Omeprazole (sodium)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.0992287
COPA coatomer protein complex, subunit alpha 0.047268
SMAD3 SMAD family member 3 0.0431197
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0383148
ZCCHC7 zinc finger, CCHC domain containing 7 0.0383096
CCNL1 cyclin L1 0.0344295
UBAP2L ubiquitin associated protein 2-like 0.0285384
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.028192
THSD4 thrombospondin, type I, domain containing 4 0.0254657
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0249887
PHF21A PHD finger protein 21A 0.0249605
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0243914
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0238492
PGK1 phosphoglycerate kinase 1 0.0233831
DENND1A DENN/MADD domain containing 1A 0.0221839
SEC31A SEC31 homolog A (S. cerevisiae) 0.0217682
PRPF8 pre-mRNA processing factor 8 0.0211793
SREBF2 sterol regulatory element binding transcription factor 2 0.0209063
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0196132
KIAA1328 KIAA1328 0.0189016
ZNF462 zinc finger protein 462 0.0188079
MAX MYC associated factor X 0.0186627
VCL vinculin 0.0184537
RLIM ring finger protein, LIM domain interacting 0.018346
RAD23B RAD23 homolog B (S. cerevisiae) 0.0177152
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0169913
RNF213 ring finger protein 213 0.0169568
DAND5 DAN domain family member 5, BMP antagonist 0.0168868
TAS2R14 taste receptor, type 2, member 14 0.0167054
MSI2 musashi RNA-binding protein 2 0.016523
EGFR epidermal growth factor receptor 0.0159544
KIF1A kinesin family member 1A 0.0159496
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0157671
ATN1 atrophin 1 0.0157077
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0156066
EPAS1 endothelial PAS domain protein 1 0.0153917
EPHA2 EPH receptor A2 0.0150155
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0147007
FAM13A family with sequence similarity 13, member A 0.0144892
FMNL2 formin-like 2 0.0144386
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.014348
RAD51B RAD51 paralog B 0.0141473
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0139929
FLNA filamin A, alpha 0.0136744
FNBP4 formin binding protein 4 0.0136702
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0136529
DIDO1 death inducer-obliterator 1 0.0135562
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0134867
COPB1 coatomer protein complex, subunit beta 1 0.0134578
COG6 component of oligomeric golgi complex 6 0.0134513
IGF2 insulin-like growth factor 2 0.0134133
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0133517
MORF4L1 mortality factor 4 like 1 0.0132064
SRRM2 serine/arginine repetitive matrix 2 0.0129478
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0128757
ANK2 ankyrin 2, neuronal 0.0128661
NFE2L1 nuclear factor, erythroid 2-like 1 0.0128634
EHBP1 EH domain binding protein 1 0.0127539
USP37 ubiquitin specific peptidase 37 0.0127465
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.0126984
TMED2 transmembrane emp24 domain trafficking protein 2 0.0126176
EGR1 early growth response 1 0.0125494
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0125058
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0124039
MOB1A MOB kinase activator 1A 0.0123572
POTEF POTE ankyrin domain family, member F 0.0122938
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0121522
SEC24A SEC24 family member A 0.0121452
CSDE1 cold shock domain containing E1, RNA-binding 0.0121159
SFTPA2 surfactant protein A2 0.0120386
OSBP oxysterol binding protein 0.0118903
ACTG1 actin gamma 1 0.0118484
PTPRF protein tyrosine phosphatase, receptor type, F 0.0118185
MBNL2 muscleblind-like splicing regulator 2 0.0116198
GPATCH2L G patch domain containing 2-like 0.0116032
PCBP1 poly(rC) binding protein 1 0.0115236
L1CAM L1 cell adhesion molecule 0.0115019
DDB1 damage-specific DNA binding protein 1, 127kDa 0.0114742
EIF4E2 eukaryotic translation initiation factor 4E family member 2 0.0113709
INTS1 integrator complex subunit 1 0.0113618
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.0112818
HCFC1 host cell factor C1 0.0112695
TOPBP1 topoisomerase (DNA) II binding protein 1 0.0112388
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.011202
SRP54 signal recognition particle 54kDa 0.0111469
WRN Werner syndrome, RecQ helicase-like 0.0111469
RBM28 RNA binding motif protein 28 0.0110657
KMT2D lysine (K)-specific methyltransferase 2D 0.010954
TMEM39A transmembrane protein 39A 0.0108428
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0106704
EIF3D eukaryotic translation initiation factor 3, subunit D 0.0105717
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0105717
DPYSL2 dihydropyrimidinase-like 2 0.0105715
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0105595
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0105558
ZBTB5 zinc finger and BTB domain containing 5 0.0105393
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0105092
