Omeprazole_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.147799
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.134288
PDE4D phosphodiesterase 4D, cAMP-specific 0.133838
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.121827
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.112516
CELF2 CUGBP, Elav-like family member 2 0.111501
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.111478
TENM3 teneurin transmembrane protein 3 0.0980691
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0877616
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0873682
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.07796
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0773775
MED13L mediator complex subunit 13-like 0.0745582
PCDH7 protocadherin 7 0.0745004
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0718667
MMP12 matrix metallopeptidase 12 0.0707049
ADGRG6 adhesion G protein-coupled receptor G6 0.0693862
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.068182
LMO7 LIM domain 7 0.0670301
XPO1 exportin 1 0.0659112
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0658668
ERRFI1 ERBB receptor feedback inhibitor 1 0.0653433
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0625022
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0620875
BIRC3 baculoviral IAP repeat containing 3 0.0610096
STARD4 StAR-related lipid transfer (START) domain containing 4 0.060513
IL6ST interleukin 6 signal transducer 0.0592639
TXNRD1 thioredoxin reductase 1 0.0583853
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0573431
NEK7 NIMA-related kinase 7 0.0572527
PCBP2 poly(rC) binding protein 2 0.0567346
ZBTB20 zinc finger and BTB domain containing 20 0.054851
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0547113
NLGN1 neuroligin 1 0.0544499
CXADR coxsackie virus and adenovirus receptor 0.0505287
PDGFC platelet derived growth factor C 0.0504985
KIF5B kinesin family member 5B 0.0504299
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0492222
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0483027
AXIN2 axin 2 0.0477159
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0465408
DPYD dihydropyrimidine dehydrogenase 0.0462913
BIRC2 baculoviral IAP repeat containing 2 0.0460598
CDK6 cyclin-dependent kinase 6 0.0459448
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0442593
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0438547
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0424238
USP9X ubiquitin specific peptidase 9, X-linked 0.0408122
EEF2 eukaryotic translation elongation factor 2 0.0407249
ECT2 epithelial cell transforming 2 0.0407006
PRKCI protein kinase C, iota 0.0405919
OXR1 oxidation resistance 1 0.0397864
ZNF217 zinc finger protein 217 0.0397293
TMEM41B transmembrane protein 41B 0.0392427
BIRC6 baculoviral IAP repeat containing 6 0.0389622
MPG N-methylpurine-DNA glycosylase 0.0378966
LDHA lactate dehydrogenase A 0.0378757
FXR1 fragile X mental retardation, autosomal homolog 1 0.0376986
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0375596
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0373243
HDLBP high density lipoprotein binding protein 0.0372323
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0371094
ETNK1 ethanolamine kinase 1 0.0370805
EIF4A2 eukaryotic translation initiation factor 4A2 0.0370654
TPI1 triosephosphate isomerase 1 0.0369239
PDE4B phosphodiesterase 4B, cAMP-specific 0.0368072
KDM3A lysine (K)-specific demethylase 3A 0.0367734
EXOC6B exocyst complex component 6B 0.0365554
AHNAK AHNAK nucleoprotein 0.0350891
ANXA1 annexin A1 0.0346252
ERBIN erbb2 interacting protein 0.03434
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0343241
SLC38A2 solute carrier family 38, member 2 0.0340416
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0339993
GJA1 gap junction protein, alpha 1, 43kDa 0.0336063
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0332518
EPHA6 EPH receptor A6 0.0330718
PLK2 polo-like kinase 2 0.0326828
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.032259
PGK1 phosphoglycerate kinase 1 0.0322467
DSPP dentin sialophosphoprotein 0.0321948
CLDN1 claudin 1 0.0321561
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0321405
TMEM131 transmembrane protein 131 0.0321088
GASK1B golgi associated kinase 1B 0.0320984
PEG10 paternally expressed 10 0.0318279
ADAM17 ADAM metallopeptidase domain 17 0.031418
MSH6 mutS homolog 6 0.0310827
USP34 ubiquitin specific peptidase 34 0.0308763
TNPO1 transportin 1 0.0305787
ANKRD28 ankyrin repeat domain 28 0.0305599
ATP11A ATPase, class VI, type 11A 0.0304053
THOC1 THO complex 1 0.0302718
NEBL nebulette 0.030258
YBX3 Y box binding protein 3 0.0299826
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0297426
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.029687
