Omeprazole (sodium)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0491487
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0383796
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0329835
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.030674
CD46 CD46 molecule, complement regulatory protein 0.0294088
AOPEP aminopeptidase O (putative) 0.0289804
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0287538
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0253261
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0252545
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0251875
BCL2L1 BCL2-like 1 0.0237349
NCEH1 neutral cholesterol ester hydrolase 1 0.0226552
KDM6A lysine (K)-specific demethylase 6A 0.0223483
TNS3 tensin 3 0.0219003
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0214096
ACTN4 actinin, alpha 4 0.0213324
YAP1 Yes-associated protein 1 0.0213032
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0212726
TGM2 transglutaminase 2 0.0212345
SMAD3 SMAD family member 3 0.0211458
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0205731
ABHD2 abhydrolase domain containing 2 0.0204891
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0203467
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0181713
CEMIP2 cell migration inducing hyaluronidase 2 0.0175114
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0175108
SAMD4A sterile alpha motif domain containing 4A 0.0174612
RNF43 ring finger protein 43 0.0173966
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.016882
TNS4 tensin 4 0.0165044
SEPTIN9 septin 9 0.0163196
SPRED2 sprouty-related, EVH1 domain containing 2 0.0161974
RICTOR RPTOR independent companion of MTOR, complex 2 0.0155536
KDM7A lysine (K)-specific demethylase 7A 0.0151827
ADAM17 ADAM metallopeptidase domain 17 0.0150095
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0148721
AVL9 AVL9 homolog (S. cerevisiase) 0.0144178
ETNK1 ethanolamine kinase 1 0.0142918
JAG1 jagged 1 0.0141883
VMP1 vacuole membrane protein 1 0.0139907
MINK1 misshapen-like kinase 1 0.0139107
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.013885
EEF2 eukaryotic translation elongation factor 2 0.0137689
KLF12 Kruppel-like factor 12 0.013527
EPHA2 EPH receptor A2 0.0135038
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0134531
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0133151
ARGLU1 arginine and glutamate rich 1 0.0131039
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0130935
CDCP1 CUB domain containing protein 1 0.0130693
ANO6 anoctamin 6 0.0130487
NCKAP1 NCK-associated protein 1 0.0125691
SPRED1 sprouty-related, EVH1 domain containing 1 0.0121581
MAN1A1 mannosidase, alpha, class 1A, member 1 0.01202
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0119737
CYTH3 cytohesin 3 0.0119516
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0119159
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.011868
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0118447
PRPF8 pre-mRNA processing factor 8 0.0116639
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0115958
SNX13 sorting nexin 13 0.011553
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0113722
PTBP2 polypyrimidine tract binding protein 2 0.0113513
SLC35F5 solute carrier family 35, member F5 0.0113445
PCM1 pericentriolar material 1 0.0113303
FLNA filamin A, alpha 0.0113232
MED13L mediator complex subunit 13-like 0.0112454
HSPA8 heat shock 70kDa protein 8 0.0111751
USP47 ubiquitin specific peptidase 47 0.0110968
USP9X ubiquitin specific peptidase 9, X-linked 0.0110945
MALT1 MALT1 paracaspase 0.0110919
HPCAL1 hippocalcin-like 1 0.0110488
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0110458
MACF1 microtubule-actin crosslinking factor 1 0.0108996
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0107805
VGLL4 vestigial-like family member 4 0.0106623
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0106065
ZNF654 zinc finger protein 654 0.0104969
CAPRIN1 cell cycle associated protein 1 0.0104285
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0104155
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0103853
STK38L serine/threonine kinase 38 like 0.0103357
ITPRID2 ITPR interacting domain containing 2 0.0102878
LRP6 low density lipoprotein receptor-related protein 6 0.0102384
ITGB5 integrin, beta 5 0.01017
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 0.0100753
ATXN1 ataxin 1 0.0100103
LENG8 leukocyte receptor cluster (LRC) member 8 0.00996357
AFAP1L2 actin filament associated protein 1-like 2 0.00992289
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.00991334
PRELID2 PRELI domain containing 2 0.00991035
HELZ helicase with zinc finger 0.00987517
DSPP dentin sialophosphoprotein 0.00985884
