Omeprazole (sodium)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0516132
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0510571
STC2 stanniocalcin 2 0.0415382
CCNL1 cyclin L1 0.0243983
ZFP36L1 ZFP36 ring finger protein-like 1 0.0231461
ENO2 enolase 2 (gamma, neuronal) 0.020896
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0198247
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0185928
RNF145 ring finger protein 145 0.0179516
SRRM2 serine/arginine repetitive matrix 2 0.0174008
ATN1 atrophin 1 0.0170148
FOSL1 FOS-like antigen 1 0.0168903
TGM2 transglutaminase 2 0.0165412
RAI14 retinoic acid induced 14 0.016074
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0160717
PLIN2 perilipin 2 0.0147025
MYH9 myosin, heavy chain 9, non-muscle 0.0135511
MRPS6 mitochondrial ribosomal protein S6 0.0134871
HDGF hepatoma-derived growth factor 0.0132052
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0130494
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0127452
CYB5R3 cytochrome b5 reductase 3 0.0126288
POTEF POTE ankyrin domain family, member F 0.0126023
NUP58 nucleoporin 58 0.012581
ARRDC3 arrestin domain containing 3 0.0121476
MSN moesin 0.0114734
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0113095
ZCCHC7 zinc finger, CCHC domain containing 7 0.0112366
TMF1 TATA element modulatory factor 1 0.011229
CD109 CD109 molecule 0.0111288
SOS1 son of sevenless homolog 1 (Drosophila) 0.0105192
ZMIZ1 zinc finger, MIZ-type containing 1 0.0102949
FTH1 ferritin, heavy polypeptide 1 0.0102473
USP8 ubiquitin specific peptidase 8 0.0101249
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0100209
ZFYVE16 zinc finger, FYVE domain containing 16 0.00986768
BCL9L B-cell CLL/lymphoma 9-like 0.00977062
MAX MYC associated factor X 0.00967981
UBAP2 ubiquitin associated protein 2 0.00946612
KMT2E lysine (K)-specific methyltransferase 2E 0.00933917
HPS3 Hermansky-Pudlak syndrome 3 0.00931004
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.00928064
BCL3 B-cell CLL/lymphoma 3 0.00917611
CLIC4 chloride intracellular channel 4 0.00917012
PRPF8 pre-mRNA processing factor 8 0.00908427
FAT1 FAT atypical cadherin 1 0.00905503
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00899454
TGFB1 transforming growth factor, beta 1 0.00886728
TTC19 tetratricopeptide repeat domain 19 0.00882232
LENG8 leukocyte receptor cluster (LRC) member 8 0.00868647
BRD2 bromodomain containing 2 0.00865896
AHRR aryl-hydrocarbon receptor repressor 0.00865633
AFDN afadin, adherens junction formation factor 0.00848974
PDLIM5 PDZ and LIM domain 5 0.00846259
CRTAC1 cartilage acidic protein 1 0.00842784
PKP2 plakophilin 2 0.00842558
NOTCH2 notch 2 0.00831926
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.00825732
HLA-G major histocompatibility complex, class I, G 0.00825249
IRF2BPL interferon regulatory factor 2 binding protein-like 0.00813329
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.00812043
CNOT3 CCR4-NOT transcription complex, subunit 3 0.00808262
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.00807014
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00805549
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00803945
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.00803307
KDM6A lysine (K)-specific demethylase 6A 0.00800317
FGFR1OP2 FGFR1 oncogene partner 2 0.00796114
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.00783272
IGFBP3 insulin-like growth factor binding protein 3 0.00781405
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.00776443
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.00772704
USP47 ubiquitin specific peptidase 47 0.00767425
ATP11A ATPase, class VI, type 11A 0.00760532
FAM219A family with sequence similarity 219, member A 0.00747248
WASF2 WAS protein family, member 2 0.00747147
PAPOLA poly(A) polymerase alpha 0.00744452
INSIG1 insulin induced gene 1 0.0074072
TRIM33 tripartite motif containing 33 0.00733102
DAPK3 death-associated protein kinase 3 0.00732105
RNF44 ring finger protein 44 0.00731698
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 0.00727196
RNF13 ring finger protein 13 0.00726391
RAD23B RAD23 homolog B (S. cerevisiae) 0.0072128
UBA6 ubiquitin-like modifier activating enzyme 6 0.00718002
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00717988
DEPP1 DEPP autophagy regulator 1 0.0071452
AKAP13 A kinase (PRKA) anchor protein 13 0.00713562
TSPYL2 TSPY-like 2 0.00710769
RPL3 ribosomal protein L3 0.00710551
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0070346
YY1AP1 YY1 associated protein 1 0.00697604
SETD5 SET domain containing 5 0.00697396
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00691941
GMCL1 germ cell-less, spermatogenesis associated 1 0.00688819
RAB8B RAB8B, member RAS oncogene family 0.00686848
INTS1 integrator complex subunit 1 0.00684862
