Omeprazole (sodium)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0802988
MT2A metallothionein 2A 0.0678832
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0640648
NDRG1 N-myc downstream regulated 1 0.0638701
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0519075
STC1 stanniocalcin 1 0.0477067
CALCA calcitonin-related polypeptide alpha 0.0436525
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0384934
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.036688
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0357038
DOCK5 dedicator of cytokinesis 5 0.0335377
ENO1 enolase 1, (alpha) 0.0331119
MCL1 myeloid cell leukemia 1 0.0311372
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0306164
TENM1 teneurin transmembrane protein 1 0.028031
RORA RAR-related orphan receptor A 0.027383
DGKD diacylglycerol kinase, delta 130kDa 0.02609
POTEF POTE ankyrin domain family, member F 0.0252896
CNTNAP2 contactin associated protein-like 2 0.0245284
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0235017
VEGFA vascular endothelial growth factor A 0.0220898
PEG10 paternally expressed 10 0.0216439
FAT1 FAT atypical cadherin 1 0.0212283
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0199792
MCTP1 multiple C2 domains, transmembrane 1 0.019911
LSAMP limbic system-associated membrane protein 0.0188568
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0182965
ELL2 elongation factor, RNA polymerase II, 2 0.0174055
IGFBP5 insulin-like growth factor binding protein 5 0.017361
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0171249
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.016251
ISG15 ISG15 ubiquitin-like modifier 0.0162328
CHGB chromogranin B 0.0157534
B2M beta-2-microglobulin 0.015732
AHR aryl hydrocarbon receptor 0.0156558
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0155358
MSN moesin 0.0154498
PCBP2 poly(rC) binding protein 2 0.0153183
PAEP progestagen-associated endometrial protein 0.0152086
BACE2 beta-site APP-cleaving enzyme 2 0.0150988
FTL ferritin, light polypeptide 0.0150441
FAM13A family with sequence similarity 13, member A 0.0144164
SRSF11 serine/arginine-rich splicing factor 11 0.0138644
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0137654
ESRRG estrogen-related receptor gamma 0.0137609
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0136497
PFN1 profilin 1 0.0133575
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0132823
MAP1B microtubule-associated protein 1B 0.0131762
NAV1 neuron navigator 1 0.013148
MT1X metallothionein 1X 0.0130333
TFF3 trefoil factor 3 (intestinal) 0.013017
TMEM255B transmembrane protein 255B 0.0129809
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0129317
EGFR epidermal growth factor receptor 0.0128408
TXNIP thioredoxin interacting protein 0.0128367
ABHD2 abhydrolase domain containing 2 0.0126916
ASCL1 achaete-scute family bHLH transcription factor 1 0.0126013
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0124146
FKBP9 FK506 binding protein 9, 63 kDa 0.0124067
PFKP phosphofructokinase, platelet 0.0123822
RPL3 ribosomal protein L3 0.0122856
SRRM2 serine/arginine repetitive matrix 2 0.0122576
HLA-A major histocompatibility complex, class I, A 0.0121984
RNPS1 RNA binding protein S1, serine-rich domain 0.0121518
COX5A cytochrome c oxidase subunit Va 0.0121279
MBNL2 muscleblind-like splicing regulator 2 0.0121128
NELL1 NEL-like 1 (chicken) 0.0120966
SNX14 sorting nexin 14 0.0119733
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 0.0119262
CBX5 chromobox homolog 5 0.0119078
CPE carboxypeptidase E 0.0119029
PNISR PNN-interacting serine/arginine-rich protein 0.0117349
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0116938
PRPF8 pre-mRNA processing factor 8 0.0116724
RPL36 ribosomal protein L36 0.0116475
RPS19 ribosomal protein S19 0.0115438
MRPS6 mitochondrial ribosomal protein S6 0.0113737
PRELID2 PRELI domain containing 2 0.0112844
DST dystonin 0.011242
NIPSNAP2 nipsnap homolog 2 0.0111537
RTN4 reticulon 4 0.0110284
ITGAV integrin, alpha V 0.010964
IRS2 insulin receptor substrate 2 0.0109246
CEMIP cell migration inducing protein, hyaluronan binding 0.0108962
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 0.0108643
HMGB3 high mobility group box 3 0.0108093
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 0.0107968
SSRP1 structure specific recognition protein 1 0.0107925
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.010758
KLHL29 kelch-like family member 29 0.0107193
TSPAN9 tetraspanin 9 0.0105937
EPHA3 EPH receptor A3 0.0105813
ZNF292 zinc finger protein 292 0.010527
FRY furry homolog (Drosophila) 0.0104898
NGLY1 N-glycanase 1 0.0104422
RPL21 ribosomal protein L21 0.0104306
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0103946
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0103878
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0103859

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0872406
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0733958
NALF1 NALCN channel auxiliary factor 1 -0.0715862
