Omeprazole (sodium)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein 0.0882629
MMP12 matrix metallopeptidase 12 0.0807274
CD109 CD109 molecule 0.0706211
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0602349
DTNA dystrobrevin, alpha 0.0591307
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0570859
MSN moesin 0.0500943
EFNA5 ephrin-A5 0.0494697
EEF2 eukaryotic translation elongation factor 2 0.0446308
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0428826
GPC6 glypican 6 0.042444
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0414097
ADAM9 ADAM metallopeptidase domain 9 0.0393473
NDRG1 N-myc downstream regulated 1 0.039233
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0390118
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0382265
ELL2 elongation factor, RNA polymerase II, 2 0.0353294
ZNF292 zinc finger protein 292 0.0351527
UBA6 ubiquitin-like modifier activating enzyme 6 0.0338305
AKAP12 A kinase (PRKA) anchor protein 12 0.0320739
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0312026
SRRM2 serine/arginine repetitive matrix 2 0.0303168
JARID2 jumonji, AT rich interactive domain 2 0.0293152
RNF145 ring finger protein 145 0.0278632
CCNL1 cyclin L1 0.0271649
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.025432
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0251798
TXNIP thioredoxin interacting protein 0.0250616
UGCG UDP-glucose ceramide glucosyltransferase 0.0249457
HELZ helicase with zinc finger 0.024613
POTEF POTE ankyrin domain family, member F 0.0243809
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0240914
DST dystonin 0.023978
PBX3 pre-B-cell leukemia homeobox 3 0.0237411
APLP2 amyloid beta (A4) precursor-like protein 2 0.0232609
RAB8B RAB8B, member RAS oncogene family 0.0229328
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0228632
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0227723
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0225878
ARRDC3 arrestin domain containing 3 0.0224176
KCMF1 potassium channel modulatory factor 1 0.0223058
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0219016
NUP58 nucleoporin 58 0.0218554
FMNL2 formin-like 2 0.021627
NGLY1 N-glycanase 1 0.0215366
ATP13A3 ATPase type 13A3 0.021279
SETD5 SET domain containing 5 0.0207722
RIC1 RAB6A GEF complex partner 1 0.0207251
MYOF myoferlin 0.0206541
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0206119
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0202104
TMF1 TATA element modulatory factor 1 0.0199466
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0198824
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0197899
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0195668
ARHGAP21 Rho GTPase activating protein 21 0.0195054
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0193044
RAB6A RAB6A, member RAS oncogene family 0.0191889
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0191884
RPL3 ribosomal protein L3 0.018899
EGFR epidermal growth factor receptor 0.0187997
MXI1 MAX interactor 1, dimerization protein 0.0187238
NCKAP1 NCK-associated protein 1 0.0187208
KMT2C lysine (K)-specific methyltransferase 2C 0.0186157
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0184393
ENO2 enolase 2 (gamma, neuronal) 0.0181434
VEGFA vascular endothelial growth factor A 0.0181315
USP3 ubiquitin specific peptidase 3 0.0180393
KDM2A lysine (K)-specific demethylase 2A 0.0178562
SMAP1 small ArfGAP 1 0.0178075
SRRM1 serine/arginine repetitive matrix 1 0.0176854
FNIP1 folliculin interacting protein 1 0.0176638
ANO6 anoctamin 6 0.0176536
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0174651
HSPA8 heat shock 70kDa protein 8 0.0172934
SPRED1 sprouty-related, EVH1 domain containing 1 0.0172597
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0168682
DGKD diacylglycerol kinase, delta 130kDa 0.0167571
NRIP1 nuclear receptor interacting protein 1 0.0167032
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0164948
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0164547
ZEB2 zinc finger E-box binding homeobox 2 0.0164264
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0163974
ESYT2 extended synaptotagmin-like protein 2 0.0162718
PHF21A PHD finger protein 21A 0.016123
TSC22D1 TSC22 domain family, member 1 0.0160492
PIAS1 protein inhibitor of activated STAT, 1 0.0160169
GOLGA4 golgin A4 0.0159545
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0155361
SNX13 sorting nexin 13 0.0154951
TRA2A transformer 2 alpha homolog (Drosophila) 0.0153567
PRPF8 pre-mRNA processing factor 8 0.0153286
BRD2 bromodomain containing 2 0.0152982
MACF1 microtubule-actin crosslinking factor 1 0.0152704
CHD1L chromodomain helicase DNA binding protein 1-like 0.0152125
PICALM phosphatidylinositol binding clathrin assembly protein 0.0151422
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0149942
