Omeprazole (sodium)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.119959
FAM13A family with sequence similarity 13, member A 0.0975861
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0609246
ARRDC3 arrestin domain containing 3 0.05255
NALF1 NALCN channel auxiliary factor 1 0.0521285
MT2A metallothionein 2A 0.0502556
ATP13A3 ATPase type 13A3 0.0471005
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.043031
SPAG9 sperm associated antigen 9 0.0420814
PDIA3 protein disulfide isomerase family A, member 3 0.0404597
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0387659
FTH1 ferritin, heavy polypeptide 1 0.0387291
MATR3 matrin 3 0.038279
IGF2 insulin-like growth factor 2 0.0381713
ELL2 elongation factor, RNA polymerase II, 2 0.0369678
AKAP12 A kinase (PRKA) anchor protein 12 0.0365213
GPC6 glypican 6 0.0364406
ZNF292 zinc finger protein 292 0.0340464
KDM3A lysine (K)-specific demethylase 3A 0.0340418
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0330184
HLA-A major histocompatibility complex, class I, A 0.0322488
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0321187
UBA6 ubiquitin-like modifier activating enzyme 6 0.0306422
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0304851
SKIC3 SKI3 subunit of superkiller complex 0.029821
HELZ helicase with zinc finger 0.0298005
CYLD cylindromatosis (turban tumor syndrome) 0.029468
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0294172
HLA-B major histocompatibility complex, class I, B 0.0292413
YEATS2 YEATS domain containing 2 0.02899
NRG1 neuregulin 1 0.0289355
INSIG2 insulin induced gene 2 0.0287335
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0286796
RSRC2 arginine/serine-rich coiled-coil 2 0.0285673
PTPRA protein tyrosine phosphatase, receptor type, A 0.028543
ANKRD11 ankyrin repeat domain 11 0.0284312
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0283713
PUM1 pumilio RNA-binding family member 1 0.0282032
FRMD6 FERM domain containing 6 0.0278993
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0276488
SHB Src homology 2 domain containing adaptor protein B 0.0273389
GARS1 glycyl-tRNA synthetase 1 0.0273258
STC1 stanniocalcin 1 0.0272051
ZNF207 zinc finger protein 207 0.0271705
CTNND1 catenin (cadherin-associated protein), delta 1 0.0268893
JARID2 jumonji, AT rich interactive domain 2 0.0266571
KCMF1 potassium channel modulatory factor 1 0.0264508
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0264321
HOOK2 hook microtubule-tethering protein 2 0.0261134
AFF4 AF4/FMR2 family, member 4 0.026099
RPS8 ribosomal protein S8 0.0257983
KCTD9 potassium channel tetramerization domain containing 9 0.0255073
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0254645
PDE4B phosphodiesterase 4B, cAMP-specific 0.0254317
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0251875
EPAS1 endothelial PAS domain protein 1 0.0249983
COPB1 coatomer protein complex, subunit beta 1 0.0243753
FBXO42 F-box protein 42 0.0240763
ARHGAP32 Rho GTPase activating protein 32 0.0237615
PDIA6 protein disulfide isomerase family A, member 6 0.0236526
IRF1 interferon regulatory factor 1 0.0235854
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0233116
CLINT1 clathrin interactor 1 0.0232812
BHLHE40 basic helix-loop-helix family, member e40 0.0231827
KIAA0319L KIAA0319-like 0.0230134
OSBPL9 oxysterol binding protein-like 9 0.0228348
FKBP1A FK506 binding protein 1A, 12kDa 0.0224626
AKAP10 A kinase (PRKA) anchor protein 10 0.0223905
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0222053
TENT5A terminal nucleotidyltransferase 5A 0.0221669
TMEM165 transmembrane protein 165 0.0221147
BSDC1 BSD domain containing 1 0.0220971
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0220917
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0220108
VMP1 vacuole membrane protein 1 0.0219414
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0218328
FNBP1L formin binding protein 1-like 0.021824
GOLGA4 golgin A4 0.0217729
SFXN1 sideroflexin 1 0.0217594
RAB18 RAB18, member RAS oncogene family 0.0215628
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0215489
RNF24 ring finger protein 24 0.0214615
BRWD3 bromodomain and WD repeat domain containing 3 0.0213963
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0213572
MORF4L1 mortality factor 4 like 1 0.0211341
SEPTIN2 septin 2 0.0210538
UBE2O ubiquitin-conjugating enzyme E2O 0.0210045
LONP2 lon peptidase 2, peroxisomal 0.0209987
KIF1B kinesin family member 1B 0.0209885
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0209577
RNMT RNA (guanine-7-) methyltransferase 0.0208909
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0208716
APAF1 apoptotic peptidase activating factor 1 0.0207035
EPS8 epidermal growth factor receptor pathway substrate 8 0.0204824
KMT2E lysine (K)-specific methyltransferase 2E 0.0204471
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.0203881
ATOSA atos homolog A 0.0203629
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.020229