RICTOR RPTOR independent companion of MTOR, complex 2 0.0296424
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0295636
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.029448

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.131585
HMGA2 high mobility group AT-hook 2 -0.0807391
RAB7A RAB7A, member RAS oncogene family -0.0740329
FTL ferritin, light polypeptide -0.073119
RPS6 ribosomal protein S6 -0.0658046
ACTG1 actin gamma 1 -0.0647336
RPL37A ribosomal protein L37a -0.0628021
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0615508
RPL35A ribosomal protein L35a -0.0611096
EGR1 early growth response 1 -0.0598274
RPS12 ribosomal protein S12 -0.0572294
PTMA prothymosin, alpha -0.0540114
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0539614
TPT1 tumor protein, translationally-controlled 1 -0.0536228
RPS8 ribosomal protein S8 -0.0527992
RPS27A ribosomal protein S27a -0.0445907
RPS19 ribosomal protein S19 -0.0419051
RPLP1 ribosomal protein, large, P1 -0.0392201
RPLP2 ribosomal protein, large, P2 -0.0379888
RPL34 ribosomal protein L34 -0.0363434
GCG glucagon -0.0363066
EHBP1 EH domain binding protein 1 -0.0356667
INTS6 integrator complex subunit 6 -0.0354051
RPL26 ribosomal protein L26 -0.0341419
RPS3 ribosomal protein S3 -0.0338695
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0337394
LOC102724023 ES1 protein homolog, mitochondrial -0.0335842
AREG amphiregulin -0.0327932
RPL23 ribosomal protein L23 -0.0317856
RPL31 ribosomal protein L31 -0.0317403
RPS27 ribosomal protein S27 -0.0298413
RPS13 ribosomal protein S13 -0.0297758
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0296679
SLC38A1 solute carrier family 38, member 1 -0.0290759
RPS29 ribosomal protein S29 -0.0286787
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0284602
RPL36 ribosomal protein L36 -0.0274719
RPL12 ribosomal protein L12 -0.0269043
EIF1 eukaryotic translation initiation factor 1 -0.026858
RPL36A ribosomal protein L36a -0.0266859
SMC4 structural maintenance of chromosomes 4 -0.0266745
RPS23 ribosomal protein S23 -0.0258369
NAV3 neuron navigator 3 -0.0255152
RPL38 ribosomal protein L38 -0.0254139
HMGB1 high mobility group box 1 -0.0250554
CUX1 cut-like homeobox 1 -0.0244833
RPS16 ribosomal protein S16 -0.0241477
RPL37 ribosomal protein L37 -0.023837
THSD4 thrombospondin, type I, domain containing 4 -0.0233848
RPL9 ribosomal protein L9 -0.0230348
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0229155
RPS14 ribosomal protein S14 -0.0227422
TPM4 tropomyosin 4 -0.0225048
RPL19 ribosomal protein L19 -0.0224249
NHSL1 NHS-like 1 -0.0220423
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0218281
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0217182
RPL10A ribosomal protein L10a -0.0215152
S100A6 S100 calcium binding protein A6 -0.0214569
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.021166
ANKRD12 ankyrin repeat domain 12 -0.0206164
S100A10 S100 calcium binding protein A10 -0.0204648
HSPB1 heat shock 27kDa protein 1 -0.0202933
S100A11 S100 calcium binding protein A11 -0.0202771
LRRC23 leucine rich repeat containing 23 -0.0199979
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.019835
TBCA tubulin folding cofactor A -0.0197778
RPL28 ribosomal protein L28 -0.0195629
CNRIP1 cannabinoid receptor interacting protein 1 -0.0189781
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0188825
JMJD1C jumonji domain containing 1C -0.0186218
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0184554
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0181188
RPS25 ribosomal protein S25 -0.01787
PRDX1 peroxiredoxin 1 -0.0175136
EIF5B eukaryotic translation initiation factor 5B -0.0173503
HM13 histocompatibility (minor) 13 -0.017207
RPL11 ribosomal protein L11 -0.0171594
GNAS GNAS complex locus -0.0171254
BABAM2 BRISC and BRCA1 A complex member 2 -0.0170866
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0170747
RPS10 ribosomal protein S10 -0.0169576
RPS26 ribosomal protein S26 -0.0168747
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0168661
RPS4X ribosomal protein S4, X-linked -0.0164728
TAS2R14 taste receptor, type 2, member 14 -0.016259
RPL5 ribosomal protein L5 -0.0161686
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0158917
DDIT3 DNA-damage-inducible transcript 3 -0.0158404
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0157609
RPL7A ribosomal protein L7a -0.0157571
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0157151
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.015676
MT2A metallothionein 2A -0.0156564
JUN jun proto-oncogene -0.0156451
RPL27A ribosomal protein L27a -0.0154605
RPS2 ribosomal protein S2 -0.0154374
MYH15 myosin, heavy chain 15 -0.015303
TUBA1B tubulin, alpha 1b -0.0147994
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0144859