SNAP25 synaptosomal-associated protein, 25kDa -0.0659662
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0515342
RIMS2 regulating synaptic membrane exocytosis 2 -0.0445946
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0427152
RAD21 RAD21 homolog (S. pombe) -0.0406225
CNKSR3 CNKSR family member 3 -0.0400957
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0371497
SMYD3 SET and MYND domain containing 3 -0.0368528
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0368286
TRIO trio Rho guanine nucleotide exchange factor -0.0355063
PDE10A phosphodiesterase 10A -0.0344564
SYT1 synaptotagmin I -0.0343696
PDE4B phosphodiesterase 4B, cAMP-specific -0.0333419
TXNRD1 thioredoxin reductase 1 -0.0328817
ZNF804A zinc finger protein 804A -0.0328603
NIPBL Nipped-B homolog (Drosophila) -0.0324873
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0321491
PTMA prothymosin, alpha -0.0311701
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0311686
NBEA neurobeachin -0.0306036
GDAP1 ganglioside induced differentiation associated protein 1 -0.0301298
NFIA nuclear factor I/A -0.0294714
TRA2A transformer 2 alpha homolog (Drosophila) -0.0292605
AOPEP aminopeptidase O (putative) -0.0290347
NAP1L1 nucleosome assembly protein 1-like 1 -0.0286395
FUS FUS RNA binding protein -0.0283741
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0282134
TOX thymocyte selection-associated high mobility group box -0.0281988
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -0.0279671
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0277085
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0274726
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0270346
IGF1R insulin-like growth factor 1 receptor -0.0269302
ZFAND3 zinc finger, AN1-type domain 3 -0.0260525
GPC6 glypican 6 -0.0247074
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0245372
SCFD2 sec1 family domain containing 2 -0.0240014
PCSK2 proprotein convertase subtilisin/kexin type 2 -0.0238421
SQSTM1 sequestosome 1 -0.0237099
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.0235997
STXBP5 syntaxin binding protein 5 (tomosyn) -0.023474
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0230517
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0230366
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0230314
STRBP spermatid perinuclear RNA binding protein -0.0226727
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0225276
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0223069
ADGRL2 adhesion G protein-coupled receptor L2 -0.0222445
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0219808
CANX calnexin -0.0218892
TENT5A terminal nucleotidyltransferase 5A -0.0217297
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0216849
HMGB2 high mobility group box 2 -0.0214089
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0211614
ZEB1 zinc finger E-box binding homeobox 1 -0.0209953
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0209478
GARS1 glycyl-tRNA synthetase 1 -0.0208226
ANKRD17 ankyrin repeat domain 17 -0.0207367
EXT1 exostosin glycosyltransferase 1 -0.0206637
TCF12 transcription factor 12 -0.0205894
YBX1 Y box binding protein 1 -0.0203333
FNDC3A fibronectin type III domain containing 3A -0.0201941
MIS18BP1 MIS18 binding protein 1 -0.0198404
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0197311
RAB7A RAB7A, member RAS oncogene family -0.0196886
RAB2A RAB2A, member RAS oncogene family -0.0195996
JAZF1 JAZF zinc finger 1 -0.0195489
CADM1 cell adhesion molecule 1 -0.0195069
TPR translocated promoter region, nuclear basket protein -0.0192856
TMSB4X thymosin beta 4, X-linked -0.019245
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0191861
TPT1 tumor protein, translationally-controlled 1 -0.0191522
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0188211
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0185774
NOVA1 neuro-oncological ventral antigen 1 -0.0185422
BIRC6 baculoviral IAP repeat containing 6 -0.0183941
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0183793
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0183636
ABI2 abl-interactor 2 -0.0183481
WSB1 WD repeat and SOCS box containing 1 -0.0183218
JAM3 junctional adhesion molecule 3 -0.0182576
FGF14 fibroblast growth factor 14 -0.0180451
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0180398
IARS1 isoleucyl-tRNA synthetase 1 -0.0180237
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0179797
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0177307
MSI2 musashi RNA-binding protein 2 -0.0176302
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0173726
HMGB1 high mobility group box 1 -0.0173538
RPL6 ribosomal protein L6 -0.01732
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.017303
RPL26 ribosomal protein L26 -0.0172168
ZMAT4 zinc finger, matrin-type 4 -0.0171932
H1-0 H1.0 linker histone -0.017191
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0171035
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0170766
GLIS3 GLIS family zinc finger 3 -0.0170436