Omeprazole (sodium)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.0986775
NDRG1 N-myc downstream regulated 1 0.0952376
POTEF POTE ankyrin domain family, member F 0.0611782
VEGFA vascular endothelial growth factor A 0.0599892
C3 complement component 3 0.0537008
G0S2 G0/G1 switch 2 0.0530651
FOSL1 FOS-like antigen 1 0.051076
CCNL1 cyclin L1 0.0500043
MEF2A myocyte enhancer factor 2A 0.0495838
TXNIP thioredoxin interacting protein 0.0490317
FTH1 ferritin, heavy polypeptide 1 0.0444068
HMGA1 high mobility group AT-hook 1 0.0430145
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0429556
MUC16 mucin 16, cell surface associated 0.0428751
TMF1 TATA element modulatory factor 1 0.041984
FNDC3B fibronectin type III domain containing 3B 0.0414938
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0414872
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0400861
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0387458
HLA-A major histocompatibility complex, class I, A 0.0385195
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0380495
CLDN4 claudin 4 0.03803
PCDH1 protocadherin 1 0.0367924
ZFP36L1 ZFP36 ring finger protein-like 1 0.0355242
KMT2E lysine (K)-specific methyltransferase 2E 0.0353393
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0338393
GOLGA4 golgin A4 0.0337806
PDIA3 protein disulfide isomerase family A, member 3 0.0334856
RICTOR RPTOR independent companion of MTOR, complex 2 0.0334082
EZR ezrin 0.031858
FAM3C family with sequence similarity 3, member C 0.0315119
APLP2 amyloid beta (A4) precursor-like protein 2 0.0295993
TGM2 transglutaminase 2 0.0295559
PCBP2 poly(rC) binding protein 2 0.0288152
KTN1 kinectin 1 (kinesin receptor) 0.0271106
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0269607
UBA6 ubiquitin-like modifier activating enzyme 6 0.0264001
SACK1A scaffolding CK1 anchoring protein A 0.0251817
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0248863
FMNL2 formin-like 2 0.0248604
MYO6 myosin VI 0.0246603
ADAM9 ADAM metallopeptidase domain 9 0.0243316
ITCH itchy E3 ubiquitin protein ligase 0.0242847
PGK1 phosphoglycerate kinase 1 0.0241061
F3 coagulation factor III (thromboplastin, tissue factor) 0.0232523
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.023216
NCEH1 neutral cholesterol ester hydrolase 1 0.0230978
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0229822
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0229789
JUP junction plakoglobin 0.022921
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0228672
BRD4 bromodomain containing 4 0.0225494
ARRDC3 arrestin domain containing 3 0.0225223
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0224759
UGCG UDP-glucose ceramide glucosyltransferase 0.0224354
YTHDC1 YTH domain containing 1 0.022408
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0222153
ESYT2 extended synaptotagmin-like protein 2 0.0213714
FAM13A family with sequence similarity 13, member A 0.0211703
FLNB filamin B, beta 0.0211661
ENO2 enolase 2 (gamma, neuronal) 0.0210319
AXL AXL receptor tyrosine kinase 0.0210262
CDCP1 CUB domain containing protein 1 0.0209342
USP9X ubiquitin specific peptidase 9, X-linked 0.0207941
MACF1 microtubule-actin crosslinking factor 1 0.0207388
AKAP9 A kinase (PRKA) anchor protein 9 0.0206681
MSN moesin 0.0205717
INSIG2 insulin induced gene 2 0.0205402
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0204885
SLK STE20-like kinase 0.02036
UBE2H ubiquitin-conjugating enzyme E2H 0.0203321
SMAP1 small ArfGAP 1 0.0202823
EPS8 epidermal growth factor receptor pathway substrate 8 0.0202159
GRB10 growth factor receptor-bound protein 10 0.0200779
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0200538
NAV2 neuron navigator 2 0.0199644
HPS3 Hermansky-Pudlak syndrome 3 0.0197725
YEATS2 YEATS domain containing 2 0.0197661
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0197632
YAP1 Yes-associated protein 1 0.0195926
CD44 CD44 molecule (Indian blood group) 0.0195773
PICALM phosphatidylinositol binding clathrin assembly protein 0.0190559
ZNF292 zinc finger protein 292 0.0189853
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0189614
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 0.0186301
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0185991
BCL2L1 BCL2-like 1 0.018572
LDHA lactate dehydrogenase A 0.018384
PPARD peroxisome proliferator-activated receptor delta 0.0181863
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0180898
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.017942
KMT2A lysine (K)-specific methyltransferase 2A 0.017919
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0178624
FRMD6 FERM domain containing 6 0.0178535
HDGF hepatoma-derived growth factor 0.0177302
LONP1 lon peptidase 1, mitochondrial 0.0176713
ANO6 anoctamin 6 0.0176017
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0174734
