Omeprazole_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.226109
FN1 fibronectin 1 0.213752
ERRFI1 ERBB receptor feedback inhibitor 1 0.174205
DSPP dentin sialophosphoprotein 0.141031
FNDC3B fibronectin type III domain containing 3B 0.0888871
PEG3 paternally expressed 3 0.0858621
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0767296
EHBP1 EH domain binding protein 1 0.0716308
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0692334
NPAS2 neuronal PAS domain protein 2 0.0669025
MAML2 mastermind-like 2 (Drosophila) 0.0648229
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0631964
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0626193
AKAP12 A kinase (PRKA) anchor protein 12 0.0625253
CP ceruloplasmin (ferroxidase) 0.0502329
DLC1 DLC1 Rho GTPase activating protein 0.0500401
GPC6 glypican 6 0.0500392
A2M alpha-2-macroglobulin 0.0499663
C3 complement component 3 0.0487648
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0478783
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0473455
LRMDA leucine rich melanocyte differentiation associated 0.0446177
TF transferrin 0.044261
DST dystonin 0.0438059
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0427283
PTPRM protein tyrosine phosphatase, receptor type, M 0.0421714
AHSG alpha-2-HS-glycoprotein 0.0408645
VCL vinculin 0.0396574
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0391542
SAMD4A sterile alpha motif domain containing 4A 0.0366005
EML4 echinoderm microtubule associated protein like 4 0.0359339
GMDS GDP-mannose 4,6-dehydratase 0.0347086
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0345781
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.031665
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0310166
SESTD1 SEC14 and spectrin domains 1 0.0301778
KDM7A lysine (K)-specific demethylase 7A 0.0287812
PLIN2 perilipin 2 0.0286728
SOX5 SRY (sex determining region Y)-box 5 0.0277464
EXT1 exostosin glycosyltransferase 1 0.0275451
ATP10A ATPase, class V, type 10A 0.0269214
GK glycerol kinase 0.0266806
PHF3 PHD finger protein 3 0.0266095
FMNL2 formin-like 2 0.0261046
ATXN1 ataxin 1 0.0260155
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0255634
CPE carboxypeptidase E 0.0255587
VEGFA vascular endothelial growth factor A 0.0249815
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0239176
ELL2 elongation factor, RNA polymerase II, 2 0.0235665
INSIG2 insulin induced gene 2 0.0232767
JMJD1C jumonji domain containing 1C 0.0231038
KIAA1217 KIAA1217 0.0229516
LYZ lysozyme 0.0227781
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0225107
RBM39 RNA binding motif protein 39 0.0218812
PTCHD4 patched domain containing 4 0.0216364
STK17A serine/threonine kinase 17a 0.0215778
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.021414
MTUS1 microtubule associated tumor suppressor 1 0.0213776
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0213198
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0210391
TNS1 tensin 1 0.020935
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0207396
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0206546
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.020342
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0200645
MALT1 MALT1 paracaspase 0.0200117
ZHX2 zinc fingers and homeoboxes 2 0.0198918
OSBPL10 oxysterol binding protein-like 10 0.0197338
WWC1 WW and C2 domain containing 1 0.019698
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0196172
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0195755
KIF1B kinesin family member 1B 0.0195693
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0194416
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0192679
CALD1 caldesmon 1 0.0189986
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0189834
PTBP3 polypyrimidine tract binding protein 3 0.0186944
RNF213 ring finger protein 213 0.0183254
KIF21A kinesin family member 21A 0.0177706
ESYT2 extended synaptotagmin-like protein 2 0.0176226
TFRC transferrin receptor 0.0174851
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0174308
TPST1 tyrosylprotein sulfotransferase 1 0.0173234
WDFY2 WD repeat and FYVE domain containing 2 0.0172577
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0172114
STC2 stanniocalcin 2 0.0171277
HP1BP3 heterochromatin protein 1, binding protein 3 0.0171212
KIF5B kinesin family member 5B 0.0170847
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0168973
FAM135A family with sequence similarity 135, member A 0.0168159
SETD5 SET domain containing 5 0.0167241
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0165313
FILIP1L filamin A interacting protein 1-like 0.0164213
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.016417
