Omeprazole (sodium)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GOLGA4 golgin A4 0.052637
RPL3 ribosomal protein L3 0.0514836
EEF2 eukaryotic translation elongation factor 2 0.0495892
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0309417
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.029867
KMT2E lysine (K)-specific methyltransferase 2E 0.0295859
UBA6 ubiquitin-like modifier activating enzyme 6 0.0281696
CCNL1 cyclin L1 0.0251072
RNF145 ring finger protein 145 0.0241503
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0235147
NKTR natural killer cell triggering receptor 0.023164
TMF1 TATA element modulatory factor 1 0.0212867
NCKAP1 NCK-associated protein 1 0.0205545
NRDC nardilysin convertase 0.0197821
ITPRID2 ITPR interacting domain containing 2 0.0189401
RPL21 ribosomal protein L21 0.0183388
CLDN4 claudin 4 0.0183001
TFG TRK-fused gene 0.0176048
EPHA2 EPH receptor A2 0.0167981
POTEF POTE ankyrin domain family, member F 0.0167474
VEGFA vascular endothelial growth factor A 0.0163749
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0163358
ZFC3H1 zinc finger, C3H1-type containing 0.0157499
PRPF8 pre-mRNA processing factor 8 0.015537
AREG amphiregulin 0.0154762
SLK STE20-like kinase 0.0153051
KMT2D lysine (K)-specific methyltransferase 2D 0.0152909
ARHGAP21 Rho GTPase activating protein 21 0.0149204
NUP58 nucleoporin 58 0.0148787
SRRM2 serine/arginine repetitive matrix 2 0.0144192
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0139588
RPS2 ribosomal protein S2 0.013862
BRD2 bromodomain containing 2 0.0137722
TNIP1 TNFAIP3 interacting protein 1 0.0136878
TES testin LIM domain protein 0.0135724
SRSF4 serine/arginine-rich splicing factor 4 0.0134763
ARRDC3 arrestin domain containing 3 0.0134492
RIC1 RAB6A GEF complex partner 1 0.0134269
FTH1 ferritin, heavy polypeptide 1 0.013284
SRP54 signal recognition particle 54kDa 0.0130571
RB1CC1 RB1-inducible coiled-coil 1 0.0129563
ADAM17 ADAM metallopeptidase domain 17 0.0128451
PSAT1 phosphoserine aminotransferase 1 0.0127721
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.0126495
SEC24A SEC24 family member A 0.0126408
MBNL1 muscleblind-like splicing regulator 1 0.0125035
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0123193
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0120342
SETD5 SET domain containing 5 0.0120164
PTEN phosphatase and tensin homolog 0.0119287
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0119032
MKRN1 makorin ring finger protein 1 0.0117541
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.011654
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0114289
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0114163
WAC WW domain containing adaptor with coiled-coil 0.011414
USP53 ubiquitin specific peptidase 53 0.0113181
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0111326
CASC3 cancer susceptibility candidate 3 0.0110246
SCAF8 SR-related CTD-associated factor 8 0.010949
SRRM1 serine/arginine repetitive matrix 1 0.0108798
RANBP9 RAN binding protein 9 0.0107893
CENPF centromere protein F, 350/400kDa 0.0106148
ITCH itchy E3 ubiquitin protein ligase 0.0105713
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0104395
SREBF2 sterol regulatory element binding transcription factor 2 0.0104154
RTN4 reticulon 4 0.0103738
COG3 component of oligomeric golgi complex 3 0.0102291
SPRED2 sprouty-related, EVH1 domain containing 2 0.0102031
CLIC4 chloride intracellular channel 4 0.0101095
PDIA6 protein disulfide isomerase family A, member 6 0.0099942
AP1AR adaptor-related protein complex 1 associated regulatory protein 0.00998409
COG6 component of oligomeric golgi complex 6 0.00997103
UBE3A ubiquitin protein ligase E3A 0.00993262
SNX9 sorting nexin 9 0.00992056
RAB6A RAB6A, member RAS oncogene family 0.00986891
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 0.00985839
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.009753
RPS7 ribosomal protein S7 0.00952185
RNPS1 RNA binding protein S1, serine-rich domain 0.00945339
SMAD4 SMAD family member 4 0.00942125
FXR1 fragile X mental retardation, autosomal homolog 1 0.0093414
PNN pinin, desmosome associated protein 0.00933694
LRP6 low density lipoprotein receptor-related protein 6 0.00929488
CCNT1 cyclin T1 0.0092345
ZRANB1 zinc finger, RAN-binding domain containing 1 0.00919665
SS18 synovial sarcoma translocation, chromosome 18 0.00910912
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00910068
GATAD2B GATA zinc finger domain containing 2B 0.00907777
AKAP12 A kinase (PRKA) anchor protein 12 0.00906968
AUH AU RNA binding protein/enoyl-CoA hydratase 0.00904084
HDGF hepatoma-derived growth factor 0.00902183
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.00901716
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.00897449
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.00897285
