Omeprazole (sodium)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.131747
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0887362
CD36 CD36 molecule (thrombospondin receptor) 0.0834361
ANXA1 annexin A1 0.0811908
NDRG1 N-myc downstream regulated 1 0.0769667
ITPRID2 ITPR interacting domain containing 2 0.0700101
EZR ezrin 0.0687368
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0677039
EREG epiregulin 0.0662141
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0564796
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0558918
FAT1 FAT atypical cadherin 1 0.0536114
FLOT1 flotillin 1 0.0530554
ESYT2 extended synaptotagmin-like protein 2 0.0530253
EEF2 eukaryotic translation elongation factor 2 0.0526888
TSC22D2 TSC22 domain family, member 2 0.0511053
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0497674
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0497413
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0473366
HSPA8 heat shock 70kDa protein 8 0.0462966
KDM6A lysine (K)-specific demethylase 6A 0.0438694
WAC WW domain containing adaptor with coiled-coil 0.0438151
RCOR1 REST corepressor 1 0.0437984
PARD3 par-3 family cell polarity regulator 0.0436411
FOSL1 FOS-like antigen 1 0.0430651
FERMT1 fermitin family member 1 0.042216
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0419347
DSPP dentin sialophosphoprotein 0.041535
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0409213
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0408801
LDHA lactate dehydrogenase A 0.0387371
USP3 ubiquitin specific peptidase 3 0.0382409
ANXA2 annexin A2 0.0375571
WDR43 WD repeat domain 43 0.0369983
PTMA prothymosin, alpha 0.0367302
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0358281
EDAR ectodysplasin A receptor 0.0354214
PUM2 pumilio RNA-binding family member 2 0.0352575
SREBF2 sterol regulatory element binding transcription factor 2 0.0341937
TOP1 topoisomerase (DNA) I 0.0339999
HDAC2 histone deacetylase 2 0.0338706
EPHA2 EPH receptor A2 0.0332881
KMT2C lysine (K)-specific methyltransferase 2C 0.0332828
CD9 CD9 molecule 0.0331661
MKI67 marker of proliferation Ki-67 0.0331449
FHIT fragile histidine triad 0.0330929
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0327561
BAMBI BMP and activin membrane-bound inhibitor 0.0326232
GOLGA4 golgin A4 0.0323466
BBX bobby sox homolog (Drosophila) 0.032269
NCKAP1 NCK-associated protein 1 0.0321674
ZFP36L1 ZFP36 ring finger protein-like 1 0.0319119
KRT18 keratin 18, type I 0.0317048
ANLN anillin, actin binding protein 0.0316979
FRAS1 Fraser extracellular matrix complex subunit 1 0.0310667
CCSER1 coiled-coil serine-rich protein 1 0.0301592
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0299323
ECPAS Ecm29 proteasome adaptor and scaffold 0.0294713
FTH1 ferritin, heavy polypeptide 1 0.0292121
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0285446
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0282516
NUP58 nucleoporin 58 0.0278509
AKAP12 A kinase (PRKA) anchor protein 12 0.0277271
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.027232
KRT8 keratin 8, type II 0.0270301
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0265694
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0265614
KLF3 Kruppel-like factor 3 (basic) 0.0265545
ITGB4 integrin, beta 4 0.0264539
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0263034
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0261748
ITGA6 integrin, alpha 6 0.0261672
PRELID2 PRELI domain containing 2 0.0258449
RPL3 ribosomal protein L3 0.0256167
INSIG1 insulin induced gene 1 0.0255443
TRAF3 TNF receptor-associated factor 3 0.0254674
MYO5B myosin VB 0.0252637
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0251371
VMP1 vacuole membrane protein 1 0.0249875
KITLG KIT ligand 0.0245844
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0245595
GTF2I general transcription factor IIi 0.0244919
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0243116
CPOX coproporphyrinogen oxidase 0.0242344
ADAM9 ADAM metallopeptidase domain 9 0.024212
FAM3C family with sequence similarity 3, member C 0.0241303
SAMD4A sterile alpha motif domain containing 4A 0.0238502
UBA6 ubiquitin-like modifier activating enzyme 6 0.0237721
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0236485
DUSP4 dual specificity phosphatase 4 0.0235721
RANBP9 RAN binding protein 9 0.0232241
SERBP1 SERPINE1 mRNA binding protein 1 0.0232163
KCMF1 potassium channel modulatory factor 1 0.0231242
SPATS2L spermatogenesis associated, serine-rich 2-like 0.023117
ZFP36L2 ZFP36 ring finger protein-like 2 0.0231107
RAD23B RAD23 homolog B (S. cerevisiae) 0.0230536
AXIN2 axin 2 0.0228338
MYO1B myosin IB 0.0226247
LOC102724023 ES1 protein homolog, mitochondrial 0.0224019
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0223896

