Omeprazole (sodium)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0597945
FMN1 formin 1 0.0559415
FN1 fibronectin 1 0.0407086
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0393588
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0383288
SREBF2 sterol regulatory element binding transcription factor 2 0.0359617
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0357107
FNDC3B fibronectin type III domain containing 3B 0.0335805
KAZN kazrin, periplakin interacting protein 0.0273941
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0268346
LINGO2 leucine rich repeat and Ig domain containing 2 0.0265333
COPA coatomer protein complex, subunit alpha 0.0246808
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.024468
DST dystonin 0.0234795
CAMTA1 calmodulin binding transcription activator 1 0.0231448
TXNRD1 thioredoxin reductase 1 0.0230778
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0204703
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0197145
SPAG9 sperm associated antigen 9 0.0194277
ABI1 abl-interactor 1 0.019189
GOLGB1 golgin B1 0.0191661
NBAS neuroblastoma amplified sequence 0.0182443
MSN moesin 0.0181428
GOLGA4 golgin A4 0.0180789
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0178122
VCL vinculin 0.0174391
FRMD4A FERM domain containing 4A 0.0174023
GDAP2 ganglioside induced differentiation associated protein 2 0.017273
ADAM17 ADAM metallopeptidase domain 17 0.0169694
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.0168937
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0168571
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0168429
ZFYVE16 zinc finger, FYVE domain containing 16 0.0166983
VMP1 vacuole membrane protein 1 0.016619
TFG TRK-fused gene 0.0164459
PEA15 phosphoprotein enriched in astrocytes 15 0.0160969
NCKAP1 NCK-associated protein 1 0.0159638
IL1RAP interleukin 1 receptor accessory protein 0.0159183
ZNF654 zinc finger protein 654 0.0158175
YEATS2 YEATS domain containing 2 0.0156204
RB1CC1 RB1-inducible coiled-coil 1 0.0153444
LAMP2 lysosomal-associated membrane protein 2 0.0152378
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.01502
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0149096
NGLY1 N-glycanase 1 0.0148781
PRELID2 PRELI domain containing 2 0.0147619
CLTC clathrin, heavy chain (Hc) 0.0146457
NFE2L1 nuclear factor, erythroid 2-like 1 0.0145748
EPS8 epidermal growth factor receptor pathway substrate 8 0.0144822
EP300 E1A binding protein p300 0.0144537
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0141111
SRRM2 serine/arginine repetitive matrix 2 0.0140296
FER fer (fps/fes related) tyrosine kinase 0.0140288
CEP70 centrosomal protein 70kDa 0.0140143
PEX5L peroxisomal biogenesis factor 5-like 0.0138624
HIPK3 homeodomain interacting protein kinase 3 0.0138253
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0137388
TRIQK triple QxxK/R motif containing 0.0135959
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0134691
CLIC4 chloride intracellular channel 4 0.0134535
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.0133148
ELL2 elongation factor, RNA polymerase II, 2 0.0132848
USP32 ubiquitin specific peptidase 32 0.0132485
THOC2 THO complex 2 0.0131329
LTN1 listerin E3 ubiquitin protein ligase 1 0.0129844
MON2 MON2 homolog (S. cerevisiae) 0.0127728
GAN gigaxonin 0.0127143
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.012656
MARCHF1 membrane associated ring-CH-type finger 1 0.0126257
SFTPA2 surfactant protein A2 0.0126006
TTC17 tetratricopeptide repeat domain 17 0.0125348
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0125297
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0125137
FNIP1 folliculin interacting protein 1 0.0122577
TMEM39A transmembrane protein 39A 0.0121958
MYH9 myosin, heavy chain 9, non-muscle 0.0120947
PCLO piccolo presynaptic cytomatrix protein 0.0118282
FHIT fragile histidine triad 0.011787
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.0117439
PTPRM protein tyrosine phosphatase, receptor type, M 0.0117244
PMM2 phosphomannomutase 2 0.0116895
DENND4A DENN/MADD domain containing 4A 0.0116552
UBE2H ubiquitin-conjugating enzyme E2H 0.0115938
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0115733
CEP95 centrosomal protein 95kDa 0.011554
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0115261
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0114094
AHCTF1 AT hook containing transcription factor 1 0.0114067
IL6ST interleukin 6 signal transducer 0.0113944
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0113904
AFF4 AF4/FMR2 family, member 4 0.0113563
NF1 neurofibromin 1 0.0112841
ZNF697 zinc finger protein 697 0.0112103
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0110323
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0110177
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0110069
