Omeprazole (sodium)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0780972
ANKRD11 ankyrin repeat domain 11 0.0764866
LMO7 LIM domain 7 0.0693576
RNF145 ring finger protein 145 0.0666624
KDM3A lysine (K)-specific demethylase 3A 0.0645965
ZFAND3 zinc finger, AN1-type domain 3 0.0635233
RBM39 RNA binding motif protein 39 0.0599746
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0598626
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0550478
PUM2 pumilio RNA-binding family member 2 0.0518628
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0486076
EEF2 eukaryotic translation elongation factor 2 0.0472006
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0460507
MBNL2 muscleblind-like splicing regulator 2 0.0453052
WDR43 WD repeat domain 43 0.0450426
IARS1 isoleucyl-tRNA synthetase 1 0.0446366
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0443104
ANKRD17 ankyrin repeat domain 17 0.0441569
GRB10 growth factor receptor-bound protein 10 0.0424056
GOLGA4 golgin A4 0.042202
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0416108
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0413961
TTC3 tetratricopeptide repeat domain 3 0.0412103
MYO1E myosin IE 0.0410444
COG5 component of oligomeric golgi complex 5 0.0400254
GARS1 glycyl-tRNA synthetase 1 0.0397155
KIF5B kinesin family member 5B 0.0394004
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0391779
WAC WW domain containing adaptor with coiled-coil 0.0386765
VEGFA vascular endothelial growth factor A 0.0386493
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0377466
HSPA8 heat shock 70kDa protein 8 0.0375942
NCKAP1 NCK-associated protein 1 0.0374532
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.036788
RPS2 ribosomal protein S2 0.0366698
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0362978
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0355486
EIF3A eukaryotic translation initiation factor 3, subunit A 0.035008
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0347755
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0346743
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0346237
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0346043
RSRC2 arginine/serine-rich coiled-coil 2 0.0345626
ZFC3H1 zinc finger, C3H1-type containing 0.0342786
BZW1 basic leucine zipper and W2 domains 1 0.0337186
EREG epiregulin 0.0324793
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0324609
RAB1A RAB1A, member RAS oncogene family 0.0324028
H2AC6 H2A clustered histone 6 0.0318506
PAPOLA poly(A) polymerase alpha 0.031722
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0303257
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0300576
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0300336
PUM1 pumilio RNA-binding family member 1 0.0298738
FUBP1 far upstream element (FUSE) binding protein 1 0.0297235
YME1L1 YME1-like 1 ATPase 0.0295793
RPL3 ribosomal protein L3 0.029505
PRRC2C proline-rich coiled-coil 2C 0.0292332
NCOR1 nuclear receptor corepressor 1 0.0292098
TFG TRK-fused gene 0.0291371
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0290919
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0290815
MYO5B myosin VB 0.0289851
EXT1 exostosin glycosyltransferase 1 0.0287576
SLMAP sarcolemma associated protein 0.0285267
EWSR1 EWS RNA-binding protein 1 0.0284016
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0279177
KMT2E lysine (K)-specific methyltransferase 2E 0.027899
SPAG9 sperm associated antigen 9 0.0278453
TRA2A transformer 2 alpha homolog (Drosophila) 0.0277945
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0276091
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0275283
MARCHF6 membrane associated ring-CH-type finger 6 0.0274861
KDM6A lysine (K)-specific demethylase 6A 0.0274806
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0274711
FAT1 FAT atypical cadherin 1 0.0274498
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.027412
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0272631
CUX1 cut-like homeobox 1 0.0271742
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0271008
GPBP1 GC-rich promoter binding protein 1 0.0267645
TES testin LIM domain protein 0.0267017
ARHGAP21 Rho GTPase activating protein 21 0.0267011
MPRIP myosin phosphatase Rho interacting protein 0.0266246
DSCAM Down syndrome cell adhesion molecule 0.0266109
FOXJ3 forkhead box J3 0.0266043
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0264072
SRRM2 serine/arginine repetitive matrix 2 0.0263885
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0260171
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0260066
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0259684
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0259019
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0258431
YTHDC1 YTH domain containing 1 0.0255623
