Omeprazole (sodium)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.291209
SOD2 superoxide dismutase 2, mitochondrial 0.264375
NAMPT nicotinamide phosphoribosyltransferase 0.174269
VCAN versican 0.142649
AKAP12 A kinase (PRKA) anchor protein 12 0.14238
PGK1 phosphoglycerate kinase 1 0.131694
CD44 CD44 molecule (Indian blood group) 0.115844
DST dystonin 0.101707
VIM vimentin 0.0993335
COL6A3 collagen, type VI, alpha 3 0.0971263
IGFBP3 insulin-like growth factor binding protein 3 0.0936142
FTH1 ferritin, heavy polypeptide 1 0.0873958
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.086786
FRMD4A FERM domain containing 4A 0.0865718
ELL2 elongation factor, RNA polymerase II, 2 0.0862243
SFTPA2 surfactant protein A2 0.0839997
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0801837
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0754132
GLIS3 GLIS family zinc finger 3 0.0730578
STC1 stanniocalcin 1 0.0728371
MYH9 myosin, heavy chain 9, non-muscle 0.0700578
VCL vinculin 0.0680402
KYNU kynureninase 0.0673471
ADM adrenomedullin 0.0664348
LDHA lactate dehydrogenase A 0.0656588
FNDC3B fibronectin type III domain containing 3B 0.0655914
UGCG UDP-glucose ceramide glucosyltransferase 0.0623563
HLA-E major histocompatibility complex, class I, E 0.0622889
ZMYND8 zinc finger, MYND-type containing 8 0.0611968
RAI14 retinoic acid induced 14 0.0601724
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0593392
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0582672
CADM1 cell adhesion molecule 1 0.0582661
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0562125
ZNF292 zinc finger protein 292 0.0560132
LAMP2 lysosomal-associated membrane protein 2 0.0543371
NAV2 neuron navigator 2 0.0537274
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0512569
ATP13A3 ATPase type 13A3 0.0503878
SMAD3 SMAD family member 3 0.0494185
LOX lysyl oxidase 0.0494176
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0492474
CTSB cathepsin B 0.0484344
MMP12 matrix metallopeptidase 12 0.0483678
ZBTB38 zinc finger and BTB domain containing 38 0.0477006
EXT1 exostosin glycosyltransferase 1 0.0470917
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.046662
MACF1 microtubule-actin crosslinking factor 1 0.0460538
VEGFA vascular endothelial growth factor A 0.0452873
RND3 Rho family GTPase 3 0.0447576
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0446819
LPP LIM domain containing preferred translocation partner in lipoma 0.0445723
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0437661
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0427188
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0417966
WTAP Wilms tumor 1 associated protein 0.0413217
CUL4B cullin 4B 0.0412446
THBS1 thrombospondin 1 0.0410928
TPM4 tropomyosin 4 0.040584
FLNB filamin B, beta 0.0401327
PHF21A PHD finger protein 21A 0.0401027
COL8A1 collagen, type VIII, alpha 1 0.0398997
HDAC9 histone deacetylase 9 0.0396759
BASP1 brain abundant, membrane attached signal protein 1 0.0395297
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0395241
APP amyloid beta (A4) precursor protein 0.0394163
LOXL2 lysyl oxidase-like 2 0.039407
USP9X ubiquitin specific peptidase 9, X-linked 0.039264
C3 complement component 3 0.0387291
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0387158
MSN moesin 0.038091
WDFY1 WD repeat and FYVE domain containing 1 0.0379392
MXI1 MAX interactor 1, dimerization protein 0.0375926
EEF2 eukaryotic translation elongation factor 2 0.0372568
SFRP1 secreted frizzled-related protein 1 0.0363393
CDCP1 CUB domain containing protein 1 0.0362341
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0361979
INHBA inhibin, beta A 0.0357515
TMSB4X thymosin beta 4, X-linked 0.0356413
ZFP36L1 ZFP36 ring finger protein-like 1 0.0353393
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0353291
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0350258
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0347719
UBC ubiquitin C 0.034555
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0344586
IRAK2 interleukin-1 receptor-associated kinase 2 0.0341918
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0341507
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.033972
RBMS3 RNA binding motif, single stranded interacting protein 3 0.033344
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0328942
PLIN2 perilipin 2 0.0326123
MKI67 marker of proliferation Ki-67 0.0325234
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0323163
TNIP1 TNFAIP3 interacting protein 1 0.0321995
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0316382
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0311768
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0309656
HMGA2 high mobility group AT-hook 2 0.0308089