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.134636
RPS24 ribosomal protein S24 -0.0666688
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0657451
VCL vinculin -0.0504125
RPL23 ribosomal protein L23 -0.0431096
RPLP1 ribosomal protein, large, P1 -0.0387276
CDK13 cyclin-dependent kinase 13 -0.0364818
IARS1 isoleucyl-tRNA synthetase 1 -0.0357366
EIF1 eukaryotic translation initiation factor 1 -0.0340366
SRP54 signal recognition particle 54kDa -0.0324514
RPL36 ribosomal protein L36 -0.031662
RPL11 ribosomal protein L11 -0.0307888
HM13 histocompatibility (minor) 13 -0.0300488
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0296306
RPL9 ribosomal protein L9 -0.0295285
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0293119
CANX calnexin -0.028648
TTC3 tetratricopeptide repeat domain 3 -0.0281214
TMSB10 thymosin beta 10 -0.0276489
RPL34 ribosomal protein L34 -0.0268579
SQSTM1 sequestosome 1 -0.0266092
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0259461
RPS8 ribosomal protein S8 -0.0257963
RPL28 ribosomal protein L28 -0.0254737
HMGA2 high mobility group AT-hook 2 -0.0253794
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0249285
RPL19 ribosomal protein L19 -0.0247466
RPL35A ribosomal protein L35a -0.0245304
NEBL nebulette -0.0243761
USP36 ubiquitin specific peptidase 36 -0.0242191
RPS29 ribosomal protein S29 -0.0241045
NAMPT nicotinamide phosphoribosyltransferase -0.0240472
USP34 ubiquitin specific peptidase 34 -0.0236899
RPS4X ribosomal protein S4, X-linked -0.0236693
LOC112694756 uncharaterized LOC112694756 -0.0236452
RPL14 ribosomal protein L14 -0.0228175
RPS6 ribosomal protein S6 -0.0227365
NIPBL Nipped-B homolog (Drosophila) -0.0221757
BTBD9 BTB (POZ) domain containing 9 -0.0221479
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0220454
TBC1D22A TBC1 domain family, member 22A -0.0219256
SPON1 spondin 1, extracellular matrix protein -0.0217824
SEC31A SEC31 homolog A (S. cerevisiae) -0.0217333
PCNX4 pecanex 4 -0.0217286
RPL31 ribosomal protein L31 -0.021599
RPL26 ribosomal protein L26 -0.021494
TMEM131 transmembrane protein 131 -0.0213397
MCPH1 microcephalin 1 -0.0213041
LAMB3 laminin, beta 3 -0.0212076
EVA1C eva-1 homolog C (C. elegans) -0.0211215
FNIP1 folliculin interacting protein 1 -0.0210794
SCFD1 sec1 family domain containing 1 -0.0210561
PHF14 PHD finger protein 14 -0.0209443
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0207709
PHF3 PHD finger protein 3 -0.0206686
ZFR zinc finger RNA binding protein -0.0206161
RPL39 ribosomal protein L39 -0.020543
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0203666
BRD2 bromodomain containing 2 -0.0202219
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0201069
MBD5 methyl-CpG binding domain protein 5 -0.0197736
PATJ PATJ crumbs cell polarity complex component -0.0196382
TBCA tubulin folding cofactor A -0.0191407
RPLP0 ribosomal protein, large, P0 -0.0190889
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0188648
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0184356
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0182926
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0182656
EXT1 exostosin glycosyltransferase 1 -0.017766
CEP350 centrosomal protein 350kDa -0.0176745
ARL15 ADP-ribosylation factor-like 15 -0.017533
GOLGB1 golgin B1 -0.0174118
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0173507
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0173312
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -0.0173142
PLEKHA7 pleckstrin homology domain containing, family A member 7 -0.0172115
CLIP2 CAP-GLY domain containing linker protein 2 -0.0171252
BIRC3 baculoviral IAP repeat containing 3 -0.0170569
RPL36A ribosomal protein L36a -0.0170315
EHBP1 EH domain binding protein 1 -0.0168643
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0165983
FNBP4 formin binding protein 4 -0.0162513
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0162392
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0159927
RPS27 ribosomal protein S27 -0.015987
RPS16 ribosomal protein S16 -0.0159815
UGDH UDP-glucose 6-dehydrogenase -0.0159776
MBTD1 mbt domain containing 1 -0.0159426
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0159069
ITPKC inositol-trisphosphate 3-kinase C -0.0159008
BCAS3 breast carcinoma amplified sequence 3 -0.0158933
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0158816
DCAF10 DDB1 and CUL4 associated factor 10 -0.0158657
RPS17 ribosomal protein S17 -0.0158418
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0157791
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0157628
FMN1 formin 1 -0.0157004
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0156743
NUP88 nucleoporin 88kDa -0.0156505
AKAP9 A kinase (PRKA) anchor protein 9 -0.0156486