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0255502
GPHN gephyrin 0.0254893
BTBD9 BTB (POZ) domain containing 9 0.0254724
GSK3B glycogen synthase kinase 3 beta 0.0253639
MATR3 matrin 3 0.0251311
RIGI RNA sensor RIG-I 0.0249353

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.384876
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.234977
NDRG1 N-myc downstream regulated 1 -0.102918
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0993824
TXNIP thioredoxin interacting protein -0.0896429
PTMA prothymosin, alpha -0.0877538
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0806376
TNS4 tensin 4 -0.0802082
RPL35A ribosomal protein L35a -0.0785725
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0783019
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0773418
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.077209
CEMIP cell migration inducing protein, hyaluronan binding -0.0735767
PERP PERP, TP53 apoptosis effector -0.0660462
FTL ferritin, light polypeptide -0.0647862
KRT19 keratin 19, type I -0.0640455
RPS19 ribosomal protein S19 -0.0617455
RPLP0 ribosomal protein, large, P0 -0.0615217
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0614529
S100A6 S100 calcium binding protein A6 -0.0609262
TPT1 tumor protein, translationally-controlled 1 -0.0593155
RPLP1 ribosomal protein, large, P1 -0.0581318
KRT18 keratin 18, type I -0.0571574
FTH1 ferritin, heavy polypeptide 1 -0.0561674
LDHA lactate dehydrogenase A -0.0555154
S100A10 S100 calcium binding protein A10 -0.0531193
RPS6 ribosomal protein S6 -0.0507105
LOC112694756 uncharaterized LOC112694756 -0.0497705
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0485651
TMSB10 thymosin beta 10 -0.0481463
PTBP3 polypyrimidine tract binding protein 3 -0.0474947
ENO1 enolase 1, (alpha) -0.0459962
MT2A metallothionein 2A -0.0455176
RPL12 ribosomal protein L12 -0.0454607
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.045058
RPL9 ribosomal protein L9 -0.0440683
TPM4 tropomyosin 4 -0.0434934
RPL23 ribosomal protein L23 -0.0416726
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0397898
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0397195
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0392683
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0392645
VDAC1 voltage-dependent anion channel 1 -0.0392266
RPL19 ribosomal protein L19 -0.0382057
AGR2 anterior gradient 2 -0.0360341
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.035303
PRSS3 protease, serine, 3 -0.0352936
RPL34 ribosomal protein L34 -0.0348223
MT1X metallothionein 1X -0.0345432
FOSL1 FOS-like antigen 1 -0.0320367
KLF3 Kruppel-like factor 3 (basic) -0.031954
AHNAK AHNAK nucleoprotein -0.0318188
GSTP1 glutathione S-transferase pi 1 -0.0315114
RPS13 ribosomal protein S13 -0.031453
RPS8 ribosomal protein S8 -0.0314104
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0312577
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0302181
PKM pyruvate kinase, muscle -0.0296106
RPL31 ribosomal protein L31 -0.0292921
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0291288
ANXA2 annexin A2 -0.0291165
PTEN phosphatase and tensin homolog -0.0289787
RNF43 ring finger protein 43 -0.0289306
TFF3 trefoil factor 3 (intestinal) -0.0286044
PFN1 profilin 1 -0.0284535
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0283423
FHIT fragile histidine triad -0.0281389
CLDN7 claudin 7 -0.0281266
EGR1 early growth response 1 -0.0280841
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0270462
CADPS Ca++-dependent secretion activator -0.0270331
RPL36 ribosomal protein L36 -0.0267298
EPCAM epithelial cell adhesion molecule -0.0266039
RPL11 ribosomal protein L11 -0.026518
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0256217
MT1E metallothionein 1E -0.0254835
POTEF POTE ankyrin domain family, member F -0.025188
CD9 CD9 molecule -0.0250294
RPS24 ribosomal protein S24 -0.0247724
TSC22D1 TSC22 domain family, member 1 -0.02469
PDIA3 protein disulfide isomerase family A, member 3 -0.0245629
CCNI cyclin I -0.0244664
RPL21 ribosomal protein L21 -0.0244521
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0243236
GCC2 GRIP and coiled-coil domain containing 2 -0.0241813
RPL7A ribosomal protein L7a -0.0240565
RPLP2 ribosomal protein, large, P2 -0.0240016
RPL8 ribosomal protein L8 -0.0235662
RPL18 ribosomal protein L18 -0.0235158
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0233812
LOC102724023 ES1 protein homolog, mitochondrial -0.023361
RPL7 ribosomal protein L7 -0.0233238
RPL27A ribosomal protein L27a -0.0231998
MUC17 mucin 17, cell surface associated -0.0230819
RPL32 ribosomal protein L32 -0.0229924
EEF1G eukaryotic translation elongation factor 1 gamma -0.0229679
ESYT2 extended synaptotagmin-like protein 2 -0.022864
HMGA1 high mobility group AT-hook 1 -0.0228474
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0225717
RPS25 ribosomal protein S25 -0.022562