TENT5A terminal nucleotidyltransferase 5A 0.00892237
MBNL2 muscleblind-like splicing regulator 2 0.00889283
ADAM9 ADAM metallopeptidase domain 9 0.00880582
TULP3 tubby like protein 3 0.0087471
SCYL2 SCY1-like 2 (S. cerevisiae) 0.00873121

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.209324
THSD4 thrombospondin, type I, domain containing 4 -0.147628
RPLP1 ribosomal protein, large, P1 -0.133352
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.132133
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.12186
PDE4D phosphodiesterase 4D, cAMP-specific -0.1132
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0905953
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0846905
EPS8 epidermal growth factor receptor pathway substrate 8 -0.08408
PTPRR protein tyrosine phosphatase, receptor type, R -0.0830682
RPLP0 ribosomal protein, large, P0 -0.0796665
RPL35A ribosomal protein L35a -0.0785489
RPS8 ribosomal protein S8 -0.0777902
RPS24 ribosomal protein S24 -0.0751084
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0750908
PTMA prothymosin, alpha -0.0725488
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0697874
KLF5 Kruppel-like factor 5 (intestinal) -0.0689211
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0674544
MSI2 musashi RNA-binding protein 2 -0.0658952
CANX calnexin -0.065726
RNF213 ring finger protein 213 -0.0649989
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0639918
PTPRK protein tyrosine phosphatase, receptor type, K -0.0634825
BACE2 beta-site APP-cleaving enzyme 2 -0.0612002
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0610707
RPL34 ribosomal protein L34 -0.0597248
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0585267
GMDS GDP-mannose 4,6-dehydratase -0.0579713
SERINC5 serine incorporator 5 -0.0571796
TMSB10 thymosin beta 10 -0.056908
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0560088
PTPRG protein tyrosine phosphatase, receptor type, G -0.0557408
FOXP1 forkhead box P1 -0.0557371
MX1 MX dynamin-like GTPase 1 -0.0557
RPL11 ribosomal protein L11 -0.0529284
ANXA2 annexin A2 -0.0525968
NAP1L1 nucleosome assembly protein 1-like 1 -0.0523984
RPS19 ribosomal protein S19 -0.0509692
MYOF myoferlin -0.0502862
RRBP1 ribosome binding protein 1 -0.0487944
AHNAK AHNAK nucleoprotein -0.0483611
RPS21 ribosomal protein S21 -0.0477763
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0472622
PATJ PATJ crumbs cell polarity complex component -0.0470687
LDHA lactate dehydrogenase A -0.0467492
RIGI RNA sensor RIG-I -0.046241
RPL26 ribosomal protein L26 -0.0460913
HDLBP high density lipoprotein binding protein -0.0456637
RPL23 ribosomal protein L23 -0.0452925
CUX1 cut-like homeobox 1 -0.0450171
RPS27A ribosomal protein S27a -0.044831
FLNB filamin B, beta -0.044014
ENO1 enolase 1, (alpha) -0.0426166
LAMB3 laminin, beta 3 -0.042485
RPS25 ribosomal protein S25 -0.042229
RPS23 ribosomal protein S23 -0.0420218
RPLP2 ribosomal protein, large, P2 -0.0416517
ITGA6 integrin, alpha 6 -0.0409499
KRT18 keratin 18, type I -0.0406959
LOC112694756 uncharaterized LOC112694756 -0.0398534
MYO1D myosin ID -0.039568
RPL13A ribosomal protein L13a -0.0395641
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0394891
PLAC8 placenta-specific 8 -0.0393838
RPL27A ribosomal protein L27a -0.0392416
RPS6 ribosomal protein S6 -0.039157
LPP LIM domain containing preferred translocation partner in lipoma -0.0390565
RPL19 ribosomal protein L19 -0.0380965
RPS16 ribosomal protein S16 -0.0379563
SP100 SP100 nuclear antigen -0.0378773
AOPEP aminopeptidase O (putative) -0.0376789
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0375078
DENND1A DENN/MADD domain containing 1A -0.0374481
VDAC1 voltage-dependent anion channel 1 -0.0373084
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0371912
RPL12 ribosomal protein L12 -0.0365518
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0364729
AGR2 anterior gradient 2 -0.0364087
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0361613
CCSER1 coiled-coil serine-rich protein 1 -0.0361254
TCF12 transcription factor 12 -0.0359461
RPL9 ribosomal protein L9 -0.0359284
RAD51B RAD51 paralog B -0.0359009
LMO7 LIM domain 7 -0.0358636
RPS13 ribosomal protein S13 -0.0355773
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0354946
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0353897
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0352944
IER3 immediate early response 3 -0.0349839
RPS29 ribosomal protein S29 -0.034718
ETV6 ets variant 6 -0.0341726
RPL4 ribosomal protein L4 -0.0340499
P3H2 prolyl 3-hydroxylase 2 -0.0339017
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0337455
EXOC4 exocyst complex component 4 -0.0336975
TAS2R14 taste receptor, type 2, member 14 -0.0335677
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0335057
RPL31 ribosomal protein L31 -0.0333274
WARS1 tryptophanyl-tRNA synthetase 1 -0.0330416