PEA15 phosphoprotein enriched in astrocytes 15 0.0149634
PRKD1 protein kinase D1 0.0148562
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0148262

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.192331
VIM vimentin -0.157663
AHNAK AHNAK nucleoprotein -0.134368
TPT1 tumor protein, translationally-controlled 1 -0.0982896
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0963986
TMSB10 thymosin beta 10 -0.0904666
EXT1 exostosin glycosyltransferase 1 -0.0847397
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0690894
LOC112694756 uncharaterized LOC112694756 -0.0623429
NTM neurotrimin -0.0618095
ACTG1 actin gamma 1 -0.058957
ADAM19 ADAM metallopeptidase domain 19 -0.0563781
VCL vinculin -0.0560175
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0549363
RPLP1 ribosomal protein, large, P1 -0.0543214
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0538311
RPS6 ribosomal protein S6 -0.0533052
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0530788
SDCCAG8 serologically defined colon cancer antigen 8 -0.0523805
SAMD3 sterile alpha motif domain containing 3 -0.0522427
NAP1L1 nucleosome assembly protein 1-like 1 -0.0507281
RAD21 RAD21 homolog (S. pombe) -0.0504713
RPL23 ribosomal protein L23 -0.0500868
RPS24 ribosomal protein S24 -0.0498494
PTMA prothymosin, alpha -0.0494962
RPL35A ribosomal protein L35a -0.0480188
NABP1 nucleic acid binding protein 1 -0.0469171
ALCAM activated leukocyte cell adhesion molecule -0.0468483
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0431391
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0430935
KYNU kynureninase -0.0430161
FOXP1 forkhead box P1 -0.0428053
RPL11 ribosomal protein L11 -0.0421427
PTCHD4 patched domain containing 4 -0.0420152
EIF1 eukaryotic translation initiation factor 1 -0.042011
RPLP0 ribosomal protein, large, P0 -0.0407689
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0405276
ANXA2 annexin A2 -0.0398016
CDK6 cyclin-dependent kinase 6 -0.0385084
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0378259
INTS6 integrator complex subunit 6 -0.0375965
AEBP2 AE binding protein 2 -0.0374935
RPL19 ribosomal protein L19 -0.0371494
PRKG1 protein kinase, cGMP-dependent, type I -0.0370726
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0367376
CAVIN1 caveolae associated protein 1 -0.0357559
CD44 CD44 molecule (Indian blood group) -0.0357514
CANX calnexin -0.0348378
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0346841
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0346551
CALD1 caldesmon 1 -0.0333486
ETV6 ets variant 6 -0.033125
RPL12 ribosomal protein L12 -0.0329623
SAMD4A sterile alpha motif domain containing 4A -0.0329225
RPS27A ribosomal protein S27a -0.0328136
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0327945
RIMS2 regulating synaptic membrane exocytosis 2 -0.0324869
SP100 SP100 nuclear antigen -0.0320422
ANTXR2 anthrax toxin receptor 2 -0.0320146
ERBIN erbb2 interacting protein -0.0315757
CFAP251 cilia and flagella associated protein 251 -0.0315323
PCDH11X protocadherin 11 X-linked -0.0312822
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0312541
RPS20 ribosomal protein S20 -0.0311986
RPLP2 ribosomal protein, large, P2 -0.0305438
RPS19 ribosomal protein S19 -0.0304415
RPL27A ribosomal protein L27a -0.030264
SASH1 SAM and SH3 domain containing 1 -0.0302344
RPS8 ribosomal protein S8 -0.0301668
RPL30 ribosomal protein L30 -0.0299673
HLA-E major histocompatibility complex, class I, E -0.0297037
MAML2 mastermind-like 2 (Drosophila) -0.0296823
RPS3 ribosomal protein S3 -0.0295468
KPNB1 karyopherin (importin) beta 1 -0.0290469
RPL26 ribosomal protein L26 -0.0289406
FMN1 formin 1 -0.0287125
APP amyloid beta (A4) precursor protein -0.0281949
GNAS GNAS complex locus -0.0280562
RPS25 ribosomal protein S25 -0.028001
DOCK4 dedicator of cytokinesis 4 -0.027768
WSB1 WD repeat and SOCS box containing 1 -0.027683
RPL13A ribosomal protein L13a -0.0274671
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0272762
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0272506
ZNF804A zinc finger protein 804A -0.0271929
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0269503
CDK14 cyclin-dependent kinase 14 -0.0269483
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0268369
RPL4 ribosomal protein L4 -0.0267397
RPS4X ribosomal protein S4, X-linked -0.0265246
RPL37A ribosomal protein L37a -0.0260749
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.025987
BMAL2 basic helix-loop-helix ARNT like 2 -0.0259056
RPL34 ribosomal protein L34 -0.0258748
PTPRK protein tyrosine phosphatase, receptor type, K -0.0256104
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0249031
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0248593
RPL8 ribosomal protein L8 -0.024785
ACTN1 actinin, alpha 1 -0.0245121
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0244069