Omeprazole (sodium)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GDA guanine deaminase 0.0935312
DST dystonin 0.0740381
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0672284
NPAS2 neuronal PAS domain protein 2 0.0566808
MYOF myoferlin 0.0523121
CTSC cathepsin C 0.0498773
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0477289
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.046775
EFNA5 ephrin-A5 0.044051
KYNU kynureninase 0.0434697
NRCAM neuronal cell adhesion molecule 0.0421769
SAMD4A sterile alpha motif domain containing 4A 0.0394195
PDLIM5 PDZ and LIM domain 5 0.036291
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0354211
IGFBP3 insulin-like growth factor binding protein 3 0.0352026
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0350714
CXCL8 chemokine (C-X-C motif) ligand 8 0.0319075
COL8A1 collagen, type VIII, alpha 1 0.031105
TFPI2 tissue factor pathway inhibitor 2 0.0306416
PCBP3 poly(rC) binding protein 3 0.0287478
ASPH aspartate beta-hydroxylase 0.0286938
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.028651
COL4A6 collagen, type IV, alpha 6 0.0277028
FNDC3B fibronectin type III domain containing 3B 0.0275528
MFF mitochondrial fission factor 0.0274169
MT2A metallothionein 2A 0.0268839
PM20D1 peptidase M20 domain containing 1 0.0259585
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0250433
NEK7 NIMA-related kinase 7 0.0209299
BCAR3 breast cancer anti-estrogen resistance 3 0.020747
CD109 CD109 molecule 0.0200599
LIMCH1 LIM and calponin homology domains 1 0.0198985
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0192134
STC2 stanniocalcin 2 0.0186792
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0184894
WWTR1 WW domain containing transcription regulator 1 0.0183092
ATXN1 ataxin 1 0.0175744
ZEB2 zinc finger E-box binding homeobox 2 0.0175123
NHSL1 NHS-like 1 0.0174242
VCL vinculin 0.017282
PTEN phosphatase and tensin homolog 0.0172277
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0166875
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0162964
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0161593
FLNB filamin B, beta 0.0159767
EPGN epithelial mitogen 0.0158978
COL4A5 collagen, type IV, alpha 5 0.0156303
TGFBI transforming growth factor, beta-induced, 68kDa 0.0154072
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0151576
VMP1 vacuole membrane protein 1 0.0150177
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.01501
TGFBR1 transforming growth factor, beta receptor 1 0.0147693
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0145546
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.014543
NFE2L2 nuclear factor, erythroid 2-like 2 0.0144154
NQO1 NAD(P)H dehydrogenase, quinone 1 0.014336
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0142825
NRG1 neuregulin 1 0.0142691
ARHGAP29 Rho GTPase activating protein 29 0.0141874
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.0135119
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0135064
NAMPT nicotinamide phosphoribosyltransferase 0.0132621
FTH1 ferritin, heavy polypeptide 1 0.0123759
GLIS3 GLIS family zinc finger 3 0.012357
MALT1 MALT1 paracaspase 0.0123549
IL1RAP interleukin 1 receptor accessory protein 0.0120706
RAB3B RAB3B, member RAS oncogene family 0.0120583
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0119331
ELL2 elongation factor, RNA polymerase II, 2 0.0118479
MB21D2 Mab-21 domain containing 2 0.0114002
DCLK2 doublecortin-like kinase 2 0.0113528
RTN1 reticulon 1 0.0112914
DNER delta/notch-like EGF repeat containing 0.0112398
ITPRID2 ITPR interacting domain containing 2 0.0111887
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0111227
MT1X metallothionein 1X 0.0109193
NCEH1 neutral cholesterol ester hydrolase 1 0.0108959
SDK1 sidekick cell adhesion molecule 1 0.010845
ANKRD28 ankyrin repeat domain 28 0.0108305
MKI67 marker of proliferation Ki-67 0.0106408
FBXL5 F-box and leucine-rich repeat protein 5 0.0105841
GPAT3 glycerol-3-phosphate acyltransferase 3 0.010357
MN1 meningioma (disrupted in balanced translocation) 1 0.0102985
AVL9 AVL9 homolog (S. cerevisiase) 0.0102719
ZNF292 zinc finger protein 292 0.0102505
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0101269
BDNF brain-derived neurotrophic factor 0.0100365
ARRDC3 arrestin domain containing 3 0.009886
COPA coatomer protein complex, subunit alpha 0.00982512
HSPA8 heat shock 70kDa protein 8 0.00977412
WDFY2 WD repeat and FYVE domain containing 2 0.0096886
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00960713
PID1 phosphotyrosine interaction domain containing 1 0.0095821
ENAH enabled homolog (Drosophila) 0.00952497
GLCCI1 glucocorticoid induced 1 0.00947589
ANKRD17 ankyrin repeat domain 17 0.00947301
GPC6 glypican 6 0.00946719
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0094365