PDE10A phosphodiesterase 10A 0.030761
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0306331

decreased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0957238
MT2A metallothionein 2A -0.0793877
RPS6 ribosomal protein S6 -0.0683576
TMSB10 thymosin beta 10 -0.0615746
RPS19 ribosomal protein S19 -0.0495886
RPL23 ribosomal protein L23 -0.0472588
RPLP1 ribosomal protein, large, P1 -0.0464714
FTL ferritin, light polypeptide -0.0464693
MARCKS myristoylated alanine-rich protein kinase C substrate -0.045377
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0418506
RPS23 ribosomal protein S23 -0.04181
RPL9 ribosomal protein L9 -0.0359756
RPL35A ribosomal protein L35a -0.034932
RPLP2 ribosomal protein, large, P2 -0.034176
RPS8 ribosomal protein S8 -0.0340016
RPL37A ribosomal protein L37a -0.033549
RPS12 ribosomal protein S12 -0.0331627
RPS4X ribosomal protein S4, X-linked -0.0327572
RPL19 ribosomal protein L19 -0.0321712
PCBP2 poly(rC) binding protein 2 -0.0316788
RPL11 ribosomal protein L11 -0.0297508
RPL36 ribosomal protein L36 -0.0287255
RPL35 ribosomal protein L35 -0.0282043
RPS21 ribosomal protein S21 -0.0264625
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0250444
PDE4D phosphodiesterase 4D, cAMP-specific -0.0245445
RPS10 ribosomal protein S10 -0.0243453
RPS29 ribosomal protein S29 -0.0237983
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0236991
ARF4 ADP-ribosylation factor 4 -0.0234744
INTS6 integrator complex subunit 6 -0.023297
RPL5 ribosomal protein L5 -0.0223264
RPS14 ribosomal protein S14 -0.0221172
RPS24 ribosomal protein S24 -0.0220226
RPS13 ribosomal protein S13 -0.0216864
RPL28 ribosomal protein L28 -0.021453
RPS20 ribosomal protein S20 -0.0209846
RPL36A ribosomal protein L36a -0.0209184
IARS1 isoleucyl-tRNA synthetase 1 -0.020279
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0201063
RPL12 ribosomal protein L12 -0.0189337
COL7A1 collagen, type VII, alpha 1 -0.0187671
TPT1 tumor protein, translationally-controlled 1 -0.0184712
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0182409
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0182374
PABPN1 poly(A) binding protein, nuclear 1 -0.0180034
RPS3 ribosomal protein S3 -0.0179221
RPL7 ribosomal protein L7 -0.0175325
HMGA1 high mobility group AT-hook 1 -0.0170835
RPS27 ribosomal protein S27 -0.0168697
RPL26 ribosomal protein L26 -0.0165479
RPL31 ribosomal protein L31 -0.0164375
RPS11 ribosomal protein S11 -0.0164142
RPL7A ribosomal protein L7a -0.016387
TRA2A transformer 2 alpha homolog (Drosophila) -0.0163649
WSB1 WD repeat and SOCS box containing 1 -0.0160648
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0159939
RPL37 ribosomal protein L37 -0.015873
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0158276
RPL32 ribosomal protein L32 -0.0156424
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0155625
KDM4B lysine (K)-specific demethylase 4B -0.0155231
HMGB1 high mobility group box 1 -0.0154633
RPL8 ribosomal protein L8 -0.0153885
TTC3 tetratricopeptide repeat domain 3 -0.0152208
CEMIP2 cell migration inducing hyaluronidase 2 -0.0151108
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0151047
AFF3 AF4/FMR2 family, member 3 -0.0150966
WWOX WW domain containing oxidoreductase -0.0150485
VDAC1 voltage-dependent anion channel 1 -0.0147674
GRB10 growth factor receptor-bound protein 10 -0.0146646
UST uronyl-2-sulfotransferase -0.0145073
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0144739
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.014259
GLS2 glutaminase 2 (liver, mitochondrial) -0.0141685
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0141684
ANO10 anoctamin 10 -0.0139572
MARCHF1 membrane associated ring-CH-type finger 1 -0.0137203
COG5 component of oligomeric golgi complex 5 -0.0137103
ISG15 ISG15 ubiquitin-like modifier -0.0136145
SRSF11 serine/arginine-rich splicing factor 11 -0.0135601
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0135598
YBX1 Y box binding protein 1 -0.0134207
RPL30 ribosomal protein L30 -0.0132726
RACK1 receptor for activated C kinase 1 -0.013247
SEC61G Sec61 gamma subunit -0.0131947
SEC24D SEC24 family member D -0.0129296
RPS15 ribosomal protein S15 -0.0128571
RPS17 ribosomal protein S17 -0.0127821
RPS27A ribosomal protein S27a -0.0127227
CST3 cystatin C -0.0127213
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0125409
ZFPM2 zinc finger protein, FOG family member 2 -0.0123022
RPL34 ribosomal protein L34 -0.0121043
GPHN gephyrin -0.0120997
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0120702
AUTS2 autism susceptibility candidate 2 -0.0120558
RBM25 RNA binding motif protein 25 -0.0120378
SPIRE1 spire-type actin nucleation factor 1 -0.0119168
RPL27A ribosomal protein L27a -0.0117029