SESN3 sestrin 3 0.00981554
SFPQ splicing factor proline/glutamine-rich 0.00964664
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.00962787
TJP1 tight junction protein 1 0.00955293
ARHGAP32 Rho GTPase activating protein 32 0.00950007
LAMA5 laminin, alpha 5 0.00948812

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.11897
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.113469
TMSB10 thymosin beta 10 -0.101861
RPS6 ribosomal protein S6 -0.0944299
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0902647
TPT1 tumor protein, translationally-controlled 1 -0.0888243
AKAP12 A kinase (PRKA) anchor protein 12 -0.0822582
CDH13 cadherin 13 -0.0768147
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0698153
EZR ezrin -0.0681239
CANX calnexin -0.064305
RPL35A ribosomal protein L35a -0.0630196
VIM vimentin -0.0615882
RPS8 ribosomal protein S8 -0.0605223
ANXA2 annexin A2 -0.0592352
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0567316
RPS3 ribosomal protein S3 -0.056081
KRT18 keratin 18, type I -0.0557126
RPL26 ribosomal protein L26 -0.0537382
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.052994
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0521741
RPLP1 ribosomal protein, large, P1 -0.0506222
RPS19 ribosomal protein S19 -0.0504278
EIF1 eukaryotic translation initiation factor 1 -0.049892
RPS24 ribosomal protein S24 -0.0492302
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0487265
RPL23 ribosomal protein L23 -0.0480234
ENO1 enolase 1, (alpha) -0.0473585
TMSB4X thymosin beta 4, X-linked -0.0451429
RPL19 ribosomal protein L19 -0.0416334
CDK6 cyclin-dependent kinase 6 -0.0403625
RPS27A ribosomal protein S27a -0.0401032
RPL12 ribosomal protein L12 -0.0400475
TPM4 tropomyosin 4 -0.0379011
RPL11 ribosomal protein L11 -0.0373599
IARS1 isoleucyl-tRNA synthetase 1 -0.0371414
RPL31 ribosomal protein L31 -0.0362375
RPS13 ribosomal protein S13 -0.0360275
ACTG1 actin gamma 1 -0.0359674
S100A10 S100 calcium binding protein A10 -0.0350657
RPS25 ribosomal protein S25 -0.0350023
RACK1 receptor for activated C kinase 1 -0.0344861
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0342802
ZBTB20 zinc finger and BTB domain containing 20 -0.0341719
RPL5 ribosomal protein L5 -0.0333817
MORF4L2 mortality factor 4 like 2 -0.0333784
KPNB1 karyopherin (importin) beta 1 -0.0323169
GOLGA4 golgin A4 -0.0322111
SLC38A1 solute carrier family 38, member 1 -0.0321969
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0321326
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0316743
RPL37A ribosomal protein L37a -0.0314039
NAP1L1 nucleosome assembly protein 1-like 1 -0.0312518
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0312003
CCND1 cyclin D1 -0.0309732
EMP1 epithelial membrane protein 1 -0.0307491
RPL34 ribosomal protein L34 -0.0303883
GMDS GDP-mannose 4,6-dehydratase -0.0303699
RPL37 ribosomal protein L37 -0.0302809
RPS21 ribosomal protein S21 -0.0301697
SYT1 synaptotagmin I -0.0298873
RPL27A ribosomal protein L27a -0.0295677
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0294109
RPS12 ribosomal protein S12 -0.0294033
S100A6 S100 calcium binding protein A6 -0.0292154
RPS16 ribosomal protein S16 -0.0289409
HMGB1 high mobility group box 1 -0.0289144
FTL ferritin, light polypeptide -0.0288674
RPL36A ribosomal protein L36a -0.0287029
RPS4X ribosomal protein S4, X-linked -0.0284353
RPL32 ribosomal protein L32 -0.0283214
RPL13A ribosomal protein L13a -0.0281997
RPLP0 ribosomal protein, large, P0 -0.0280772
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0280271
AHNAK AHNAK nucleoprotein -0.0276954
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0274874
RBM39 RNA binding motif protein 39 -0.0272246
VCL vinculin -0.0268193
GNAS GNAS complex locus -0.0264274
RPS14 ribosomal protein S14 -0.0261828
RPL18 ribosomal protein L18 -0.0261748
CALR calreticulin -0.0261676
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0260213
LDHA lactate dehydrogenase A -0.0257718
RPL8 ribosomal protein L8 -0.025715
RPS11 ribosomal protein S11 -0.0256042
RPL38 ribosomal protein L38 -0.0255758
RPLP2 ribosomal protein, large, P2 -0.025512
EIF5B eukaryotic translation initiation factor 5B -0.0251603
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0250667
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0249687
RPL9 ribosomal protein L9 -0.0248883
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0248418
RPS23 ribosomal protein S23 -0.0247933
RUNX1 runt-related transcription factor 1 -0.0245429
PIBF1 progesterone immunomodulatory binding factor 1 -0.0244313
RPL36 ribosomal protein L36 -0.0242914
PERP PERP, TP53 apoptosis effector -0.0239376
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0237809
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0234745