Omeprazole (sodium)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole (sodium) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole (sodium)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.256315
HMGA2 high mobility group AT-hook 2 0.155051
COL6A2 collagen, type VI, alpha 2 0.115565
ATP13A3 ATPase type 13A3 0.109129
NDRG1 N-myc downstream regulated 1 0.101585
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0926609
TRIO trio Rho guanine nucleotide exchange factor 0.0790307
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0772992
DST dystonin 0.0768985
LOX lysyl oxidase 0.0768052
JARID2 jumonji, AT rich interactive domain 2 0.0758646
EEF2 eukaryotic translation elongation factor 2 0.0717452
COL6A1 collagen, type VI, alpha 1 0.0714207
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.070785
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0696194
SPAG9 sperm associated antigen 9 0.0624886
ADM adrenomedullin 0.060757
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0586625
VEGFA vascular endothelial growth factor A 0.0567636
ARHGAP21 Rho GTPase activating protein 21 0.0564823
MYH9 myosin, heavy chain 9, non-muscle 0.0559232
AKAP12 A kinase (PRKA) anchor protein 12 0.0545773
GOLGA4 golgin A4 0.0517221
STC1 stanniocalcin 1 0.0512006
TTC3 tetratricopeptide repeat domain 3 0.0499911
FMNL2 formin-like 2 0.0499277
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0478088
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0434947
MMP12 matrix metallopeptidase 12 0.0415386
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0407966
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0398438
TNS1 tensin 1 0.0384624
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0384196
FBN1 fibrillin 1 0.0379342
SEPTIN9 septin 9 0.0370023
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.03572
MCL1 myeloid cell leukemia 1 0.0349863
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0348547
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0343754
MYO10 myosin X 0.0343725
FNDC3A fibronectin type III domain containing 3A 0.0343667
MSN moesin 0.0341381
COL6A3 collagen, type VI, alpha 3 0.0326309
RUNX1 runt-related transcription factor 1 0.032559
TMEM165 transmembrane protein 165 0.0320905
TMF1 TATA element modulatory factor 1 0.0317091
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0311346
NAV1 neuron navigator 1 0.0307234
COG6 component of oligomeric golgi complex 6 0.0306675
LOXL2 lysyl oxidase-like 2 0.0304497
TIMP2 TIMP metallopeptidase inhibitor 2 0.0299993
DUSP10 dual specificity phosphatase 10 0.029812
ZCCHC7 zinc finger, CCHC domain containing 7 0.0296081
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0294442
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0292947
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0290753
MEIS1 Meis homeobox 1 0.0288306
UBA6 ubiquitin-like modifier activating enzyme 6 0.0281206
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0265335
NGLY1 N-glycanase 1 0.0261778
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0259579
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0257146
FGFR1 fibroblast growth factor receptor 1 0.0254314
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0253051
RND3 Rho family GTPase 3 0.0250131
RAI14 retinoic acid induced 14 0.0248541
CEMIP cell migration inducing protein, hyaluronan binding 0.0245704
SBF2 SET binding factor 2 0.0245477
PRRX1 paired related homeobox 1 0.0245143
FNIP1 folliculin interacting protein 1 0.0243077
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0242624
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.024248
SETD5 SET domain containing 5 0.0239944
CHD1 chromodomain helicase DNA binding protein 1 0.0238691
HIPK2 homeodomain interacting protein kinase 2 0.0235445
KDM4C lysine (K)-specific demethylase 4C 0.0235122
VEGFC vascular endothelial growth factor C 0.0233686
TGFBI transforming growth factor, beta-induced, 68kDa 0.0232061
CEP350 centrosomal protein 350kDa 0.0230093
DNER delta/notch-like EGF repeat containing 0.0228224
AMPD3 adenosine monophosphate deaminase 3 0.0227978
PRRC2C proline-rich coiled-coil 2C 0.022684
SLIT2 slit homolog 2 (Drosophila) 0.0226734
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0225989
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0225379
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0221509
ADAM9 ADAM metallopeptidase domain 9 0.02212
NOTCH2 notch 2 0.0219884
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0219255
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0218503
SEC31A SEC31 homolog A (S. cerevisiae) 0.0216432
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0214832
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0214284
KMT2E lysine (K)-specific methyltransferase 2E 0.0214248
ANKRD28 ankyrin repeat domain 28 0.0213159
FAM219A family with sequence similarity 219, member A 0.0213136
