Omeprazole (sodium)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.137349
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.128425
FN1 fibronectin 1 0.0878752
NAMPT nicotinamide phosphoribosyltransferase 0.0679042
ELL2 elongation factor, RNA polymerase II, 2 0.0650267
ASPH aspartate beta-hydroxylase 0.0502188
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0467543
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0456079
NDRG1 N-myc downstream regulated 1 0.0442226
BHLHE40 basic helix-loop-helix family, member e40 0.042014
RNF145 ring finger protein 145 0.0355324
MARCHF6 membrane associated ring-CH-type finger 6 0.0351399
FAM13A family with sequence similarity 13, member A 0.033752
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0335404
FNDC3B fibronectin type III domain containing 3B 0.031763
TSC22D2 TSC22 domain family, member 2 0.0310439
KDM3A lysine (K)-specific demethylase 3A 0.0291051
ZNF292 zinc finger protein 292 0.0290949
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0274415
USP3 ubiquitin specific peptidase 3 0.0270817
RAD21 RAD21 homolog (S. pombe) 0.0266155
UBA6 ubiquitin-like modifier activating enzyme 6 0.0259929
TFG TRK-fused gene 0.0256244
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0251914
QKI QKI, KH domain containing, RNA binding 0.0251336
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0249901
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0249747
PAPOLA poly(A) polymerase alpha 0.024614
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0244551
HSPA8 heat shock 70kDa protein 8 0.0241759
MSMO1 methylsterol monooxygenase 1 0.0240877
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0240022
FXR1 fragile X mental retardation, autosomal homolog 1 0.0239874
KMT2E lysine (K)-specific methyltransferase 2E 0.0239698
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.02387
CDC73 cell division cycle 73 0.0238028
CCNL1 cyclin L1 0.0236696
HMGB2 high mobility group box 2 0.0235207
NCKAP1 NCK-associated protein 1 0.023282
NUP58 nucleoporin 58 0.0230729
LAMC2 laminin, gamma 2 0.0230001
RLF rearranged L-myc fusion 0.0227344
RYBP RING1 and YY1 binding protein 0.0226353
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0222617
MATR3 matrin 3 0.0222067
SSBP2 single-stranded DNA binding protein 2 0.02197
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0215889
ANXA5 annexin A5 0.0211042
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0207836
ECT2 epithelial cell transforming 2 0.0206564
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0205348
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0197863
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0195314
SPAG9 sperm associated antigen 9 0.0188236
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0187474
APP amyloid beta (A4) precursor protein 0.0177943
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0175319
SUCO SUN domain containing ossification factor 0.0173206
GARS1 glycyl-tRNA synthetase 1 0.0172839
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0172151
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0170961
MYH9 myosin, heavy chain 9, non-muscle 0.0170632
CLINT1 clathrin interactor 1 0.0166967
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0164054
ERRFI1 ERBB receptor feedback inhibitor 1 0.0163806
ANLN anillin, actin binding protein 0.0163087
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0162103
ATP13A3 ATPase type 13A3 0.0161964
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0158209
EEF2 eukaryotic translation elongation factor 2 0.0156449
RAD23B RAD23 homolog B (S. cerevisiae) 0.0154244
TNIP1 TNFAIP3 interacting protein 1 0.0153682
MEF2A myocyte enhancer factor 2A 0.0149259
IFRD1 interferon-related developmental regulator 1 0.0148499
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0148294
TOP2B topoisomerase (DNA) II beta 180kDa 0.0148261
BZW1 basic leucine zipper and W2 domains 1 0.0147384
NPTN neuroplastin 0.0147096
ADAM9 ADAM metallopeptidase domain 9 0.0146793
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0146286
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0145422
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0145021
PEG10 paternally expressed 10 0.0144004
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0143304
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0142879
ANXA1 annexin A1 0.0142649
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0142328
RHEB Ras homolog enriched in brain 0.014226
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.014136
DSCAM Down syndrome cell adhesion molecule 0.0139686
CANX calnexin 0.013939
OSBPL9 oxysterol binding protein-like 9 0.0138012
TFRC transferrin receptor 0.0137137
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0136716
CKAP5 cytoskeleton associated protein 5 0.0135295
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0133511
CDK17 cyclin-dependent kinase 17 0.0132892