ETNK1 ethanolamine kinase 1 0.0107381
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0107347
RASAL2 RAS protein activator like 2 0.0107231
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough 0.0107136

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.1643
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0981819
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.088366
MT2A metallothionein 2A -0.0817842
NLGN1 neuroligin 1 -0.0730066
RPS6 ribosomal protein S6 -0.0576621
TMSB10 thymosin beta 10 -0.0523835
RPLP1 ribosomal protein, large, P1 -0.0515873
PTMA prothymosin, alpha -0.0484564
RPS3 ribosomal protein S3 -0.0474769
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0464337
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0446875
CCND1 cyclin D1 -0.0438456
RPL23 ribosomal protein L23 -0.0432197
FTL ferritin, light polypeptide -0.0391387
PKM pyruvate kinase, muscle -0.0380323
NAP1L1 nucleosome assembly protein 1-like 1 -0.0368925
CENPF centromere protein F, 350/400kDa -0.0359888
ENO1 enolase 1, (alpha) -0.0355596
B2M beta-2-microglobulin -0.0352821
RPS8 ribosomal protein S8 -0.0349616
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0332105
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0324117
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0323641
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0323183
RPL34 ribosomal protein L34 -0.0321011
RPL35A ribosomal protein L35a -0.0315404
RPLP2 ribosomal protein, large, P2 -0.0282241
RPL31 ribosomal protein L31 -0.0278927
LITAF lipopolysaccharide-induced TNF factor -0.0278359
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0276824
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0276263
LMNA lamin A/C -0.0272549
IGF1R insulin-like growth factor 1 receptor -0.0269814
TPT1 tumor protein, translationally-controlled 1 -0.0268239
RACK1 receptor for activated C kinase 1 -0.0263886
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0262645
RPL32 ribosomal protein L32 -0.0261357
RPS23 ribosomal protein S23 -0.0259479
NDRG1 N-myc downstream regulated 1 -0.0255231
RPL36 ribosomal protein L36 -0.024993
SEPTIN7 septin 7 -0.0248905
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0245227
RPS19 ribosomal protein S19 -0.0236069
KPNB1 karyopherin (importin) beta 1 -0.0235867
SMC4 structural maintenance of chromosomes 4 -0.0235618
RPS29 ribosomal protein S29 -0.0234656
SQSTM1 sequestosome 1 -0.0234022
KTN1 kinectin 1 (kinesin receptor) -0.0233231
RPL37A ribosomal protein L37a -0.0227512
IFI6 interferon, alpha-inducible protein 6 -0.0224609
LOC112694756 uncharaterized LOC112694756 -0.0224502
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0223937
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0222317
NRG3 neuregulin 3 -0.022124
RPS21 ribosomal protein S21 -0.0220957
RPL19 ribosomal protein L19 -0.021287
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0210766
RPS20 ribosomal protein S20 -0.0209814
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0209413
RPS24 ribosomal protein S24 -0.0208645
RPL5 ribosomal protein L5 -0.0205831
CDK6 cyclin-dependent kinase 6 -0.0198757
RPL36A ribosomal protein L36a -0.0198073
RPL38 ribosomal protein L38 -0.0195397
CANX calnexin -0.0195029
EIF1 eukaryotic translation initiation factor 1 -0.019099
RPS4X ribosomal protein S4, X-linked -0.0190311
RPS13 ribosomal protein S13 -0.0190193
ANXA2 annexin A2 -0.0189667
IFI44L interferon-induced protein 44-like -0.0188343
RPL11 ribosomal protein L11 -0.018826
RNF213 ring finger protein 213 -0.0188028
SP100 SP100 nuclear antigen -0.018512
HLA-B major histocompatibility complex, class I, B -0.0184919
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.018341
MAML3 mastermind-like 3 (Drosophila) -0.0177426
RUNX1 runt-related transcription factor 1 -0.0176651
S100A9 S100 calcium binding protein A9 -0.017531
RPS16 ribosomal protein S16 -0.0173695
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0172717
RPL30 ribosomal protein L30 -0.0172303
NAV2 neuron navigator 2 -0.0171467
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0170297
RPL27 ribosomal protein L27 -0.0170158
NAMPT nicotinamide phosphoribosyltransferase -0.0168307
PRRC2C proline-rich coiled-coil 2C -0.0166912
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0166689
CBX3 chromobox homolog 3 -0.0165879
VDAC1 voltage-dependent anion channel 1 -0.016569
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0163984
RPL37 ribosomal protein L37 -0.0163632
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0162995
DSTN destrin (actin depolymerizing factor) -0.0161782
RPS14 ribosomal protein S14 -0.0160306
S100A6 S100 calcium binding protein A6 -0.0158112
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0156619
RPS27A ribosomal protein S27a -0.015645
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0156313
RPS12 ribosomal protein S12 -0.0155682