IGF2 insulin-like growth factor 2 0.0068379
MNT MAX network transcriptional repressor 0.00680451
MAST2 microtubule associated serine/threonine kinase 2 0.00677842

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.215795
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175696
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.171564
FN1 fibronectin 1 -0.156743
SQSTM1 sequestosome 1 -0.126663
CANX calnexin -0.121456
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.120771
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.116584
ASPH aspartate beta-hydroxylase -0.0977467
NAMPT nicotinamide phosphoribosyltransferase -0.0903179
HLA-B major histocompatibility complex, class I, B -0.0824233
EXT1 exostosin glycosyltransferase 1 -0.0756182
VIM vimentin -0.0746621
NRG1 neuregulin 1 -0.0717473
TPT1 tumor protein, translationally-controlled 1 -0.0700849
MT2A metallothionein 2A -0.0686973
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0623415
PTMA prothymosin, alpha -0.0617012
TRIO trio Rho guanine nucleotide exchange factor -0.0600908
GLIS3 GLIS family zinc finger 3 -0.0587559
S100A6 S100 calcium binding protein A6 -0.0530692
FNDC3B fibronectin type III domain containing 3B -0.052786
RPS24 ribosomal protein S24 -0.0527361
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0526894
TMSB10 thymosin beta 10 -0.0514418
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0510156
HMGA2 high mobility group AT-hook 2 -0.0499168
RPL26 ribosomal protein L26 -0.0490396
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0489901
TMSB4X thymosin beta 4, X-linked -0.0486641
RPL35A ribosomal protein L35a -0.0486198
NAP1L1 nucleosome assembly protein 1-like 1 -0.0482116
ARID4B AT rich interactive domain 4B (RBP1-like) -0.04703
RBM39 RNA binding motif protein 39 -0.0451659
MCTP2 multiple C2 domains, transmembrane 2 -0.0445714
SYT1 synaptotagmin I -0.0441012
IFI16 interferon, gamma-inducible protein 16 -0.0440432
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0435153
EFNA5 ephrin-A5 -0.0425806
RACK1 receptor for activated C kinase 1 -0.0418641
LOC112694756 uncharaterized LOC112694756 -0.0416188
ENO1 enolase 1, (alpha) -0.0408715
RPL12 ribosomal protein L12 -0.0403867
FOXP1 forkhead box P1 -0.0400693
RPL9 ribosomal protein L9 -0.0393173
ETV1 ets variant 1 -0.038969
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.038358
ARF1 ADP-ribosylation factor 1 -0.0383207
RPS12 ribosomal protein S12 -0.0364188
RPL23 ribosomal protein L23 -0.0360823
OSMR oncostatin M receptor -0.0360457
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0355968
NRP1 neuropilin 1 -0.035282
RPLP1 ribosomal protein, large, P1 -0.0351574
MAP1B microtubule-associated protein 1B -0.0349202
GNAS GNAS complex locus -0.0348671
PTK2 protein tyrosine kinase 2 -0.0347208
RPS21 ribosomal protein S21 -0.0342937
FTL ferritin, light polypeptide -0.034288
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0341902
AHR aryl hydrocarbon receptor -0.0338561
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0335993
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0334554
IFI27 interferon, alpha-inducible protein 27 -0.0334545
PRRC2C proline-rich coiled-coil 2C -0.0333639
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0329285
RPL34 ribosomal protein L34 -0.0326502
RRBP1 ribosome binding protein 1 -0.0322631
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0321942
RPS6 ribosomal protein S6 -0.0320638
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0318676
ITGA1 integrin, alpha 1 -0.0317576
OGA O-GlcNAcase -0.0314809
RAB1A RAB1A, member RAS oncogene family -0.0313237
RPL31 ribosomal protein L31 -0.0312901
SMYD3 SET and MYND domain containing 3 -0.0311497
WSB1 WD repeat and SOCS box containing 1 -0.0311031
RPS20 ribosomal protein S20 -0.0310979
LMNA lamin A/C -0.0310368
NCOA7 nuclear receptor coactivator 7 -0.0307875
CD44 CD44 molecule (Indian blood group) -0.0305815
LRMDA leucine rich melanocyte differentiation associated -0.0305119
RAD21 RAD21 homolog (S. pombe) -0.0303886
PDE4D phosphodiesterase 4D, cAMP-specific -0.0300997
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0298391
TXNRD1 thioredoxin reductase 1 -0.0297634
KLHL5 kelch-like family member 5 -0.029577
RPS8 ribosomal protein S8 -0.0292402
H1-0 H1.0 linker histone -0.0291743
FNBP1 formin binding protein 1 -0.028982
AHNAK AHNAK nucleoprotein -0.0289167
RPL37A ribosomal protein L37a -0.0287856
TMEM263 transmembrane protein 263 -0.0287225
RPL11 ribosomal protein L11 -0.0286644
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0286208
RPS27A ribosomal protein S27a -0.028527
BICD1 bicaudal D homolog 1 (Drosophila) -0.0284766
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0282123
RPL38 ribosomal protein L38 -0.0281284
RPS25 ribosomal protein S25 -0.0280672