.0245534
ANXA2 annexin A2 -0.024488
RPS19 ribosomal protein S19 -0.0243106
ZFP36L1 ZFP36 ring finger protein-like 1 -0.024211
RPL37A ribosomal protein L37a -0.0240069
TLE4 transducin-like enhancer of split 4 -0.0238912
RPL5 ribosomal protein L5 -0.0237914
RPL11 ribosomal protein L11 -0.0236609
RPS12 ribosomal protein S12 -0.0235754
YBX1 Y box binding protein 1 -0.0234725
RPL19 ribosomal protein L19 -0.0233574
VDAC1 voltage-dependent anion channel 1 -0.0228832
IFITM3 interferon induced transmembrane protein 3 -0.022809
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0225712
PHACTR1 phosphatase and actin regulator 1 -0.0223683
IFI6 interferon, alpha-inducible protein 6 -0.022296
RPL31 ribosomal protein L31 -0.0222032
SMC4 structural maintenance of chromosomes 4 -0.0221205
RPS23 ribosomal protein S23 -0.0217993
SET SET nuclear proto-oncogene -0.0215276
LOC112694756 uncharaterized LOC112694756 -0.0213466
SQSTM1 sequestosome 1 -0.0209594
RPL30 ribosomal protein L30 -0.0208578
MAP1B microtubule-associated protein 1B -0.0208511
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0206792
RPL26 ribosomal protein L26 -0.020654
RPS20 ribosomal protein S20 -0.0205947
RPL35 ribosomal protein L35 -0.020347
ENO2 enolase 2 (gamma, neuronal) -0.0203194
PLIN2 perilipin 2 -0.0201525
IGFBP5 insulin-like growth factor binding protein 5 -0.0198695
RPL34 ribosomal protein L34 -0.0197805
RPL28 ribosomal protein L28 -0.0197264
RPS14 ribosomal protein S14 -0.0195569
RPS17 ribosomal protein S17 -0.0195074
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0194825
RACK1 receptor for activated C kinase 1 -0.0193462
EIF1 eukaryotic translation initiation factor 1 -0.0193226
TPI1 triosephosphate isomerase 1 -0.0192424
RPS16 ribosomal protein S16 -0.0190433
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0189566
FOSL1 FOS-like antigen 1 -0.0189549
RPL9 ribosomal protein L9 -0.0187375
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0186678
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0186611
RPL7 ribosomal protein L7 -0.0184984
RPL27A ribosomal protein L27a -0.0184341
HMGA1 high mobility group AT-hook 1 -0.0184043
RPS24 ribosomal protein S24 -0.0179444