Omeprazole_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FBN1 fibrillin 1 0.235015
LOX lysyl oxidase 0.14706
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.134604
COL5A2 collagen, type V, alpha 2 0.112813
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.112406
COL1A2 collagen, type I, alpha 2 0.109943
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.109198
AKAP12 A kinase (PRKA) anchor protein 12 0.0995496
LOXL2 lysyl oxidase-like 2 0.0995412
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0941045
SOD2 superoxide dismutase 2, mitochondrial 0.0921804
RSAD2 radical S-adenosyl methionine domain containing 2 0.0903577
COL8A1 collagen, type VIII, alpha 1 0.086713
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0843004
ANXA2 annexin A2 0.0806518
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0800853
UBC ubiquitin C 0.0789012
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0785725
COL3A1 collagen, type III, alpha 1 0.0762635
IQGAP1 IQ motif containing GTPase activating protein 1 0.0762593
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0745446
FNDC3B fibronectin type III domain containing 3B 0.0718266
CANX calnexin 0.0677553
IGFBP3 insulin-like growth factor binding protein 3 0.0650002
DST dystonin 0.062033
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0620151
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0586564
THBS2 thrombospondin 2 0.0585736
B2M beta-2-microglobulin 0.0582527
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0546107
SQSTM1 sequestosome 1 0.0540141
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0537273
MEIS2 Meis homeobox 2 0.0513867
DPYSL3 dihydropyrimidinase-like 3 0.0508301
TNIP1 TNFAIP3 interacting protein 1 0.0497266
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0491553
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0490713
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0477098
CALR calreticulin 0.0458534
AUTS2 autism susceptibility candidate 2 0.0455554
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0441975
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.043928
SAMD9 sterile alpha motif domain containing 9 0.043773
OPTN optineurin 0.0436661
ZBTB20 zinc finger and BTB domain containing 20 0.0435158
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0432934
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0425648
PSD3 pleckstrin and Sec7 domain containing 3 0.0418366
CD44 CD44 molecule (Indian blood group) 0.0414912
NFE2L1 nuclear factor, erythroid 2-like 1 0.0401609
HDLBP high density lipoprotein binding protein 0.0401328
APP amyloid beta (A4) precursor protein 0.0396133
IFIH1 interferon induced with helicase C domain 1 0.0380074
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0375049
ZEB2 zinc finger E-box binding homeobox 2 0.0373377
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0372014
KDM3A lysine (K)-specific demethylase 3A 0.0366837
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0366532
PDIA3 protein disulfide isomerase family A, member 3 0.0357558
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0357238
RIGI RNA sensor RIG-I 0.0343899
SFTPA2 surfactant protein A2 0.0338633
SPAG9 sperm associated antigen 9 0.0337808
CYLD cylindromatosis (turban tumor syndrome) 0.0333235
RTN4 reticulon 4 0.0329923
AHNAK AHNAK nucleoprotein 0.0324904
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0323421
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0322165
COPA coatomer protein complex, subunit alpha 0.0322147
ARL15 ADP-ribosylation factor-like 15 0.0319374
WDFY1 WD repeat and FYVE domain containing 1 0.0317274
CLU clusterin 0.0316384
FTH1 ferritin, heavy polypeptide 1 0.031611
MYH9 myosin, heavy chain 9, non-muscle 0.0313478
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0313276
XRN1 5'-3' exoribonuclease 1 0.0308972
OGA O-GlcNAcase 0.0307846
ARRDC3 arrestin domain containing 3 0.0307075
MX2 MX dynamin-like GTPase 2 0.0305857
LDHA lactate dehydrogenase A 0.03034
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.0299478
KIFAP3 kinesin-associated protein 3 0.0294199
BHLHE40 basic helix-loop-helix family, member e40 0.029404
CTSB cathepsin B 0.0293127
ELL2 elongation factor, RNA polymerase II, 2 0.0287512
CLIC4 chloride intracellular channel 4 0.0285781
ITPRID2 ITPR interacting domain containing 2 0.0285455
ATP13A3 ATPase type 13A3 0.0284449
SLFN5 schlafen family member 5 0.0282783
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0281871
GPC6 glypican 6 0.0281734
SVIL supervillin 0.0280909
VCL vinculin 0.0279466
AFF4 AF4/FMR2 family, member 4 0.0276953
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0274573
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0273178
MYOF myoferlin 0.0272012
