Omeprazole_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.149514
FMN1 formin 1 0.0758776
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0657929
VCL vinculin 0.0655827
DST dystonin 0.0627233
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0589689
SPTBN1 spectrin, beta, non-erythrocytic 1 0.058927
DSCAM Down syndrome cell adhesion molecule 0.0586672
FAM13A family with sequence similarity 13, member A 0.053027
EXT1 exostosin glycosyltransferase 1 0.0512722
MAP1B microtubule-associated protein 1B 0.0491535
ITPRID2 ITPR interacting domain containing 2 0.0478505
MEF2A myocyte enhancer factor 2A 0.0465205
HELZ helicase with zinc finger 0.0456699
ENO1 enolase 1, (alpha) 0.0446702
COL3A1 collagen, type III, alpha 1 0.0442738
FNBP1 formin binding protein 1 0.0433302
TRIB2 tribbles pseudokinase 2 0.0429404
PTPRD protein tyrosine phosphatase, receptor type, D 0.0428908
CDH10 cadherin 10, type 2 (T2-cadherin) 0.041381
SOS1 son of sevenless homolog 1 (Drosophila) 0.0409666
PCDH9 protocadherin 9 0.0406157
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.040541
PSD3 pleckstrin and Sec7 domain containing 3 0.0382486
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0378085
SLITRK6 SLIT and NTRK-like family, member 6 0.0367557
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0350945
ERRFI1 ERBB receptor feedback inhibitor 1 0.033962
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0333878
RGS4 regulator of G-protein signaling 4 0.0323602
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0315225
ZNF292 zinc finger protein 292 0.0305851
KDM3A lysine (K)-specific demethylase 3A 0.0302867
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0301422
YEATS2 YEATS domain containing 2 0.0300051
LSAMP limbic system-associated membrane protein 0.029946
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0298818
ZMIZ1 zinc finger, MIZ-type containing 1 0.0290122
ADGRB3 adhesion G protein-coupled receptor B3 0.0278009
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0271642
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0269158
MXI1 MAX interactor 1, dimerization protein 0.0266873
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0262554
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0261297
INSIG2 insulin induced gene 2 0.0258
APP amyloid beta (A4) precursor protein 0.0257312
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0255763
NPAS2 neuronal PAS domain protein 2 0.0251512
KLF7 Kruppel-like factor 7 (ubiquitous) 0.025132
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.024842
TOX thymocyte selection-associated high mobility group box 0.0246173
BBX bobby sox homolog (Drosophila) 0.0245027
SEC31A SEC31 homolog A (S. cerevisiae) 0.0240433
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0238308
TET2 tet methylcytosine dioxygenase 2 0.0237966
DLC1 DLC1 Rho GTPase activating protein 0.0234176
NES nestin 0.0233789
RALYL RALY RNA binding protein-like 0.0228445
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.022722
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0227182
CEP350 centrosomal protein 350kDa 0.0225605
ADGRG6 adhesion G protein-coupled receptor G6 0.0224081
EIF4A2 eukaryotic translation initiation factor 4A2 0.021976
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.02187
CSDE1 cold shock domain containing E1, RNA-binding 0.0216663
CADM1 cell adhesion molecule 1 0.0215705
SPAG9 sperm associated antigen 9 0.021504
PHF21A PHD finger protein 21A 0.0214999
MYH9 myosin, heavy chain 9, non-muscle 0.0214797
MACF1 microtubule-actin crosslinking factor 1 0.0214755
SEPTIN9 septin 9 0.0214006
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0212927
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0212753
HSPA8 heat shock 70kDa protein 8 0.0211632
MEIS2 Meis homeobox 2 0.0211227
GPC5 glypican 5 0.021116
CTNND1 catenin (cadherin-associated protein), delta 1 0.0211092
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.02105
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0207521
LINGO2 leucine rich repeat and Ig domain containing 2 0.0207069
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0205795
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0205443
TTC3 tetratricopeptide repeat domain 3 0.0205248
RSL1D1 ribosomal L1 domain containing 1 0.0204996
AFF3 AF4/FMR2 family, member 3 0.0204966
PDIA3 protein disulfide isomerase family A, member 3 0.0204661
AMOTL1 angiomotin like 1 0.0204365
IGFBP5 insulin-like growth factor binding protein 5 0.0202999
MYO9A myosin IXA 0.0202252
SDCBP syndecan binding protein (syntenin) 0.0200511
CEMIP2 cell migration inducing hyaluronidase 2 0.0199123
TET1 tet methylcytosine dioxygenase 1 0.0198377
ANO6 anoctamin 6 0.0198179
ADARB1 adenosine deaminase, RNA-specific, B1 0.019808
DUSP16 dual specificity phosphatase 16 0.0196172