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0212714
KMT2C lysine (K)-specific methyltransferase 2C 0.0211789
SUCO SUN domain containing ossification factor 0.0211067
C1D C1D nuclear receptor corepressor 0.0209245

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.245967
VIM vimentin -0.141795
COL1A1 collagen, type I, alpha 1 -0.104743
INHBA inhibin, beta A -0.10329
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0979801
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0845501
TPT1 tumor protein, translationally-controlled 1 -0.0845436
PTMA prothymosin, alpha -0.079964
FTL ferritin, light polypeptide -0.0708801
AHNAK AHNAK nucleoprotein -0.0638869
RPS24 ribosomal protein S24 -0.0588705
RPL23 ribosomal protein L23 -0.0583271
RPL35A ribosomal protein L35a -0.0573204
TMSB10 thymosin beta 10 -0.0572476
MT2A metallothionein 2A -0.0542358
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0504531
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0487596
CANX calnexin -0.048438
NALF1 NALCN channel auxiliary factor 1 -0.0434099
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0433643
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0428477
ASPH aspartate beta-hydroxylase -0.0417003
TM4SF1 transmembrane 4 L six family member 1 -0.0416305
S100A6 S100 calcium binding protein A6 -0.0412457
GREM1 gremlin 1, DAN family BMP antagonist -0.0412117
RPLP1 ribosomal protein, large, P1 -0.0410323
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0409645
RPS13 ribosomal protein S13 -0.0391622
RPL9 ribosomal protein L9 -0.0380552
ALCAM activated leukocyte cell adhesion molecule -0.0372691
DLG1 discs, large homolog 1 (Drosophila) -0.0368754
ANXA2 annexin A2 -0.0365979
RPL34 ribosomal protein L34 -0.0363475
PDE4B phosphodiesterase 4B, cAMP-specific -0.0363439
RPS6 ribosomal protein S6 -0.0360097
H1-0 H1.0 linker histone -0.0320355
RPS8 ribosomal protein S8 -0.0318561
RPS23 ribosomal protein S23 -0.031811
SLC38A2 solute carrier family 38, member 2 -0.0315951
CALD1 caldesmon 1 -0.0315523
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0312207
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0309859
TPI1 triosephosphate isomerase 1 -0.030869
S100A10 S100 calcium binding protein A10 -0.0300235
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0298
TM9SF3 transmembrane 9 superfamily member 3 -0.0295738
HMGB1 high mobility group box 1 -0.0295588
RTN4 reticulon 4 -0.0287842
IER3 immediate early response 3 -0.0286175
ENO1 enolase 1, (alpha) -0.0285486
COL1A2 collagen, type I, alpha 2 -0.0282679
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0280689
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0279134
RPL12 ribosomal protein L12 -0.0278402
VDAC1 voltage-dependent anion channel 1 -0.0277896
TXNRD1 thioredoxin reductase 1 -0.0276806
RRBP1 ribosome binding protein 1 -0.0273797
RPS19 ribosomal protein S19 -0.0261776
RPL19 ribosomal protein L19 -0.0261272
KLF6 Kruppel-like factor 6 -0.0261143
YBX1 Y box binding protein 1 -0.0260344
PDIA4 protein disulfide isomerase family A, member 4 -0.0254554
RPS27A ribosomal protein S27a -0.0252893
CALU calumenin -0.0252478
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0252469
RPL32 ribosomal protein L32 -0.0251263
EIF1 eukaryotic translation initiation factor 1 -0.0251097
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0250488
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0248599
RPLP0 ribosomal protein, large, P0 -0.0242654
RPS15 ribosomal protein S15 -0.0240712
RPS21 ribosomal protein S21 -0.0238925
CENPF centromere protein F, 350/400kDa -0.0234848
CALR calreticulin -0.0231999
RPS25 ribosomal protein S25 -0.0223274
RPL31 ribosomal protein L31 -0.0223239
ARF1 ADP-ribosylation factor 1 -0.0222334
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0221957
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0221488
S100A9 S100 calcium binding protein A9 -0.0220406
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0220339
H3-3B H3.3 histone B -0.0216508
BIRC2 baculoviral IAP repeat containing 2 -0.0214003
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0213076
UBC ubiquitin C -0.0208875
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0202127
MORF4L2 mortality factor 4 like 2 -0.0202022
ADGRB3 adhesion G protein-coupled receptor B3 -0.0200527
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0199466
SLC38A1 solute carrier family 38, member 1 -0.019875
COL4A2 collagen, type IV, alpha 2 -0.0195195
CCDC47 coiled-coil domain containing 47 -0.0195179
ZBTB20 zinc finger and BTB domain containing 20 -0.019456
YME1L1 YME1-like 1 ATPase -0.0194354
MYL12B myosin, light chain 12B, regulatory -0.0194191
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0193903
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0193878
AFF4 AF4/FMR2 family, member 4 -0.0192856
RPL27 ribosomal protein L27 -0.0192725
RPLP2 ribosomal protein, large, P2 -0.0191095