KLF7 Kruppel-like factor 7 (ubiquitous) 0.026822
WARS1 tryptophanyl-tRNA synthetase 1 0.0267891
IFI16 interferon, gamma-inducible protein 16 0.0266468

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.230344
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.135389
MT2A metallothionein 2A -0.121289
PODXL podocalyxin-like -0.106415
VIM vimentin -0.10325
CDH13 cadherin 13 -0.0995835
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0788845
ABI3BP ABI family, member 3 (NESH) binding protein -0.0756063
SUCNR1 succinate receptor 1 -0.062974
SLC39A11 solute carrier family 39, member 11 -0.0625634
FN1 fibronectin 1 -0.0590336
CSTB cystatin B (stefin B) -0.0553706
S100A6 S100 calcium binding protein A6 -0.0548269
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0517287
PBX3 pre-B-cell leukemia homeobox 3 -0.0506377
LMNA lamin A/C -0.0492237
EFNA5 ephrin-A5 -0.0473964
PLAT plasminogen activator, tissue -0.0465938
TPT1 tumor protein, translationally-controlled 1 -0.0439305
PTMA prothymosin, alpha -0.0430115
EGFR epidermal growth factor receptor -0.042764
COL5A1 collagen, type V, alpha 1 -0.0394165
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0393886
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0376656
RPL37A ribosomal protein L37a -0.0367682
RPS6 ribosomal protein S6 -0.0360912
SEPTIN7 septin 7 -0.0337824
RPL23 ribosomal protein L23 -0.0331898
MAP1B microtubule-associated protein 1B -0.033054
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0322111
DGKG diacylglycerol kinase, gamma 90kDa -0.0319451
SEC61G Sec61 gamma subunit -0.0316218
PFN1 profilin 1 -0.0300949
RPL28 ribosomal protein L28 -0.0298592
CYTH3 cytohesin 3 -0.0298559
FLT1 fms-related tyrosine kinase 1 -0.0295786
RPL26 ribosomal protein L26 -0.0293152
PLXNA2 plexin A2 -0.0291697
S100A11 S100 calcium binding protein A11 -0.029118
RPL12 ribosomal protein L12 -0.0290531
FRMD4A FERM domain containing 4A -0.0290411
RPS19 ribosomal protein S19 -0.0285791
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0281652
SORBS2 sorbin and SH3 domain containing 2 -0.0272454
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0272146
RPLP2 ribosomal protein, large, P2 -0.0270091
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0264992
RPL36 ribosomal protein L36 -0.0264813
KRT81 keratin 81, type II -0.0256242
NAV1 neuron navigator 1 -0.0252591
FMN2 formin 2 -0.0252173
RPS8 ribosomal protein S8 -0.0252107
RPL35A ribosomal protein L35a -0.02521
MYADM myeloid-associated differentiation marker -0.0251499
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0250795
POTEF POTE ankyrin domain family, member F -0.0240173
KIAA1549L KIAA1549-like -0.0240051
IFITM3 interferon induced transmembrane protein 3 -0.0239014
S100A4 S100 calcium binding protein A4 -0.0235265
ASPH aspartate beta-hydroxylase -0.0235249
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0233862
MACF1 microtubule-actin crosslinking factor 1 -0.0233722
ANKRD11 ankyrin repeat domain 11 -0.0224354
RPLP1 ribosomal protein, large, P1 -0.0223821
SASH1 SAM and SH3 domain containing 1 -0.0222285
FTL ferritin, light polypeptide -0.0220195
TUBB4B tubulin, beta 4B class IVb -0.0220074
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0218855
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0218346
S100A10 S100 calcium binding protein A10 -0.02122
RPS12 ribosomal protein S12 -0.0209934
CD59 CD59 molecule, complement regulatory protein -0.0207865
ADARB1 adenosine deaminase, RNA-specific, B1 -0.020711
RPL35 ribosomal protein L35 -0.0204344
LRRC17 leucine rich repeat containing 17 -0.0203305
MT1X metallothionein 1X -0.019525
HSPB1 heat shock 27kDa protein 1 -0.0192133
RPL31 ribosomal protein L31 -0.0190817
RPS14 ribosomal protein S14 -0.0189348
DCLK2 doublecortin-like kinase 2 -0.0189251
TBCA tubulin folding cofactor A -0.0188153
RPS24 ribosomal protein S24 -0.0181189
RPS3 ribosomal protein S3 -0.0180016
DSTN destrin (actin depolymerizing factor) -0.0179915
RPL9 ribosomal protein L9 -0.0176764
MBNL1 muscleblind-like splicing regulator 1 -0.0173833
C12ORF75 chromosome 12 open reading frame 75 -0.0171072
CCND1 cyclin D1 -0.0170411
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0167802
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.016753
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0165929
POMP proteasome maturation protein -0.0162907
ISG15 ISG15 ubiquitin-like modifier -0.0162708
RPS17 ribosomal protein S17 -0.0161511
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.015986
LARP1B La ribonucleoprotein domain family, member 1B -0.015959
EIF5B eukaryotic translation initiation factor 5B -0.0158046
RPL27 ribosomal protein L27 -0.015626
HMGB1 high mobility group box 1 -0.0155312
FLNA filamin A, alpha -0.0153937