SCARB1 scavenger receptor class B, member 1 0.0163967
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0163027
TMEM123 transmembrane protein 123 0.015996
CAMTA1 calmodulin binding transcription activator 1 0.0159374

decreased expression

Symbol Name Standardized Value
RPS27A ribosomal protein S27a -0.127284
MT2A metallothionein 2A -0.119437
IGFBP1 insulin-like growth factor binding protein 1 -0.118603
UBC ubiquitin C -0.105185
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0897706
RPS12 ribosomal protein S12 -0.0886169
RPL37A ribosomal protein L37a -0.0804773
RPL23 ribosomal protein L23 -0.0777886
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0770948
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0756963
EEF2 eukaryotic translation elongation factor 2 -0.0706135
RPLP1 ribosomal protein, large, P1 -0.0695416
RPS8 ribosomal protein S8 -0.0659639
TMSB10 thymosin beta 10 -0.0632344
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0600922
RPS19 ribosomal protein S19 -0.0559827
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0553026
RPS24 ribosomal protein S24 -0.051551
RPS3 ribosomal protein S3 -0.0483648
ENO1 enolase 1, (alpha) -0.0480754
RPL34 ribosomal protein L34 -0.0452774
RPL5 ribosomal protein L5 -0.0442411
RPS6 ribosomal protein S6 -0.0426517
RPLP2 ribosomal protein, large, P2 -0.0419339
NAP1L1 nucleosome assembly protein 1-like 1 -0.0416771
RPL9 ribosomal protein L9 -0.0411056
JUN jun proto-oncogene -0.0396763
PTMA prothymosin, alpha -0.039375
SVIL supervillin -0.039049
RPL26 ribosomal protein L26 -0.0380081
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0373694
RPS29 ribosomal protein S29 -0.0373428
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0364142
APOE apolipoprotein E -0.0363639
RPS25 ribosomal protein S25 -0.0360418
TPT1 tumor protein, translationally-controlled 1 -0.0351241
CCL20 chemokine (C-C motif) ligand 20 -0.0344062
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0340873
RPS17 ribosomal protein S17 -0.0332881
KRT8 keratin 8, type II -0.0318436
RPL12 ribosomal protein L12 -0.0316985
RPL35A ribosomal protein L35a -0.0316577
RPL31 ribosomal protein L31 -0.0305476
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0304738
FTL ferritin, light polypeptide -0.0297608
RPS13 ribosomal protein S13 -0.0297062
RPL19 ribosomal protein L19 -0.0295226
RPS14 ribosomal protein S14 -0.0293995
RACK1 receptor for activated C kinase 1 -0.0292226
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0288995
RPL36 ribosomal protein L36 -0.0277129
RPS21 ribosomal protein S21 -0.027405
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0268535
EEF1G eukaryotic translation elongation factor 1 gamma -0.0266002
CFB complement factor B -0.0264505
RPL38 ribosomal protein L38 -0.0264228
ENAH enabled homolog (Drosophila) -0.0255605
RPS5 ribosomal protein S5 -0.0255424
RPL10A ribosomal protein L10a -0.0254642
LOC112694756 uncharaterized LOC112694756 -0.0253895
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0251414
RPS10 ribosomal protein S10 -0.0250862
ZFAND3 zinc finger, AN1-type domain 3 -0.0250216
RPL36A ribosomal protein L36a -0.0247972
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0245947
APOB apolipoprotein B -0.0242911
RRBP1 ribosome binding protein 1 -0.0242413
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0241448
BCL2L1 BCL2-like 1 -0.0240232
SOD2 superoxide dismutase 2, mitochondrial -0.0238901
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0238871
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0236866
RPL18 ribosomal protein L18 -0.0231712
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0229246
VMP1 vacuole membrane protein 1 -0.0228982
LCN2 lipocalin 2 -0.0224312
SDC4 syndecan 4 -0.0222762
RPS16 ribosomal protein S16 -0.0220755
MRTFA myocardin related transcription factor A -0.0217483
SMAD3 SMAD family member 3 -0.0215983
RPS27 ribosomal protein S27 -0.0211759
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0207333
KLF6 Kruppel-like factor 6 -0.0205417
MCL1 myeloid cell leukemia 1 -0.020514
B2M beta-2-microglobulin -0.0200698
S100A9 S100 calcium binding protein A9 -0.0199912
DIAPH1 diaphanous-related formin 1 -0.0198814
RPL11 ribosomal protein L11 -0.019668
CRLS1 cardiolipin synthase 1 -0.0194367
CELF1 CUGBP, Elav-like family member 1 -0.0194188
MARCKS myristoylated alanine-rich protein kinase C substrate -0.019407
RPL7A ribosomal protein L7a -0.0194053
RBM25 RNA binding motif protein 25 -0.0193642
RPL28 ribosomal protein L28 -0.0191986
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0191452
DOCK5 dedicator of cytokinesis 5 -0.019041
RPL35 ribosomal protein L35 -0.0188482
GPC3 glypican 3 -0.0188451
RPS23 ribosomal protein S23 -0.0187621
RPL27 ribosomal protein L27 -0.0183208