ZC3H12C zinc finger CCCH-type containing 12C 0.00943009
ZBTB41 zinc finger and BTB domain containing 41 0.00939596

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.152707
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.145377
TPT1 tumor protein, translationally-controlled 1 -0.116701
PTMA prothymosin, alpha -0.103248
TMSB10 thymosin beta 10 -0.0951796
VIM vimentin -0.0862648
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0763226
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0745176
RPLP1 ribosomal protein, large, P1 -0.0737362
RPS6 ribosomal protein S6 -0.0688813
RPS24 ribosomal protein S24 -0.0662127
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0640301
FN1 fibronectin 1 -0.0608207
RPL37A ribosomal protein L37a -0.0589241
CDH13 cadherin 13 -0.0588933
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0581663
RPL26 ribosomal protein L26 -0.0570483
RPS8 ribosomal protein S8 -0.0543944
RPL35A ribosomal protein L35a -0.0513293
NAP1L1 nucleosome assembly protein 1-like 1 -0.0495502
RPL31 ribosomal protein L31 -0.0473699
RPS12 ribosomal protein S12 -0.046489
COL5A2 collagen, type V, alpha 2 -0.046171
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0457108
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0452418
RPS19 ribosomal protein S19 -0.0442909
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.043891
B2M beta-2-microglobulin -0.0437112
NALF1 NALCN channel auxiliary factor 1 -0.043699
RPL12 ribosomal protein L12 -0.0421263
WARS1 tryptophanyl-tRNA synthetase 1 -0.0421259
RPL19 ribosomal protein L19 -0.0415056
RPL34 ribosomal protein L34 -0.0414913
RPLP0 ribosomal protein, large, P0 -0.0397133
RPS21 ribosomal protein S21 -0.0392238
RPL23 ribosomal protein L23 -0.0391739
SPAG9 sperm associated antigen 9 -0.0390684
RPL9 ribosomal protein L9 -0.0380529
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0378892
RPS23 ribosomal protein S23 -0.036815
RPS27A ribosomal protein S27a -0.0368147
S100A6 S100 calcium binding protein A6 -0.0357415
TM4SF1 transmembrane 4 L six family member 1 -0.035506
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0349726
RPL36A ribosomal protein L36a -0.034776
RPS3 ribosomal protein S3 -0.0341791
SMYD3 SET and MYND domain containing 3 -0.0341695
RPS14 ribosomal protein S14 -0.0341007
RPL11 ribosomal protein L11 -0.0339142
HLA-B major histocompatibility complex, class I, B -0.033861
RPS25 ribosomal protein S25 -0.0338406
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0337206
RPL37 ribosomal protein L37 -0.0334105
RPL7A ribosomal protein L7a -0.0325245
S100A10 S100 calcium binding protein A10 -0.0312997
RPLP2 ribosomal protein, large, P2 -0.0311171
PTPRM protein tyrosine phosphatase, receptor type, M -0.0305608
RPS16 ribosomal protein S16 -0.0304794
RPS29 ribosomal protein S29 -0.0298388
CANX calnexin -0.0297977
KIAA0825 KIAA0825 -0.0294702
EIF1 eukaryotic translation initiation factor 1 -0.029375
IFIH1 interferon induced with helicase C domain 1 -0.029217
RPS13 ribosomal protein S13 -0.0288402
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0287431
RPL38 ribosomal protein L38 -0.0282706
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0282218
LMNA lamin A/C -0.0277924
ACTG1 actin gamma 1 -0.0274488
GNAS GNAS complex locus -0.0266864
RPL36 ribosomal protein L36 -0.026327
RPS4X ribosomal protein S4, X-linked -0.0262924
RPS27 ribosomal protein S27 -0.0261005
FTL ferritin, light polypeptide -0.0258836
LSAMP limbic system-associated membrane protein -0.0255245
PSD3 pleckstrin and Sec7 domain containing 3 -0.0254663
KPNB1 karyopherin (importin) beta 1 -0.0254109
OASL 2'-5'-oligoadenylate synthetase-like -0.0253931
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0249374
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0249055
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0248193
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0244373
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0241216
WSB1 WD repeat and SOCS box containing 1 -0.0240949
RPL32 ribosomal protein L32 -0.0239435
HLA-A major histocompatibility complex, class I, A -0.0239382
RPS17 ribosomal protein S17 -0.0238201
ENO1 enolase 1, (alpha) -0.023764
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0233949
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0233028
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0229267
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0228905
YBX3 Y box binding protein 3 -0.0224335
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0223362
RPL5 ribosomal protein L5 -0.0222858
RPL35 ribosomal protein L35 -0.022184
RPL13A ribosomal protein L13a -0.0219759
NT5C2 5'-nucleotidase, cytosolic II -0.0216307
ANXA2 annexin A2 -0.0215852
RPS11 ribosomal protein S11 -0.0211587