DTNA dystrobrevin, alpha 0.0195662
MBNL1 muscleblind-like splicing regulator 1 0.0193815
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0193515
PGK1 phosphoglycerate kinase 1 0.0192804
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0191162

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.155646
PTMA prothymosin, alpha -0.143905
IGF2 insulin-like growth factor 2 -0.109212
RPS6 ribosomal protein S6 -0.100782
RPLP1 ribosomal protein, large, P1 -0.0972468
RPL35A ribosomal protein L35a -0.0946943
TMSB10 thymosin beta 10 -0.0822255
RPL34 ribosomal protein L34 -0.0787363
RPS19 ribosomal protein S19 -0.0785773
ACTG1 actin gamma 1 -0.0765102
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0739569
RPL19 ribosomal protein L19 -0.0729356
RPL38 ribosomal protein L38 -0.062861
TPT1 tumor protein, translationally-controlled 1 -0.0543629
RPS24 ribosomal protein S24 -0.0538459
RPL36 ribosomal protein L36 -0.05384
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0537703
NRG1 neuregulin 1 -0.0536554
RPS12 ribosomal protein S12 -0.0513028
VIM vimentin -0.0508719
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0482546
RPL26 ribosomal protein L26 -0.0469043
RPL12 ribosomal protein L12 -0.0458905
RPS8 ribosomal protein S8 -0.0446618
S100A9 S100 calcium binding protein A9 -0.0441619
RPS14 ribosomal protein S14 -0.0437084
RPS17 ribosomal protein S17 -0.0434453
RPL37A ribosomal protein L37a -0.0431334
TBX2 T-box 2 -0.0429414
RPL27 ribosomal protein L27 -0.041156
RPS29 ribosomal protein S29 -0.0411297
RPS27A ribosomal protein S27a -0.04078
RPS3 ribosomal protein S3 -0.0401231
FTL ferritin, light polypeptide -0.0399615
RPL31 ribosomal protein L31 -0.0392425
RPL28 ribosomal protein L28 -0.0388259
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0385014
RPL32 ribosomal protein L32 -0.0382192
RPL9 ribosomal protein L9 -0.0358039
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0356286
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0350959
PRRC2C proline-rich coiled-coil 2C -0.0346905
RPS25 ribosomal protein S25 -0.0338138
ANKRD12 ankyrin repeat domain 12 -0.0336745
DCAF7 DDB1 and CUL4 associated factor 7 -0.0335808
RPS23 ribosomal protein S23 -0.0333691
THSD4 thrombospondin, type I, domain containing 4 -0.0326482
RPS27 ribosomal protein S27 -0.0325519
RPL36A ribosomal protein L36a -0.0324314
RPL37 ribosomal protein L37 -0.0323254
ENAH enabled homolog (Drosophila) -0.030676
LMNA lamin A/C -0.0303967
RPL35 ribosomal protein L35 -0.0298495
GNAS GNAS complex locus -0.0295187
RPS11 ribosomal protein S11 -0.0286192
RPL7A ribosomal protein L7a -0.0285267
HMGB2 high mobility group box 2 -0.0278906
GREM2 gremlin 2, DAN family BMP antagonist -0.0273503
RPL30 ribosomal protein L30 -0.0267438
SOX4 SRY (sex determining region Y)-box 4 -0.0264396
RPL13A ribosomal protein L13a -0.0263044
NAP1L1 nucleosome assembly protein 1-like 1 -0.0262789
RPS20 ribosomal protein S20 -0.0261563
GATA3 GATA binding protein 3 -0.0260701
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0259581
EIF1 eukaryotic translation initiation factor 1 -0.0258613
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0257748
RPS5 ribosomal protein S5 -0.0256333
PIAS1 protein inhibitor of activated STAT, 1 -0.0255899
B2M beta-2-microglobulin -0.0254006
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0253993
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0251231
RPS15 ribosomal protein S15 -0.0248286
PNISR PNN-interacting serine/arginine-rich protein -0.0242711
RPL11 ribosomal protein L11 -0.0241994
RPS16 ribosomal protein S16 -0.0240482
WSB1 WD repeat and SOCS box containing 1 -0.0237132
RPL18 ribosomal protein L18 -0.0235977
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0233683
MX2 MX dynamin-like GTPase 2 -0.0231842
IGFBP3 insulin-like growth factor binding protein 3 -0.0231673
RACK1 receptor for activated C kinase 1 -0.0229538
BCAS3 breast carcinoma amplified sequence 3 -0.0227084
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0226901
RPLP2 ribosomal protein, large, P2 -0.0226252
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0225058
TPST1 tyrosylprotein sulfotransferase 1 -0.0224217
RPS21 ribosomal protein S21 -0.0219206
FBXL20 F-box and leucine-rich repeat protein 20 -0.0217765
NPEPPS aminopeptidase puromycin sensitive -0.021642
MT2A metallothionein 2A -0.0215475
CEMIP cell migration inducing protein, hyaluronan binding -0.0215376
SMC4 structural maintenance of chromosomes 4 -0.0215308
LDHB lactate dehydrogenase B -0.0209479
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0209417
RPL5 ribosomal protein L5 -0.0209
H3-3B H3.3 histone B -0.0206071
NALF1 NALCN channel auxiliary factor 1 -0.0200878
BTN3A3 butyrophilin, subfamily 3, member A3 -0.019946
ATF4 activating transcription factor 4 -0.0195392