CBX3 chromobox homolog 3 0.0174645
RPL21 ribosomal protein L21 0.0172957

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.191015
PTMA prothymosin, alpha -0.108393
AHNAK AHNAK nucleoprotein -0.100439
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.096386
ANXA2 annexin A2 -0.0908315
LAMB3 laminin, beta 3 -0.0895381
TMSB10 thymosin beta 10 -0.0848881
TMSB4X thymosin beta 4, X-linked -0.0824997
KRT17 keratin 17, type I -0.0711584
RPS24 ribosomal protein S24 -0.0612142
RPLP1 ribosomal protein, large, P1 -0.0571399
CANX calnexin -0.0570194
RPL23 ribosomal protein L23 -0.0565823
RAD21 RAD21 homolog (S. pombe) -0.0560576
EMP1 epithelial membrane protein 1 -0.0545592
RPL35A ribosomal protein L35a -0.0540078
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0523284
RPS21 ribosomal protein S21 -0.0499686
KDM3A lysine (K)-specific demethylase 3A -0.0488086
RPL34 ribosomal protein L34 -0.0460535
HLA-C major histocompatibility complex, class I, C -0.0457995
EFNA5 ephrin-A5 -0.0454258
TM4SF1 transmembrane 4 L six family member 1 -0.0454192
HLA-B major histocompatibility complex, class I, B -0.0426384
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0423487
KRT18 keratin 18, type I -0.0405781
PLSCR1 phospholipid scramblase 1 -0.0399738
RPL19 ribosomal protein L19 -0.039449
SVIL supervillin -0.0390184
PATJ PATJ crumbs cell polarity complex component -0.0383817
INTS6 integrator complex subunit 6 -0.0377805
RPS3 ribosomal protein S3 -0.0377794
ETV6 ets variant 6 -0.0365036
ACTG1 actin gamma 1 -0.0361335
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0356263
RPL12 ribosomal protein L12 -0.034887
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.034867
EIF1 eukaryotic translation initiation factor 1 -0.0342577
SMYD3 SET and MYND domain containing 3 -0.0340314
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0337125
ZBTB20 zinc finger and BTB domain containing 20 -0.0334667
HLA-E major histocompatibility complex, class I, E -0.0329017
ANKRD10 ankyrin repeat domain 10 -0.0326657
OSBPL3 oxysterol binding protein-like 3 -0.0325403
HDLBP high density lipoprotein binding protein -0.0324877
RPS15 ribosomal protein S15 -0.0318791
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0316866
S100A10 S100 calcium binding protein A10 -0.0313899
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0313739
USP34 ubiquitin specific peptidase 34 -0.0310176
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0305579
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.030556
SENP5 SUMO1/sentrin specific peptidase 5 -0.0304349
NF1 neurofibromin 1 -0.030324
RPS25 ribosomal protein S25 -0.030097
GNAS GNAS complex locus -0.0300937
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0293427
KPNB1 karyopherin (importin) beta 1 -0.0292282
YBX3 Y box binding protein 3 -0.029108
KRT7 keratin 7, type II -0.028919
DIAPH3 diaphanous-related formin 3 -0.0286099
RPL38 ribosomal protein L38 -0.0280349
RPS8 ribosomal protein S8 -0.0278802
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0278008
TAS2R14 taste receptor, type 2, member 14 -0.027666
SLC38A1 solute carrier family 38, member 1 -0.0275753
GOLGB1 golgin B1 -0.0274786
ACTN4 actinin, alpha 4 -0.0274103
H1-0 H1.0 linker histone -0.0273033
MORF4L2 mortality factor 4 like 2 -0.0272284
RACK1 receptor for activated C kinase 1 -0.0271809
CELF1 CUGBP, Elav-like family member 1 -0.0271787
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0271555
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0270951
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0269192
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0268132
RPS20 ribosomal protein S20 -0.0267233
VCL vinculin -0.0263616
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0262733
DPYD dihydropyrimidine dehydrogenase -0.0261921
NSD3 nuclear receptor binding SET domain protein 3 -0.0261765
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0261143
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0260193
RSRC1 arginine/serine-rich coiled-coil 1 -0.0259735
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0257106
FRMD5 FERM domain containing 5 -0.0256274
RPL37 ribosomal protein L37 -0.0254679
EPCAM epithelial cell adhesion molecule -0.025237
BTBD9 BTB (POZ) domain containing 9 -0.0251322
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0249461
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0248718
KLF5 Kruppel-like factor 5 (intestinal) -0.0246754
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0245948
XRN1 5'-3' exoribonuclease 1 -0.0245221
RPS19 ribosomal protein S19 -0.0244076
NCOA7 nuclear receptor coactivator 7 -0.0243988
RPS4X ribosomal protein S4, X-linked -0.024224
RPS29 ribosomal protein S29 -0.0241415
CAV1 caveolin 1, caveolae protein, 22kDa -0.0241119
LAMA4 laminin, alpha 4 -0.0239395