NCOR2 nuclear receptor corepressor 2 0.0104866
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 0.0104238
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.0103845

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.247283
YBX3 Y box binding protein 3 -0.146353
KTN1 kinectin 1 (kinesin receptor) -0.139547
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.117488
NIPBL Nipped-B homolog (Drosophila) -0.112582
PTMA prothymosin, alpha -0.102975
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.102857
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0810861
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0804267
TMSB10 thymosin beta 10 -0.0752859
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0730047
GRAMD1B GRAM domain containing 1B -0.0728716
TPM3 tropomyosin 3 -0.0680392
RTN4 reticulon 4 -0.0679241
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0643465
ZFAND3 zinc finger, AN1-type domain 3 -0.0634431
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0625325
TPI1 triosephosphate isomerase 1 -0.0625224
VIM vimentin -0.0609909
AKAP12 A kinase (PRKA) anchor protein 12 -0.0589359
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.058846
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0586825
RPL37 ribosomal protein L37 -0.0574716
RPS8 ribosomal protein S8 -0.0570357
MCL1 myeloid cell leukemia 1 -0.0563889
RPS21 ribosomal protein S21 -0.055901
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0548037
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0545717
RPL19 ribosomal protein L19 -0.0543573
MYL12B myosin, light chain 12B, regulatory -0.0540675
STK4 serine/threonine kinase 4 -0.053671
WSB1 WD repeat and SOCS box containing 1 -0.0536236
RPS29 ribosomal protein S29 -0.0529263
RPS19 ribosomal protein S19 -0.0527022
RPL26 ribosomal protein L26 -0.0522438
TPT1 tumor protein, translationally-controlled 1 -0.0513084
PCBP2 poly(rC) binding protein 2 -0.0507707
RPS12 ribosomal protein S12 -0.0506771
EIF5B eukaryotic translation initiation factor 5B -0.0502362
HLA-B major histocompatibility complex, class I, B -0.0500742
FBXO11 F-box protein 11 -0.0500698
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0497215
RPL37A ribosomal protein L37a -0.0494949
RPLP1 ribosomal protein, large, P1 -0.0483233
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0481908
RPS3 ribosomal protein S3 -0.0478493
NAP1L1 nucleosome assembly protein 1-like 1 -0.0476391
RPL23 ribosomal protein L23 -0.047526
PDE4D phosphodiesterase 4D, cAMP-specific -0.0466789
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0465586
RPS2 ribosomal protein S2 -0.0464604
RPL38 ribosomal protein L38 -0.0464313
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.046365
XPO1 exportin 1 -0.0459671
WNK1 WNK lysine deficient protein kinase 1 -0.0450731
RPS6 ribosomal protein S6 -0.04484
RPS10 ribosomal protein S10 -0.044301
RPS15 ribosomal protein S15 -0.0434147
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0433776
ADAR adenosine deaminase, RNA-specific -0.043276
SEPTIN7 septin 7 -0.0431623
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0425765
RPL35A ribosomal protein L35a -0.0422162
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0414457
IGF1R insulin-like growth factor 1 receptor -0.0412057
TM4SF1 transmembrane 4 L six family member 1 -0.0411125
IFI6 interferon, alpha-inducible protein 6 -0.0408175
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0405171
RPS27 ribosomal protein S27 -0.0400419
SET SET nuclear proto-oncogene -0.0395921
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0395443
CCND2 cyclin D2 -0.0393435
RIMS2 regulating synaptic membrane exocytosis 2 -0.0392203
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0390898
CTTN cortactin -0.0388833
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0386499
RPL9 ribosomal protein L9 -0.038511
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0382826
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0382144
GPHN gephyrin -0.038009
RPS24 ribosomal protein S24 -0.0377831
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0377413
PHIP pleckstrin homology domain interacting protein -0.0374956
MORF4L2 mortality factor 4 like 2 -0.0372023
RPL31 ribosomal protein L31 -0.0369743
RPL12 ribosomal protein L12 -0.0368398
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0366923
MT2A metallothionein 2A -0.0366273
IPO7 importin 7 -0.0362415
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0354003
RPLP2 ribosomal protein, large, P2 -0.0351464
CLTC clathrin, heavy chain (Hc) -0.0349455
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0348718
YAP1 Yes-associated protein 1 -0.0345383
ANKRD12 ankyrin repeat domain 12 -0.0337923
RPL5 ribosomal protein L5 -0.0336925
MED13L mediator complex subunit 13-like -0.0336661
RAB10 RAB10, member RAS oncogene family -0.0334545
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0328462
RRM2 ribonucleotide reductase M2 -0.0327589