LRRC1 leucine rich repeat containing 1 0.0132618
TRA2B transformer 2 beta homolog (Drosophila) 0.0132174
IL6ST interleukin 6 signal transducer 0.0131232

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.18738
FTL ferritin, light polypeptide -0.164425
IFI27 interferon, alpha-inducible protein 27 -0.142504
POTEF POTE ankyrin domain family, member F -0.135804
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.135389
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.120707
PTMA prothymosin, alpha -0.088256
LPP LIM domain containing preferred translocation partner in lipoma -0.0873691
IFI6 interferon, alpha-inducible protein 6 -0.080341
FBXO32 F-box protein 32 -0.0789846
RPL35A ribosomal protein L35a -0.0733725
S100A6 S100 calcium binding protein A6 -0.0715513
KRT7 keratin 7, type II -0.0655702
SOX4 SRY (sex determining region Y)-box 4 -0.063846
ISG15 ISG15 ubiquitin-like modifier -0.0635629
CSTB cystatin B (stefin B) -0.0580493
EXT1 exostosin glycosyltransferase 1 -0.0575246
ACTG1 actin gamma 1 -0.057036
HLA-B major histocompatibility complex, class I, B -0.0562254
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0554605
IFITM3 interferon induced transmembrane protein 3 -0.0515436
HLA-A major histocompatibility complex, class I, A -0.0501228
MDK midkine (neurite growth-promoting factor 2) -0.048561
TPM4 tropomyosin 4 -0.0460945
TPT1 tumor protein, translationally-controlled 1 -0.0458811
RPLP1 ribosomal protein, large, P1 -0.0455117
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.045073
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0449899
LIMCH1 LIM and calponin homology domains 1 -0.0448851
IFI16 interferon, gamma-inducible protein 16 -0.0429102
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0425866
CCND1 cyclin D1 -0.0423727
HSPB1 heat shock 27kDa protein 1 -0.0420669
IFITM1 interferon induced transmembrane protein 1 -0.0417419
RPS19 ribosomal protein S19 -0.0417316
LY6E lymphocyte antigen 6 complex, locus E -0.040928
ERBIN erbb2 interacting protein -0.0399956
TMSB4X thymosin beta 4, X-linked -0.0398883
RPS13 ribosomal protein S13 -0.0394762
RPL8 ribosomal protein L8 -0.0394677
WSB1 WD repeat and SOCS box containing 1 -0.0393174
RPL23 ribosomal protein L23 -0.0388207
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0384753
EFNA5 ephrin-A5 -0.0383836
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0383675
RPS23 ribosomal protein S23 -0.0383118
RPL34 ribosomal protein L34 -0.0375112
RPLP2 ribosomal protein, large, P2 -0.0372927
TPI1 triosephosphate isomerase 1 -0.0369296
LMNA lamin A/C -0.0368717
MX2 MX dynamin-like GTPase 2 -0.0362686
MAP1B microtubule-associated protein 1B -0.0351211
TMEM165 transmembrane protein 165 -0.0349985
MACC1 metastasis associated in colon cancer 1 -0.0349064
IGFBP3 insulin-like growth factor binding protein 3 -0.0347068
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0341503
ENO2 enolase 2 (gamma, neuronal) -0.0339964
KRT19 keratin 19, type I -0.0338265
ENO1 enolase 1, (alpha) -0.0325245
F3 coagulation factor III (thromboplastin, tissue factor) -0.0321863
RPS21 ribosomal protein S21 -0.032038
S100A10 S100 calcium binding protein A10 -0.0320296
VIM vimentin -0.0318868
RNF213 ring finger protein 213 -0.0316767
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0314616
ZBTB20 zinc finger and BTB domain containing 20 -0.031434
EIF1 eukaryotic translation initiation factor 1 -0.0310551
RPS6 ribosomal protein S6 -0.0310409
UBE2H ubiquitin-conjugating enzyme E2H -0.0309063
RPS14 ribosomal protein S14 -0.0308725
UBC ubiquitin C -0.030704
RPL15 ribosomal protein L15 -0.0303522
ACBD3 acyl-CoA binding domain containing 3 -0.0298413
RPS29 ribosomal protein S29 -0.0298405
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0295377
PGBD5 piggyBac transposable element derived 5 -0.0293361
RPS8 ribosomal protein S8 -0.0291473
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0291141
FTH1 ferritin, heavy polypeptide 1 -0.0291135
RPL9 ribosomal protein L9 -0.0290342
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.028996
BASP1 brain abundant, membrane attached signal protein 1 -0.0289328
RPS24 ribosomal protein S24 -0.0287336
RPS25 ribosomal protein S25 -0.028657
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0285978
SAMD4A sterile alpha motif domain containing 4A -0.0281562
RPL19 ribosomal protein L19 -0.028062
ETV6 ets variant 6 -0.0274015
H3-3B H3.3 histone B -0.0272741
MAML2 mastermind-like 2 (Drosophila) -0.0270249
RPL37 ribosomal protein L37 -0.0269755
JUP junction plakoglobin -0.0269117
AKAP9 A kinase (PRKA) anchor protein 9 -0.0266831
MYO6 myosin VI -0.0266121
RAI14 retinoic acid induced 14 -0.0265573
KRT18 keratin 18, type I -0.0263122
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0262236
RPL32 ribosomal protein L32 -0.0260789
TM4SF1 transmembrane 4 L six family member 1 -0.0259475
KRT8 keratin 8, type II -0.0258502