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0201984
AGO3 argonaute RISC catalytic component 3 0.0201608

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.295931
CDH13 cadherin 13 -0.133751
FN1 fibronectin 1 -0.101106
HMGA2 high mobility group AT-hook 2 -0.0996043
AHNAK AHNAK nucleoprotein -0.0912696
F3 coagulation factor III (thromboplastin, tissue factor) -0.0796064
MYH9 myosin, heavy chain 9, non-muscle -0.0775517
TGFBI transforming growth factor, beta-induced, 68kDa -0.0717263
RUNX1 runt-related transcription factor 1 -0.0713914
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0675904
COL1A1 collagen, type I, alpha 1 -0.0675386
MAP1B microtubule-associated protein 1B -0.0656168
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0652795
COL6A3 collagen, type VI, alpha 3 -0.0650184
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0644449
CALR calreticulin -0.0642504
PRKCA protein kinase C, alpha -0.0641043
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0635827
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0628337
PRSS23 protease, serine, 23 -0.06148
TRIO trio Rho guanine nucleotide exchange factor -0.0609037
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0556716
EGFR epidermal growth factor receptor -0.0532395
PKM pyruvate kinase, muscle -0.0521809
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0512499
EXT1 exostosin glycosyltransferase 1 -0.0501263
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.047324
PDLIM5 PDZ and LIM domain 5 -0.047256
VEGFC vascular endothelial growth factor C -0.0468431
RRBP1 ribosome binding protein 1 -0.0465331
GLIS3 GLIS family zinc finger 3 -0.045819
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0449219
NDRG1 N-myc downstream regulated 1 -0.0445341
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0443357
COL5A1 collagen, type V, alpha 1 -0.0441316
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0441089
CAV1 caveolin 1, caveolae protein, 22kDa -0.0440487
NRXN3 neurexin 3 -0.0431814
RAB7A RAB7A, member RAS oncogene family -0.0416316
ASPH aspartate beta-hydroxylase -0.0415972
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0411318
CHD9 chromodomain helicase DNA binding protein 9 -0.0409269
COL6A1 collagen, type VI, alpha 1 -0.0401003
AFF3 AF4/FMR2 family, member 3 -0.039947
ANO6 anoctamin 6 -0.0397697
JPH2 junctophilin 2 -0.0394278
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0394183
COL1A2 collagen, type I, alpha 2 -0.0392603
LDHA lactate dehydrogenase A -0.0391796
TTC3 tetratricopeptide repeat domain 3 -0.0391294
DST dystonin -0.0390565
LOX lysyl oxidase -0.0384212
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0376196
EFNA5 ephrin-A5 -0.0375202
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0374182
HM13 histocompatibility (minor) 13 -0.0372643
MAML2 mastermind-like 2 (Drosophila) -0.0372179
ATXN1 ataxin 1 -0.0371565
MYLK myosin light chain kinase -0.0368623
TNNC1 troponin C type 1 (slow) -0.0367943
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0366052
CANX calnexin -0.03641
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0363797
HDAC9 histone deacetylase 9 -0.0359626
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0359562
PDE4D phosphodiesterase 4D, cAMP-specific -0.0353617
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.035346
BLTP1 bridge-like lipid transfer protein family member 1 -0.0349713
RAD51B RAD51 paralog B -0.034933
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0348073
LPP LIM domain containing preferred translocation partner in lipoma -0.0347129
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0334137
TNS3 tensin 3 -0.033202
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0331735
EXOC4 exocyst complex component 4 -0.0331086
HDLBP high density lipoprotein binding protein -0.0330155
SMYD3 SET and MYND domain containing 3 -0.0327209
FNIP1 folliculin interacting protein 1 -0.0326783
MARCHF6 membrane associated ring-CH-type finger 6 -0.0322022
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0321705
TMSB10 thymosin beta 10 -0.0319595
INTS6 integrator complex subunit 6 -0.0312067
LMNA lamin A/C -0.0310712
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0310335
FBN1 fibrillin 1 -0.0308343
TAS2R14 taste receptor, type 2, member 14 -0.0298001
RPL28 ribosomal protein L28 -0.029738
ALCAM activated leukocyte cell adhesion molecule -0.0297336
MACF1 microtubule-actin crosslinking factor 1 -0.0296294
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0296194
TUBB tubulin, beta class I -0.0295248
CD44 CD44 molecule (Indian blood group) -0.0292078
TENM3 teneurin transmembrane protein 3 -0.0285639
PALLD palladin, cytoskeletal associated protein -0.0284354
PRELID2 PRELI domain containing 2 -0.0282
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0280375
GNAS GNAS complex locus -0.0279549
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0278698
DSCAM Down syndrome cell adhesion molecule -0.0277415
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0275377